NCOG-17. FACTORS INFLUENCING POOR INDEPENDENCE LEVEL FOLLOWING RESECTION OF THE RIGHT TEMPORO-PARIETAL GLIOBLASTOMAS

Abstract In glioma surgeries, cognitive outcomes for the dominant hemisphere have gained much attention compared to the non-dominant hemisphere. For non-dominant hemispheric glioblastomas, we previously observed decreased independence level following glioblastoma resection of the posterior temporal to the parietal lobes. Here, we investigated the reason for the poor Karnofsky Performance Status (KPS) in such glioblastomas. A total of 41 patients with resection of the right cerebral hemispheric primary glioblastoma were enrolled for the study. Several kinds of neuropsychological functions and KPS of the brain regions were evaluated at pre- and postoperative 3 months by performing the Spearman’s correlation analysis and voxel-based lesion symptom mapping (VLSM). Additionally, the correlation between the resected volume of each gyrus or white matter tract and neuropsychological function score was analyzed. KPS at chronic phase (73.6) declined significantly compared with preoperation (81.0, p = 0.020). Functional factors influencing the KPS were general cognitive function, visuospatial cognition, emotion recognition, executive function, and apathy. The VLSM analysis revealed that the resection of the ventral parietal lobe and supramarginal gyrus (VPL-SMG) resulted in significantly poor KPS. Among the functional factors affecting KPS, VPL-SMG resection contributed to significantly lower scores in visuospatial cognition, emotion recognition, and apathy than those without resection (p = 0.0045, 0.047, and 0.0002, respectively). Further, we investigated whether the damage of the VPL-SMG could result in KPS related functional deficit. We found visuospatial cognition related to the posterior occipital lobe, SMG, arcuate fasciculus (AF), and dorsal superior longitudinal fasciculus, emotion recognition to the middle to inferior occipital gyrus and AF, and apathy to the inferior parietal lobe and middle temporal gyrus. We concluded that deficits of visuospatial cognition, emotion recognition, and apathy due to the damage of the cortical and white matter areas, including the VPL-SMG, were responsible for KPS of the non-dominant hemispheric glioblastomas.

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Emotion Recognition Deficits in Psychiatric Disorders as a Target of Non-invasive Neuromodulation: A Systematic Review

Clinical EEG and Neuroscience ◽

10.1177/1550059421991688 ◽

2021 ◽

pp. 155005942199168

Author(s):

Yuji Yamada ◽

Takuma Inagawa ◽

Naotsugu Hirabayashi ◽

Tomiki Sumiyoshi

Keyword(s):

Systematic Review ◽

Social Cognition ◽

Emotion Recognition ◽

Psychiatric Disorders ◽

Parietal Lobe ◽

Repetitive Transcranial Magnetic Stimulation ◽

Inclusion Criteria ◽

Cognitive Benefits ◽

The Right ◽

English Articles

Background. Social cognition deficits are a core feature of psychiatric disorders, such as schizophrenia and mood disorder, and deteriorate the functionality of patients. However, no definite strategy has been established to treat social cognition (eg, emotion recognition) impairments in these illnesses. Here, we provide a systematic review of the literature regarding transcranial direct current stimulation (tDCS) and repetitive transcranial magnetic stimulation (rTMS) for the treatment of social cognition deficits in individuals with psychiatric disorders. Methods. A literature search was conducted on English articles identified by PubMed, PsycINFO, and Web of Science databases, according to the guidelines of the PRISMA statement. We defined the inclusion criteria as follows: (1) randomized controlled trials (RCTs), (2) targeting patients with psychiatric disorders (included in F20-F39 of the 10th revision of the International Statistical Classification of Diseases and Related Health Problems [ICD-10]), (3) evaluating the effect of tDCS or rTMS, (4) reporting at least one standardized social cognition test. Results. Five papers (3 articles on tDCS and 2 articles on rTMS) met the inclusion criteria which deal with schizophrenia or depression. The significant effects of tDCS or rTMS targeting the left dorsolateral prefrontal cortex on the emotion recognition domain were reported in patients with schizophrenia or depression. In addition, rTMS on the right inferior parietal lobe was shown to ameliorate social perception impairments of schizophrenia. Conclusions. tDCS and rTMS may enhance some domains of social cognition in patients with psychiatric disorders. Further research is warranted to identify optimal parameters to maximize the cognitive benefits of these neuromodulation methods.

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Abnormal Functional Connectivity of Ventral Anterior Insula in Asthmatic Patients with Depression

Neural Plasticity ◽

10.1155/2017/7838035 ◽

2017 ◽

Vol 2017 ◽

pp. 1-11

Author(s):

Yuqun Zhang ◽

Yuan Yang ◽

Rongrong Bian ◽

Yingying Yin ◽

Zhenghua Hou ◽

...

Keyword(s):

Parietal Lobe ◽

Resting State Fmri ◽

Underlying Mechanism ◽

Anterior Insula ◽

Anterior Cingulate ◽

Middle Temporal Gyrus ◽

Asthmatic Patients ◽

Severity Of Depression ◽

The Right ◽

Left Middle Temporal Gyrus

Objective. To explore the underlying mechanism of depression in asthmatic patients, the ReHo in the insula and its FC was used to probe the differences between depressed asthmatic (DA) and nondepressed asthmatic (NDA) patients. Methods. 18 DA patients, 24 NDA patients, and 60 healthy controls (HCs) received resting-state fMRI scan, severity of depression, and asthma control assessment. Results. DA patients showed increased FC between the left ventral anterior insula (vAI) and the left middle temporal gyrus compared with both NDA and HC groups. In addition, compared with HCs, the DA and NDA patients both exhibited increased FC between the left vAI and the right anterior cingulate cortex (ACC), decreased FC between the left vAI and the bilateral parietal lobe, and increased FC between the right vAI and the left putamen and the right caudate, respectively. Furthermore, the increased FC between the left vAI and the right ACC could differentiate HCs from both DA and NDA patients, and the increased FC between the right vAI and both the left putamen and the right caudate could separate NDA patients from HCs. Conclusions. This study confirmed that abnormal vAI FC may be involved in the neuropathology of depression in asthma. The increased FC between the left vAI and the left MTG could distinguish DA from the NDA and HC groups.

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White Matter Abnormalities in Body Integrity Dysphoria

10.1101/2021.08.18.21262224 ◽

2021 ◽

Author(s):

Gianluca Saetta ◽

Kathy Ruddy ◽

Laura Zapparoli ◽

Martina Gandola ◽

Gerardo Salvato ◽

...

Keyword(s):

White Matter ◽

Diffusion Tensor ◽

Inferior Frontal Gyrus ◽

Structural Connectivity ◽

The Body ◽

Limb Amputation ◽

Middle Temporal Gyrus ◽

Imaging Data ◽

Severe Condition ◽

The Right

Body integrity dysphoria (BID) is a severe condition affecting non-psychotic individuals where a limb may be experienced as non-belonging, despite normal anatomical development and intact sensorimotor functions. Limb amputation is desired for restoring their own identity. We previously demonstrated altered brain structural (gray matter) and functional connectivity in 16 men with a long-lasting and exclusive desire for left leg amputation. Here we aimed to identify in the same sample altered patterns of white matter structural connectivity. Fractional anisotropy (FA), derived from Diffusion Tensor Imaging data, was considered as a measure of structural connectivity. Results showed reduced structural connectivity of: i) the right superior parietal lobule (rSPL) with the right cuneus, superior occipital and posterior cingulate gyri, and cuneus, ii) the pars orbitalis of the right middle frontal gyrus (rMFGOrb) with the putamen iii) the left middle temporal gyrus (lMTG) with the pars triangularis of the left inferior frontal gyrus. Increased connectivity was observed between the right paracentral lobule (rPLC) and the right caudate nucleus. By using a complementary method of investigation, we confirmed and extended previous results showing alterations in areas tuned to the processing of the sensorimotor representations of the affected leg (rPCL), and to higher-order components of bodily representation such as the body image (rSPL). Alongside this network for bodily awareness, other networks such as the limbic (rMFGOrb) and the mirror (lMTG) systems showed structural alterations as well. These findings consolidate current understanding of the neural correlates of BID, which might in turn guide diagnostics and rehabilitative treatments.

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Brain structures associated with reading and their abnormalities in dyslexia: a whole-brain analysis

10.1101/2020.03.27.011577 ◽

2020 ◽

Author(s):

T. Kujala ◽

A. Thiede ◽

P. Palo-oja ◽

P. Virtala ◽

M. Laasonen ◽

...

Keyword(s):

White Matter ◽

Grey Matter ◽

Neurodevelopmental Disorder ◽

Neuropsychological Testing ◽

Brain Structures ◽

Middle Temporal Gyrus ◽

Subcortical Structures ◽

Whole Brain ◽

Technical Reading ◽

The Right

AbstractDevelopmental dyslexia (DD) is a highly prevalent neurodevelopmental disorder, which often has a devastating influence on the individual’s academic achievement and career. Research on the neural origins of DD has continued for half a century, yielding, however, inconsistent results. The current study was set out to determine abnormalities of grey and white matter volumes in adults with DD and to shed light on neural architectures associated with reading and related skills. To this end, we conducted a whole-brain voxel based morphometry following current recommendations on analysis approaches, coupled with rigorous neuropsychological testing, to characterize the associations between neuroanatomy and skills vital for reading in DD. We found decreased volumes of grey matter in DD, comprising a left-hemispheric network including superior temporal and inferior frontal gyri, insula, the limbic system, and basal ganglia, and white matter, including the right middle temporal gyrus and hippocampus, as well as the right precuneus. These results are both consistent with the most robust previous findings on cortical abnormalities in DD and yield novel insight to the role of subcortical structures in DD, scarcely studied so far. Crucially, areas with decreased grey matter in DD overlapped with brain areas associated with technical reading skills. This supports the conclusion that the grey matter regions that we identified to have a low volume in DD are associated with the core areas vital for reading.

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Using EEG and MEG to characterize extreme delta brush in a patient with anti-NMDA receptor encephalitis

BMC Neurology ◽

10.1186/s12883-021-02157-0 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Ailiang Miao ◽

Yongwei Shi ◽

Jing Xiang ◽

Xiaoshan Wang ◽

Jianqing Ge ◽

...

Keyword(s):

Parietal Lobe ◽

Inferior Frontal Gyrus ◽

Brain Regions ◽

Middle Temporal Gyrus ◽

Beta Activity ◽

Delta Wave ◽

Nmda Receptor Encephalitis ◽

Nmdar Encephalitis ◽

Potential Marker ◽

The Right

Abstract Background Extreme delta brush (EDB) is considered a potential marker for anti-N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis. The brain regions involved in EDB are unclear. Case presentation A 16-year-old woman with anti-NMDAR encephalitis who was experiencing psychosis was admitted. Electroencephalography (EEG) and magnetoencephalography (MEG) were used to analyze EDB in the patient. EDB on EEG could be disturbed by opening and closing the eyes, by occipital alpha rhythms and by sleep-wake cycles. The MEG results showed beta activity originating from bilateral superior parietal lobes. However, the delta wave originated from bilateral superior temporal gyri, the right middle temporal gyrus, the right inferior frontal gyrus, and the left inferior parietal lobe. Conclusions Delta wave and beta activity might originate from different brain regions. Beta activity might be transmitted forward to the frontotemporal lobe and superimposed with delta activity to form EDB on EEG.

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Fatigue in multiple sclerosis is associated with the disruption of frontal and parietal pathways

Multiple Sclerosis Journal ◽

10.1177/1352458508098373 ◽

2009 ◽

Vol 15 (3) ◽

pp. 337-344 ◽

Cited By ~ 119

Author(s):

J Sepulcre ◽

JC Masdeu ◽

J Goñi ◽

G Arrondo ◽

N Vélez de Mendizábal ◽

...

Keyword(s):

Multiple Sclerosis ◽

White Matter ◽

Gray Matter ◽

Parietal Lobe ◽

White Matter Lesion ◽

Lesion Load ◽

Attentional Processes ◽

Fatigue Score ◽

Gray Matter Atrophy ◽

The Right

Background Fatigue is one of the most frequent and disturbing symptoms in multiple sclerosis (MS), directly affecting the patient’s quality of life. However, many questions remain unclear regarding the anatomic brain correlate of MS-related fatigue. Objective To assess the relationship between fatigue and white matter lesion location and gray matter atrophy. Methods In this study, 60 patients with MS were evaluated with the Modified Fatigue Impact Scale and magnetic resonance imaging. Location of white matter lesion was analyzed using a voxel-by-voxel lesion probability mapping approach and gray matter atrophy degree and location using an optimized voxel-based morphometry method. Results We found a correlation between lesion load and fatigue score (T2 lesion load: r = 0.415, P = 0.001; T1 lesion load r = 0.328, P = 0.011). Moreover, fatigue correlated with lesions in the right parietotemporal (periatrial area, juxtaventricular white matter deep in the parietal lobe and callosal forceps) and left frontal (middle-anterior corpus callosum, anterior cingulum and centrum semiovale of the superior and middle frontal gyri) white matter regions ( P < 0.001 in all cases). Finally, fatigue score significantly correlated with gray matter atrophy in frontal regions, specifically, the left superior frontal gyrus and bilateral middle frontal gyri ( P < 0.001 in all cases). Conclusion Our results suggest that the symptom of fatigue is associated with a disruption of brain networks involved in cognitive/attentional processes.

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Association of venous varix and developmental venous anomaly: report of a case and review of literature

BMJ Case Reports ◽

10.1136/bcr-2018-228067 ◽

2019 ◽

Vol 12 (3) ◽

pp. e228067

Author(s):

Suprava Naik ◽

Sanjeev K Bhoi

Keyword(s):

White Matter ◽

Parietal Lobe ◽

Symptomatic Treatment ◽

Developmental Venous Anomaly ◽

Mri Findings ◽

Cortical Vein ◽

Vascular Flow ◽

Flow Void ◽

The Right ◽

Venous Varix

Cerebral developmental venous anomalies (DVAs) are the most frequently encountered cerebral vascular malformation. Most are asymptomatic and incidentally detected. Here we present a case of DVA associated with venous varix presented with chronic headache. A 50-year-old woman presented with right hemicranial headache since 6 months. There was no neurological deficit. MRI showed a well-defined oval T2 hyperintense, T1 isointense extra-axial lesion in the right parietal region showing intense homogeneous enhancement. Prominent vascular flow void was extending from the lesion up to the deep parietal white matter. Subtle thin linear areas of blooming noted in the parietal white matter converging towards the vascular flow void. The venous sac is in communication with the cortical vein draining to the superior sagittal sinus. These MRI findings favoured a diagnosis of DVA in the right parietal lobe with prominent draining vein forming a cortical venous varix. The patient was managed conservatively with symptomatic treatment for headache.

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Right Superior Temporal Gyrus Altered Functional Activity in Patients With Definite Vestibular Migraine

10.21203/rs.3.rs-1206351/v1 ◽

2022 ◽

Author(s):

Xu Yang ◽

Zhe-Yuan Li ◽

Li-Hong Si ◽

Bo Shen ◽

Xia Ling

Keyword(s):

Frontal Lobe ◽

Temporal Lobe ◽

Functional Activity ◽

Cluster Size ◽

Parietal Lobe ◽

Brain Activity ◽

Superior Temporal Gyrus ◽

Vestibular Migraine ◽

Middle Temporal Gyrus ◽

The Right

Abstract The study aimed to investigate resting-state functional brain activity alterations in patients with definite vestibular migraine (dVM). Seventeen patients with dVM, 8 patients with migraine, 17 health controls (HCs) were recruited. The amplitude of low frequency fluctuation (ALFF), fractional ALFF (fALFF) and regional homogeneity (ReHo) were calculated to observe the changes in spontaneous brain activity. Then brain regions with altered fALFF were selected for seed-based functional connectivity analysis. Compared with HCs, VM patients showed significantly increased ALFF values in the right temporal lobe (Cluster size = 91 voxels, P=0.002, FWE corrected), and significantly increased ReHo values in the right superior temporal gyrus (STG), middle temporal gyrus (MTG) and inferior temporal gyrus (ITG) (Cluster size = 136 voxels, P=0.013, FWE corrected). Compared with patients with migraine, patients with VM showed significantly increased fALFF values in the right parietal lobe (Cluster size = 43 voxels, P=0.011, FWE corrected) and right frontal lobe (Cluster size =36 voxels, P=0.026, FWE corrected), significantly increased ReHo values in the right thalamus (Cluster size = 92 voxels, P=0.043, FWE corrected). Our findings documented that patients with VM showed enhanced spontaneous functional activity in the right temporal lobe (STG, MTG, and ITG) compared with HCs, and increased spontaneous activity in the right parietal lobe-frontal lobe-thalamus compared with patients with migraine. Patients with VM and migraine both had altered brain function, but the regions involved are different.

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White matter sexual dimorphism of the adult human brain

Translational Neuroscience ◽

10.1515/tnsci-2017-0009 ◽

2017 ◽

Vol 8 (1) ◽

Cited By ~ 6

Author(s):

Ali K. Bourisly ◽

Grace Gejo ◽

Abrar A. Hayat ◽

Lamya Alsarraf ◽

Fatima M. Dashti ◽

...

Keyword(s):

Sexual Dimorphism ◽

White Matter ◽

Parietal Lobe ◽

Brain Regions ◽

Brain Images ◽

Brain White Matter ◽

Significant Difference ◽

Males And Females ◽

The Right ◽

Mri Brain Images

AbstractSex-biased psychophysiology, behavior, brain function, and conditions are extensive, yet underlying structural brain mechanisms remain unclear. There is contradicting evidence regarding sexual dimorphism when it comes to brain structure, and there is still no consensus on whether or not there exists such a dimorphism for brain white matter. Therefore, we conducted a voxel-based morphometry (VBM) analysis along with global volume analysis for white matter across sex. We analyzed 384 T1-weighted MRI brain images (192 male, 192 female) to investigate any differences in white matter (WM) between males and females. In the VBM analysis, we found males to have larger WM, compared to females, in occipital, temporal, insular, parietal, and frontal brain regions. In contrast, females showed only one WM region to be significantly larger than males: the right postcentral gyrus in the parietal lobe region. Although, on average, males showed larger global WM volume, we did not find any significant difference in global WM volume between males and females.

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The white matter network in cognitive normal elderly predict the rate of cognitive decline

10.1101/2020.04.16.044479 ◽

2020 ◽

Author(s):

Weijie Huang ◽

Ni Shu

Keyword(s):

Diffusion Tensor Imaging ◽

White Matter ◽

Cognitive Decline ◽

Parietal Lobe ◽

Diffusion Tensor ◽

Cognitive Changes ◽

Cognitive Domains ◽

Age Related ◽

The Right ◽

White Matter Connectivity

AbstractWhite matter degradation has been proposed as one possible explanation for age-related cognitive decline. The human brain is, however, a network and it may be more appropriate to relate cognitive functions to properties of the network rather than specific brain regions. Cognitive domains were measured annually (mean follow-up = 1.25 ± 0.61 years), including processing speed, memory, language, visuospatial, and executive functions. Diffusion tensor imaging was performed at baseline in 90 clinically normal older adults (aged 54–86). We report on graph theory-based analyses of diffusion tensor imaging tract-derived connectivity. The machine learning approach was used to predict the rate of cognitive decline from white matter connectivity data. The reduced efficacy of white matter networks could predict the performance of these cognitive domains except memory. The predicted scores were significantly correlated with the real scores. For the local regions for predicting the cognitive changes, the right precuneus, left inferior parietal lobe and cuneus are the most important regions for predicting monthly change of executive function; some left partial and occipital regions are the most important for the changed of attention; the right frontal and temporal regions are the most important for the changed of language. Our findings suggested that the global white matter connectivity characteristics are the valuable predictive index for the longitudinal cognitive decline. For the first time, topological efficiency of white matter connectivity maps which related to special domains of cognitive decline in the elderly are identified.

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