scholarly journals MET-4 Clinical investigation of the cases recurred as dissemination after postoperative local irradiation for metastatic brain tumors

2021 ◽  
Vol 3 (Supplement_6) ◽  
pp. vi25-vi25
Author(s):  
Tetsuo Hashiba ◽  
Katsuya Ueno ◽  
Nobuaki Naito ◽  
Natsumi Yamamura ◽  
Yumiko Komori ◽  
...  
Keyword(s):  
Clinical Investigation ◽  
Observation Interval ◽  
Recurrence Pattern ◽  
Local Irradiation ◽  
Whole Brain Irradiation ◽  
Female Ratio ◽  
Brain Irradiation ◽  
Male Female Ratio ◽  
Postoperative Irradiation ◽  
One Year

Abstract Last year, the authors examined the outcome of the patients with metastatic brain tumor (MBT)treated by whole-brain irradiation (WBRT)or local irradiation (LRT)after surgery. As a result, it was shown that the overall survival (OS) was same but the recurrence pattern was different. Furthermore, it was shown that there were some cases with disseminated recurrence in the LRT group. One year has passed, cases showing disseminated recurrence after LRT were examined. The subjects were 28 patients for whom LRT was selected as post-surgical irradiation since December 2017, with an average age of 66.2 years and a male-female ratio of 19: 9. Non-small cell lung cancer was the most in 17 cases. During the observation period, recurrence was observed in 12 cases, new outbreaks at other sites in 8 cases, disseminated recurrence in 4 cases, and no local recurrence. There was no clear difference in kinds of carcinoma and removal fashion between disseminated recurrence cases and other cases. Disseminated recurrence occurred between 3–10 months after surgery, 2 presented with headache, 1 with convulsions, 1 confirmed during follow-up of images, and all underwent WBRT. The lesions shrank after irradiation, but they were easy to re-grow, and the prognosis was poor. On the other hand, 10 cases died in 24 cases other than disseminated recurrence, but all cases died of primary cancer. Although LRT after surgery is non-inferior to WBRT in terms of OS and has the advantage of maintaining cognitive function, this study shows that there is a considerable risk of disseminated recurrence regardless of the removal fashion or kinds of carcinoma. It was also shown that prognosis after disseminated recurrence was poor. It is desirable to select postoperative irradiation after explaining the recurrence pattern, and when LRT is adopted, it is necessary to consider setting a short observation interval immediately after irradiation.

scholarly journals Role of Multidetector Computerised Tomography in Evaluation of Proptosis

2019 ◽  
Vol 9 (2) ◽  
pp. 24-31
Author(s):  
Elina Shrestha ◽  
Narayan Bikram Thapa ◽  
Shankar Bahadur Singh Rajbhandari
Keyword(s):  
Predictive Value ◽  
Clinical Information ◽  
Cross Sectional Study ◽  
Computerised Tomography ◽  
Cross Sectional ◽  
Female Ratio ◽  
Male Female Ratio ◽  
One Year ◽  
Female Male Female

Introduction: Proptosis is defined as bulging of eye anteriorly out of the orbit. Our main objective was to analyze the pattern of computerised tomographic findings in evaluation of proptosis. Computerised tomography (CT) is noninvasive, easily accessible, affordable and reliable imaging which helps in early diagnosis and prompt treatment. Methods: A descriptive cross sectional study of total 58 patients presenting with proptosis referred to our department of radiology for computerised tomography evaluation during one year period were undertaken into study. The clinical information provided by ophthalmologist also helped our study to derive into conclusion. SPSS version 20 software was used for statistical data analysis. Results: Out of 58 patients, the most common cause of proptosis was neoplasm constituting of 25 cases (43.1%). Retinoblastoma was the commonest orbital tumor. Out of remaining cases, 15 (25.8%) were infective, 14 (24.1%) were inflammatory, two (3.44%) were traumatic and remaining two cases (3.44%) had no definitive cause for proptosis. Bilateral proptosis was commonly associated with thyroid ophthalmopathy. Among the subjects 32 were male, 26 were female. Male: Female ratio was 1:1.23. Age group was ranging from 1 month to 73 years.Mean age was 26.4 ± 22 years. Conclusions: Computerised tomography has an important role in distinguishing the different types of lesions based on their characteristics, location and extension prior to undertaking definitive surgical and medical treatment. Overall accuracy of CT in our study was 81%, sensitivity of 82.6%, specificity of 80.6%, positive predictive value of 76% and negative predictive value of 86.2%.

scholarly journals Camouflage effects following resin infiltration of postorthodontic white-spot lesions in vivo: One-year follow-up

2015 ◽  
Vol 85 (3) ◽  
pp. 374-380 ◽  
Author(s):  
Amely Eckstein ◽  
Hans-Joachim Helms ◽  
Michael Knösel
Keyword(s):  
White Spot ◽  
White Spot Lesions ◽  
Female Ratio ◽  
Significance Level ◽  
Resin Infiltration ◽  
Male Female Ratio ◽  
The Difference ◽  
One Year

ABSTRACT Objective:  To assess camouflage effects by concealment of postorthodontic white-spot lesions (WSLs) to sound adjacent enamel (SAE) achieved over 12 months with resin infiltration (Icon, DMG, Hamburg, Germany). Methods:   Twenty subjects (trial teeth nteeth = 111) who had received resin infiltration treatment of noncavitated postorthodontic WSLs were contacted for a 1-year follow-up assessment of CIE-L*a*b* colors (T12). Color and lightness (CIE-L*a*b*) data for WSLs and SAE were compared to baseline data assessed before infiltration (T0) and those assessed after 6 months (T6), using a spectrophotometer. The target parameter was the difference between the summarized color and lightness values (ΔEWSL/SAE). Intergroup (WSL, SAE) and intertime comparisons (T0 vs T6, T12) were performed using paired t-tests at a significance level of α = 5%. Results:  Nine subjects (trial teeth nteeth = 49; male/female ratio 5/4; age range 13–19 years) were available at T12. After the highly significant reduction of ΔEWSL/SAE discrepancies between T0 and T6, analysis of 12-month records revealed color and lightness discrepancy of WSL vs SAE that was significantly decreased compared with baseline, indicating an assimilation of WSL color to SAE appearance after infiltration, while an additional reduction of discrepancies between T6 and T12 was not significant. Conclusion:  As color and lightness characteristics of the Icon infiltrant as well as the esthetic camouflage effects achieved by WSL infiltration were not altered significantly or clinically relevant after 12 months, the method of resin infiltration can be recommended for an enduring esthetic improvement of postorthodontic WSL. (Angle Orthod. 2015;85:374–380.)

scholarly journals Clinical benefits of surgical management of concha bullosa

2017 ◽  
Vol 3 (4) ◽  
pp. 833 ◽  
Author(s):  
Kulwinder Singh Mehta ◽  
Aamir Yousuf ◽  
Iftikhar Ali Wazir ◽  
Kouser Sideeq
Keyword(s):  
Surgical Management ◽  
Nasal Obstruction ◽  
Facial Pain ◽  
Anatomical Variation ◽  
Concha Bullosa ◽  
Female Ratio ◽  
Male Female Ratio ◽  
Clinical Benefits ◽  
Proper Diagnosis ◽  
One Year

<p class="abstract"><strong>Background:</strong> <span lang="EN-IN">Concha bullosa is a common anatomical variation in nasal cavity, responsible for headache, Rhinogenic origin is an important cause for headache wrongly managed now a day, which may be treated by medical or surgical intervention, proper diagnosis and patient’s selection is very important to achieve good results with surgery of CB. The aim of this study is to evaluate the efficacy and assess the clinical benefits outcome results of our endoscopic turbinoplasty technique for CB. </span></p><p class="abstract"><strong>Methods:</strong> <span lang="EN-IN">This study was done in SMHS GMC Srinagar for a period of one year and about 30 patients with mild/moderate DNS and associated CB with symptoms of facial pain, head ache, nasal obstruction, anosmia, recurrent rhinitis were selected for surgical management and symptoms assessment was done using VAS.  </span></p><p class="abstract"><strong>Results:</strong> <span lang="EN-IN">The 30 patient group with 1: 1 male: female ratio predominatly in 3<sup>rd</sup> decade of life presented with nasal obstruction more on concha bullosa side, 26 with facial pain and 27 patients with head ache and nasal obstruction, anosmia/hyposmia in 20 and recurrent rhinitis in 26. There was statistical significant benefit on symptoms score in patients managed with endoscopic chonchoplasty. </span></p><p class="abstract"><strong>Conclusions:</strong> <span lang="EN-IN">The endoscopic turbinoplasty is safe and efficacious procedure for concha bullosa and is causuative factor for rhinogenic origin of headache and facial pain.</span></p>

scholarly journals Cognitive Dysfunction and Histological Findings in Adult Rats One Year After Whole Brain Irradiation.

2001 ◽  
Vol 41 (12) ◽  
pp. 590-598 ◽  
Author(s):  
Katsuhiko AKIYAMA ◽  
Ryuichi TANAKA ◽  
Mitsuya SATO ◽  
Norio TAKEDA
Keyword(s):  
Cognitive Dysfunction ◽  
Histological Findings ◽  
Whole Brain Irradiation ◽  
Adult Rats ◽  
Whole Brain ◽  
Brain Irradiation ◽  
One Year

scholarly journals A profile of poisoning in pediatric population in rural hospital in Jammu

2021 ◽  
Vol 10 (9) ◽  
pp. 1106
Author(s):  
Niraj Kumar ◽  
Shallini Gupta ◽  
Sanjeev Sharma ◽  
Vikram Gupta
Keyword(s):  
Pediatric Population ◽  
Public Awareness ◽  
Food Poisoning ◽  
Pediatric Emergency ◽  
Acute Poisoning ◽  
Favourable Outcome ◽  
Female Ratio ◽  
Male Female Ratio ◽  
One Year ◽  
Poisoning In Children

Background: Acute poisoning is one of the commonest Pediatric emergencies and an important cause of morbidity and mortality. This study is aimed at understanding the incidence, aetiology and manner of poisoning, outcome among children less than 18 years reporting to Pediatric department at sub district Hospital level in Jammu region.Methods: All the children between one month and eighteen years of age reporting to the Pediatric Emergency of SDH Akhnoor, Jammu over a period of one year as a case of acute poisoning were included in the study. The information obtained from subjects/parents/guardians and examinations of subjects was recorded on a pretested proforma and analyzed.Results: A total of 150 patients were admitted as a case of poisoning over a study period of one year. Male: Female ratio was 1.41:1. Total incidence rate was 2.94/100 0 population over a period of one year. Majority of the cases were accidental (94.67%) while suicidal attempt cases were 5.33%. Most the cases (49.33%) were due to accidental ingestion of household products followed by drug ingestion (21.33%), food poisoning (14%) and then agricultural/industrial products (8%). Maximum patients (86.6%) recovered while 2% referred to higher centre and rest 11.3% either absconded or lost to follow up.Conclusions: Acute poisoning in children is usually accidental with favourable outcome. Death can happen depending upon nature of poison and the stage at which the patient is brought to the hospital. Poisoning can be prevented by increasing public awareness, counselling and right guidance to the parents. 

scholarly journals Non-fatal drowning in under-five rural children of Bangladesh

2016 ◽  
Vol 9 (2) ◽  
pp. 37-41 ◽  
Author(s):  
Syed Hassan Abdullah ◽  
Meerjady Sabrina Flora
Keyword(s):  
Health Centre ◽  
Open Water ◽  
Water Source ◽  
Rural Children ◽  
Female Ratio ◽  
Medical Response ◽  
Environmental Attributes ◽  
Total Respondent ◽  
Male Female Ratio ◽  
One Year

Drowning has been identified as a major cause of death in children in both developed and developing countries. Non-fatal drowning is several times higher than the fatal drowning. To describe the socio-demographic and environmental attributes of non-fatal drowning in rural children this community based descriptive study was conducted on 122 children having non-fatal drowning events within one year of study period. This study was undertaken in Raigonj sub-district of Sirajgonj district in Bangladesh. Mothers of those children were interviewed using a structured questionnaire. Out of all participants 56.6% children were 2-4 years of age and male-female ratio was almost equal. Of the total respondent mothers 55% were illiterate and 41.8% were below the age of 25 years. Seasonal variation was observed in non-fatal drowning. Rainy season (50.8%) appeared as the most risky period followed by summer (29.5%). Higher incidence occurred (53.3%) between 10 am to 2 pm of the day. Although most of the drowning occurred outside the home, 9% drowning occurred in water container (like drum, tub) within the home. Pond (50.5%) was found as the most common place among open water source. During the occurrence, 23% child was not accompanied by parents or any caregivers. At the time of drowning, 47.5% mothers were engaged with usual household work and were not present at the place of occurrence whereas 13% mothers were present around the place of occurance. Before drowning, 45.1% victim was either playing, bathing or swimming in the water. Only 10.7% needed resuscitation, 25% were taken to health centre and reached the health centre within an hour, about a fifth (22.6%) of them were admitted. Restriction in dangerous water activities, strengthening supervision of children might decrease the incidence of drowning while quick and effective medical response might prevent its fatal consequences.Ibrahim Med. Coll. J. 2015; 9(2): 37-41

scholarly journals Clinico-epidemiological study of leprosy from a North Indian tertiary care hospital

2018 ◽  
Vol 4 (4) ◽  
pp. 518
Author(s):  
Mohammad Adil ◽  
Syed Suhail Amin ◽  
Mohd Mohtashim ◽  
Sabha Mushtaq ◽  
Mehtab Alam ◽  
...  
Keyword(s):  
Urban Areas ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Public Health Problem ◽  
Lepromatous Leprosy ◽  
Care Hospital ◽  
Female Ratio ◽  
Male Female Ratio ◽  
One Year ◽  
Epidemiological Characteristics

<p class="abstract"><strong>Background:</strong> Leprosy was eliminated as a public health problem in India in 2005. Yet, more than 60% of all new cases of leprosy are reported from India.</p><p class="abstract"><strong>Methods:</strong> A retrospective analysis of the records of patients attending the leprosy clinic of the Dermatology Out Patient Department was done for a period of one year from May 2017 to April 2018. The data was analysed for clinical and epidemiological characteristics of the patients.<strong></strong></p><p class="abstract"><strong>Results:</strong> A total of 225 patients visited the leprosy clinic during the study period. Almost half of all patients (47.1%) were aged between 21-40 years. Among the patients were 32 children (14.2%) below 16 years. There were 60 patients (26.6%) suffering from paucibacillary disease and 158 patients (70.2%) had multibacillary disease. Seven patients (3.2%) presented with other forms of leprosy like historic leprosy and pure neuritic leprosy. Borderline lepromatous leprosy was found to be the commonest subtype seen in 86 patients (38.2%). There were 152 males (67.6%) and 73 females (32.4%). The male female ratio was 2.08:1. A total of 118 patients (52.4%) were from rural background and 107 (47.6%) hailed from urban areas. Multibacillary disease was seen in 83.6% of the total females compared to 63.8% of males.</p><p class="abstract"><strong>Conclusions:</strong> Leprosy may be down but is not yet out. The high proportion of children diagnosed with leprosy is a warning regarding the active transmission of the disease in the community. Continued efforts are required to prevent the disease from making a resurgence.</p>

scholarly journals Evaluation of haematological findings in cases of pancytopenia

2020 ◽  
Vol 8 (12) ◽  
pp. 4311
Author(s):  
Roshny Jacob ◽  
Deepthi M. L. Raj
Keyword(s):  
Bone Marrow ◽  
Disease Process ◽  
Final Diagnosis ◽  
Underlying Disease ◽  
Diagnostic Challenge ◽  
Female Ratio ◽  
Male Female Ratio ◽  
Bone Marrow Study ◽  
Proper Diagnosis ◽  
One Year

Background: Pancytopenia is a clinical condition which poses diagnostic challenge to the haematologist. The aetiology of pancytopenia is varied and depends on many factors. A bone marrow study is highly indicated in cases of pancytopenia and it provides information regarding the underlying disease process. This study was done to learn the causes of pancytopenia and to document how each case was evaluated and followed up.Methods: The present study is a descriptive retrospective one year study on bone marrow samples received in the laboratory. Bone marrow samples included aspirate smears, imprint and trephine and their findings were correlated to arrive at a final diagnosis.Results: Out of the total 28 patients with pancytopenia, 35.71% were from the age group between 61 and 80 years. A male female ratio of 1.5:1 was observed. Most common presenting complaint documented was easy fatiguability. Anisocytosis with macrocytes and ovalocytes were the most common peripheral smear finding. In current study, a cellular marrow was described in 24 (85.71%) cases and hypocellularity in two (7.14%) cases. Final diagnosis was evident in 16 cases, in which the most common cause was acute leukaemia (14.28% each) followed by lymphoma infiltration and myelodysplastic syndromes in 3 cases (10.71%).Conclusions: Bone marrow study helps to arrive at a diagnosis of pancytopenia. But proper technique for sampling, good clinical workup and history taking and clinico haematological correlation is mandatory for the proper diagnosis of a pancytopenia case.

scholarly journals 50. RISK OF TRACT RECURRENCE WITH STEREOTACTIC BIOPSY OF BRAIN METASTASES: AN 18-YEAR CANCER CENTER EXPERIENCE

2020 ◽  
Vol 2 (Supplement_2) ◽  
pp. ii10-ii10
Author(s):  
Joseph Carnevale ◽  
Graham Winston ◽  
Jacob Goldberg ◽  
Cameron Brennan ◽  
Viviane Tabar ◽  
...  
Keyword(s):  
Brain Metastases ◽  
Stereotactic Biopsy ◽  
Multimodality Treatment ◽  
Cancer Center ◽  
Cns Lymphoma ◽  
Tumor Type ◽  
Whole Brain Irradiation ◽  
Brain Irradiation ◽  
Systemic Treatments ◽  
Postoperative Irradiation

Abstract BACKGROUND Stereotactic biopsy is increasingly performed on brain metastases (BrM) as improving cancer outcomes drive aggressive multimodality treatment, however the risk of tract recurrence for such biopsies, in both the upfront and recurrent settings, are poorly defined in an era defined by focused-irradiation paradigms. As such, the rate of tract recurrence was evaluated. METHODS A retrospective review was performed to identify stereotactic biopsies performed for BrM at Memorial Sloan Kettering Cancer Center from 2002–2020. Data including surgical indications, tumor type, radiographic characteristics, stereotactic planning, pre- and post-operative CNS-directed and systemic treatments, and clinical courses were collected. Recurrence was evaluated using RANO-BM criteria. RESULTS Four-hundred-and-seventy-nine patients underwent stereotactic intracranial biopsy for any diagnosis (&gt;80% were gliomas or CNS lymphoma). Twenty-two (4.5%) were for pathologically-confirmed viable BrM and 91% (20/22) of these underwent postoperative irradiation with either stereotactic radiotherapy (14/20, 70%; SBRT) in plans that did not specifically target the biopsy tract, or whole-brain irradiation (6/20, 30%; WBRT). Eleven patients (50%) had &gt;/=3 months radiographic follow-up (median 11.9; 4.5–30.6), of which 6 (55%) developed discontinuous enhancement along the tract at a median 6.4 months (2.3–17.1) post-biopsy. Of these, 2 had previously been treated with SBRT and were sampled in the setting of diagnostic ambiguity (one additionally with WBRT for small cell carcinoma) and underwent intraoperative laser interstitial thermal therapy (LITT) immediately following biopsy. The remainder were treated with SBRT +/- LITT (n=3 and 4, respectively) following biopsy. Tract recurrences were treated with resection (n=2, both with pathologic confirmation), re-irradiation (n=1) or observation/systemic therapy. CONCLUSIONS In this largest reported series of biopsied BrM, we identify a nontrivial rate, higher than previously described, of recurrence along stereotactic biopsy tracts. As BrM are most commonly treated with focused radiotherapy centered on enhancing tumor margins, consideration should be made to include biopsy tracts where feasible.

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