scholarly journals Occurrence of Four Dengue Virus Serotypes and Chikungunya Virus in Kilombero Valley, Tanzania during Dengue Outbreak in 2018

2020 ◽  
Author(s):  
Beatrice Chipwaza ◽  
Robert David Sumaye ◽  
Maja Weisser ◽  
Winfrid Gingo ◽  
Nicholas Kim-Wah Yeo ◽  
...  
Keyword(s):  
Large Scale ◽  
Age Groups ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Denv Serotypes ◽  
Kilombero Valley ◽  
First Occurrence ◽  
Dry Seasons ◽  
Dengue Virus Serotypes ◽  
And Gender

Abstract Background Dengue and Chikungunya viruses can cause large-scale epidemics with attack rates up to 80%. In Tanzania, there have been repeated outbreaks of dengue fever, the most recent one in 2018 and 2019, mostly affecting the coastal areas. Despite its importance, there is limited knowledge on epidemiology of dengue (DENV) and chikungunya (CHIKV) in Tanzania. This study was conducted to investigate the prevalence of DENV and CHIKV in Kilombero valley, Tanzania. Methods A cross-sectional study was conducted at Kibaoni Health Center, in Kilombero valley, South-eastern Tanzania in the rainy and dry seasons of 2018. Febrile patients of any age and gender were enrolled from the outpatient department. Blood samples were taken and screened for DENV and CHIKV viral RNA by real-time RT-PCR assays. Results Overall, 294 patients were recruited. Most were females (65%),and one third of patients aged between 14─25 years. DENV and CHIKV were detected in 29(9.9%) and 3(1.0%) patients, respectively. DENV was detected across all age groups during both dry and rainy seasons. Although all four DENV serotypes were detected, serotypes 1 and 3 dominated and were present in 14 patients (42.4%) each. Additionally, the study showed DENV-1 and DENV-3 co-infections. Conclusion This study reveals the co-circulation of all four DENV serotypes and CHIKV in Kilombero. Importantly, we report the first occurrence of DENV-4 in Tanzania. Unlike previous DENV outbreaks caused by DENV-2, the 2018 outbreak was dominated by DENV-1 and DENV-3. Occurrence of all serotypes suggests the possibility of severe clinical outcomes in future DENV epidemics in Tanzania.

scholarly journals Occurrence of Four Dengue Virus Serotypes and Chikungunya Virus in Kilombero, Tanzania during Dengue Outbreak in 2018

2020 ◽  
Author(s):  
Beatrice Chipwaza ◽  
Robert David Sumaye ◽  
Maja Weisser ◽  
Winfrid Gingo ◽  
Nicholas Kim-Wah Yeo ◽  
...  
Keyword(s):  
Large Scale ◽  
Age Groups ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Denv Serotypes ◽  
First Occurrence ◽  
Dry Seasons ◽  
Dengue Virus Serotypes ◽  
And Gender ◽  
Dry And Rainy Seasons

AbstractBackgroundDengue and Chikungunya viruses can cause large-scale epidemics with attack rates exceeding 80%. In Tanzania, there have been repeated outbreaks of dengue fever, the most recent one in 2018 and 2019 mostly reported in coastal areas. Despite its importance, there is limited knowledge on epidemiology of dengue (DENV) and chikungunya (CHIKV) in Tanzania. This study was conducted to investigate the prevalence of DENV and CHIKV in Kilombero district, South-Eastern Tanzania.MethodsA cross-sectional study was conducted at Kibaoni Health Center, in Kilombero district, in the rainy and dry seasons of 2018. Febrile patients of any age and gender were enrolled. Blood samples were taken and screened for DENV and CHIKV viral RNA by real-time RT-PCR assays.ResultsA total of 294 patients were recruited. Most were females (65%), and aged between 14⍰25 years (33%). DENV and CHIKV were detected in 29 (9.9%) and 3 (1.0%) patients, respectively. DENV was detected across all age groups and during both dry and rainy seasons. Although all four DENV serotypes were detected, serotypes 1 and 3 dominated and were present in 14 patients (42.4%) each. Additionally, the study showed DENV-1 and DENV-3 co-infections.ConclusionThis study reveals the co-circulation of all four DENV serotypes and CHIKV in Kilombero district. Importantly, we report the first occurrence of DENV-4 in Tanzania. Unlike previous DENV outbreaks caused by DENV-2, the 2018 outbreak was dominated by DENV-1 and DENV-3. Occurrence of all serotypes suggests the possibility of having severe clinical outcomes in future DENV epidemics in Tanzania.

CONCENTRATION OF THE SERUM TGF-BETA1 IN HEALTHY ADULT PEOPLE

2014 ◽  
pp. 90-93
Author(s):  
Van Tuan Nguyen ◽  
Tam Vo ◽  
Bui Bao Hoang
Keyword(s):  
Transforming Growth Factor ◽  
Healthy Adult ◽  
Age Groups ◽  
Elevated Serum ◽  
Cross Sectional Study ◽  
Healthy People ◽  
Sectional Study ◽  
Transforming Growth Factor Beta1 ◽  
Cross Sectional ◽  
And Gender

Elevated serum Transforming growth factor-beta1 (TGF-beta1) levels have been linked to tissue fibrosis including chronic kidney disease. Objectives: (1) Investigate serum TGF-beta1 levels in healthy adult people and (2) Examined the relation between serum TGF-beta1 level and gender, age, body mass index (BMI). Method: A cross-sectional study. TGF-beta1 were quantified by ELISA. Results: Levels of serum TGF-beta1 in healthy people were 13,45 ± 7,17 ng/mL mL (0,59 - 33,10 ng/mL). There are no difference of serum TGF-beta1 levels between men and women, between the age groups (<40 years, 40 to < 60 years and ≥ 60 years), between BMI groups < 23 and BMI group ≥ 23. Key words: TGF-beta1, healthy people

scholarly journals Correlation between bone turnover and metabolic markers with age and gender: a cross-sectional study of hospital information system data

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Ju Shao ◽  
Shao-Song Zhou ◽  
Yuan Qu ◽  
Bi-Bo Liang ◽  
Qing-Hong Yu ◽  
...  
Keyword(s):  
Bone Turnover ◽  
Clinical Research ◽  
Age Groups ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Hospital Data ◽  
Medication History ◽  
Cross Sectional ◽  
Age And Gender ◽  
And Gender

Abstract Background Bone turnover and metabolic indicators are related to age and gender. Age and gender should be matched in subjects in disease control research of bone turnover and metabolism, but strict matching of gender and age increases the difficulty and cost of the research. Therefore, the aim of this study was to solve it is necessary to strictly match age and gender in clinical research in bone metabolism. Methods A cross-sectional study was conducted from the data were extracted from the HIS of ZhuJiang Hospital. Data relating to seven bone turnover and metabolic indicators from 1036 patients between January 2018 and October 2019 were analyzed. Results P1NP, β-CTx and 25(OH)D were significant different in individuals younger than 20 years of age. ALP was significantly higher in those under 20 years of age and lower at age 20–39 compared with other age groups. The concentrations of Ca and P were different among the groups aged 0–19, 20–39, and 40–59 years of age groups but exhibited no difference above 60 years of age. PTH expression was not dependent on age. P1NP, β-CTx and PTH concentrations were not significantly different between the genders within the same age group. ALP was significantly different between genders within the age range 20–59 years. Ca and 25(OH)D were significantly different between the genders for those older than 60. Serum P was significantly different in the two genders for those aged 40–79. Patients received both alfacalcidol and calcium treatment differently from the others in P1NP, β-CTx, Serum Ca, P and ALP. Conclusion P1NP and β-CTx were highly correlated with age. If these two indictors require analysis in a case control study, the patients and controls should be strictly matched by age under 20 years. The demarcation point for ALP was 40 years of age. Ca and P were strongly recommended strict matching according to age in disease research. The difference in P1NP, β-CTx, 25(OH)D and ALP between genders depends on age differences. Medication history should be considered in bone turnover and metabolic clinical research.

scholarly journals Visible Portion of Anterior Teeth at Rest and Analysis of Different Smile Characteristics in the Saudi Population of the Jeddah Region

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Mohamed Abdelmageed Awad ◽  
Doaa Saleh Alghamdi ◽  
Aljawharah Talal Alghamdi
Keyword(s):  
Age Groups ◽  
Cross Sectional Study ◽  
Saudi Population ◽  
Cross Sectional ◽  
Crown Length ◽  
Anterior Teeth ◽  
Dental Hospital ◽  
Mandibular Teeth ◽  
And Gender ◽  
Age Range

This cross-sectional study aimed to determine the degree of visibility of maxillary and mandibular anterior teeth at rest in different age groups and to evaluate the smile line, smile arc, and number of maxillary teeth displayed during smiling among the Saudi population visiting King Abdulaziz University Dental Hospital, Jeddah, Saudi Arabia. A total of 157 participants (77 males and 80 females) were included in this study with an age range of 19 to 69 years. All participants had maxillary and mandibular anterior teeth without restorations. Crown length and visible portions of anterior teeth at rest were measured using a Fowler Electronic Digital Caliper. Three measurements of each variable were recorded by two independent dental interns and calibrating their measurements was performed. Smile line, smile arc, and number of teeth displayed during smiling were examined. The collected data were statistically analyzed using SPSS software. It was found that the average clinical crown lengths in the maxillary lateral incisor, mandibular central incisor, and canine were significantly higher in males than females. At rest position, females displayed more maxillary central and lateral incisors. The displayed length of maxillary teeth at rest is inversely proportional to increasing age; the reverse occurs in mandibular teeth. The common visibility of maxillary teeth during smiling was from the second bicuspid to its counterpart. Average smile line and consonant smile arc were the most common characteristics. It was concluded that both age and gender affect the characteristics of tooth display at rest and in smiling. These effects should be considered during treatment planning and restoration of anterior teeth to obtain a more predictable esthetic outcome.

scholarly journals Prevalence and gender differences of buccally displaced canines of 12 years school children and 18-23 years adults in Shah-Alam, Malaysia

2021 ◽  
Vol 6 (2) ◽  
pp. 39-42
Author(s):  
Majda T. Elfseyie ◽  
◽  
Nagham M.A. Al-Jaf ◽  
Mohamed I. Abu Hassan ◽  
◽  
...  
Keyword(s):  
Gender Differences ◽  
School Children ◽  
Treatment Plan ◽  
Age Groups ◽  
Clinical Signs ◽  
Clinical Situation ◽  
Cross Sectional Study ◽  
Chi Square ◽  
Cross Sectional ◽  
And Gender

Background: The buccally displaced canines (BDC) are more commonly encountered conditions in orthodontic clinics. It is a positional variation result of several factors such as retained deciduous canines, crowding, and lateral incisors anomalous. Aims: To determine the prevalence and gender differences of one-two-three-four buccally displaced canines in the area of Shah-Alam, Malaysia. Methods: A cross-sectional study of 399 subjects; was consist of two age groups; 208 subjects of school children aged 12 years and 191 subjects of adults aged 18-23 years were examined clinically to determine the prevalence of BDC. Statistical analysis: The data were statistically analyzed using SPSS version 16; a Chi-square test was performed to assess the gender differences. Results: No gender differences were found in the school-children group while in the adults group a significant gender difference was found regarding one and four canine displacements (P < 0.05). The prevalence of one-two-three canine displacement was higher significantly between the two groups (P < 0.05). However, the frequency of one canine displacement was higher significantly in adult females and girls (P < 0.05). The frequency of three canines displacement was approximately equal in both genders. Conclusion: The frequency of one canine displacement was higher significantly in females. However, the frequency of four canines displacement was higher significantly in males. These features may help in providing additional clinical signs in diagnosis and interception of such clinical situation. It will be effective in treatment plan procedure if canine displacement is detected early, help clinicians on the prevention of impaction possibility.

scholarly journals Correlation between bone turnover and metabolic markers with age and gender: a cross-sectional study of hospital information system data

2020 ◽  
Author(s):  
Shao Ju ◽  
Shaosong Zhou ◽  
Yuan Qu ◽  
bibo liang ◽  
Qing-Hong Yu ◽  
...  
Keyword(s):  
Bone Turnover ◽  
Age Groups ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Age And Gender ◽  
Metabolic Markers ◽  
The Difference ◽  
Highly Correlated ◽  
And Gender

Abstract Background: Bone turnover and metabolic indicators are related to age and gender. Age and gender should be matched in subjects in disease control research of bone turnover and metabolism, but strict matching of gender and age increases the difficulty and cost of the research. Therefore, the aim of this study was to solve the question of whether it is necessary to strictly match age and gender in clinical research in bone metabolism.METHODS: Patient data were extracted from the HIS of ZhuJiang Hospital, Southern Medical University. From these data, a cross-sectional study was conducted. Data relating to seven bone turnover and metabolic indicators from 1036 patients between January 2018 and October 2019 were analyzed. A total of 156 patients aged under 20 were identified and analyzed separately. RESULTS: P1NP, β-CTx and 25(OH)D were significant different in individuals younger than 20 years of age. ALP was significantly higher in those under 20 years of age and lower at age 20-39 compared with other age groups. The concentrations of Ca and P were different among the groups aged 0-19, 20-39, and 40-59 years of age groups but exhibited no difference above 60 years of age. PTH expression was not dependent on age. P1NP, β-CTx and PTH concentrations were not significantly different between the genders within the same age group. ALP was significantly different between genders within the age range 20-59 years. Ca and 25(OH)D were significantly different between the genders for those older than 60. Serum P was significantly different in the two genders for those aged 40-79. CONCLUSION: P1NP and β-CTx were highly correlated with age. If these two indictors require analysis in a case control study, the patients and controls should be strictly matched by age under 20 years. The demarcation point for ALP was 40 years of age. Ca and P were strongly recommended strict matching according to age in disease research. The difference in P1NP, β-CTx, 25(OH)D and ALP between genders depends on age differences.

scholarly journals Multimorbidity Patterns in the General Population: Results from the EpiChron Cohort Study

2020 ◽  
Vol 17 (12) ◽  
pp. 4242
Author(s):  
Ignatios Ioakeim-Skoufa ◽  
Beatriz Poblador-Plou ◽  
Jonás Carmona-Pírez ◽  
Jesús Díez-Manglano ◽  
Rokas Navickas ◽  
...  
Keyword(s):  
General Population ◽  
Large Scale ◽  
Musculoskeletal Diseases ◽  
Epidemiological Studies ◽  
Population Based ◽  
Cross Sectional Study ◽  
Real World Data ◽  
Cross Sectional ◽  
Complex Interactions ◽  
And Gender

The correct management of patients with multimorbidity remains one of the main challenges for healthcare systems worldwide. In this study, we analyze the existence of multimorbidity patterns in the general population based on gender and age. We conducted a cross-sectional study of individuals of all ages from the EpiChron Cohort, Spain (1,253,292 subjects), and analyzed the presence of systematic associations among chronic disease diagnoses using exploratory factor analysis. We identified and clinically described a total of 14 different multimorbidity patterns (12 in women and 12 in men), with some relevant differences in the functions of age and gender. The number and complexity of the patterns was shown to increase with age in both genders. We identified associations of circulatory diseases with respiratory disorders, chronic musculoskeletal diseases with depression and anxiety, and a very consistent pattern of conditions whose co-occurrence is known as metabolic syndrome (hypertension, diabetes, obesity, and dyslipidaemia), among others. Our results demonstrate the potential of using real-world data to conduct large-scale epidemiological studies to assess the complex interactions among chronic conditions. This could be useful in designing clinical interventions for patients with multimorbidity, as well as recommendations for healthcare professionals on how to handle these types of patients in clinical practice.

scholarly journals Aptidão cardiorrespiratória em crianças e adolescentes

2019 ◽  
Vol 20 (6) ◽  
pp. 535-543
Author(s):  
Kenia Rejane de Oliveira Batista ◽  
Mona Gizelle Dreger de Oliveira ◽  
Carla Fabiane dos Santos Lemos ◽  
Josiene De Oliveira Couto ◽  
Nara Michelle Moura Soares ◽  
...  
Keyword(s):  
Cardiorespiratory Fitness ◽  
Age Groups ◽  
Peak Height ◽  
Cross Sectional Study ◽  
Height Velocity ◽  
Age Group ◽  
Peak Height Velocity ◽  
Cross Sectional ◽  
Significance Level ◽  
And Gender

Cardiorespiratory fitness is an important health status indicator. The purpose of this study was to verify the cardiorespiratory fitness according to age group and gender in children and adolescents from Sergipe, Brazil. It is a cross-sectional study with sample consisting of 195 adolescents of both genders with mean age of 11.75 ± 3.0 years. For the characterization of participants, a questionnaire with age and gender identification designed by researchers was used. Subsequently, participants were submitted to anthropometric evaluation in order to estimate the maturational stage by means of the peak height velocity (PHV). The 20-meter back-and-forth test was used to estimate cardiorespiratory fitness. Two-way ANOVA was applied with sample divided into two groups (“up to 13 years” and “above 13 years”). Polynomial contrast was used to identify the type of tendency for cardiorespiratory fitness, and simple contrast for multiple comparisons. All procedures were performed using SPSS version 22.0 software, considering 5% significance level. In the “over 13 years” group, there was a significant effect on the cardiorespiratory capacity behavior according to “gender” [F(1, 45) = 5.54, p = 0.02, r = 0.33] and “age” [F(4.45) = 3.37, p = 0.02, r = 0.48]. The simple contrast identified increased cardiorespiratory fitness behavior in relation to age groups of 15 and 16 year when compared to the age group of 14 years. It was concluded that gender and age positively influence cardiorespiratory fitness from the maturational reference age in the study group.

Alexithymia and anxiety symptoms in Pakistani adolescents: a study of compounded directions

2021 ◽  
pp. 1-13
Author(s):  
Sadia jafer ◽  
Farzana Ashraf ◽  
Amna Arif ◽  
Admin
Keyword(s):  
Psychological Health ◽  
Clinical Symptoms ◽  
Interactive Effect ◽  
Age Groups ◽  
Cross Sectional Study ◽  
Anxiety Symptoms ◽  
Cross Sectional ◽  
Physical And Psychological Health ◽  
And Gender ◽  
Effect Of Age

Abstract     Objectives: There is an empirical evidence that symptoms of internalizing disorders such as alexithymia and anxiety increase in adolescence and these symptoms varies across gender and age groups. The purpose of this study was to explore these differences in adolescents. Method: In this cross-sectional study conducted since November 2018 to March 2019, the sample of 185 adolescents selected through random sampling method from different schools. They were assessed on alexithymia and anxiety symptoms by administering Toronto Alexithymia Scale and Hamilton Anxiety Scale respectively. Multiple Analysis of Variance (MANOVA) was applied to determine the direct and interactive effect of age groups and gender on alexithymia and anxiety symptoms. Results: The results demonstrate that boys reported significantly (p<0.05) higher level of alexithymia symptoms partially (externally oriented) as compared to their counterparts. Further significant (p<0.05) interactive effect of age group and gender was also seen. Conclusion: The present study concluded that the presence of clinical symptoms in school going adolescents may hinder in the physical and psychological health of adolescents, which should be managed through suitable interventions. Keywords: Alexithymia symptoms, Anxiety symptoms, Continuous...

scholarly journals Correlation between bone turnover and metabolic markers with age and gender: a cross-sectional study of hospital information system data

2020 ◽  
Author(s):  
Shao Ju ◽  
Shaosong Zhou ◽  
Yuan Qu ◽  
Bibo Liang ◽  
Qing-Hong Yu ◽  
...  
Keyword(s):  
Bone Turnover ◽  
Clinical Research ◽  
Age Groups ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Hospital Data ◽  
Medication History ◽  
Cross Sectional ◽  
Age And Gender ◽  
And Gender

Abstract Background: Bone turnover and metabolic indicators are related to age and gender. Age and gender should be matched in subjects in disease control research of bone turnover and metabolism, but strict matching of gender and age increases the difficulty and cost of the research. Therefore, the aim of this study was to solve it is necessary to strictly match age and gender in clinical research in bone metabolism.METHODS: A cross-sectional study was conducted from the data were extracted from the HIS of ZhuJiang Hospital. Data relating to seven bone turnover and metabolic indicators from 1036 patients between January 2018 and October 2019 were analyzed.RESULTS: P1NP, β-CTx and 25(OH)D were significant different in individuals younger than 20 years of age. ALP was significantly higher in those under 20 years of age and lower at age 20-39 compared with other age groups. The concentrations of Ca and P were different among the groups aged 0-19, 20-39, and 40-59 years of age groups but exhibited no difference above 60 years of age. PTH expression was not dependent on age. P1NP, β-CTx and PTH concentrations were not significantly different between the genders within the same age group. ALP was significantly different between genders within the age range 20-59 years. Ca and 25(OH)D were significantly different between the genders for those older than 60. Serum P was significantly different in the two genders for those aged 40-79. Patients received both alfacalcidol and calcium treatment differently from the others in P1NP, β-CTx, Serum Ca, P and ALP.CONCLUSION: P1NP and β-CTx were highly correlated with age. If these two indictors require analysis in a case control study, the patients and controls should be strictly matched by age under 20 years. The demarcation point for ALP was 40 years of age. Ca and P were strongly recommended strict matching according to age in disease research. The difference in P1NP, β-CTx, 25(OH)D and ALP between genders depends on age differences. Medication history should be considered in bone turnover and metabolic clinical research.

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