522. Evaluation of Three COVID-19 Monoclonal Antibody Regimens in the Context of Rising B.1.526 Prevalence in New York City

Abstract Background Monoclonal antibodies were given emergency use authorization (EUA) by the Food and Drug Administration for the treatment of high-risk, outpatient COVID-19 infection. In New York City (NYC), the emergence and rapid growth of the B.1.526 variant of concern (VOC) possessing the E484K mutation was first noted in February 2021. In-vitro studies subsequently confirmed attenuated monoclonal antibody neutralization against VOCs. At our institution, bamlanivimab (BAM) alone or with etesevimab (B/E) and casirivimab/imdevimab (C/I) were utilized at different phases of the pandemic. The objective of this study was to assess their comparative efficacies in a highly variant prevalent setting. Methods This retrospective analysis was conducted at an urban hospital in the Bronx, NY and evaluated adult monoclonal antibody recipients from any of our infusion sites. Patients initially received BAM but given the high prevalence of variants, treatment was transitioned to first B/E and then C/I exclusively. We compared BAM versus combination therapy as well as B/E versus C/I individually. The primary outcome was all-cause hospital admission within 30 days post infusion. Results From February 1 to March 7, 2021, 358 patients received BAM and from March 17 to May 9, 2021, 86 and 179 patients received B/E and C/I, respectively. Compared to any combination infusion, patients who received BAM were significantly older, more likely to possess ≥ 2 qualifying EUA criteria, and less likely to be vaccinated for COVID-19 prior to infusion (Table 1). Following B/E and C/I, 4.5% of patients were admitted versus 10.1% for BAM, p=0.011. There were no significant differences in admission between B/E and C/I recipients, p=0.485. After excluding fully vaccinated patients (n=14) and adjusting for age and ≥ 2 EUA criteria, combination therapy remained associated with decreased odds of hospitalization compared to BAM (odds ratio, 0.48; 95% confidence interval, 0.24-0.94). Conclusion Combination therapy may be associated with fewer hospital admissions following infusion, although there were no statistically significant differences between the individual combination infusions. We suggest similar studies be conducted by other sites to understand the clinical impact of local SARS-CoV-2 variants on antibody efficacy. Disclosures Yi Guo, PharmD, BCIDP, Merck (Research Grant or Support) Kelsie Cowman, MPH, Merck (Research Grant or Support) Priya Nori, MD, Merck (Grant/Research Support) Priya Nori, MD, Nothing to disclose

Download Full-text

Post-SARS-CoV-2 monoclonal antibody treatment hospitalizations as a sentinel for emergence of viral variants in New York City

Open Forum Infectious Diseases ◽

10.1093/ofid/ofab313 ◽

2021 ◽

Author(s):

Kelsie Cowman ◽

Yi Guo ◽

Liise-anne Pirofski ◽

David Wong ◽

Hongkai Bao ◽

...

Keyword(s):

New York ◽

Monoclonal Antibody ◽

New York City ◽

York City ◽

Human Services ◽

Antibody Treatment ◽

Health And Human Services ◽

Department Of Health ◽

Monoclonal Antibody Treatment ◽

The U.S

Abstract We partnered with the U.S. Department of Health and Human Services to treat high-risk, non-admitted COVID-19 patients with bamlanivimab in the Bronx, NY per Emergency Use Authorization criteria. Increasing post-treatment hospitalizations were observed monthly between December 2020-March 2021 in parallel to the emergence of SARS-CoV-2 variants in New York City.

Download Full-text

Effects of Charging Infrastructure and Non-Electric Taxi Competition on Electric Taxi Adoption Incentives in New York City

Transportation Research Record Journal of the Transportation Research Board ◽

10.1177/0361198119837955 ◽

2019 ◽

Vol 2673 (4) ◽

pp. 262-274 ◽

Cited By ~ 4

Author(s):

Jaeyoung Jung ◽

Joseph Y. J. Chow

Keyword(s):

New York ◽

New York City ◽

York City ◽

Operating Costs ◽

Charging Infrastructure ◽

Trade Offs ◽

Average Revenue ◽

The Individual ◽

Queue Delay ◽

Charging Stations

With major investments in electric taxis emerging around the world, there is a need to better understand resource allocation trade-offs in subsidizing electric vehicle taxis (e-taxis) and investing in electric charging infrastructure. This is addressed using simulation experiments conducted in New York City: 2016 taxi pickups/drop-offs, a Manhattan road network (16,782 nodes, 23,337 links), and 212 charging stations specified by a 2013 Taxi & Limousine Commission study. The simulation is based on a platform used to evaluate taxi operations in California and Seoul. Eleven scenarios are analyzed: a baseline of 7,000 non-electric taxis, five scenarios ranging from 1,000 e-taxis to 5,000 e-taxis, and another five scenarios in which the e-taxis have infinite chargers as an upper bound. The study finds that the number of charging locations recommended in the earlier study may be insufficient at some locations even under the 3,000+ e-taxi scenarios. More importantly, despite an average revenue of $260 per taxi for the 7,000 non-electric taxis and about $247 per taxi for electric taxis over the finite charger scenarios, the revenue gap between e-taxis and non-electric taxis in a mixed fleet increases significantly as the e-taxi share increases. This is because the increasing queue delay imposed on e-taxis gives non-electric taxis an increasing competitive advantage, raising their average revenue from $260 per taxi (1,000 e-taxis) up to $286 per taxi (5,000 e-taxis, 150% revenue gap increase), all other operating costs being equal. This has implications for individual versus whole-fleet policies, as the individual-oriented policies may be less effective.

Download Full-text

Adaptation to Future Risks in Coastal Megacities — New York City Case Study: Local Assessment and Survey Findings in Water Front Neighborhoods

Journal of Extreme Events ◽

10.1142/s2345737618500021 ◽

2018 ◽

Vol 05 (01) ◽

pp. 1850002 ◽

Cited By ~ 1

Author(s):

Hildegaard Link ◽

Chris Barrett

Keyword(s):

New York ◽

New York City ◽

York City ◽

Extreme Weather ◽

Hurricane Sandy ◽

Extreme Weather Events ◽

Household Level ◽

Survey Results ◽

The Individual ◽

Water Front

Risk management regimes develop as stakeholders attempt to reduce vulnerability to hazards and limit the damage and disruption from disasters. Urban coastal regions are often hotspots of climate change-related risks. Analysis of different characteristics of vulnerability, resilience, and transformation is an important precursor to planning and decision making. While these concepts are not new, in many areas they remain very abstract. This paper offers a method to assess vulnerability at the individual household scale in different New York City water front neighborhoods that were extensively damaged during hurricane Sandy in 2012. Household Surveys were conducted in Red Hook, Brooklyn and Edgemere/Arverne, Queens in early 2016. Survey results suggest that at the household level, feelings of preparedness and trust in local government’s ability to effectively manage and respond to extreme weather differ with the varying political/economic climates of each neighborhood. Our survey results also indicate that residents are changing their emergency planning behavior, regardless of politics or economics. Responses show residents adapting their thinking to acknowledge the potential for increasing risk from extreme weather events in both locations studied.

Download Full-text

Impact of Local and Transported PM2.5 on Elderly Hospital Admissions in New York City

Epidemiology ◽

10.1097/00001648-200611001-00511 ◽

2006 ◽

Vol 17 (Suppl) ◽

pp. S201

Author(s):

R Lall ◽

K Ito ◽

G Thurston

Keyword(s):

New York ◽

New York City ◽

York City ◽

Hospital Admissions

Download Full-text

Learning Freedom: Education, Elevation, and New York's African-American Community, 1827–1829

History of Education Quarterly ◽

10.1111/hoeq.12213 ◽

2016 ◽

Vol 56 (4) ◽

pp. 618-645

Author(s):

Michael Hines

Keyword(s):

United States ◽

New York ◽

New York City ◽

African American ◽

York City ◽

The United States ◽

African American Community ◽

The Enlightenment ◽

American Citizenship ◽

The Individual

Even though the black community of antebellum New York City lived in a society that marginalized them socially and economically, they were intent on pursuing the basic privileges of American citizenship. One tactic African Americans employed to this end was the tenacious pursuit of education, which leaders believed would act both as an aid in economic advancement and as a counterargument against the widely assumed social inferiority of their race. The weekly newspaper, Freedom's Journal, the first African American owned and operated newspaper in the United States, was an avid supporter of this strategy of social elevation through education. From 1827 to 1829, the paper's editors, John Russwurm and Samuel Cornish, used their platform to advertise for a range of schools, editorialize on the importance of learning, and draw connections between the enlightenment of the individual and the progress of the race.

Download Full-text

B.1.526 SARS-CoV-2 Variants Identified in New York City are Neutralized by Vaccine-Elicited and Therapeutic Monoclonal Antibodies

mBio ◽

10.1128/mbio.01386-21 ◽

2021 ◽

Author(s):

Hao Zhou ◽

Belinda M. Dcosta ◽

Marie I. Samanovic ◽

Mark J. Mulligan ◽

Nathaniel R. Landau ◽

...

Keyword(s):

New York ◽

Monoclonal Antibody ◽

New York City ◽

Monoclonal Antibodies ◽

York City ◽

Antibody Therapy ◽

Spike Protein ◽

Monoclonal Antibody Therapy ◽

Therapeutic Monoclonal Antibodies

A novel SARS-CoV-2 variant termed B.1.526 was recently identified in New York City and has been found to be spreading at an alarming rate. The variant has mutations in its spike protein that might allow it to escape neutralization by vaccine-elicited antibodies and might cause monoclonal antibody therapy for COVID-19 to be less successful.

Download Full-text

Asthma Hospital Admissions and Ambient Air Pollution Concentrations in New York City

Epidemiology ◽

10.1097/00001648-200611001-00692 ◽

2006 ◽

Vol 17 (Suppl) ◽

pp. S266 ◽

Cited By ~ 1

Author(s):

C Restrepo ◽

J Simonoff ◽

G Thurston ◽

R Zimmerman

Keyword(s):

New York ◽

Air Pollution ◽

New York City ◽

York City ◽

Hospital Admissions ◽

Ambient Air ◽

Ambient Air Pollution ◽

Pollution Concentrations

Download Full-text

A Synoptic Evaluation of Asthma Hospital Admissions in New York City

American Journal of Respiratory and Critical Care Medicine ◽

10.1164/ajrccm.156.6.96-05028 ◽

1997 ◽

Vol 156 (6) ◽

pp. 1781-1788 ◽

Cited By ~ 40

Author(s):

PAUL F. JAMASON ◽

LAURENCE S. KALKSTEIN ◽

PETER J. GERGEN

Keyword(s):

New York ◽

New York City ◽

York City ◽

Hospital Admissions

Download Full-text

Characterization of streptomycin resistance mechanisms among Mycobacterium tuberculosis isolates from patients in New York City.

Antimicrobial Agents and Chemotherapy ◽

10.1128/aac.40.5.1186 ◽

1996 ◽

Vol 40 (5) ◽

pp. 1186-1188 ◽

Cited By ~ 52

Author(s):

R C Cooksey ◽

G P Morlock ◽

A McQueen ◽

S E Glickman ◽

J T Crawford

Keyword(s):

New York ◽

New York City ◽

Mycobacterium Tuberculosis ◽

York City ◽

Resistance Mechanism ◽

Ribosomal Protein Gene ◽

Resistance Mechanisms ◽

Coding Region ◽

Low Level

From a collection of 367 isolates of Mycobacterium tuberculosis from patients in New York City in 1994, 45 isolates (12.3%) were resistant in vitro to 2 micrograms or more of streptomycin (SM) per ml. We further evaluated these isolates for levels of SM resistance and for mutations previously associated with resistance in the rpsL (S12 ribosomal protein) gene and the rrs (16S rRNA)-coding region. Twenty-four isolates, representing nine distinct patterns of susceptibility to antituberculosis drugs, were resistant to 500 micrograms of SM per ml and shared a common point mutation at nucleotide 128 in the rpsL gene. This mutation, which substitutes lysine for arginine in the S12 ribosomal binding protein, was not present in isolates with low-level SM resistance or in SM-susceptible control isolates. Among 20 isolates with low-level SM resistance, one possessed a substitution (C-->G865) in the 912 loop of the rrs gene. No mutations in the 530 loop of the rrs coding region were detected, suggesting the presence of an alternative SM resistance mechanism in 19 isolates. Single-strand conformation polymorphisms of mutants were readily detected by a nonradioactive gel screen.

Download Full-text