scholarly journals 2677. Infection-Related Outcomes in Patients With Malignancy-Related Febrile Neutropenia: A National Perspective

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S939-S940
Author(s):  
Arish Noor ◽  
Aakash Desai ◽  
Varun Tandon ◽  
Pradeep K Siddappa ◽  
Kathir Balakumaran ◽  
...  
Keyword(s):  
Septic Shock ◽  
Febrile Neutropenia ◽  
Data Set ◽  
Infectious Colitis ◽  
Hodgkins Lymphoma ◽  
Oncological Emergency ◽  
Objective Evidence ◽  
Clinical Classification Software ◽  
Non Hodgkins Lymphoma ◽  
National Perspective

Abstract Background Febrile neutropenia (FBN) is a life-threatening oncological emergency requiring hospitalization and early treatment with broad-spectrum antibiotics. We aimed to study differences in infection-related outcomes for febrile neutropenia in various malignancies. Methods The National Inpatient Sample (NIS) data set was queried from 2007 to 2014 to identify all patients with a diagnosis of neutropenic fever (ICD-9: 780.6x and 288.5x or 288.0x or 284.1x). Diagnoses for various cancers were determined via their respective Clinical Classification Software (CCS) codes. Diagnoses of pneumonia (481.x, 482x), bacterial meningitis (320.x), Clostridium difficile (008.45), infectious colitis due to neoplastic agents (009.x), urinary tract infection (599.0x), pyelonephritis (590.1x, 590.80), skin and soft-tissue infection (682.x, 684.x, 686.8x, 686.9x), mucositis (528.01), influenza (CCS 487), sepsis (995.91), severe sepsis (995.92), septic shock (785.52), E. coli septicemia (038.42), Pseudomonas septicemia (038.43), MRSA septicemia (038.12) and Streptococcal septicemia (038.0) were identified using their respective ICD/CCS codes. Variables were analyzed via multivariate analysis using the program SAS. Results We studied 381,043 patients with FBN. Leukemia was the most common malignancy associated with FBN (140,190, patients, 36.8%). Meningitis was found to be significantly associated with brain cancer, while other infections were associated with a range of malignancies. (Table.1) Methicillin-resistant Staphylococcus aureus was associated with cancers of the bone, breast, uterus and non- hodgkins lymphoma, while other microorganisms varied across different malignancies (Table 2). Septic Shock was associated with cancer of the pancreas, lung, bone, breast, leukemia, bladder, kidney, thyroid, myeloma, prostate, testis, cervix, brain, melanoma, non-hodgkins lymphoma, compared with other malignancies (Table 3). Conclusion Pathogen-specific and targeted antibiotic therapy is the cornerstone of treatment in FBN. Our study provides evidence of specific presentations and organisms causing infections in various malignancies. We hope that further outcomes-based research will provide objective evidence of certain high-risk infections, improving patient outcomes and minimizing redundant testing. Disclosures All authors: No reported disclosures.

Monoclonal Antibodies: A New Era in the Treatment of Non-Hodgkins Lymphoma

2001 ◽  
Vol 2 (4) ◽  
pp. 301-311 ◽  
Author(s):  
A. J. Grillo-Lopez ◽  
B.K. Dallaire ◽  
A. McClure ◽  
R. Weaver ◽  
C. Varns ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
New Era ◽  
Hodgkins Lymphoma ◽  
Non Hodgkins Lymphoma

Effect of Undertriage on the Outcomes of Cancer Patients with Febrile Neutropenia, Sepsis, and Septic Shock

2021 ◽  
pp. 105477382199968
Author(s):  
Anas Alsharawneh
Keyword(s):  
Emergency Department ◽  
Septic Shock ◽  
Length Of Stay ◽  
Febrile Neutropenia ◽  
Cancer Patients ◽  
Emergency Setting ◽  
Extended Length ◽  
Life Threatening ◽  
Sepsis And Septic Shock ◽  
Timely Treatment

Sepsis and neutropenia are considered the primary life-threatening complications of cancer treatment and are the leading cause of hospitalization and death. The objective was to study whether patients with neutropenia, sepsis, and septic shock were identified appropriately at triage and receive timely treatment within the emergency setting. Also, we investigated the effect of undertriage on key treatment outcomes. We conducted a retrospective analysis of all accessible records of admitted adult cancer patients with febrile neutropenia, sepsis, and septic shock. Our results identified that the majority of patients were inappropriately triaged to less urgent triage categories. Patients’ undertriage significantly prolonged multiple emergency timeliness indicators and extended length of stay within the emergency department and hospital. These effects suggest that triage implementation must be objective, consistent, and accurate because of the several influences of the assigned triage scoring on treatment and health outcomes.

Ovarian follicular Non-Hodgkins lymphoma

Pathology ◽  
1991 ◽  
Vol 23 (2) ◽  
pp. 164-166 ◽  
Author(s):  
Frances M. Boyle ◽  
Kerry McD. Taylor ◽  
John R. Bell
Keyword(s):  
Hodgkins Lymphoma ◽  
Non Hodgkins Lymphoma

Septic shock and systemic inflammatory response syndrome patients' CD15+ granulocytes were subjected to global transcriptional profiling (SIRS)

2021 ◽  
Author(s):  
Marni Mack ◽  
Argo Easston
Keyword(s):  
Gene Expression ◽  
United States ◽  
Septic Shock ◽  
Immune Cells ◽  
Transcriptional Profiling ◽  
The United States ◽  
Transcriptional Level ◽  
Data Set ◽  
Transcriptional Alterations ◽  
Level I

In the United States, sepsis, the body's response to infection in a typically sterile circulation, is a leading causeof death (1). To assess the primary transcriptional alterations associated with each illness state, I utilized amicroarray data set from a cohort of thirtyone individuals with septic shock or systemic inflammatory responsesyndrome (2). At the transcriptional level, I discovered that the granulocytes of patients with SIRS weresimilar to those of patients with septic shock. SIRS showed a “intermediate” gene expression state betweenthat of control patients and that of septic shock patients for numerous genes expressed in the granulocyte. Thediscovery of the most differentially expressed genes in the granulocytic immune cells of patients with septicshock might aid the development of new therapies or diagnostics for an illness with a 14.7 percent to 29.9% inhospitaldeath rate despite decades of study (1).

Regime Type and Political Destabilization in Cross-National Perspective

2016 ◽  
Vol 51 (1) ◽  
pp. 26-50 ◽  
Author(s):  
Elena Slinko ◽  
Stanislav Bilyuga ◽  
Julia Zinkina ◽  
Andrey Korotayev
Keyword(s):  
Cold War ◽  
Political Stability ◽  
Authoritarian Regimes ◽  
Political Regime ◽  
Sufficient Evidence ◽  
Data Set ◽  
Regime Types ◽  
The Asymmetry ◽  
National Perspective ◽  
The Cold War

In this article, we re-analyze the hypothesis that the relationship between the type of political regime and its political instability forms an inverted U shape. Following this logic, consistent democracies and autocracies are more stable regimes, whereas intermediate regimes (anocracies) display the lowest levels of political stability. We re-test this hypothesis using a data set that has not been previously used for this purpose, finding sufficient evidence to support the hypothesis pertaining to the aforementioned U-shaped relationship. Our analysis is specifically focused on the symmetry of this U shape, whereby our findings suggest that the U-shaped relationship between regime types and sociopolitical destabilization is typically characterized by an asymmetry, with consistently authoritarian regimes being generally less stable than consolidated democracies. We also find that the character of this asymmetry can change with time. In particular, our re-analysis suggests that U-shaped relationship experienced significant changes after the end of the Cold War. Before the end of the Cold War (1946-1991), the asymmetry of inverted U-shaped relationship was much less pronounced—though during this period consistent authoritarian regimes were already less stable than consolidated democracies, this very difference was only marginally significant. In the period that follows the end of the Cold War (1992-2014), this asymmetry underwent a substantial change: Consolidated democracies became significantly more stable, whereas consolidated autocracies became significantly more unstable. As a result, the asymmetry of the U-shaped relationship has become much more pronounced. The article discusses a number of factors that could account for this change.

Acute isolated cerebral mucormycosis in a patient with high grade �non-Hodgkins lymphoma

2000 ◽  
Vol 7 (4) ◽  
pp. 443-447 ◽  
Author(s):  
M. Zarei ◽  
J. Morris ◽  
V. Aachi ◽  
R. Gregory ◽  
C. Meanock ◽  
...  
Keyword(s):  
High Grade ◽  
Hodgkins Lymphoma ◽  
Non Hodgkins Lymphoma

PRIMARY NON-HODGKINS LYMPHOMA OF THE MAXILLARY SINUS

1999 ◽  
Vol 92 (Supplement) ◽  
pp. S65
Author(s):  
GLIY Zeringue ◽  
Paul L. Friedlander
Keyword(s):  
Maxillary Sinus ◽  
Hodgkins Lymphoma ◽  
Non Hodgkins Lymphoma

scholarly journals A Rare Case of Pyoderma Gangrenosum in a HIV Positive Patient

2011 ◽  
Vol 2 (2) ◽  
pp. 128-130
Author(s):  
Eswari Loganathan ◽  
Asima Banu
Keyword(s):  
Pyoderma Gangrenosum ◽  
Rare Case ◽  
Positive Patient ◽  
Neutrophilic Dermatosis ◽  
Hiv Positive ◽  
Medical Sciences ◽  
First Line ◽  
Hodgkins Lymphoma ◽  
Lymphoid Malignancies ◽  
Non Hodgkins Lymphoma

HIV infection can lead to varied spectrum of associated disease conditions. Pyoderma gangrenosum is a neutrophilic dermatosis that may be associated with myeloid malignancies. Less information is available about the association of pyoderma gangrenosum with lymphoid malignancies. We report a rare case of pyoderma gangrenosum in association with Non hodgkins lymphoma(NHL) of diffuse large B cell type. In this case the lesion which showed NHL features occurred in the perianal region, coexisting with pyoderma gangrenosum lesions in the perianal, lower limb and abdominal region. Another interesting feature is the occurrence of both these conditions in a HIV-positive patient with severe immunologic failure to first line antiretroviral therapy contributing to the refractoriness to treatment. Key Words: HIV; pyoderma gangrenosum; Non Hodgkins Lymphoma DOI: http://dx.doi.org/10.3126/ajms.v2i2.4029 Asian Journal of Medical Sciences 2 (2011) 128-130

Sign in / Sign up

Export Citation Format

Share Document