Bioseparations Science and Engineering

2015 ◽  
Author(s):  
Roger G. Harrison ◽  
Paul W. Todd ◽  
Scott R. Rudge ◽  
Demetri P. Petrides
Keyword(s):  
Process Design ◽  
Qualitative Description ◽  
Engineering Practice ◽  
Unit Operation ◽  
Science And Engineering ◽  
Scientific Application ◽  
General Application ◽  
Unit Operations ◽  
Analysis Computer ◽  
Consistent Method

Designed for undergraduates, graduate students, and industry practitioners, Bioseparations Science and Engineering fills a critical need in the field of bioseparations. Current, comprehensive, and concise, it covers bioseparations unit operations in unprecedented depth. In each of the chapters, the authors use a consistent method of explaining unit operations, starting with a qualitative description noting the significance and general application of the unit operation. They then illustrate the scientific application of the operation, develop the required mathematical theory, and finally, describe the applications of the theory in engineering practice, with an emphasis on design and scaleup. Unique to this text is a chapter dedicated to bioseparations process design and economics, in which a process simular, SuperPro Designer® is used to analyze and evaluate the production of three important biological products. New to this second edition are updated discussions of moment analysis, computer simulation, membrane chromatography, and evaporation, among others, as well as revised problem sets. Unique features include basic information about bioproducts and engineering analysis and a chapter with bioseparations laboratory exercises. Bioseparations Science and Engineering is ideal for students and professionals working in or studying bioseparations, and is the premier text in the field.

scholarly journals Developing Process Designs for Biorefineries—Definitions, Categories, and Unit Operations

Energies ◽  
2020 ◽  
Vol 13 (6) ◽  
pp. 1493 ◽  
Author(s):  
Tanmay Chaturvedi ◽  
Ana I. Torres ◽  
George Stephanopoulos ◽  
Mette Hedegaard Thomsen ◽  
Jens Ejbye Schmidt
Keyword(s):  
Process Design ◽  
Unit Operation ◽  
Unit Operations

In this review, we focus on the literature that described the various unit operations in a process design flowsheet of biorefineries. We begin by establishing the accepted definitions of a biorefinery, go on to describe how to categorize biorefineries, and finally review the literature on biorefinery process designs by listing the unit operation in each process design. Distinguishing biorefineries based on feedstock, the types of processing units, and the products emanating from the biorefinery are discussed.

Reality brings excitement to engineering education

1998 ◽  
Vol 12 (1) ◽  
pp. 83-86
Author(s):  
LARRY LEIFER ◽  
SHERI SHEPPARD
Keyword(s):  
Engineering Education ◽  
Social Activity ◽  
Thinking Skills ◽  
Engineering Practice ◽  
Engineering Science ◽  
Science And Engineering ◽  
Engineering Product ◽  
Intellectual Content ◽  
Versus Communication ◽  
Constant Source

The intellectual content and social activity of engineering product development are a constant source of surprise, excitement, and challenge for engineers. When our students experience product-based-learning (PBL), they experience this excitement (Brereton et al., 1995). They also have fun and perform beyond the limits required for simple grades. We, their teachers, experience these things too. Why, then, are so few students and faculty getting the PBL message? How, then, can we put the excitement back in engineering education? In part, we think this is because of three persistent mistakes in engineering education:1. We focus on individual students.2. We focus on engineering analysis versus communication between engineers.3. We fail to integrate thinking skills in engineering science and engineering practice.

scholarly journals Cavitation patterns in high-pressure homogenization nozzles with cylindrical orifices: Influence of mixing stream in Simultaneous Homogenization and Mixing

2021 ◽  
Author(s):  
V. Gall ◽  
E. Rütten ◽  
H. P. Karbstein
Keyword(s):  
High Pressure ◽  
Process Design ◽  
High Speed ◽  
State Of The Art ◽  
Back Pressure ◽  
High Pressure Homogenization ◽  
Unit Operation ◽  
Mixing Chamber ◽  
Cavitation Intensity ◽  
Droplet Sizes

AbstractHigh-pressure homogenization is the state of the art to produce high-quality emulsions with droplet sizes in the submicron range. In simultaneous homogenization and mixing (SHM), an additional mixing stream is inserted into a modified homogenization nozzle in order to create synergies between the unit operation homogenization and mixing. In this work, the influence of the mixing stream on cavitation patterns after a cylindrical orifice is investigated. Shadow-graphic images of the cavitation patterns were taken using a high-speed camera and an optically accessible mixing chamber. Results show that adding the mixing stream can contribute to coalescence of cavitation bubbles. Choked cavitation was observed at higher cavitation numbers σ with increasing mixing stream. The influence of the mixing stream became more significant at a higher orifice to outlet ratio, where a hydraulic flip was also observed at higher σ. The decrease of cavitation intensity with increasing back-pressure was found to be identical with conventional high-pressure homogenization. In the future, the results can be taken into account in the SHM process design to improve the efficiency of droplet break-up by preventing cavitation or at least hydraulic flip.

Educating the Engineer of 2020

2008 ◽  
Author(s):  
Alice M. Agogino
Keyword(s):  
Engineering Education ◽  
Gender Equity ◽  
Practice Change ◽  
Academic Science ◽  
Engineering Practice ◽  
Science And Engineering ◽  
The Us

How will engineering practice change in the next twenty years? What are the implications to engineering education? Will we have achieved gender equity? These questions will be discussed in the context of three recent reports of the US. National Academy of Engineering – The Engineer of 2020: Global Visions of Engineering in the New Century; Educating the Engineer of 2020: Adapting Engineering Education to the New Century; and Beyond Bias and Barriers: Fulfilling the Potential of Women in Academic Science and Engineering.

Design of Heat Exchanger Based on SW6

2012 ◽  
Vol 550-553 ◽  
pp. 3033-3036
Author(s):  
Deng Li Yi
Keyword(s):  
Heat Exchanger ◽  
Wall Thickness ◽  
Process Design ◽  
Structure Design ◽  
Unit Operation ◽  
Strength Design

According to GB151 and GB150, the process design and structure design have been done for the floating head heat exchanger which is common in the chemical unit operation equipment. The software SW6 is used to compute the wall thickness, loading and etc. Strength design and structure design of the Tube-sheets, Tube-Chambers and Supports have also been finished on SW6. The results show that the equipment can meet the required strength.

scholarly journals Industrial Automation in Unit Operations Labs

2015 ◽  
Author(s):  
Konstantinos Apostolou ◽  
Ishwar Singh
Keyword(s):  
Chemical Engineering ◽  
Field Work ◽  
Pilot Scale ◽  
Unit Operation ◽  
Sensors And Actuators ◽  
Industrial Automation ◽  
Control Loops ◽  
Unit Operations ◽  
Processing Facility ◽  
Set Up

Chemical engineering unit operation labsdo an excellent job of integrating the whole curriculumand exposing students to pilot-scale systems. Where theyare often lacking, though, is the exposure to and use ofreal-life industrial automation by the future graduates. Aunit operation lab that has been automated usingindustrial level paradigms and equipment is the focus ofthis paper. A partnership with a global automationmanufacturer (Emerson) was established and the lab wasretrofitted using industrial sensors and actuators, aDistributed Control System (DeltaV DCS), industrialnetworks (FOUNDATION Fieldbus and AS-i), HumanMachine Interface (HMI) screens, and systemredundancy. The details of the automation along with itsuse through the lab curriculum will be discussed. Thiscross-curricular approach benefits students as, throughthe regular unit operation labs, they become familiar withkey elements of an automated set-up, understand the needfor it and its limitations, see control loops in action,communicate to the units through the HMI, and use theHMI to recover historical data on the processes. The labis a meso-scale of a processing facility and preparesstudents for field work after graduation. At the sametime, the traditional exposure to “manually operated”sensors and final elements is maintained as some of theunits have not been converted to fully automated systems

scholarly journals Story beats in videogames as value-driven choice-based unit operations

2021 ◽  
Vol 29 (38) ◽  
pp. 5-31
Author(s):  
Michał Mochocki ◽  
Raine Koskimaa
Keyword(s):  
Narrative Analysis ◽  
Game Design ◽  
Design Patterns ◽  
Game Studies ◽  
Unit Operation ◽  
Action Unit ◽  
Unit Operations ◽  
Cognitive Narratology ◽  
Recent Trends ◽  
Game Design Patterns

We present a framework of story beats, defined as microunits of dramatic action, as a tool for the ludonarrative analysis of videogames. First, we explain the Goal - Action - Reaction - Outcome model of the story beat. Then, we present six types of story beats, Action, Interaction, Inaction, Mental, Emotion, and Sensory, providing videogame examples for each category. In the second half of the paper, we contextualise this framework in the classic game studies theory of videogame narrative and player action: unit operations, gamic action, anatomy of choice, and game design patterns, wrapping it up in the most recent trends in cognitive narratology. Ultimately, we present the story beat as a ludonarrative unit, working simultaneously as a ‘unit operation’ in the study of games as systems, and as a microunit of character action in narrative analysis. The conclusion outlines prospective directions for using story beats in formal, experiential, and cultural game research.

scholarly journals A Novel Framework to Aid the Development of Design Space across Multi-Unit Operation Pharmaceutical Processes—A Case Study of Panax Notoginseng Saponins Immediate Release Tablet

Pharmaceutics ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 474 ◽  
Author(s):  
Fei Sun ◽  
Bing Xu ◽  
Shengyun Dai ◽  
Yi Zhang ◽  
Zhaozhou Lin ◽  
...  
Keyword(s):  
Process Modeling ◽  
Design Space ◽  
Panax Notoginseng ◽  
Immediate Release ◽  
Path Model ◽  
Unit Operation ◽  
Panax Notoginseng Saponins ◽  
Holistic View ◽  
Unit Operations ◽  
Release Tablet

The fundamental principle of Quality by Design (QbD) is that the product quality should be designed into the process through an upstream approach, rather than be tested in the downstream. The keystone of QbD is process modeling, and thus, to develop a process control strategy based on the development of design space. Multivariate statistical analysis is a very useful tool to support the implementation of QbD in pharmaceutical process development and manufacturing. Nowadays, pharmaceutical process modeling is mainly focused on one-unit operations and system modeling for the development of design space across multi-unit operations is still limited. In this study, a general procedure that gives a holistic view for understanding and controlling the process settings for the entire manufacturing process was investigated. The proposed framework was tested on the Panax Notoginseng Saponins immediate release tablet (PNS IRT) production process. The critical variables and the critical units acting on the process were identified according to the importance of explaining the variability in the multi-block partial least squares path model. This improved understanding of the process by illustrating how the properties of the raw materials, the process parameters in the wet granulation and the compaction and the intermediate properties affect the tablet properties. Furthermore, the design space was developed to compensate for the variability source from the upstream. The results demonstrated that the proposed framework was an important tool to gain understanding and control the multi-unit operation process.

scholarly journals Collaborative Approach for Teaching Chemical Process Design

2013 ◽  
Author(s):  
Michel F. Couturier ◽  
Guida Bendrich
Keyword(s):  
Process Design ◽  
Chemical Engineering ◽  
Local Economy ◽  
Faculty Members ◽  
Engineering Practice ◽  
Final Report ◽  
Collaborative Approach ◽  
Chemical Process Design ◽  
Engineering Program ◽  
Design Activities

A collaborative approach has been successfully used to teach the senior process design course in the Chemical Engineering program at UNB since 2010. Every design project in the course is sponsored by an outside client. Two teams of four or five students are assigned to each project. The teams work independently and are co-mentored by a faculty member and a practicing engineer. This collaborative approach brings engineering practice in the classroom while keeping faculty members in control of academic requirements. Eight evenly-spaced milestones pace students and co-mentors by defining the tasks that need to be accomplished, by setting the marking scheme for the deliverables and by providing a framework for the progressive assembly of a high-quality final report. Our approach has increased the number of faculty members interested in design activities and allows students to contribute to the local economy while becoming proficient in engineering design. Comments received from students, clients and co-mentors have been highly positive.

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