Neurology

Author(s):  
Ross Paterson ◽  
Laszlo Sztriha

The face of neurology in clinical practice is changing. Neurology is no longer primarily a diagnostic specialty. As more therapeutic treatments become available in all fields from epilepsy to multiple sclerosis, early and accurate diagnosis is increasingly required so that patients can benefit from early treatment aiming to reduce the lifelong burden of neuro­logical disease. Diagnosis of neurological disorders is often considered by junior doc­tors to be highly complex and, as such, is responsible for a great deal of anxiety. One of the most difficult challenges can be determining the loca­tion of the lesion. A helpful approach to this is by analysis of the patterns that each lesion produces. Table 8.1 describes some of the common patterns seen in clinical practice, and the questions in this chapter will attempt to highlight some of the other specific presentations needed in assessing the neurology patient.

2018 ◽  
Vol 8 (4) ◽  
pp. 65-69
Author(s):  
Mao Nguyen Van ◽  
Dong Tran Nam

Background: Pigmented tumour of the skin is one of the common tumour in human including the benign pigmented tumours (more common) called Nevi tumours and the malignant one called melanoma which was less frequent but the most poor in prognosis. In addition, the others not belonging to these group had the same clinical appearance, so the application of histopathology and immunohistochemistry for the definitive diagnosis was indespensible. Objectives: 1. To describe the macroscopic features of the pigmented tumoral-like lesions; 2. To classify the histopathologic types of the pigmented cell tumours and the other pigmented tumours of the skin. Materials and Method: Cross-sectional research on 55 patients diagnosed as pigmented tumoral lesions by clinician, then all definitively diagnosed by histopathology combining the immunohistochemistry in difficult cases. Results: There was no difference in gender, the disease was discovered most common in adult, especially with the age over 51 years old (58.1%). the most region located was in the face accounting for 60%, following the trunk and limbs (14.6%, 12.8% respectively). All 3 malignant melanomas happened in foot. The most common color of the lesions was black (65.4%), the other ones were rose, grey and blue. Histopathology and immunohisthochemistry showed that the true pigmented cell tumours were 52.6% encompassing benign ones (Nevi tumour) (41.8%), melanoma (5.4%) and lentigo (5.4%). 47.4% was not the true pigmented cell tumour including pigmented basocellular carcinoma (36.4%) and the others less common as histiofibromas, acanthoma and papilloma. Conclusion: the pigmented tumoral-like lesions of the skin could be the true pigmented cell tumours and the others, so the application of the histopathology and the immunohistochemistry after the clinical discovery helps to determine and classify the disease definitely and for the best orientation of treatment as well. Key words: skin tumour, benign pigmented tumour (Nevi), malignant pigmented tumour (melanoma), pigmented basocellular carcinoma


Author(s):  
Kristine O’Phelan

The purpose of the Oral Board Examination is to determine a candidate’s competency in neurosurgical disorders, but also neurological disorders, which may mimic neurosurgical conditions. It is not uncommon for a candidate to be presented imaging studies that clearly appear surgical; however, after carefully listening to the history and relevant neurological findings, it will become apparent that the imaging does not explain the patient’s symptoms. Some of the common neurological ailments that the Oral Board examinee needs to be well aware of include amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), Guillain-Barré syndrome, and Parsonage=Turner syndrome (brachial plexitis), some of which are covered either in this chapter or in other relevant chapters.


Author(s):  
Andrew Graham

Dementia in old age is usually due to Alzheimer’s disease, cerebrovascular disease, or mixed pathology. Dementia due to other neurological disorders is uncommon, but important to recognise because management may be very different to that in primary or vascular dementia. This chapter surveys five neurological conditions that may present with dementia in later life: idiopathic normal pressure hydrocephalus (INPH); Huntington’s disease (HD); multiple sclerosis (MS); autoimmune limbic encephalitis (LE); and prion disease. For each disorder the epidemiology, clinical features, investigations & treatment are reviewed, with examples of the characteristic brain imaging changes. Accurate diagnosis of these conditions can be challenging even for physicians with a special interest in dementia, and often requires a neurological referral.


1988 ◽  
Vol 23 (4) ◽  
pp. 395-412 ◽  
Author(s):  
Ronald Dore

THE STEADY EXPANSION OF THE FUNCTIONS OF GOVERNMENT and its increasingly interventionist role in the economy has for much of the twentieth century seemed an inexorable and irreversible trend. The jurist, Dicey, already saw it as such at the beginning of the century. In a famous series of lectures, he traced the retreat of Benthamite individualist liberalism in the face of what he called ‘collectivism’. The common theme in all the developments he considered — the protection given to trade unions on the one hand, compulsory education and municipal trading on the other — was their limitation of the freedom of contract, the limitation of — the buzz-word of British politics in the late 1980s — ‘choice’.


2017 ◽  
Vol 2 (2) ◽  
pp. 66-78
Author(s):  
Muhammad Iqbal Rahim ◽  
Hesti Gunarti ◽  
Nurhuda Hendra Setyawan

Craniosynostosis is a condition in which there is premature fusion of one or more cranial sutures, causing neurological disorders, distinctive deformities of the face and skull, also accompanied by increased intracranial pressure, visual impairment, deafness and cognitive deficits.  Craniosynostosis may appear in primary or secondary secondary to other disorders. As many as 85% of primary craniosynostosis emerged as a single condition while the remaining 15% as part of the multisystem syndrome. Radiological examination is important for accurate diagnosis, surgical planning, therapeutic evaluation and identification of comorbid anomalies and complications related to craniosynostosis. Computed Tomography (CT) with 3-D reconstruction is a technique used to diagnose craniosynostosis because it can provide a better picture of bone. Nevertheless, the presence of radiation exposure from CT scan, especially in infants causes the authors to look for alternatives to other radiological examination techniques including the use of ultrasonography, plain cranial rontgen and MRI


2021 ◽  
Vol 14 (10) ◽  
pp. 1031
Author(s):  
Atefeh Rayatpour ◽  
Sahar Farhangi ◽  
Ester Verdaguer ◽  
Jordi Olloquequi ◽  
Jesus Ureña ◽  
...  

Despite the significant differences in pathological background of neurodegenerative diseases, epileptic seizures are a comorbidity in many disorders such as Huntington disease (HD), Alzheimer’s disease (AD), and multiple sclerosis (MS). Regarding the last one, specifically, it has been shown that the risk of developing epilepsy is three to six times higher in patients with MS compared to the general population. In this context, understanding the pathological processes underlying this connection will allow for the targeting of the common and shared pathological pathways involved in both conditions, which may provide a new avenue in the management of neurological disorders. This review provides an outlook of what is known so far about the bidirectional association between epilepsy and MS.


Author(s):  
Marcus Morris

Moving beyond simplistic assumptions of a pro-cuts to defence spending ILP (and their allies) and a jingoistic, verging on pro-war Labour right, Morris invites us to reconsider how the common goal of peace could be pursued through seemingly divergent means. On the one side stood those who viewed military spending as inevitably leading to war – why improve one’s military, after all, not to use it – but on the other emerged a ‘patriotic Labour’ who urged Britain not to remain defenceless in the face of German aggression


2012 ◽  
Vol 53 (2) ◽  
pp. 171-180
Author(s):  
Marcin Telicki

Summary The article examines a parallel between Emmanuel Lévinas’s and Czesław Miłosz’s philosophical reflection about the duties of literature. The common ground can be found in Lévinas’s well-known idea of encountering the Other through the Face. This form of communication, which is by no means easy, is given extra depth by liminal experiences of transience and death. As the examples from the second part of this article show these experiences seem to mark the greatest achievements of twentieth-century literature. Finally, the question is asked about the two writers’ views on the place of philosophy and reflection on transcendence. Even though they do not see eye to eye on these points, the plurality of values and judgments expressed by them should not compel us to classify their work as completely disparate and incomparable.


2015 ◽  
Vol 3 (1) ◽  
pp. 38
Author(s):  
Ali K. Bidan ◽  
Nisreen A. Hamzah

<p>Multiple sclerosis (MS) is a disease characterized by inflammation and demyelination. Currently, the cause of MS is unknown. An early and accurate diagnosis of multiple sclerosis (MS) is very important, since it allows early treatment initiation, which reduces the activity of the disease. The present study aimed to focus a light on the contribution of interlukin-35 (IL-35) and its relation to some hormones such as testosterone, progesterone, and prolactin (PRL) in the pathogenesis of multiple sclerosis. Twenty two enrollers (samples) attended from Teaching hospital of Baghdad were divided into two groups. Ten enrollers were described as healthy subject as control group as group 1 (G1) in range ages (20-30) years. Twelve male patients as group 2 (2) have been relapsing remitting multiple sclerosis (RRMS) matched in age with group 1 (G1).</p>


1916 ◽  
Vol 2 (2) ◽  
pp. 222-229
Author(s):  
A. E. Peake
Keyword(s):  
The Face ◽  

In the County of Herts., gravel is worked for road metal in many places, and in 1915, when staying at Harpenden, I was able to give some attention to a spot not far from that place, already known to me from descriptions in Evans' “Stone Implements,” and Worthington Smith's “Primeval Man,” viz., No Man's Common.This common extends over the face of a shallow valley, now dry, which as Sir J. Evans (“Ancient Stone Implements,” p. 602) remarks, was formerly the course of a stream, either the Lea itself or one of its branches. Two sections have been opened at this spot, one superficial, the other deep and extensive. It is from the latter—from which an immense amount of gravel has been removed—that I obtained the implements described in this paper. The common lies about a mile south of Wheathampstead.


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