Disorders of Musical Cognition

2012 ◽  
Author(s):  
Lauren Stewart ◽  
Katharina von Kriegstein ◽  
Simone Dalla Bella ◽  
Jason D. Warren ◽  
Timothy D. Griffiths
Keyword(s):  
Case Studies ◽  
Cognitive Neuroscience ◽  
Cognitive Architecture ◽  
Critical Role ◽  
Theoretical Models ◽  
Systematic Evaluation ◽  
Neural Basis ◽  
The Past ◽  
Musical Cognition ◽  
Musical Listening

This article presents an overview of case studies of acquired disorders of musical listening. Like any cognitive faculty, music is multifaceted, and the identification of the neural basis of any complex faculty must proceed, hand in hand, with an elucidation of its cognitive architecture. The past decade has seen an evolution in the theoretical models of musical processing, allowing the development of theoretically motivated instruments for the systematic evaluation of musical disorders. Such developments have allowed reports of musical disorders to evolve from historical anecdotes to systematic, verifiable accounts that can play a critical role in contributing to our understanding of the cognitive neuroscience of music.

scholarly journals fMRI Evidence for the Role of Recollection in Suppressing Misattribution Errors: The Illusory Truth Effect

2005 ◽  
Vol 17 (5) ◽  
pp. 800-810 ◽  
Author(s):  
Jason P. Mitchell ◽  
Chad S. Dodson ◽  
Daniel L. Schacter
Keyword(s):  
Cognitive Neuroscience ◽  
Neural Basis ◽  
Subsequent Performance ◽  
The Past ◽  
Cognitive Studies ◽  
Truth Effect ◽  
The Mind ◽  
Performance Results ◽  
Illusory Truth Effect

Misattribution refers to the act of attributing a memory or idea to an incorrect source, such as successfully remembering a bit of information but linking it to an inappropriate person or time [Jacoby, L. L., Kelley, C., Brown, J., & Jasechko, J. (1989). Becoming famous overnight: Limits on the ability to avoid unconscious influences of the past. Journal of Personality and Social Psychology, 56, 326–338; Schacter, D. L. (1999). The seven sins of memory: Insights from psychology and cognitive neuroscience. American Psychologist, 54, 182–203; Schacter, D. L. (2001). The seven sins of memory: How the mind forgets and remembers. Boston: Houghton Mifflin]. Cognitive studies have suggested that misattribution errors may occur in the absence of recollection for the details of an initial encounter with a stimulus, but little is known about the neural basis of this memory phenomenon. Here we used functional magnetic resonance imaging (fMRI) to examine the hypothesized role of recollection in counteracting the illusory truth effect, a misattribution error whereby perceivers systematically overrate the truth of previously presented information. Imaging was conducted during the encoding and subsequent judgment of unfamiliar statements that were presented as true or false. Event-related fMRI analyses were conditionalized as a function of subsequent performance. Results demonstrated that encoding activation in regions previously associated with successful recollection—including the hippocampus and the ventrolateral prefrontal cortex (PFC)—correlated with the successful avoidance of misattribution errors, providing initial neuroimaging support for earlier cognitive accounts of misattribution.

scholarly journals Neurocognitive Basis of Schizophrenia: Information Processing Abnormalities and Clues for Treatment

2014 ◽  
Vol 2014 ◽  
pp. 1-15 ◽  
Author(s):  
André Aleman
Keyword(s):  
Information Processing ◽  
Social Cognition ◽  
Cognitive Neuroscience ◽  
Emotional Processing ◽  
Treatment Strategies ◽  
Specific Information ◽  
Neural Basis ◽  
Brain Areas ◽  
Cognition And Emotion ◽  
The Past

Schizophrenia is a chronic and severe psychiatric disorder that affects all aspects of patients’ lives. Over the past decades, research applying methods from psychology and neuroscience has increasingly been zooming in on specific information processing abnormalities in schizophrenia. Impaired activation of and connectivity between frontotemporal, frontoparietal, and frontostriatal brain networks subserving cognitive functioning and integration of cognition and emotion has been consistently reported. Major issues in schizophrenia research concern the cognitive and neural basis of hallucinations, abnormalities in cognitive-emotional processing, social cognition (including theory of mind), poor awareness of illness, and apathy. Recent findings from cognitive neuroscience studies in these areas are discussed. The findings may have implications for treatment, for example, noninvasive neurostimulation of specific brain areas. Ultimately, a better understanding of the cognitive neuroscience of schizophrenia will pave the way for the development of effective treatment strategies.

Application of AFP in Resolving Systematic Issue in Wafer Fabrication

2013 ◽  
Author(s):  
Hui Peng Ng ◽  
Ghim Boon Ang ◽  
Chang Qing Chen ◽  
Alfred Quah ◽  
Angela Teo ◽  
...  
Keyword(s):  
Failure Analysis ◽  
Case Studies ◽  
Failure Mechanisms ◽  
Critical Role ◽  
Electrical Characterization ◽  
Process Technology ◽  
Atomic Force ◽  
Defect Localization ◽  
Non Volatile Memory ◽  
Visual Failure

Abstract With the evolution of advanced process technology, failure analysis is becoming much more challenging and difficult particularly with an increase in more erratic defect types arising from non-visual failure mechanisms. Conventional FA techniques work well in failure analysis on defectively related issue. However, for soft defect localization such as S/D leakage or short due to design related, it may not be simple to identify it. AFP and its applications have been successfully engaged to overcome such shortcoming, In this paper, two case studies on systematic issues due to soft failures were discussed to illustrate the AFP critical role in current failure analysis field on these areas. In other words, these two case studies will demonstrate how Atomic Force Probing combined with Scanning Capacitance Microscopy were used to characterize failing transistors in non-volatile memory, identify possible failure mechanisms and enable device/ process engineers to make adjustment on process based on the electrical characterization result. [1]

Trail-Blazer Dependency – A Roadmap for the Sustainability Revolution

2020 ◽  
Vol 13 (2) ◽  
pp. 317-337
Author(s):  
Jan Kunnas
Keyword(s):  
Case Studies ◽  
Environmental Problems ◽  
Pulp And Paper ◽  
Historical Research ◽  
The Past ◽  
Success Stories ◽  
Electric Car ◽  
Major Benefit ◽  
Quality Movement

While geologists are still considering whether the Anthropocene should be accepted as a formal geological epoch, it is up to us humanists to search for ways making this human era a good one. In this article, I will examine how we can use historical research to provide such tracks based on past regularities or similarities. Positive success stories from the past can at least provide faith that we can do something about our current environmental problems. This investigation is based on two case studies: the Tesla Model S electric car, and the Swedish pulp and paper industry's transition to chlorine-free bleaching. It argues that the sustainability revolution doesn't just share similarities with the quality movement of the 1970s and 1980s, but is essentially a continuation of it. In concordance with previous megatrends, the major benefit of the sustainability revolution will be reaped by countries and companies running ahead of the curve. A new term, 'trail-blazer dependency' is introduced; by setting an example, the first-movers are opening a trail for late-comers to follow.

scholarly journals Small Molecule Inhibitors of Influenza Virus Entry

2021 ◽  
Vol 14 (6) ◽  
pp. 587
Author(s):  
Zhaoyu Chen ◽  
Qinghua Cui ◽  
Michael Caffrey ◽  
Lijun Rong ◽  
Ruikun Du
Keyword(s):  
Influenza Virus ◽  
Membrane Fusion ◽  
Small Molecule ◽  
Drug Target ◽  
Small Molecule Inhibitors ◽  
Virus Entry ◽  
Critical Role ◽  
Structural Basis ◽  
Future Directions ◽  
The Past

Hemagglutinin (HA) plays a critical role during influenza virus receptor binding and subsequent membrane fusion process, thus HA has become a promising drug target. For the past several decades, we and other researchers have discovered a series of HA inhibitors mainly targeting its fusion machinery. In this review, we summarize the advances in HA-targeted development of small molecule inhibitors. Moreover, we discuss the structural basis and mode of action of these inhibitors, and speculate upon future directions toward more potent inhibitors of membrane fusion and potential anti-influenza drugs.

scholarly journals The fruitless gene affects female receptivity and species isolation

2020 ◽  
Vol 287 (1923) ◽  
pp. 20192765 ◽  
Author(s):  
Tabashir Chowdhury ◽  
Ryan M. Calhoun ◽  
Katrina Bruch ◽  
Amanda J. Moehring
Keyword(s):  
Mate Choice ◽  
Critical Role ◽  
Sensory Modality ◽  
Female Mate Choice ◽  
Neural Basis ◽  
Female Receptivity ◽  
Female Mate ◽  
Multiple Transcripts ◽  
Female Behaviour ◽  
Substrate Vibrations

Female mate rejection acts as a major selective force within species, and can serve as a reproductive barrier between species. In spite of its critical role in fitness and reproduction, surprisingly little is known about the genetic or neural basis of variation in female mate choice. Here, we identify fruitless as a gene affecting female receptivity within Drosophila melanogaster , as well as female Drosophila simulans rejection of male D. melanogaster . Of the multiple transcripts this gene produces, by far the most widely studied is the sex-specifically spliced transcript involved in the sex determination pathway. However, we find that female rejection behaviour is affected by a non-sex-specifically spliced fruitless transcript. This is the first implication of fruitless in female behaviour, and the first behavioural role identified for a fruitless non-sex-specifically spliced transcript. We found that this locus does not influence preferences via a single sensory modality, examining courtship song, antennal pheromone perception, or perception of substrate vibrations, and we conclude that fruitless influences mate choice via the integration of multiple signals or through another sensory modality.

scholarly journals Usage-Based Collection Evaluation with a Curricular Focus

2013 ◽  
Vol 74 (1) ◽  
pp. 85-97 ◽  
Author(s):  
Karen C. Kohn
Keyword(s):  
Academic Library ◽  
Evaluation Methods ◽  
Systematic Evaluation ◽  
Collection Development ◽  
The Past

Systematic evaluation of a library’s collection can be a useful tool for collection development. After reviewing three evaluation methods and their usefulness for our small academic library, I undertook a usage-based evaluation, focusing on narrow segments of our collection that served specific undergraduate courses. For each section, I collected data on the number of books owned, number of checkouts in the past four years, and number of unique books used. Using examples from the data, I discuss possible ways to interpret and act on the data. I also note how the knowledge gained from this evaluation fits into the larger toolkit of librarian competencies for collection development.

Systematic Evaluation of Office Ergonomics Training Programs

2000 ◽  
Vol 44 (12) ◽  
pp. 2-709-2-712 ◽  
Author(s):  
Michelle M. Robertson ◽  
Marie Robinson
Keyword(s):  
Case Studies ◽  
Training Programs ◽  
Evaluation Process ◽  
Systematic Evaluation ◽  
Office Environment ◽  
Positive Effects

This paper presents a systematic evaluation process to measure the effectiveness and benefits of office ergonomic training programs. Positive effects of such training is illustrated by two case studies involving office environment technologies. Successful components of office ergonomics training are also described.

Negotiating without the victim state: the exclusiveness of anticorruption settlements

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Nadja Capus ◽  
Kei Hannah Brodersen
Keyword(s):  
Case Studies ◽  
Design Methodology ◽  
Criminal Proceedings ◽  
International Guidelines ◽  
England And Wales ◽  
Content Type ◽  
The Past ◽  
Settlement Agreements ◽  
To Receive ◽  
Obligation To Inform

Purpose Corporate foreign bribery can have devastating consequences on communities and states. Over the past decade, there have been several promising developments, both national and international, that might increase the chances of victim states to receive remediation for the harm they suffered from foreign bribery. In particular, awareness has risen that victim states must be considered and new innovative items have been added to the toolbox of prosecutors in the fight against corruption that is assumed to also improve victim states’ standing in these procedures. This study aims to assess whether indeed victim states receive compensation through these novel procedures. Design/methodology/approach This study uses the three case studies of Switzerland, France and England and Wales for a comprehensive empirical and normative analysis of settlement agreements between defendants and prosecution authorities and of court jurisprudence. Findings This study shows that although de jure, it seems warranted to order the payment of remedies to victim states within domestic criminal proceedings, in practice, this rarely happens. A number of legal and practical obstacles account for this situation. This study, therefore, calls for the formulation of international guidelines containing the obligation to inform victim states of ongoing criminal proceedings on corporate foreign bribery, and guidance on how to identify the victim of this crime, as well as the damage caused. Originality/value This is the first contribution to verify whether claims that settlement agreements, recently introduced in England and Wales and France (and similar procedures are available in Switzerland), are beneficial for victim states in their quest to receive compensation. As this study shows that this is – not yet – the case in practice, this study proposes solutions that could lead the way for remediation of the harm caused by corporate corruption – and thereby, ultimately, to a more just outcome.

scholarly journals The Neural Basis of Reversible Sentence Comprehension: Evidence from Voxel-based Lesion Symptom Mapping in Aphasia

2012 ◽  
Vol 24 (1) ◽  
pp. 212-222 ◽  
Author(s):  
Malathi Thothathiri ◽  
Daniel Y. Kimberg ◽  
Myrna F. Schwartz
Keyword(s):  
Working Memory ◽  
Parietal Cortex ◽  
Sentence Comprehension ◽  
Critical Role ◽  
Broca's Area ◽  
Neural Basis ◽  
Phonological Working Memory ◽  
Large Group ◽  
Complex Sentences ◽  
Lesion Symptom Mapping

We explored the neural basis of reversible sentence comprehension in a large group of aphasic patients (n = 79). Voxel-based lesion symptom mapping revealed a significant association between damage in temporo-parietal cortex and impaired sentence comprehension. This association remained after we controlled for phonological working memory. We hypothesize that this region plays an important role in the thematic or what–where processing of sentences. In contrast, we detected weak or no association between reversible sentence comprehension and the ventrolateral pFC, which includes Broca's area, even for syntactically complex sentences. This casts doubt on theories that presuppose a critical role for this region in syntactic computations.

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