The influence of different electrode configurations on the inhibitory effect of subthreshold high-frequency stimuli

1994 ◽  
Vol 15 (12) ◽  
pp. 1681-1688 ◽  
Author(s):  
F. J. CHORRO ◽  
J. SANCHIS ◽  
V. LóPEZ-MERINO ◽  
M. BURGUERA ◽  
M. L. MARTINEZ-MAS ◽  
...  
Perception ◽  
10.1068/p3466 ◽  
2003 ◽  
Vol 32 (1) ◽  
pp. 111-120 ◽  
Author(s):  
Jeesun Kim ◽  
Chris Davis

We investigated audio-visual (AV) perceptual integration by examining the effect of seeing the speaker's synchronised moving face on masked-speech detection ability. Signal amplification and higher-level cognitive accounts of an AV advantage were contrasted, the latter by varying whether participants knew the language of the speaker. An AV advantage was shown for sentences whose mid-to-high-frequency acoustic envelope was highly correlated with articulator movement, regardless of knowledge of the language. For low-correlation sentences, knowledge of the language had a large impact; for participants with no knowledge of the language an AV inhibitory effect was found (providing support for reports of a compelling AV illusion). The results indicate a role for both sensory enhancement and higher-level cognitive factors in AV speech detection.


1969 ◽  
Vol 51 (3) ◽  
pp. 787-802 ◽  
Author(s):  
J. M. McKAY

1. The responses of the auditory interneurones indicate that the tettigoniid ear discriminates frequencies. 2. The T fibre receives strong ipsilateral and weak contralateral excitatory inputs and a strong contralateral inhibitory input, from the tympanic nerves. These inputs are frequency-sensitive, the response being greatest at 30 kcyc./sec. and above. Responsiveness is low in the region of 15 kcyc./sec., which is the dominant song frequency. 3. At 30 kcyc./sec. the T fibre is most sensitive to amplitude increments, and conveys maximal directional information. Both the T fibre and the ear (as judged by the compound potential in the tympanic nerve) respond to steps of 2 dB. The directionality of the ear is enhanced by the contralateral inhibitory connexions of the T fibre. At 15 kcyc./sec. directionality is poor, but is present at 10 kcyc./sec. 4. The T fibre is inhibited by continuous sounds, including the species song. The extent of the inhibitory effect varies with the amplitude of the continuous sound. This may assist in explaining the ‘phasic’ response of the T fibre. There is little habituation to repetitive stimuli. 5. A small interneurone seen in split connectives gives a ‘tonic’ response to song and to continuous sound. It may inhibit the T fibre. Two other auditory fibres are occasionally recorded in the connectives. 6. The T fibre has all the properties required of a warning system responding to pulsed high-frequency sound, and it responds well to bat cries. There is, however, no evidence that it mediates a behavioural response.


1981 ◽  
Vol 36 (1-2) ◽  
pp. 87-92 ◽  
Author(s):  
Patrick C. Hallenbeck ◽  
Leon V. Kochian ◽  
John R. Benemann

Abstract Cultures of Anabaena cylindrica, grown on media containing 5 mᴍ NH4Cl (which represses heterocyst formation), evolved hydrogen after a period of dark incubation under an argon atmosphere. This hydrogen production was not due to nitrogenase activity, which was nearly undetectable, but was due to a hydrogenase. Cultures grown on media with tungsten substituted for molybdenum had a high frequency of heterocysts (15%) and inactive nitrogenase after nitrogen starvation. The hydrogenase activity of these cultures was three-fold greater than the activity of non-heterocystous cultures. The effects of oxygen inhibition on hydrogen evolution by hetero-cystous cultures suggest that two pools of hydrogenase activity exist - an oxygen sensitive hydrogen evolution in vegetative cells and a relatively oxygen-resistent hydrogen evolution in heterocysts. In either case, inhibition by oxygen was reversible. Light had an inhibitory effect on net hydrogen evolution. Hydrogen production in vitro was much higher than in vivo, indicating that in vivo hydrogenase activity is limited by endogenous reductant supply.


Cancers ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1141
Author(s):  
Kae Nakamura ◽  
Nobuhisa Yoshikawa ◽  
Yuko Mizuno ◽  
Miwa Ito ◽  
Hiromasa Tanaka ◽  
...  

Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy. The major cause of EOC’s lethality is that intraperitoneal recurrence occurs with high frequency due to occult metastasis. We had demonstrated that plasma-activated medium (PAM) exerts a metastasis-inhibitory effect on ovarian cancer in vitro and in vivo. Here we investigated how PAM inhibits intraperitoneal metastasis. We studied PAM’s inhibition of micro-dissemination onto the omentum by performing in vivo imaging in combination with a sequential histological analysis. The results revealed that PAM induced macrophage infiltration into the disseminated lesion. The iNOS-positive signal was co-localized at the macrophages in the existing lesion, indicating that PAM might induce M1-type macrophages. This may be another mechanism of the antitumor effect through a PAM-evoked immune response. Intraperitoneal lavage with plasma-activated lactate Ringer’s solution (PAL) significantly improved the overall survival rate in an ovarian cancer mouse model. Our results demonstrated the efficiency and practicality of aqueous plasma for clinical applications.


2001 ◽  
Vol 420 (2-3) ◽  
pp. 119-122 ◽  
Author(s):  
Kiyoshi Ichikawa ◽  
Natsu Koyama ◽  
Sumiyoshi Kiguchi ◽  
Masami Kojima ◽  
Toshikatsu Yokota

1961 ◽  
Vol 200 (4) ◽  
pp. 715-717 ◽  
Author(s):  
Wei Young ◽  
Frank Upham

Effects of frequency of stimulation were studied in the isolated vagal heart preparation of Rana pipiens. Normal inhibitory effects were readily obtainable by stimulating the vagus nerve at pulse rates between 10 pulses/sec. and 100 pulses/sec. for a period of 10 seconds. A little above 100 pulses/sec. or below 10 pulses/ sec. the heart was usually less responsive to the same period of vagal stimulation. Below 5 pulses/sec. or above 200 pulses/ sec. the isolated preparation was practically nonresponsive to vagal stimulation for the 10-second period. The heart was responsive to the lower pulse rate but not to the higher rate when stimulated for a longer period. Arrhythmia usually was induced by frequent application of high-frequency stimulation. This suggests that the pacemaker is somehow temporarily impaired by high-frequency bombardment. The inhibitory effect is proportional to the duration of the impulse for any optimal frequency. The observed inhibitory vagal phenomenon results primarily from the liberation of an acetylcholine-like substance from the vagal nerve endings. The amount of this substance liberated can be assayed quantitatively. It was estimated that each optimal volley liberated approximately 2.5 x 10–11 gm of acetylcholine-like substance.


2015 ◽  
Vol 713-715 ◽  
pp. 1081-1085
Author(s):  
Guan Qun Zhao ◽  
Ze Zhong Wang ◽  
Bo Dong ◽  
Li Li Zhao ◽  
Ke Wang

With the deep and promotion of unattended work in substations, the correct rate of remote signal becomes an important index in automation scheduling system. For remote signal false caused by high-frequency interferences in substation, we propose the use of Ni-Zn ferrite ring to suppress high-frequency interferences. The frequency-impedance characteristics of ferrite ring with different turns are tested. And the inhibitory effect of ferrite ring on interferences below and above 100MHz is measured separately. We installed ferrite rings in remote signal loops, and compared the voltage waveforms before and after installation. Experimental results provide some references to suppress high-frequency interferences by Ni-Zn ferrite ring.


2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
Chi-Chung Kuo ◽  
Huei-Yann Tsai ◽  
Jaung-Geng Lin ◽  
Hong-Lin Su ◽  
Yuh-Fung Chen

The present study was conducted to evaluate the effect of electroacupuncture-(EAc-) induced antinociception (EAA) at different currents and frequencies in rat spinal cord. We found that naloxone (0.05 μg i.t.) blocked EAA at different frequencies. Naltrindole (0.05 μg i.t.) blocked EAA on the 7th day after EAc of 100 Hz. 5,7-Dihydroxytryptamine (100 μg i.t.) significantly inhibited EAA at different frequencies on the 7th day after EAc. Pindobind (0.5μg i.t.), a 5-HT1Aantagonist, notably attenuated EAA at different frequencies. Ketanserin (0.5 μg i.t.), inhibited EEA at a lower frequency (<10 Hz) than at a higher frequency (100 Hz). LY-278584 (0.5 μg i.t.) significantly inhibited EAA at a higher frequency (100 Hz) on the 7th day after EAc. The direction of effect of 8-OH-DPAT, on EAA was dependent on dosage. It had an inhibitory effect at a low dose (0.5 μg i.t.) and a high frequency (100 Hz) but enhanced EAA at a higher dose at lower frequencies (<10 Hz). DOI (10 μg, i.t.), did not affect EAA. These data indicate that the mechanism of EAA involves opioid receptors, and the serotonergic system, particularly,μ-,δ-opioid and 5-HT1A, 5-HT3receptors and it is also dependent on the EAc frequency.


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