A Comparative study between topical 15% potassium hydroxide and 20% Salicylic acid in treatment of multiple palmoplantar warts

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Wafa Sleman Elmoalef ◽  
Mahira Hamdy Elsayed ◽  
Rania Mahmoud Elhusseiny
Keyword(s):  
Salicylic Acid ◽  
Patient Satisfaction ◽  
Human Papillomavirus ◽  
Side Effects ◽  
Clinical Improvement ◽  
Potassium Hydroxide ◽  
Benign Neoplasms ◽  
Significant Treatment ◽  
Acid Therapy ◽  
Plantar Warts

Abstract Warts are one of the most common benign neoplasms. Warts are induced by over 100 types of human papillomavirus (HPVs) and can affect any race. Various treatments were considered to treat warts, of which topical salicylic acid and KOH are the most commonly used choices. Aim of the study To compare between the efficacy, safety and recurrence rate of topical 15% potassium hydroxide (KOH) and 20% Salicylic acid in the treatment of multiple palm plantar warts. Patients and methods study included 40 patients complaining of multiple palmar and/or planter warts 2 lesions at least. Each patient was treated by: Salicylic acid 20% used on one lesion and topical 15% KOH preparation used on another lesion. Assessment of patients’ response was done through clinical and dermoscopic examination. Results Salicylic acid results revealed that 5% of the treated lesions showed Clinical improvement without dermoscopic clearance, 40% showed Clinical clearance with dermoscopic remnants while 55% showed Clinical and dermoscopic clearance. KOH treated warts showed 5% of the treated lesions had clinical improvement without dermoscopic clearance, 25% showed clinical clearance with dermoscopic remnants while 70% showed clinical and dermoscopic clearance. Conclusion KOH therapy as well as patient satisfaction showed higher significant treatment response compared to salicylic acid therapy with less encountered side effects.

scholarly journals Comparison of Safety and Efficacy of Potassium Hydroxide versus Combination of Salicylic and Lactic Acid for Molluscum Contagiosum

2019 ◽  
Vol 8 (3) ◽  
pp. 131-134
Author(s):  
Durre-Shehwar Arshad Pirzada ◽  
Sumaira Abdullah ◽  
Qurat-ul Ain Zia ◽  
Syed Afaq Ahmed ◽  
Hamid Ali
Keyword(s):  
Salicylic Acid ◽  
Lactic Acid ◽  
Side Effects ◽  
Potassium Hydroxide ◽  
Pediatric Population ◽  
Molluscum Contagiosum ◽  
Final Visit ◽  
Local Irritation ◽  
Group A ◽  
Group B

Background: Molluscum contagiosum (MC) is a contagious cutaneous infection caused by MC virus, affecting mainly the pediatric population. It is characterized by flesh-colored umbilicated papules occurring on the skin surface. Potassium hydroxide (KOH) and salicylic acid plus lactic acid combination being keratolytic agents, are effective treatment options. The objective of the study was to compare the efficacy and safety of 10% KOH solution versus salicylic acid/ lactic acid combination in treating Molluscum contagiosum in pediatric population. Material and Methods: A total of 80 children (age range 1-13 years) with Molluscum contagiosum lesions were selected from the Dermatology Out-Patient Department, and were randomly allocated into two groups by lottery method. Group A was given topical 10% KOH solution and group B was given Salicylic plus Lactic acid preparations for topical application. Patients were followed after two weeks to see regression in size of the lesion, and development of any side-effects. Final visit was scheduled at 6 weeks. Statistical analysis was carried out using SPSS (version 16) with p value less than 0.05 considered as statistically significant. Results: Patients with MC (n = 80) were equally divided into group A (treated with 10% KOH) and group B (treated with combination of Salicylic acid and Lactic acid). After 6 weeks, complete remission from Molluscum contagiosum virus was seen in 29 (72.5%) patients of group A and 34 (85%) patients of group B. There were 12 (30%) patients in group A who developed local irritation and 4 (10%) developed local erythema after 6 weeks. None of the patients of group B had any such side effects. Conclusion: 10% KOH solution is as effective as the combination of Salicylic and Lactic acids for treatment of Molluscum contagiosum in pediatric population, however it is associated with side effects of local irritation and erythema.

scholarly journals A Case of Recalcitrant Plantar Warts Associated with Statin Use

2015 ◽  
Vol 2015 ◽  
pp. 1-2
Author(s):  
Aaron G. Wernham ◽  
Shireen S. Velangi
Keyword(s):  
T Cells ◽  
Salicylic Acid ◽  
Photodynamic Therapy ◽  
Human Papillomavirus ◽  
Regulatory T Cells ◽  
Standard Therapy ◽  
Rapid Clearance ◽  
Statin Medication ◽  
Plantar Warts ◽  
Statin Use

Background. Plantar warts are a common presenting skin complaint caused by the human papillomavirus. 1st line therapies include cryotherapy and topical salicylic acid. Where there is resistance to these treatments, consideration is made for 2nd line therapies, including intralesional bleomycin, imiquimod, 5-fluorouracil, and photodynamic therapy. We present a case of bilateral persistent plantar warts, resistant to treatment with repeated cryotherapy and topical salicylic acid over a 6-year period. Following a patient initiated decision to discontinue their statin medication, we observed rapid clearance of plantar warts without change to standard therapy or their environment. This case correlates with emerging literature demonstrating a link between statin medication and proliferation of HPV through increased levels of FOXP3+ regulatory T cells.

scholarly journals Efficacy Of 10% Potassium Hydroxide Solution Versus 10% Salicylic Acid Ointment in Treatment of Molluscum Contagiosum - the Low - Cost Dermatologic Therapy in Vietnam

2019 ◽  
Vol 7 (2) ◽  
pp. 269-271
Author(s):  
Sau Nguyen Huu ◽  
Minh Nguyen Quang ◽  
Thuong Nguyen Van ◽  
Kiem Pham Cao ◽  
Hiem Do Thi Thu ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Salicylic Acid ◽  
Side Effects ◽  
Potassium Hydroxide ◽  
Low Cost ◽  
Potassium Hydroxide Solution ◽  
Viral Disease ◽  
Molluscum Contagiosum ◽  
Solution Versus ◽  
Better Than

BACKGROUND: Molluscum contagiosum is a common viral disease primarily affecting children. AIM: The objective is to compare the efficacy of 10% potassium hydroxide (KOH) solution versus 10% salicylic pomade in the treatment of molluscum contagiosum. METHODS: Clinical trials on 70 patients were randomised into 2 groups: 39 patients treated with 10% KOH solution and 31 patients treated with 10% salicylic pomade. The evaluation was based on the complete clearance of lesions, side effects and complications of the drug. RESULTS: The clearance of all lesions after 2, 4, 6, 8 weeks of treatment in both groups were 7.7%; 23.1%; 53.8%; 79.5% and 0%; 3.2%, 9.7% 22.6%, respectively (p < 0.05). Side effects were seen in both groups include burning (76.9% versus 19.4%; p < 0.05); redness (59% versus 14%; p < 0.01); desquamation (12.8% versus 19.3%; p < 0.05). CONCLUSION: The efficacy of KOH solution in the treatment of MC was better than that of salicylic pomade and both products are safe, effective, and easy to apply at home.

scholarly journals Comparison of the Cerumenolytic Activities of New and Currently Used Agents

2021 ◽  
pp. 014556132098606
Author(s):  
Nguyen Quynh Anh ◽  
Pawin Numthavaj ◽  
Thongchai Bhongmakapat
Keyword(s):  
Salicylic Acid ◽  
Sodium Bicarbonate ◽  
Potassium Hydroxide ◽  
Glycolic Acid ◽  
Statistical Significance ◽  
In Vitro Study ◽  
Distilled Water ◽  
Moderate Amount ◽  
All Solutions

Objectives: This study compared the cerumen dissolution activities of 7.5% sodium bicarbonate, 5% potassium hydroxide, 10% lactic acid, 3% salicylic acid, 10% glycolic acid, and distilled water. Methods: An in vitro study was conducted with 36 cerumen samples. The cerumenolytic activities of the 6 agents were assessed by recording the degree of cerumen disintegration using digital photography at 15 minutes, 30 minutes, 1 hour, 2 hours, and 12 hours. The undissolved cerumen that remained after 12 hours was removed from the solutions and weighed after drying. Results: Potassium hydroxide showed the fastest cerumenolytic activity, dissolving a moderate amount of cerumen at 30 minutes, while glycolic acid and salicylic acid caused no visible changes in the cerumen samples. Samples treated with potassium hydroxide and sodium bicarbonate exhibited higher degrees of disintegration compared to samples treated with distilled water (odds ratio and 95% CI: 273.237 [0.203-367 470.4] and 1.129 [0.002-850.341], respectively). The greatest reduction in cerumen weight was associated with the use of sodium bicarbonate; however, this result did not reach statistical significance. Conclusions: Among the solutions tested, 5% potassium hydroxide showed the fastest dissolution activity, yielding moderate disintegration within only 30 minutes. In terms of residual cerumen weight within 12 hours, all solutions exhibited equivalent effectiveness in the disintegration of cerumen.

scholarly journals Early outcomes and predictors of patient satisfaction after TKA: a prospective study of 200 cases with a contemporary cemented rotating platform implant design

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Corné van Loon ◽  
Niels Baas ◽  
Verdonna Huey ◽  
James Lesko ◽  
Geert Meermans ◽  
...  
Keyword(s):  
Patient Satisfaction ◽  
Clinical Improvement ◽  
Patient Characteristics ◽  
Patient Reported Outcome ◽  
Implant Design ◽  
Rotating Platform ◽  
Radiographic Outcomes ◽  
Operative Outcomes ◽  
Patient Reported ◽  
Time Point

Abstract Purpose The purpose of the study was to identify the earliest time point where subjects realized the greatest clinical improvement after TKA, and the time when post-operative scores became superior to pre-operative scores. Post-hoc exploratory analyses were conducted to investigate predictors of early post-operative outcomes and patient satisfaction. Methods Six investigators across 4 sites in the Netherlands prospectively implanted 200 subjects with a contemporary cemented rotating platform device. Patient Reported Outcome Measurements (PROMs) KOOS-PS, PKIP, and EQ-5D were collected pre-operatively and post-operatively through 2-years. PROMs change from pre-operative baseline were summarized, along with radiographic outcomes and adverse events (AEs). Pre-operative patient characteristics were explored for correlation with patient outcomes, and patient satisfaction for correlation with KOOS-PS. Results Follow-up compliance was 99% at 6-months, and 95.5% at 2-years. The percentage with higher KOOS-PS compared to baseline was 81.3% at 6-months. KOOS-PS, PKIP, and PKIP subscore means were all better at 6-weeks versus baseline. Gender, BMI, hypertension, and pre-operative KOOS-PS were weakly correlated with 6-week KOOS-PS (multivariate R-squared = 14.1%), but only pre-operative KOOS-PS demonstrated correlation with post-operative KOOS-PS at 6-months or later (R-squared < 5% at 6-months and 2 years). Satisfaction was moderately correlated with concurrent KOOS-PS at each post-operative time point, with (R-squared = 35.3% at 6-months, and 37.5% at 2 years). Conclusion The greatest mean clinical improvement occurred within the first 6-weeks. Although some pre-operative factors were correlated with higher early post-operative KOOS-PS outcomes, these advantages disappeared by 6-months aside from weak correlation with pre-operative KOOS-PS. Post-operative KOOS-PS was moderately correlated with concurrent post-operative satisfaction. These results may be used for pre-operative counseling and management of patient’s postoperative expectations. Trial registration Clinicaltrials.gov, NCT02339610. Registered 15 January 2015.

Topical Ethanol Therapy for Human Papillomavirus in Atheroma

2021 ◽  
Author(s):  
Etsuo Murata ◽  
Kazutaka Tokita ◽  
Shigeyuki Tsurusaki ◽  
Hidetaka Murata
Keyword(s):  
Human Papillomavirus ◽  
Side Effects ◽  
Simple Procedure ◽  
Ring Test ◽  
Pathological Examination ◽  
Open Drainage ◽  
Hpv 16 ◽  
Follow Up Study ◽  
Study Results

We have developed ethanol therapy for infectious atheroma based on the experience of two cases in which ethanol was injected into the liver cyst and the cyst shrank. For 64 infectious atheromas, atheroma contents were excreted and the cyst wall was contacted with 76% ethanol gauze for 5 minutes. Postoperatively, the cyst was washed daily as an open drainage. All cases were cured 10 days postoperatively, and no side effects. Postoperative follow up study results in 36 cases showed no recurrence in an average of 5 years. Pathological examination revealed koilocytosis in 14 of 25 cases (56%), which is considered to be an in direct finding of viral infection. The changes in human papillomavirus (HPV 16) before and after ethanol therapy in 25 cases using the Bi Digital O Ring Test (BDORT) decreased significantly from 10 26 ng (BDORT units) preoperatively to 1.6 ng (BDORT units) postoperatively. In also 12 cases follow up study without microscopy HPV 16 same decreased from 1064ng to 1.2 ng (BDORT unit) using BDORT with atheroma photographs. In total, HPV 16 could be demonstrated in 37 of 64 cases (57.8%) using BDOR T. Temporal changes of HPV 16 used for BDORT in 7 cases after contact with ethanol were inactivated after 3 minutes 30 seconds. The involvement of HPV 16 is suggested as the cause of atheroma. It is speculated that ethanol inactivated HPV 16 of atheroma, which stopped the turnover of the squamous epithelium and prevented recurrence. Ethanol therapy for infectious atheroma is useful as an original new one stage surgery because it is a simple procedure and has no side effects or recurrence.

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