scholarly journals O35 Long-Term Opioid Prescribing and the Risk of Adverse Events in Patients with Musculoskeletal Pain: A Cohort Study

Rheumatology ◽  
2016 ◽  
Keyword(s):  
Cohort Study ◽  
Adverse Events ◽  
Musculoskeletal Pain ◽  
Opioid Prescribing

scholarly journals Biological and Functional Changes in Healthy Adult Smokers Who Are Continuously Abstinent From Smoking for One Year: Protocol for a Prospective, Observational, Multicenter Cohort Study (Preprint)

2018 ◽  
Author(s):  
Cam Tuan Tran ◽  
Loyse Felber Medlin ◽  
Nicola Lama ◽  
Brindusa Taranu ◽  
Weeteck Ng ◽  
...  
Keyword(s):  
Cohort Study ◽  
Adverse Events ◽  
Clinical Chemistry ◽  
Risk Level ◽  
Functional Changes ◽  
Biomarkers Of Exposure ◽  
Quit Smoking ◽  
Study Results ◽  
Biomarkers Of Effect

BACKGROUND The harm of smoking results mainly from long-term exposure to harmful and potentially harmful constituents (HPHCs) generated by tobacco combustion. Smoking cessation (SC) engenders favorable changes of clinical signs, pathomechanisms, and metabolic processes that together could reduce the harm of smoking-related diseases to a relative risk level approximating that of never-smokers over time. In most SC studies, the main focus is on the quitting rate of the SC program being tested. As there is limited information in the literature on short to multiple long-term functional or biological changes following SC, more data on short to mid-term favorable impacts of SC are needed. OBJECTIVE The overall aim of the study was to assess the reversibility of the harm related to smoking over 1 year of continuous smoking abstinence (SA). This has been verified by assessing a set of biomarkers of exposure to HPHCs and a set of biomarkers of effect indicative of multiple pathophysiological pathways underlying the development of smoking-related diseases. METHODS This multiregional (United States, Japan, and Europe), multicenter (42 sites) cohort study consisting of a 1-year SA period in an ambulatory setting was conducted from May 2015 to May 2017. A total of 1184 male and female adult healthy smokers, willing to quit smoking, were enrolled in the study. Nicotine replacement therapy (NRT) was provided for up to 3 months upon the subject’s request. SC counseling and behavioral support were continuously provided. Biomarkers of exposure to HPHCs and biomarkers of effect were assessed in urine and blood at baseline, Month 3, Month 6, and Month 12. Cardiovascular biomarkers of effect included parameters reflecting inflammation (white blood cell), lipid metabolism (high-density lipoprotein cholesterol), endothelial function (soluble intercellular adhesion molecule-1), platelet function (11-dehydrothromboxane B2), oxidative stress (8-epi-prostaglandin F2 alpha), and carbon monoxide exposure (carboxyhemoglobin). Respiratory biomarkers of effect included lung function parameters and cough symptoms. The biomarkers of effect to evaluate genotoxicity (total 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol) and xenobiotic metabolism (cytochrome P450 2A6 activity) were also assessed. Continuous SA was verified at each visit following the actual quit date using self-reporting and chemical verification. Safety assessments included adverse events and serious adverse events, body weight, vital signs, spirometry, electrocardiogram, clinical chemistry, hematology and urine analysis safety panel, physical examination, and concomitant medications. RESULTS In total, 1184 subjects (50.1% male) were enrolled; 30% of them quit smoking successfully for 1 year. Data analyses of the study results are ongoing and will be published after study completion. CONCLUSIONS This study provides insights into biological and functional changes and health effects, after continuous SA over 1 year. Study results will be instrumental in assessing novel alternative products to cigarettes considered for tobacco harm reduction strategies. CLINICALTRIAL ClinicalTrials.gov NCT02432729; http://clinicaltrials.gov/ct2/show/NCT02432729 (Archived by WebCite at http://www.webcitation.org/78QxovZrr) INTERNATIONAL REGISTERED REPOR DERR1-10.2196/12138

scholarly journals Short- and Long-Term Major Cardiovascular Adverse Events in Carotid Artery Interventions: A Nationwide Population-Based Cohort Study in Taiwan

PLoS ONE ◽  
2015 ◽  
Vol 10 (3) ◽  
pp. e0121016 ◽  
Author(s):  
Ming-Lung Tsai ◽  
Chun-Tai Mao ◽  
Dong-Yi Chen ◽  
I-Chang Hsieh ◽  
Ming-Shien Wen ◽  
...  
Keyword(s):  
Cohort Study ◽  
Carotid Artery ◽  
Adverse Events ◽  
Population Based ◽  
Short And Long Term

scholarly journals Influence of opioid prescribing standards on health outcomes among patients with long-term opioid use: a longitudinal cohort study

CMAJ Open ◽  
2020 ◽  
Vol 8 (4) ◽  
pp. E869-E876
Author(s):  
Richard L. Morrow ◽  
Ken Bassett ◽  
James M. Wright ◽  
Greg Carney ◽  
Colin R. Dormuth
Keyword(s):  
Cohort Study ◽  
Health Outcomes ◽  
Longitudinal Cohort Study ◽  
Opioid Use ◽  
Longitudinal Cohort ◽  
Opioid Prescribing

scholarly journals P504 Effectiveness and safety of ustekinumab maintenance therapy in 103 patients with real-world ulcerative colitis: A GETAID multicentre cohort study

2021 ◽  
Vol 15 (Supplement_1) ◽  
pp. S486-S487
Author(s):  
M Fumery ◽  
J Filippi ◽  
V Abitbol ◽  
A Biron ◽  
D Laharie ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Cohort Study ◽  
Adverse Events ◽  
Real World ◽  
Clinical Remission ◽  
Real Life ◽  
Phase Iii ◽  
Phase Iii Trials ◽  
One Year

Abstract Background Phase III trials have demonstrated the efficacy and safety of ustekinumab in moderate-to-severe ulcerative colitis (UC), but no real-life long-term data is currently available. Methods From January to September 2019, all consecutive patients with active UC treated with ustekinumab in a GETAID centre were included. Patients were evaluated at week 52. Remission was defined by a partial Mayo Clinic score ≤ 2. The aim of the present study was to assess long-term effectiveness and safety of ustekinumab in UC. Results 103 UC patients (62 men; mean age: 41.2 ± 16.2 years; 52% pancolitis E3) were included in 21 centres. History of immunomodulator, anti-TNF and vedolizumab therapies was noted in 84.5%, 99.0% and 85.4% of the cases, respectively. At week 54, 44 (43%) patients discontinued ustekinumab, for lack of efficacy (n=41), pregnancy (n=1), persistence of eczematiform lesions (n=1) or personal decision (n=1). Cumulative probabilities of ustekinumab persistence were 96.1%, 81.6%, 71.7%, and 58.4% after 3, 6, 9, and 12 months, respectively. In multivariate analysis, a CRP>5 mg/L at week 0 (OR=2.91, CI95%[1.15–7.36]; p=0.02) and concomitant steroids at week 0 (OR=3.05, CI95%[1.30–7.14]; p=0.01) were significantly associated with ustekinumab discontinuation within one year. The overall rate of steroid-free clinical remission at week 52 was 32% of whom 71% had null rectal bleeding and stool frequency subscores. Ten patients (9.7%) underwent colectomy within a median of 6.7 [4.3–10.6] months. Adverse events were observed in 15 (16.9%) patients, of whom 4 (4.5%) had severe adverse events including three patients with exacerbation of UC leading to hospitalization, and a 62 years-old men who died from a myocardial infarction four months after ustekinumab initiation. Conclusion In this real-world cohort study that included patients with refractory ulcerative colitis to multiple therapies, more than one-half of patients were still treated by ustekinumab and one-third were in steroid-free clinical remission, after 52 weeks.

scholarly journals Number of musculoskeletal pain sites leads to increased long-term healthcare contacts and healthcare related costs – a Danish population-based cohort study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
S. Mose ◽  
P. Kent ◽  
A. Smith ◽  
J. H. Andersen ◽  
D. H. Christiansen
Keyword(s):  
Cohort Study ◽  
Musculoskeletal Pain ◽  
Health Anxiety ◽  
Population Based ◽  
Care Seeking ◽  
Healthcare Use ◽  
Danish Population ◽  
Term Care ◽  
Pain Site

Abstract Background People with musculoskeletal pain seek more healthcare than the general population, however little is known about the long-term effect on healthcare use. The aim of this study was to examine the consequences of number of musculoskeletal pain sites on long-term care-seeking and healthcare-related costs and explore how health anxiety influences this relationship. Methods We conducted a Danish population-based longitudinal cohort study of 4883 participants combining self-reported survey data from 2008 with ten-year follow-up data from national health registers. Using a causal inference framework, we examined associations between number of pain sites (range 0–7)/level of health anxiety (high/low level) and face-to-face healthcare contacts/healthcare-related costs. Data were analyzed using negative binomial regression with generalized estimating equations. Regression models were adjusted for sex, age, duration of pain, level of education, comorbidity, personality traits, risk of depression, marital status, physical job exposure, and previous healthcare utilization. Results For each additional pain site general healthcare contacts (Incidence Rate Ratio (IRR): 1.04 (95% CI: 1.03–1.05)), healthcare-related costs (IRR: 1.06 (95% CI: 1.03–1.08) and musculoskeletal healthcare contacts (IRR: 1.11 (95% CI:1.09–1.14) increased. Those with high levels of health anxiety at baseline had a slightly higher number of general healthcare contacts (IRR 1.06 (1.01–1.11), independent of number of pain sites. However, level of anxiety did not influence the effect of number of pain sites on any healthcare use or cost outcomes. Conclusions We found evidence for a causal association between increasing number of pain sites and greater healthcare use and cost, and high levels of health anxiety did not increase the strength of this association. This suggests that number of pain sites could be a potential target for biopsychosocial interventions in order to reduce the need for future care-seeking.

scholarly journals Influence of opioid prescribing standards on health outcomes among patients with long-term opioid use: a longitudinal cohort study

CMAJ Open ◽  
2020 ◽  
Vol 8 (4) ◽  
pp. E869-E876
Author(s):  
Richard L. Morrow ◽  
Ken Bassett ◽  
James M. Wright ◽  
Greg Carney ◽  
Colin R. Dormuth
Keyword(s):  
Cohort Study ◽  
Health Outcomes ◽  
Longitudinal Cohort Study ◽  
Opioid Use ◽  
Longitudinal Cohort ◽  
Opioid Prescribing

scholarly journals Influence of opioid prescribing standards on drug use among patients with long-term opioid use: a longitudinal cohort study

CMAJ Open ◽  
2019 ◽  
Vol 7 (3) ◽  
pp. E484-E491 ◽  
Author(s):  
Richard L. Morrow ◽  
Ken Bassett ◽  
James M. Wright ◽  
Greg Carney ◽  
Colin R. Dormuth
Keyword(s):  
Cohort Study ◽  
Drug Use ◽  
Longitudinal Cohort Study ◽  
Opioid Use ◽  
Longitudinal Cohort ◽  
Opioid Prescribing
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