Gut microbiota alterations associated with reduced bone mineral density in older adults

Abstract Objective To investigate compositional differences in the gut microbiota associated with bone homeostasis and fractures in a cohort of older adults. Methods Faecal microbiota profiles were determined from 181 individuals with osteopenia (n = 61) or osteoporosis (n = 60), and an age- and gender-matched group with normal BMD (n = 60). Analysis of the 16S (V3-V4 region) amplicon dataset classified to the genus level was used to identify significantly differentially abundant taxa. Adjustments were made for potential confounding variables identified from the literature using several statistical models. Results We identified six genera that were significantly altered in abundance in the osteoporosis or osteopenic groups compared with age- and gender-matched controls. A detailed study of microbiota associations with meta-data variables that included BMI, health status, diet and medication revealed that these meta-data explained 15–17% of the variance within the microbiota dataset. BMD measurements were significantly associated with alterations in the microbiota. After controlling for known biological confounders, five of the six taxa remained significant. Overall microbiota alpha diversity did not correlate to BMD in this study. Conclusion Reduced BMD in osteopenia and osteoporosis is associated with an altered microbiota. These alterations may be useful as biomarkers or therapeutic targets in individuals at high risk of reductions in BMD. These observations will lead to a better understanding of the relationship between the microbiota and bone homeostasis.

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Older Adults Living with Osteoarthritis: Examining the Relationship of Age and Gender to Medicine Use

Canadian Journal on Aging / La Revue canadienne du vieillissement ◽

10.1017/s0714980812000256 ◽

2012 ◽

Vol 31 (3) ◽

pp. 323-333 ◽

Cited By ~ 15

Author(s):

Judith E. Fisher ◽

Peri J. Ballantyne ◽

Gillian A. Hawker

Keyword(s):

Older Adults ◽

Nous Avons ◽

Personnes Âgées ◽

Medicine Use ◽

Age And Gender ◽

And Gender ◽

Varient Selon ◽

Relationship Of ◽

The Relationship

RÉSUMÉL’ostéoarthrite (OA) chez les personnes âgées constitue une condition chronique et répandue associée à des douleurs importantes d’invalidité. L’utilisation d’analgésiques par voie orale est un élément central de la gestion des symptômes. L’utilisation de médicaments par cette population, cependant, est complexe et la nécessité de contrôler les symptômes doivent être mis en balance avec les préoccupations concernant la sécurité des médicaments. Notre étude s’est concentrée à illustrer et à explorer les variations entre divers médicaments différents utilisés pour gérer les symptômes liés à l’ostéoarthrite. Nous avons analysé les données provenant d’un échantillon de personnes âgées de 55 ans et plus, qui vivent dans les communautés, et qui souffrent d’arthrite de la hanche ou du genou pour examiner les facteurs sociaux et médicaux associés à la variation dans les médicaments rapporté. Une conclusion principale est que les types de médicaments utilisés par les patients atteints d’ostéoarthrite varient selon l’âge et le sexe, indépendamment de la maladie et du contexte médical et social. Les explications possibles ont été considérés comme relatives aux préférences des patients et des professionnels.

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Racial and gender differences in the relationship between sarcopenia and bone mineral density among older adults

Osteoporosis International ◽

10.1007/s00198-020-05744-y ◽

2020 ◽

Author(s):

H.-T. Ning ◽

Y. Du ◽

L.-J. Zhao ◽

Q. Tian ◽

H. Feng ◽

...

Keyword(s):

Bone Mineral Density ◽

Older Adults ◽

Gender Differences ◽

Bone Mineral ◽

Mineral Density ◽

And Gender ◽

The Relationship

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Age and Gender Differences in Depression Among Mexican American Older Adults

PsycEXTRA Dataset ◽

10.1037/e649132012-001 ◽

2012 ◽

Author(s):

Jodi D. Bremer ◽

Grace I. L. Caskie

Keyword(s):

Older Adults ◽

Gender Differences ◽

Mexican American ◽

Age And Gender ◽

Age And Gender Differences ◽

And Gender

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Understanding the moderation effect of age and gender on the relationship between employee career attitude and organizational citizenship behavior: A developing country perspective

Managerial and Decision Economics ◽

10.1002/mde.3325 ◽

2021 ◽

Author(s):

Meha Joshi ◽

Girish Chandra Maheshwari ◽

Rajan Yadav

Keyword(s):

Developing Country ◽

Organizational Citizenship ◽

Organizational Citizenship Behavior ◽

Citizenship Behavior ◽

Age And Gender ◽

Moderation Effect ◽

And Gender ◽

The Relationship ◽

Effect Of Age

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No Self Without Salience: Affective and Self-relevance Ratings of 552 Emotionally Valenced and Neutral Dutch Words

Journal of Psycholinguistic Research ◽

10.1007/s10936-021-09784-1 ◽

2021 ◽

Author(s):

Lora I. Dimitrova ◽

Eline M. Vissia ◽

Hanneke Geugies ◽

Hedwig Hofstetter ◽

Sima Chalavi ◽

...

Keyword(s):

Repeated Measures ◽

Emotional Valence ◽

Age And Gender ◽

Gender And Age ◽

Main Effect ◽

Emotional Salience ◽

And Gender ◽

The Relationship

AbstractIt is unknown how self-relevance is dependent on emotional salience. Emotional salience encompasses an individual's degree of attraction or aversion to emotionally-valenced information. The current study investigated the interconnection between self and salience through the evaluation of emotional valence and self-relevance. 56 native Dutch participants completed a questionnaire assessing valence, intensity, and self-relevance of 552 Dutch nouns and verbs. One-way repeated-measures ANCOVA investigated the relationship between valence and self, age and gender. Repeated-measures ANCOVA also tested the relationship between valence and self with intensity ratings and effects of gender and age. Results showed a significant main effect of valence for self-relevant words. Intensity analyses showed a main effect of valence but not of self-relevance. There were no significant effects of gender and age. The most important finding presents that self-relevance is dependent on valence. These findings concerning the relationship between self and salience opens avenues to study an individual's self-definition.

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Association Between Frailty and Gut Microbiota Metabolite TMAO in Older People With Cardiovascular Disease

Innovation in Aging ◽

10.1093/geroni/igaa057.680 ◽

2020 ◽

Vol 4 (Supplement_1) ◽

pp. 210-211

Author(s):

Wei He ◽

Hua Wang ◽

Jiefu Yang

Keyword(s):

Older Adults ◽

Cardiovascular Diseases ◽

Gut Microbiota ◽

Linear Trend ◽

Frailty Index ◽

Concentration Data ◽

Dependent Relationship ◽

The Status ◽

Cubic Spline Curve ◽

The Relationship

Abstract The potential for the gut microbiota to affect health has particular relevance for older adults. Recent evidence suggests that microbiota-derived metabolites may modulate aging-related changes in immunity, sarcopenia, and cognitive function, all of which are elements of frailty. Trimethylamine N-oxide (TMAO) produced by the metaorganismal metabolism of choline, has been implicated in disease pathogenesis. However, relatively little geroscience research has been carried out on TMAO，and even less on other gut microbiota metabolites. The purpose of this study was to explore the relationship between frailty and circulating TMAO concentration. Data and fasting blood samples came from a prospective comprehensive geriatric assessment cohort of older adults (age≥65, n=451) with cardiovascular diseases. The frailty index based on the accumulated deficits model (48 variables) was used for evaluating the status of frailty. TMAO levels differed between groups with a significant increase for people with frailty (p＜0.001). Compared with the lowest quartile of TMAO levels, patients in the highest quartile had increased 3.07-fold risk of frailty (OR=3.07, 95%CI, 1.69-2.97). After adjusting for age, gender, BMI, history of diseases, hsCRP, LDLc, TMAO levels remained associated with frailty (OR=2.11, 95%CI, 1.01-4.38). Similarly, a cubic spline curve showed a dose-dependent relationship between the odds ratio for the risk of frailty and circulating TMAO in a linear trend (p = 0.006). This study suggests that circulating TMAO are independently associated with frailty in older adult with cardiovascular diseases. Efforts to further characterize the relationship between gut microbiota metabolite and frailty should be further pursued.

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The Analysis of the Relationship Between Subjective Tinnitus and Vascular Loop, and Age and Gender Distribution: An MRI Study

Eurasian Journal of Medicine and Oncology ◽

10.14744/ejmo.2018.0038 ◽

2018 ◽

Author(s):

Esen Derin Cicek

Keyword(s):

Age And Gender ◽

Gender Distribution ◽

Subjective Tinnitus ◽

And Gender ◽

Mri Study ◽

The Relationship ◽

Vascular Loop

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Focus on Text Messages: A Review of Studies in French

Encyclopedia of Mobile Phone Behavior ◽

10.4018/978-1-4666-8239-9.ch085 ◽

2015 ◽

pp. 1037-1050

Author(s):

Olga Volckaert-Legrier ◽

Antonine Goumi ◽

Alain Bert-Erboul ◽

Josie Bernicot

Keyword(s):

Text Message ◽

Text Messages ◽

French Language ◽

Age And Gender ◽

Future Studies ◽

Linguistic Markers ◽

Production Processes ◽

Language Research ◽

And Gender ◽

The Relationship

The study of text messages has given rise to a number of French language research topics. First, databases of natural text messages have been created in multiple Francophone countries in an effort to link the texters' characteristics with the linguistic markers of the text messages. Many studies have focused on textisms (changes in spelling as compared to the traditional written code), creating repertoires of spelling processes and classifying them into typologies. With regard to linguistic aspects, a few studies have analyzed vocabulary and syntax. Sociolinguistic aspects have also been studied, taking into account the relationship among textisms, age, and gender. To address the question of whether text message writing is a threat to spelling, several studies have analyzed the link between text message writing and traditional writing. Finally, a number of studies have focused on the production processes of text message writing. Future studies will need to take into account the dialogical and conversational aspects of text messages.

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