scholarly journals Influence of prior antibiotic use on risk of rheumatoid arthritis: case control study in general practice

Rheumatology ◽  
2019 ◽  
Vol 59 (6) ◽  
pp. 1281-1287 ◽  
Author(s):  
David Armstrong ◽  
Alex Dregan ◽  
Mark Ashworth ◽  
Patrick White ◽  
Chris McGee ◽  
...  
Keyword(s):  
Case Control Study ◽  
Significant Risk ◽  
Immunological Response ◽  
Significant Risk Factor ◽  
Antibiotic Use ◽  
Case Control ◽  
Control Group ◽  
Centre Database ◽  
New Diagnosis ◽  
Control Study

Abstract Objectives To test the hypothesis that prior antibiotics influences the risk of developing RA. Methods A case–control study was conducted over 15 years using the UK’s Royal College of General Practitioners Research and Surveillance Centre database. The frequency and type of antibiotic prescription for patients who subsequently developed RA were compared with antibiotic prescriptions in a control group of patients who remained free of RA. Cases, defined as patients with a new diagnosis of RA made between 2006 and 2018, were matched with up to four RA-free controls on practice, age, gender and date of diagnosis. Exposure was measured by the number and type of prescriptions for antibiotics prior to the RA diagnosis or to the index date in controls. Results A total of 8482 patients with a new diagnosis of RA between 2006 and 2018 were compared with 22 661 controls. There was a higher likelihood of an RA diagnosis after antibiotic prescriptions within 1 year, 5 years and ever with a strong dose–response. Patients receiving >10 antibiotics in a 5 year period were more than twice as likely to receive an RA diagnosis as controls [adjusted odds ratio 2.65 (CI 2.40, 2.93)]. Conclusion Exposure to antibiotics prior to the diagnosis was a significant risk factor for RA. This could reflect an immunological response to a compromised microbiome. Alternatively, patients with pre-symptomatic or early undiagnosed RA may have been more likely to present to their general practitioner with infections due to an unrecognized effect of RA.

An Outbreak of Pyodermas Among Neonates Caused by Ultrasound Gel Contaminated With Methicillin-SusceptibleStaphylococcus Aureus

2000 ◽  
Vol 21 (12) ◽  
pp. 761-764 ◽  
Author(s):  
Klaus Weist ◽  
Constanze Wendt ◽  
Lyle R. Petersen ◽  
Hans Versmold ◽  
Henning Rüden
Keyword(s):  
Hip Joint ◽  
Case Control Study ◽  
Tertiary Care ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Case Control ◽  
University Hospital ◽  
Good Physical Condition ◽  
Rapd Pcr ◽  
Control Study

Objective:To investigate an outbreak of methicillin-susceptibleStaphylococcus aureus(MSSA); infections in a neonatal clinic.Design:Prospective chart review, environmental sampling, and genotyping by two independent methods: pulsed-field gel electrophoresis (PFGE) and randomly amplified polymorphic DNA polymerase chain reaction (RAPD-PCR). A case-control study was performed with 31 controls from the same clinic.Setting:A German 1,350-bed tertiary-care teaching university hospital.Results:There was a significant increase in the incidence of pyodermas with MSSA 10 neonates in good physical condition with no infection immediately after birth developed pyodermas. A shared spatula and ultrasound gel were the only identified infection sources. The gel contained MSSA and was used for hip-joint sonographies in all neonates. PFGE and RAPD-PCR patterns from 6 neonates and from the gel were indistinguishable and thus genetically related clones. The case-control study revealed no significant risk factor with the exception of cesarean section (P=.006). The attack rate by days of hip-joint sonography between April 15 and April 27, 1994, was 11.8% to 40%.Conclusions:Inappropriate hygienic measures in connection with lubricants during routine ultrasound scanning may lead to nosocomialS aureusinfections of the skin. To our knowledge this source ofS aureusinfections has not previously been described.

Abstract 126: Importance of Untreated Hypertension for Intracerebral Hemorrhage

Stroke ◽  
2016 ◽  
Vol 47 (suppl_1) ◽  
Author(s):  
Kyle B Walsh ◽  
Opeolu Adeoye ◽  
Padmini Sekar ◽  
Jennifer Osborne ◽  
Charles J Moomaw ◽  
...  
Keyword(s):  
Risk Factor ◽  
Ethnic Groups ◽  
Case Control Study ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Case Control ◽  
Insurance Status ◽  
Race Ethnicity ◽  
Untreated Hypertension ◽  
Control Study

Introduction: Hypertension (HTN), particularly untreated HTN, has been found to be a significant risk factor for ICH in predominately white ICH populations. We evaluated the risk of treated and untreated HTN on ICH in a multi-ethnic case-control study. Hypothesis: Treated and untreated HTN confer variable risk for ICH by race/ethnicity. Methods: The Ethnic/Racial Variations of ICH (ERICH) study is a prospective, multicenter, case-control study of ICH among whites, blacks, and Hispanics. Cases were enrolled from 42 recruitment centers using hot-pursuit. Controls matched to cases 1:1 by age (±5 years), sex, race/ethnicity, and metropolitan area were recruited by random-digit dialing. Subjects were interviewed to determine whether they had a history of HTN and if they took medications to reduce blood pressure. Results: Between 9/2010 and 6/2015, 891 white, 833 black, and 599 Hispanic case/control pairs were enrolled. Higher proportions of black and Hispanic ICH with HTN were untreated, compared with whites (43.3% and 48.3% vs. 33.2%; p=.0002 and p<.0001, respectively). When adjusted for medical insurance status, a significant difference persisted for whites vs. Hispanics (p=.002), but not whites vs. blacks (p=.197). In multivariate analyses adjusted for alcohol use, anticoagulation, hypercholesterolemia, education, and insurance status, treated HTN was a significant risk factor for ICH in whites (OR=1.72, 95% CI 1.33-2.22, p<.0001), blacks (3.04, 2.13-4.34, <.0001), and Hispanics (2.57, 1.64-4.00, <.0001). Untreated HTN was a substantially greater risk factor for ICH for all three racial/ethnic groups: whites (9.53, 5.88-15.45, <.0001), blacks (11.10, 7.06-17.47, <.0001), Hispanics (9.65, 5.49-16.95, <.0001). In the subtype analyses of deep, lobar, and infratentorial ICH, untreated HTN resulted in ORs of 3.50 to 24.81, with statistical significance for all subtypes and ethnic groups. Conclusion: Treatment of HTN reduces the risk of ICH conferred by HTN markedly, but not completely. Untreated hypertension, which is significantly more prevalent among black and Hispanic ICH cases than among white cases, confers at least a 9-fold risk of ICH regardless of race. Treatment of hypertension is expected to have substantial impact on risk of ICH.

scholarly journals A case–control study of risk factors for sporadic campylobacter infections in Denmark

2003 ◽  
Vol 130 (3) ◽  
pp. 353-366 ◽  
Author(s):  
J. NEIMANN ◽  
J. ENGBERG ◽  
K. MØLBAK ◽  
H. C. WEGENER
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Case Control Study ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Case Control ◽  
Final Model ◽  
Unpasteurized Milk ◽  
Frequent Consumption ◽  
Control Study

A case control study comprising 282 cases and 319 matched controls was conducted in Denmark during 1996–7. Two estimates of the odds ratio (OR) were determined for each risk factor with and without ‘protective factors’ fitted into the final model. Consumption of undercooked poultry (OR 4·5; 8·2), consumption of red meat at a barbecue (OR 2·3; 4·1), consumption of grapes (OR 1·6; 2·8) and drinking unpasteurized milk (OR 2·3; 11·8) were identified as risk factors in both models. Frequent consumption of pork chops (OR 4·4) and daily contact with domestic animals and pets were identified as risk factors in one of the two models only. Finally, foreign travel was found to be a significant risk factor (OR 2·5). Seasonal and regional interaction was observed for several risk factors and the time elapsed from interviewing of cases to interviewing of controls seemed to influence the effect of certain seasonal dependent risk factors.

scholarly journals Differential Effects of Levofloxacin and Ciprofloxacin on the Risk for Isolation of Quinolone-Resistant Pseudomonas aeruginosa

2006 ◽  
Vol 50 (6) ◽  
pp. 2192-2196 ◽  
Author(s):  
Keith S. Kaye ◽  
Zeina A. Kanafani ◽  
Ashley E. Dodds ◽  
John J. Engemann ◽  
Stephen G. Weber ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Case Control Study ◽  
Multivariable Analysis ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Clinical Strain ◽  
Control Group ◽  
Multivariable Analyses ◽  
Control Study

ABSTRACT Due to the greater in vitro activity of ciprofloxacin than that of levofloxacin against Pseudomonas aeruginosa, the likelihood of isolating a clinical strain of quinolone-resistant (QR) P. aeruginosa might be greater after exposure to levofloxacin than ciprofloxacin. We examined the risk of isolating QR P. aeruginosa in association with prior levofloxacin or ciprofloxacin exposure. A case-case-control study was conducted. Two groups of cases, one with nosocomial QR P. aeruginosa infections and one with nosocomial quinolone-susceptible (QS) P. aeruginosa infections, were compared to a control group of hospitalized patients without P. aeruginosa infections. Bivariable and multivariable analyses were used to determine risk factors for isolation of QR P. aeruginosa and QS P. aeruginosa. One hundred seventeen QR P. aeruginosa and 255 QS P. aeruginosa cases were identified, and 739 controls were selected. Exposures to ciprofloxacin were similar among all three groups (8% for controls, 9.4% for QR P. aeruginosa cases, and 7.5% for QS P. aeruginosa cases; P ≥ 0.6). Levofloxacin use was more frequent in the QR P. aeruginosa cases than in the controls (35.9% and 22.1%, respectively; odds ratio [OR] = 2.0; 95% confidence interval [CI] = 1.3 to 3.0) and less frequent in QS P. aeruginosa cases (14.1% of QS P. aeruginosa cases; OR = 0.6; 95% CI = 0.4 to 0.9). In multivariable analysis, levofloxacin, but not ciprofloxacin, was a significant risk factor for isolation of QR P. aeruginosa (OR for levofloxacin = 1.7 [95% CI = 1.0 to 2.9]; OR for ciprofloxacin = 1.2 [95% CI = 0.6 to 2.5]). Levofloxacin was associated with a reduced risk of isolation of QS P. aeruginosa (OR = 0.6; 95% CI = 0.4 to 0.9), whereas ciprofloxacin had no significant effect (OR = 1.0; 95% CI = 0.6 to 1.8). In conclusion, the use of levofloxacin, but not ciprofloxacin, was associated with isolation of QR P. aeruginosa.

scholarly journals Adherence to DASH Dietary Pattern and Polycystic Ovarian Syndrome: A Case-control Study

2021 ◽  
Author(s):  
asieh panjeshahin ◽  
Akram Ghadiri-Anari ◽  
Mahdieh Hosseinzadeh
Keyword(s):  
Case Control Study ◽  
Polycystic Ovary ◽  
Case Control ◽  
Control Group ◽  
Case Group ◽  
Dash Score ◽  
Dash Diet ◽  
New Diagnosis ◽  
Reproductive Aged Women ◽  
Control Study

Abstract Objective: Polycystic Ovary Syndrome (PCOS) as one of the endocrine and metabolic abnormalities is prevalent in reproductive-aged women. This study aimed to investigate the relevance between adherence to the DASH diet and PCOS.Results: This is an age and BMI-matched case-control study including (n=108) new diagnosis PCOS women as a case group and women without PCOS as a control group (n=108). Also, the validated 168-item food frequency questionnaire was used to determine the usual dietary intake. The method of Fung et al. was used to calculate the DASH score. Moreover, logistic regression was assessed to evaluate the relationship between adherence to the DASH diet and the odds of PCOS. After adjustment for potential confounders, an increase in adherence to the DASH diet significantly reduced the odds of PCOS (OR for the highest vs. lowest quartile = 0.18; 95% CI 0.07, 0.47). There was a significant decreasing trend in the odds of PCOS across increasing quintiles of the DASH diet (p-trend <0.001). The results showed that adherence to the DASH diet could reduce the odds of PCOS by 82 percent. It’s worth noting that more prospective studies are required to confirm the findings of the current study.

scholarly journals Well-managed gestational diabetes mellitus is no longer a risk factor for neonatal RDS — a case-control study

2020 ◽  
Author(s):  
Guannan Xi ◽  
Qian Ying ◽  
Xuefeng Wang ◽  
Fei Luo ◽  
Chengqiu Lu ◽  
...  
Keyword(s):  
Risk Factor ◽  
Gestational Diabetes ◽  
Subgroup Analysis ◽  
Case Control Study ◽  
Diabetes Management ◽  
Significant Risk ◽  
Case Control ◽  
Control Group ◽  
Control Study ◽  
Hba1c Levels

Abstract Abstract BACKGROUND Diabetes in pregnancy used to be considered associated with a higher risk of respiratory distress syndrome(RDS) in neonates. However, as antenatal examinations have improved, whether well-managed gestational diabetes remains an independent risk factor is unclear. This study was to determine the associations of well-managed gestational diabetes with morbidity and complications of RDS. Method This was a case-control study conducted at the Obstetrics & Gynecology Hospital of Fudan University, Shanghai, China. We collected data from 101 RDS infants and 101 RDS infants from among 1749 infants, through a standardized protocol with predefined inclusion and exclusion criteria. Assessment of diabetes management was based on HbA1c and random blood glucose measurements. Univariable and multivariable logistic regression was performed to calculate the odds ratio (OR). An intergroup analysis was conducted between RDS infants and those without RDS, and a subgroup analysis was conducted between RDS neonates born to women with gestational diabetes and those born to women without gestational diabetes. RESULTS The mean (±SD) gestational age of the RDS infants was 35.9 (1.9) weeks, which was similar to that of the non-RDS infants (35.7 (±1.3) weeks). The HbA1c levels at diabetes diagnosed, the HbA1c levels right before delivery and the RBG levels before delivery had no significant differences, and all of them were below a well-controlled level. In the intergroup analysis, the morbidity of gestational diabetes between the two groups showed no significant differences in the adjusted analyses (adjusted OR 1.40, 95% CI 0.59-3.36). However, the case group had significantly more placental abnormalities (adjusted OR 3.61, 95% CI 1.63-8.00), fetal distress (adjusted OR 4.20, 95% CI 1.87-9.46), and asphyxia (adjusted OR 3.74, 95% CI 1.59-8.81) than the control group. In the subgroup analysis, the total dose of the PS applications, incidence of complications, and need for respiratory support (total and separate) were not significantly different between the two groups. CONCLUSIONS Well managed gestational diabetes is no longer a significant risk factor for RDS, while acute or chronic ischemia factors are. With regards to most GDM, diet and exercise are sufficient for maintaining an HbA1c below 6.5%

scholarly journals Association of gout medications and risk of cataract: a population-based case–control study

QJM ◽  
2019 ◽  
Vol 112 (11) ◽  
pp. 841-846
Author(s):  
Y-J Li ◽  
W-T Perng ◽  
K-Y Tseng ◽  
Y-H Wang ◽  
J C-C Wei
Keyword(s):  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
World Health ◽  
Control Group ◽  
Defined Daily Dose ◽  
New Diagnosis ◽  
Nested Case Control ◽  
Stratified Analysis ◽  
Control Study

Abstract Background The relationship between gout medication use and cataract development is controversial. Moreover, limited clinical studies have evaluated this relationship. Aim To assess the effects of colchicine, allopurinol and benzbromarone on the risk of cataract in patients with gout. Design Population-based nested case–control study. Methods We enrolled 7900 patients who had received a new diagnosis of cataract >3 years after gout diagnosis into the study group and 33 475 patients who did not receive a diagnosis of cataract into the control group by matching for age, sex and the year of gout diagnosis at a ratio of 1:1. We used World Health Organization’s defined daily dose (DDD) as a measure to assess the dosage of colchicine, allopurinol and benzbromarone exposure. Logistic regression was used to estimate crude and adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for the risk of cataract. Results The risk of cataract significantly increased in patients who received colchicine at a cumulative DDD of ≥66.5 (OR = 1.17, 95% CI = 1.01–1.36, P = 0.041). In the age-stratified analysis, patients with gout aged >60 years had a higher risk of cataract (OR = 1.27, 95% CI = 1.06–1.53, P = 0.011) than did patients aged <60 years. Allopurinol and benzbromarone had no association with cataract. Conclusions In this population-based nested case–control study, we observed that colchicine use increased the risk of cataract in patients with gout, especially in those aged >60 years who received colchicine at a cumulative DDD of >66.5.

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