T136. DO VITAMIN D SUPPLEMENTATION DURING THE FIRST YEAR OF LIFE PREDICT COGNITION IN PSYCHOSES DURING MIDLIFE?

ABSTRACT Objective: To determine the prevalence of vitamin D deficiency/insufficiency in children 0-18 years of age with recurrent wheezing and/or asthma residing in the microregion of Viçosa, Minas Gerais, Brazil, and treated at a referral center, and to determine its association with major risk factors for wheezing. Methods: A cross-sectional study was performed using a semi-structured questionnaire, which was administered by trained interviewers to the legal guardians of the study participants. Data were obtained regarding general characteristics of recurrent wheezing; general sociodemographic, environmental, and biologic factors; and atopy-related factors. The magnitude of the statistical association was assessed by calculating ORs and their corresponding 95% CIs by using multiple logistic regression. Results: We included 124 children in the study. The prevalence of vitamin D deficiency/insufficiency in the sample was 57.3%. Vitamin D deficiency/insufficiency was found to be associated with wheezing in the first year of life, personal history of atopic dermatitis, environmental pollution, and vitamin D supplementation until 2 years of age. Conclusions: The prevalence of vitamin D deficiency/insufficiency was high in our sample. Vitamin D concentrations were directly associated with vitamin D supplementation until 2 years of age and were inversely associated with wheezing events in the first year of life, personal history of atopic dermatitis, and environmental pollution.

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Vitamin D supplementation during the first year of life and risk of schizophrenia: A finnish birthcohort study

Schizophrenia Research ◽

10.1016/s0920-9964(03)80131-7 ◽

2003 ◽

Vol 60 (1) ◽

pp. 44-45 ◽

Cited By ~ 1

Author(s):

J.J. McGrath ◽

S. Kaisa ◽

H. Hakko ◽

J. Jokelainen ◽

P.B. Jones ◽

...

Keyword(s):

Vitamin D ◽

Vitamin D Supplementation ◽

First Year ◽

First Year Of Life

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Cross-sectional analysis of universal vitamin D supplementation in former East Germany during the first year of life

Journal of Pediatric Endocrinology and Metabolism ◽

10.1515/jpem-2016-0310 ◽

2017 ◽

Vol 30 (4) ◽

Cited By ~ 2

Author(s):

Aris Siafarikas ◽

Alfons Deichl ◽

Gerhard Jahreis ◽

Angela Pieplow ◽

Hartmut Vogel ◽

...

Keyword(s):

Vitamin D ◽

Vitamin D3 ◽

East Germany ◽

Vitamin D Supplementation ◽

First Year ◽

Cross Sectional ◽

Cross Sectional Analysis ◽

First Year Of Life ◽

Sectional Analysis ◽

The Impact

AbstractBackground:Universal vitamin D supplementation is controversial. Preventative examinations and public health initiatives in former East Germany that included vitamin D prophylaxis for children were regulated by official recommendations and guidelines. The aim of this study is to analyse the impact of a standardised nationwide guideline for universal supplementation with 400 International Units (IU) vitamin D3/day during the first year of life on clinical and biochemical parameters and the influence of surrounding factors.Methods:This is a cross-sectional analysis looking at data from a field study of 3481 term-born children during their first year of life that was conducted in 1989.Results:There were no significant clinical signs of rickets. 25 hydroxyvitamin D (25(OH)D) (mean and SEM, total analyses n=572) after birth (n=28) was 36(7) nmol/L, at 1 month 64(4) nmol/L (n=70, p<0.0001), 91(5) nmol/L at 3 months (n=95, p<0.0001), 65(8) nmol/L at 8 months (n=21, p=0.005) and ranged between 33 and 109 nmol/L until 12 months. Less than 0.2% of analyses revealed pathological levels for calcium or phosphate. Alkaline phosphatase (ALP) levels (n=690) were >1500 U/L (95th percentile) in 3.6%. Participants were on breastmilk or vitamin D-free formula, with solids added from 6 months of age. There were seasonal variations in 25(OH)D levels with a rise during spring and autumn. Thus this analysis is unique as sun exposure and supplementation can be considered as the only vitamin D sources.Conclusions:We conclude that universal supplementation with 400 IU of vitamin D3 during the first year of life is safe and provides sufficient 25(OH)D levels in Germany.

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Factors Influencing Initiation and Discontinuation of Vitamin D Supplementation Among Infants

10.20944/preprints202104.0487.v1 ◽

2021 ◽

Author(s):

Selen HURMUZLU KOZLER ◽

Tulin Revide SAYLI

Keyword(s):

Vitamin D ◽

Healthcare Providers ◽

Family Physicians ◽

Cross Sectional Study ◽

Vitamin D Supplementation ◽

Further Education ◽

First Year ◽

Cross Sectional ◽

Breastfed Infants ◽

First Year Of Life

Background: To determine vitamin D supplementation frequency among infants, factors that influence adherence, and reasons for discontinuation of initiated vitamin D. Methods: This cross-sectional study was conducted using a questionnaire administered to the mothers via a face-to-face interview on 560 infants aged from 1 to 24 months admitted to outpatient clinics from June to December 2017. Results: A total of 351 infants were administered vitamin D, and the rate of supplementation in the first year of life was 83%, while it was only 28% between 13 and 24 months. The rate of vitamin D supplementation was higher among infants who were exclusively formula-fed (p<.05). When the data were analyzed using logistic regression analysis, only visit family physicians seems to be a statistically significant independent variable in increasing supplementation (p<.05). Compared with family refusal, the rate of discontinuation of vitamin D by the healthcare providers was higher after the first year of life (p<.05). The rates of vitamin D discontinuation by healthcare providers, especially by nurses who considered the duration of supplementation adequate, were statistically significantly higher when compared with the fontanel closure and other reasons (p<0.05). Conclusions: The rate of vitamin D supplementation was higher among families who visited family physicians, which suggests the importance of well-baby visits. Since vitamin D supplementation was less common among exclusively breastfed infants, mothers should be educated. Healthcare professionals need further education about the importance of vitamin D supplementation and indications for discontinuation.

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Congenital erythropoietic porphyria (Gunther disease): a case report

Oxford Medical Case Reports ◽

10.1093/omcr/omaa051 ◽

2020 ◽

Vol 2020 (7) ◽

Author(s):

Ali Kahila ◽

Ali Zamlout ◽

Abdaljawad Mazloum ◽

Omar Laila ◽

Ayham Badran

Keyword(s):

Vitamin D ◽

Laboratory Tests ◽

Vitamin D Supplementation ◽

Psychological Development ◽

First Year ◽

Blood Transfusions ◽

Conflict Zone ◽

The Family ◽

Congenital Erythropoietic Porphyria ◽

First Year Of Life

ABSTRACT Congenital erythropoietic porphyria (CEP or Gunther disease) is a very rare subtype of porphyria with a prevalence of <0.9 per 1 000 000. A 13-year-old female patient came to our hospital complaining of a severe cutaneous ulceration and scarring. The symptoms began in her first year of life as urine discoloration and skin blistering in sun-exposed areas. The family had been trapped in a high-risk conflict zone in Syria for many years, which precipitated the aggravation of symptoms. Based on clinical examination and laboratory tests, we diagnosed the patient with CEP and treated her with vitamin D supplementation alongside chronic blood transfusions, strict photoprotection and psychotherapy. After 7 months, there were no longer active ulcers or novel complications. Psychotherapy and patient education were important for her psychological development at this age. This treatment limited the deterioration of the symptoms and made the patient more committed to the periodic examinations.

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Vitamin D Status and Factors Associated with Vitamin D Deficiency during the First Year of Life in Preterm Infants

Nutrients ◽

10.3390/nu13062019 ◽

2021 ◽

Vol 13 (6) ◽

pp. 2019

Author(s):

Jae-Hun Jung ◽

Eun-Ah Kim ◽

Sang-Yoon Lee ◽

Jung-Eun Moon ◽

Eun-Joo Lee ◽

...

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Preterm Infants ◽

Vitamin D Supplementation ◽

First Year ◽

Factors Associated ◽

Hydroxyvitamin D ◽

Vitamin D Levels ◽

National University ◽

First Year Of Life

We aimed to investigate the changes in vitamin D levels and factors associated with vitamin D deficiency (VDD) during the first year of life in Korean preterm infants. We enrolled 333 preterm infants who were born at Kyungpook National University Children’s Hospital between March 2013 and December 2019. 25-hydroxyvitamin D (25-OHD) levels and medical records were collected at birth, 6 months, and 12 months of age. The mean gestational age was 33.4 ± 2.3 weeks and mean 25-OHD levels at birth were 18.2 ± 13.5 ng/mL. The incidence of VDD was 82.8%, 30.6%, and 27.0% at birth, 6 months, and 12 months, respectively. The incidence of severe VDD (25-OHD < 10 ng/mL) was 31.5%, 1.5%, and 0%, at birth, 6 months, and 12 months, respectively. Among infants with severe VDD, the deficiency persisted in 49.6% at 6 months, and 35.3% at 12 months. The strongest predictor of VDD during follow-up was 25-OHD concentration at birth. Vitamin D supplementation at 400 IU/day did not affect vitamin D levels during the first year of life. Therefore, it is important to prevent neonatal VDD through maternal vitamin D supplementation during pregnancy. Further research is needed to determine the optimal vitamin D supplementation dose for Korean preterm infants.

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Early Infant Feeding Practices as Possible Risk Factors for Immunoglobulin E-Mediated Food Allergies in Kuwait

International Journal of Pediatrics ◽

10.1155/2018/1701903 ◽

2018 ◽

Vol 2018 ◽

pp. 1-12 ◽

Cited By ~ 3

Author(s):

Dalal Alkazemi ◽

Munirah Albeajan ◽

Stan Kubow

Keyword(s):

Risk Factors ◽

Vitamin D ◽

Immunoglobulin E ◽

Food Allergies ◽

First Year ◽

Antibiotic Exposure ◽

Pediatric Allergy ◽

Potential Risk Factors ◽

Ige Mediated ◽

First Year Of Life

Objective. Early feeding and infant exposures have been suggested as potential risk factors for immunoglobulin E- (IgE-) mediated food allergy (FA). We aimed to evaluate the association between IgE-mediated FA in children and early exposures including the child’s nutritional status, breastfeeding and its duration, the age at which the solid food was first introduced, antibiotic exposure during the first year of life, and the child’s vitamin D status during infancy. Design. A case-control study. Setting and Subjects. Children aged 0–13 years were recruited from pediatric allergy and immunology clinics (PAICs) located at major government hospitals in Kuwait (total FA cases: n=100; boys = 67%), and healthy controls (n=100, boys 55%) were recruited from various vaccination units at primary healthcare centers. Results. Cow’s milk allergy was the most common type of FA. FA status was independently associated with the early exposures of exclusive breastfeeding (aOR = 15.55 (3.26–74.19), p=0.001), vitamin D deficiency or insufficiency during infancy (aOR = 5.42 (1.92–15.30), p=0.001), and antibiotic exposure during the first year of life (aOR = 5.00 (1.58–15.84), p=0.006). Conclusions. FA is highly prevalent among children in Kuwait, and our data indicate that early nutrition-related and antibiotic exposures are associated with FA risk.

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