scholarly journals 0015 Manipulating Body Temperature: Effects on Sleep in Postmenopausal Women

SLEEP ◽  
2020 ◽  
Vol 43 (Supplement_1) ◽  
pp. A6-A7
Author(s):  
K J Reid ◽  
K Kräuchi ◽  
D Grimaldi ◽  
J Sbarboro ◽  
H Attarian ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heat Capacity ◽  
Body Temperature ◽  
Postmenopausal Women ◽  
Slow Wave ◽  
Slow Wave Sleep ◽  
Core Body Temperature ◽  
High Heat ◽  
Oscillatory Activity ◽  
High Heat Capacity

Abstract Introduction A decline in sleep quality and reduction in slow wave sleep (SWS) and slow wave activity (SWA) are common in older adults. Prior studies have shown that manipulating body temperature during sleep can increase SWS/SWA. The aim of this study was to determine the effects of manipulation of body temperatures during sleep, using a high heat capacity mattress, on SWS/SWA and heart rate variability in post-menopausal women. Methods Twenty-four healthy postmenopausal women between 40–75 years of age (mean age 62.4 ± 8.2 years, mean BMI 25.4 ± 3.5 kg/m2) were randomized in a single-blind, counterbalanced, cross-over manner to sleep on either a high heat capacity mattress (HHCM) or a low heat capacity mattress(LHCM) a week apart. Sleep was recorded using polysomnography during an 8-hour sleep opportunity. Core and peripheral temperatures were recorded using Equivital and ibutton respectively. Results In comparison to the LHCM, sleep on HHCM exhibited a selective increase in SWS (average increase in Stage N3 of 9.6 minutes (2.1%), p = 0.04) and in slow oscillatory activity (0.5-1Hz) in the first NREM/REM cycle (p=0.04). In addition, the HHCM induced a greater reduction in core body temperature (p=0.002), and delayed the increase in mattress surface temperature (maximal difference LHCM-HHCM: 4.66±0.17°C). Average heart rate was 2.7 beats/minute lower across the night on the HHCM compared to the LHCM (p=0.001). Conclusion The results of this study indicate that manipulation of body temperature during sleep may be a useful approach to enhance SWS sleep and cardiovascular function in postmenopausal women. Support Technogel

scholarly journals Effects of sleep on a high-heat capacity mattress on sleep stages, EEG power spectra, cardiac interbeat intervals and body temperatures in healthy middle-aged men‡

SLEEP ◽  
2019 ◽  
Vol 43 (5) ◽  
Author(s):  
Sebastian Herberger ◽  
Kurt Kräuchi ◽  
Martin Glos ◽  
Katharina Lederer ◽  
Lisa Assmus ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heat Capacity ◽  
Body Temperature ◽  
Wave Energy ◽  
Sleep Stage ◽  
High Heat ◽  
Body Temperatures ◽  
High Heat Capacity ◽  
Eeg Power ◽  
Core Body

Abstract Study Objectives This study deals with the question whether a slow (non-disturbing) reduction of core body temperature (CBT) during sleep increases sleep stage N3 and EEG slow wave energy (SWE) and leads to a slowing of heart rate in humans. Participants Thirty-two healthy male subjects with a mean ± SD age 46 ± 4 years and body mass index 25.2 ± 1.8 kg/m2. Methods A high-heat capacity mattress (HM) was used to lower body temperatures in sleep and was compared to a conventional low-heat capacity mattress (LM) in a double-blinded fashion. Polysomnography was performed accompanied by measurements of skin-, core body- and mattress surface-temperatures, and heart rate. EEG power spectral analyses were carried out using Fast Fourier Transform. Interbeat intervals were derived from the electrocardiogram. Results The HM led to a larger decline in CBT, mediated through higher heat conduction from the core via the proximal back skin onto the mattress together with reduced heart rate. These effects occurred together with a significant increase in sleep stage N3 and standardized slow wave energy (sSWE, 0.791–4.297 Hz) accumulated in NREM sleep. In the 2nd half of the night sSWE increase was significantly correlated with body temperature changes, for example with CBT decline in the same phase. Conclusions A HM subtly decreases CBT, leading to an increased amount of sleep stage N3 and of sSWE, as well as a slowing of heart rate.

Sleep on a high heat capacity mattress increases conductive body heat loss and slow wave sleep

2018 ◽  
Vol 185 ◽  
pp. 23-30 ◽  
Author(s):  
Kurt Kräuchi ◽  
Elisa Fattori ◽  
Alessandra Giordano ◽  
Maria Falbo ◽  
Antonella Iadarola ◽  
...  
Keyword(s):  
Heat Capacity ◽  
Heat Loss ◽  
Slow Wave ◽  
Slow Wave Sleep ◽  
High Heat ◽  
Conductive Body ◽  
High Heat Capacity ◽  
Body Heat

Ambulatory Estimation of Circadian Rhythms Shows Core Body Temperature Phase Precedes Slow Wave Sleep Phase in the Normal Elderly

2020 ◽  
Vol 87 (9) ◽  
pp. S251
Author(s):  
Esther Blessing ◽  
Ankit Paresh ◽  
Arleener Turner ◽  
Andrew Varga ◽  
David Rapoport ◽  
...  
Keyword(s):  
Body Temperature ◽  
Circadian Rhythms ◽  
Slow Wave ◽  
Slow Wave Sleep ◽  
Core Body Temperature ◽  
Temperature Phase ◽  
Sleep Phase ◽  
Core Body

scholarly journals Estimation of cardiovascular drift through ear temperature during prolonged steady-state cycling: a study protocol

2021 ◽  
Vol 7 (1) ◽  
pp. e000907
Author(s):  
Giovanni Polsinelli ◽  
Angelo Rodio ◽  
Bruno Federico
Keyword(s):  
Heart Rate ◽  
Steady State ◽  
Body Temperature ◽  
Study Protocol ◽  
External Auditory Canal ◽  
Exercise Intensity ◽  
Core Body Temperature ◽  
Cardiovascular Drift ◽  
Core Body ◽  
Steady State Cycling

IntroductionThe measurement of heart rate is commonly used to estimate exercise intensity. However, during endurance performance, the relationship between heart rate and oxygen consumption may be compromised by cardiovascular drift. This physiological phenomenon mainly consists of a time-dependent increase in heart rate and decrease in systolic volume and may lead to overestimate absolute exercise intensity in prediction models based on heart rate. Previous research has established that cardiovascular drift is correlated to the increase in core body temperature during prolonged exercise. Therefore, monitoring body temperature during exercise may allow to quantify the increase in heart rate attributable to cardiovascular drift and to improve the estimate of absolute exercise intensity. Monitoring core body temperature during exercise may be invasive or inappropriate, but the external auditory canal is an easily accessible alternative site for temperature measurement.Methods and analysisThis study aims to assess the degree of correlation between trends in heart rate and in ear temperature during 120 min of steady-state cycling with intensity of 59% of heart rate reserve in a thermally neutral indoor environment. Ear temperature will be monitored both at the external auditory canal level with a contact probe and at the tympanic level with a professional infrared thermometer.Ethics and disseminationThe study protocol was approved by an independent ethics committee. The results will be submitted for publication in academic journals and disseminated to stakeholders through summary documents and information meetings.

“On-” and “off-” cells in the rostral ventromedial medulla of rats held in thermoneutral conditions: are they involved in thermoregulation?

2014 ◽  
Vol 112 (9) ◽  
pp. 2199-2217 ◽  
Author(s):  
Nabil El Bitar ◽  
Bernard Pollin ◽  
Daniel Le Bars
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Body Temperature ◽  
Core Body Temperature ◽  
Rostral Ventromedial Medulla ◽  
Sequence Of Events ◽  
Ventromedial Medulla ◽  
Cyclic Variations ◽  
On And Off Cells ◽  
Core Body

In thermal neutral condition, rats display cyclic variations of the vasomotion of the tail and paws, synchronized with fluctuations of blood pressure, heart rate, and core body temperature. “On-” and “off-” cells located in the rostral ventromedial medulla, a cerebral structure implicated in somatic sympathetic drive, 1) exhibit similar spontaneous cyclic activities in antiphase and 2) are activated and inhibited by thermal nociceptive stimuli, respectively. We aimed at evaluating the implication of such neurons in autonomic regulation by establishing correlations between their firing and blood pressure, heart rate, and skin and core body temperature variations. When, during a cycle, a relative high core body temperature was reached, the on-cells were activated and within half a minute, the off-cells and blood pressure were depressed, followed by heart rate depression within a further minute; vasodilatation of the tail followed invariably within ∼3 min, often completed with vasodilatation of hind paws. The outcome was an increased heat loss that lessened the core body temperature. When the decrease of core body temperature achieved a few tenths of degrees, sympathetic activation switches off and converse variations occurred, providing cycles of three to seven periods/h. On- and off-cell activities were correlated with inhibition and activation of the sympathetic system, respectively. The temporal sequence of events was as follows: core body temperature → on-cell → off-cell ∼ blood pressure → heart rate → skin temperature → core body temperature. The function of on- and off-cells in nociception should be reexamined, taking into account their correlation with autonomic regulations.

scholarly journals The Impact of Central and Peripheral Cyclooxygenase Enzyme Inhibition on Exercise-Induced Elevations in Core Body Temperature

2017 ◽  
Vol 12 (5) ◽  
pp. 662-667 ◽  
Author(s):  
Matthijs T.W. Veltmeijer ◽  
Dineke Veeneman ◽  
Coen C.C.W. Bongers ◽  
Mihai G. Netea ◽  
Jos W. van der Meer ◽  
...  
Keyword(s):  
Heart Rate ◽  
Body Temperature ◽  
Skin Temperature ◽  
Core Body Temperature ◽  
Exercise Tests ◽  
Hypothalamic Temperature ◽  
Set Point ◽  
Exercise Induced ◽  
Core Body ◽  
The Impact

Purpose:Exercise increases core body temperature (TC) due to metabolic heat production. However, the exercise-induced release of inflammatory cytokines including interleukin-6 (IL-6) may also contribute to the rise in TC by increasing the hypothalamic temperature set point. This study investigated whether the exercise-induced increase in TC is partly caused by an altered hypothalamic temperature set point.Methods:Fifteen healthy, active men age 36 ± 14 y were recruited. Subjects performed submaximal treadmill exercise in 3 randomized test conditions: (1) 400 mg ibuprofen and 1000 mg acetaminophen (IBU/APAP), (2) 1000 mg acetaminophen (APAP), and (3) a control condition (CTRL). Acetaminophen and ibuprofen were used to block the effect of IL-6 at a central and peripheral level, respectively. TC, skin temperature, and heart rate were measured continuously during the submaximal exercise tests.Results:Baseline values of TC, skin temperature, and heart rate did not differ across conditions. Serum IL-6 concentrations increased in all 3 conditions. A significantly lower peak TC was observed in IBU/APAP (38.8°C ± 0.4°C) vs CTRL (39.2°C ± 0.5°C, P = .02) but not in APAP (38.9°C ± 0.4°C) vs CTRL. Similarly, a lower ΔTC was observed in IBU/APAP (1.7°C ± 0.3°C) vs CTRL (2.0°C ± 0.5°C, P < .02) but not in APAP (1.7°C ± 0.5°C) vs CTRL. No differences were observed in skin temperature and heart-rate responses across conditions.Conclusions:The combined administration of acetaminophen and ibuprofen resulted in an attenuated increase in TC during exercise compared with a CTRL. This observation suggests that a prostaglandin-E2-induced elevated hypothalamic temperature set point may contribute to the exercise-induced rise in TC.

scholarly journals Autonomic Modulation During Baseline and Recovery Sleep in Adult Sleepwalkers

2021 ◽  
Vol 12 ◽  
Author(s):  
Geneviève Scavone ◽  
Andrée-Ann Baril ◽  
Jacques Montplaisir ◽  
Julie Carrier ◽  
Alex Desautels ◽  
...  
Keyword(s):  
Heart Rate ◽  
Sleep Deprivation ◽  
Slow Wave ◽  
Slow Wave Sleep ◽  
Low Frequency ◽  
Medium Effect ◽  
Sleep Cycle ◽  
Autonomic Modulation ◽  
Decomposition Group ◽  
Recovery Sleep

Sleepwalking has been conceptualized as deregulation between slow-wave sleep and arousal, with its occurrence in predisposed patients increasing following sleep deprivation. Recent evidence showed autonomic changes before arousals and somnambulistic episodes, suggesting that autonomic dysfunctions may contribute to the pathophysiology of sleepwalking. We investigated cardiac autonomic modulation during slow-wave sleep in sleepwalkers and controls during normal and recovery sleep following sleep deprivation. Fourteen adult sleepwalkers (5M; 28.1 ± 5.8 years) and 14 sex- and age-matched normal controls were evaluated by video-polysomnography for one baseline night and during recovery sleep following 25 h of sleep deprivation. Autonomic modulation was investigated with heart rate variability during participants' slow-wave sleep in their first and second sleep cycles. 5-min electrocardiographic segments from slow-wave sleep were analyzed to investigate low-frequency (LF) and high-frequency (HF) components of heart rate spectral decomposition. Group (sleepwalkers, controls) X condition (baseline, recovery) ANOVAs were performed to compare LF and HF in absolute and normalized units (nLF and nHF), and LF/HF ratio. When compared to controls, sleepwalkers' recovery slow-wave sleep showed lower LF/HF ratio and higher nHF during the first sleep cycle. In fact, compared to baseline recordings, sleepwalkers, but not controls, showed a significant decrease in nLF and LF/HF ratio as well as increased nHF during recovery slow-wave sleep during the first cycle. Although non-significant, similar findings with medium effect sizes were observed for absolute values (LF, HF). Patterns of autonomic modulation during sleepwalkers' recovery slow-wave sleep suggest parasympathetic dominance as compared to baseline sleep values and to controls. This parasympathetic predominance may be a marker of abnormal neural mechanisms underlying, or interfere with, the arousal processes and contribute to the pathophysiology of sleepwalking.

scholarly journals Sleep-promoting effects of endogenous pyrogen (interleukin-1)

1984 ◽  
Vol 246 (6) ◽  
pp. R994-R999 ◽  
Author(s):  
J. M. Krueger ◽  
J. Walter ◽  
C. A. Dinarello ◽  
S. M. Wolff ◽  
L. Chedid
Keyword(s):  
Body Temperature ◽  
Intravenous Injection ◽  
Slow Wave ◽  
Slow Wave Sleep ◽  
Interleukin 1 ◽  
Cerebral Ventricles ◽  
Endogenous Pyrogen ◽  
Temperature Heating ◽  
Dose Dependent ◽  
Pyrogenic Activity

When infused into the lateral cerebral ventricles of rabbits, human endogenous pyrogen (EP) preparations induced dose-dependent increases in slow-wave sleep concomitant with increasing body temperature. Heating EP to 70 degrees C destroyed its sleep-promoting and pyrogenic activity. Anisomycin (an antipyretic) prevented EP from increasing body temperature without affecting its sleep-promoting activity. Intravenous injection of EP induced fever and transient increases in slow-wave sleep but failed to induce prolonged increases in slow-wave sleep. We conclude that the somnogenic activity of EP is not secondary to its pyrogenic activity.

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