scholarly journals Nuclear factor κB‐associated inflammation mediates impaired vascular endothelial function in non‐diabetic middle‐aged and older overweight/obese men

2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
Gary L. Pierce ◽  
Lisa A. Lesniewski ◽  
Brooke Lawson ◽  
Stacy D. Beske ◽  
Douglas R. Seals
Keyword(s):  
Endothelial Function ◽  
Nuclear Factor Κb ◽  
Vascular Endothelial ◽  
Nuclear Factor ◽  
Vascular Endothelial Function ◽  
Middle Aged

scholarly journals Absence of Inhibitor of Nuclear Factor κ B Kinase‐Mediated Suppression of Vascular Endothelial Function in Middle‐Aged/Older Adults Who Exercise

2009 ◽  
Vol 23 (S1) ◽  
Author(s):  
Ashley E Walker ◽  
Gary L Pierce ◽  
Lisa A Lesniewski ◽  
Brooke R Lawson ◽  
Katherine A Magerko ◽  
...  
Keyword(s):  
Older Adults ◽  
Endothelial Function ◽  
Vascular Endothelial ◽  
Nuclear Factor ◽  
Vascular Endothelial Function ◽  
Middle Aged ◽  
Nuclear Factor Κ B

scholarly journals The Efficacy of Stretching Exercises on Arterial Stiffness in Middle-Aged and Older Adults: A Meta-Analysis of Randomized and Non-Randomized Controlled Trials

2020 ◽  
Vol 17 (16) ◽  
pp. 5643 ◽  
Author(s):  
Michitaka Kato ◽  
Fumi Nihei Green ◽  
Kazuki Hotta ◽  
Toshiya Tsukamoto ◽  
Yasunari Kurita ◽  
...  
Keyword(s):  
Older Adults ◽  
Arterial Stiffness ◽  
Endothelial Function ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Vascular Endothelial ◽  
Vascular Endothelial Function ◽  
Middle Aged ◽  
Randomized Controlled ◽  
Stretching Exercises

Background: Aerobic exercise is known to reduce arterial stiffness; however, high-intensity resistance exercise is associated with increased arterial stiffness. Stretching exercises are another exercise modality, and their effect on arterial stiffness remains unclear. The purpose of this study was to determine whether stretching exercises reduce arterial stiffness in middle-aged and older adults, performing the first meta-analysis of currently available studies. Methods: We searched the literature for randomized controlled trials (RCTs) and non-RCTs published up to January 2020 describing middle-aged and older adults who participated in a stretching intervention vs. controls without exercise training. The primary and secondary outcomes were changes in arterial stiffness and vascular endothelial function and hemodynamic status. Pooled mean differences (MDs) and standard MDs (SMDs) with 95% confidence intervals (CIs) between the intervention and control groups were calculated using a random effects model. Results: We identified 69 trials and, after an assessment of relevance, eight trials, including a combined total of 213 subjects, were analyzed. Muscle stretching exercises were shown to significantly reduce arterial stiffness and improve vascular endothelial function (SMD: −1.00, 95% CI: −1.57 to −0.44, p = 0.0004; SMD: 1.15, 95% CI: 0.26 to 2.03, p = 0.01, respectively). Resting heart rate (HR) and diastolic blood pressure (DBP) decreased significantly after stretching exercise intervention (MD: −0.95 beats/min, 95% CI: −1.67 to −0.23 beats/min, p = 0.009; MD: −2.72 mm Hg, 95% CI: −4.01 to −1.43 mm Hg, p < 0.0001, respectively) Conclusions: Our analyses suggest that stretching exercises reduce arterial stiffness, HR, and DBP, and improve vascular endothelial function in middle-aged and older adults.

scholarly journals Nuclear Factor-κB Activation Contributes to Vascular Endothelial Dysfunction via Oxidative Stress in Overweight/Obese Middle-Aged and Older Humans

Circulation ◽  
2009 ◽  
Vol 119 (9) ◽  
pp. 1284-1292 ◽  
Author(s):  
Gary L. Pierce ◽  
Lisa A. Lesniewski ◽  
Brooke R. Lawson ◽  
Stacy D. Beske ◽  
Douglas R. Seals
Keyword(s):  
Oxidative Stress ◽  
Endothelial Dysfunction ◽  
Nuclear Factor Κb ◽  
Vascular Endothelial ◽  
Nuclear Factor ◽  
Vascular Endothelial Dysfunction ◽  
Middle Aged

scholarly journals Acute effects of ingestion of a novel whey‐derived extract on vascular endothelial function in middle‐aged men and women

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Kevin D. Ballard ◽  
Brian R. Kupchak ◽  
Brittanie M. Volk ◽  
Eunice Mah ◽  
Aida Shkreta ◽  
...  
Keyword(s):  
Endothelial Function ◽  
Vascular Endothelial ◽  
Acute Effects ◽  
Vascular Endothelial Function ◽  
Middle Aged ◽  
Men And Women

scholarly journals Vascular Endothelial Function Is Related to White Blood Cell Count and Myeloperoxidase Among Healthy Middle-Aged and Older Adults

Hypertension ◽  
2010 ◽  
Vol 55 (2) ◽  
pp. 363-369 ◽  
Author(s):  
Ashley E. Walker ◽  
Sara Marian Seibert ◽  
Anthony J. Donato ◽  
Gary L. Pierce ◽  
Douglas R. Seals
Keyword(s):  
Older Adults ◽  
Blood Cell ◽  
Endothelial Function ◽  
Cell Count ◽  
White Blood Cell Count ◽  
White Blood Cell ◽  
Vascular Endothelial ◽  
Vascular Endothelial Function ◽  
Blood Cell Count ◽  
Middle Aged

scholarly journals Sodium Nitrite Supplementation Improves Vascular Endothelial Function but not Motor or Cognitive Function in Middle‐Aged and Older Adults

2019 ◽  
Vol 33 (S1) ◽  
Author(s):  
Kayla A. Woodward ◽  
Jessica R. Santos‐Parker ◽  
Kara L. Lubieniecki ◽  
Erzsebet Nagy ◽  
Nathan S. Bryan ◽  
...  
Keyword(s):  
Older Adults ◽  
Cognitive Function ◽  
Endothelial Function ◽  
Sodium Nitrite ◽  
Vascular Endothelial ◽  
Vascular Endothelial Function ◽  
Middle Aged

scholarly journals Evaluation of Vascular Endothelial Function in Young and Middle-Aged Women with Respect to a History of Pregnancy, Pregnancy-Related Complications, Classical Cardiovascular Risk Factors, and Epigenetics

2020 ◽  
Vol 21 (2) ◽  
pp. 430 ◽  
Author(s):  
Ilona Hromadnikova ◽  
Katerina Kotlabova ◽  
Lenka Dvorakova ◽  
Ladislav Krofta
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Endothelial Dysfunction ◽  
Endothelial Function ◽  
Peripheral Blood ◽  
Vascular Endothelial ◽  
Vascular Endothelial Dysfunction ◽  
Vascular Endothelial Function ◽  
Middle Aged ◽  
Cholesterol Levels

The aim of the study was to examine the effect of previous pregnancies and classical cardiovascular risk factors on vascular endothelial function in a group of 264 young and middle-aged women 3 to 11 years postpartum. We examined microvascular functions by peripheral arterial tonometry and EndoPAT 2000 device with respect to a history of gestational hypertension, preeclampsia, fetal growth restriction, the severity of the disease with regard to the degree of clinical signs and delivery date. Besides, we compared Reactive Hyperemia Index (RHI) values and the prevalence of vascular endothelial dysfunction among the groups of women with normal and abnormal values of BMI, waist circumference, systolic and diastolic blood pressures, heart rate, total serum cholesterol levels, serum high-density lipoprotein cholesterol levels, serum low-density lipoprotein cholesterol levels, serum triglycerides levels, serum lipoprotein A levels, serum C-reactive protein levels, serum uric acid levels, and plasma homocysteine levels. Furthermore, we determined the effect of total number of pregnancies and total parity per woman, infertility and blood pressure treatment, presence of trombophilic gene mutations, current smoking of cigarettes, and current hormonal contraceptive use on the vascular endothelial function. We also examined the association between the vascular endothelial function and postpartum whole peripheral blood expression of microRNAs involved in pathogenesis of cardiovascular/cerebrovascular diseases (miR-1-3p, miR-16-5p, miR-17-5p, miR-20a-5p, miR-20b-5p, miR-21-5p, miR-23a-3p, miR-24-3p, miR-26a-5p, miR-29a-3p, miR-92a-3p, miR-100-5p, miR-103a-3p, miR-125b-5p, miR-126-3p, miR-130b-3p, miR-133a-3p, miR-143-3p, miR-145-5p, miR-146a-5p, miR-155-5p, miR-181a-5p, miR-195-5p, miR-199a-5p, miR-210-3p, miR-221-3p, miR-342-3p, miR-499a-5p, and miR-574-3p). A proportion of overweight women (17.94% and 20.59%) and women with central obesity (18.64% and 21.19%) had significantly lower RHI values at 10.0% false positive rate (FPR) both before and after adjustment of the data for the age of patients. At 10.0% FPR, a proportion of women with vascular endothelial dysfunction (RHI ≤ 1.67) was identified to have up-regulated expression profile of miR-1-3p (11.76%), miR-23a-3p (17.65%), and miR-499a-5p (18.82%) in whole peripheral blood. RHI values also negatively correlated with expression of miR-1-3p, miR-23a-3p, and miR-499a-5p in whole peripheral blood. Otherwise, no significant impact of other studied factors on vascular endothelial function was found. We suppose that screening of these particular microRNAs associated with vascular endothelial dysfunction may help to stratify a highly risky group of young and middle-aged women that would benefit from early implementation of primary prevention strategies. Nevertheless, it is obvious, that vascular endothelial dysfunction is just one out of multiple cardiovascular risk factors which has only a partial impact on abnormal expression of cardiovascular and cerebrovascular disease associated microRNAs in whole peripheral blood of young and middle-aged women.

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