scholarly journals Salmonella enterica serovar Typhimurium flagellin modulates CD4+ T cell apoptosis in Peyer's patches and spleen

2009 ◽  
Vol 23 (S1) ◽  
Author(s):  
Benedicte Marie Fournier ◽  
Andrew Gewirtz ◽  
Ifor Williams ◽  
Andrew Neish
Keyword(s):  
T Cell ◽  
Cell Apoptosis ◽  
Salmonella Enterica ◽  
Salmonella Enterica Serovar Typhimurium ◽  
Peyer's Patches ◽  
Cd4 T Cell ◽  
Peyer’S Patches ◽  
T Cell Apoptosis ◽  
Serovar Typhimurium

scholarly journals Solitary Intestinal Lymphoid Tissue Provides a Productive Port of Entry for Salmonella enterica Serovar Typhimurium

2007 ◽  
Vol 75 (4) ◽  
pp. 1577-1585 ◽  
Author(s):  
Stephan Halle ◽  
Dirk Bumann ◽  
Heike Herbrand ◽  
Yvonne Willer ◽  
Sabrina Dähne ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Salmonella Enterica ◽  
Lymphoid Tissue ◽  
Salmonella Enterica Serovar Typhimurium ◽  
De Novo ◽  
Peyer's Patches ◽  
Peyer’S Patches ◽  
Serovar Typhimurium ◽  
Strong Inflammatory Response ◽  
Intestinal Lymphoid Tissue

ABSTRACT Oral infection of mice with Salmonella enterica serovar Typhimurium results in the colonization of Peyer's patches, triggering a vigorous inflammatory response and immunopathology at these sites. Here we demonstrate that in parallel to Peyer's patches a strong inflammatory response occurs in the intestine, resulting in the appearance of numerous inflammatory foci in the intestinal mucosa. These foci surround small lymphoid cell clusters termed solitary intestinal lymphoid tissue (SILT). Salmonella can be observed inside SILT at early stages of infection, and the number of infected structures matches the number of inflammatory foci arising at later time points. Infection leads to enlargement and morphological destruction of SILT but does not trigger de novo formation of lymphoid tissue. In conclusion, SILT, a lymphoid compartment mostly neglected in earlier studies, represents a major site for Salmonella invasion and ensuing mucosal pathology.

scholarly journals Angiogenin is upregulated during the alloreactive immune response and has no effect on the T-cell expansion phase, whereas it affects the contraction phase by inhibiting CD4+ T-cell apoptosis

2016 ◽  
Vol 12 (5) ◽  
pp. 3471-3475 ◽  
Author(s):  
Theodoros Eleftheriadis ◽  
Georgios Pissas ◽  
Maria Sounidaki ◽  
Nikolaos Antoniadis ◽  
Georgia Antoniadi ◽  
...  
Keyword(s):  
Immune Response ◽  
T Cell ◽  
Cell Apoptosis ◽  
Cell Expansion ◽  
Cd4 T Cell ◽  
Expansion Phase ◽  
Contraction Phase ◽  
T Cell Apoptosis ◽  
T Cell Expansion

scholarly journals MiR-let-7i inhibits CD4+ T cell apoptosis in patients with acute coronary syndrome

2021 ◽  
Vol 30 (8) ◽  
pp. 0-0
Author(s):  
lijuan huang ◽  
boxin zhao ◽  
zhiyong zhang ◽  
lin gui ◽  
yingyu xiang ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
T Cell ◽  
Cell Apoptosis ◽  
Cd4 T Cell ◽  
T Cell Apoptosis ◽  
Coronary Syndrome

Polycomb chromobox (Cbx) 7 modulates activation-induced CD4+ T cell apoptosis

2014 ◽  
Vol 564 ◽  
pp. 184-188 ◽  
Author(s):  
Jian Li ◽  
Yang Li ◽  
Yinyin Cao ◽  
Meifen Yuan ◽  
Zhengfeng Gao ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Apoptosis ◽  
Cd4 T Cell ◽  
T Cell Apoptosis

scholarly journals Oral Immunization with ATP-Dependent Protease-Deficient Mutants Protects Mice against Subsequent Oral Challenge with Virulent Salmonella enterica Serovar Typhimurium

2003 ◽  
Vol 71 (1) ◽  
pp. 30-39 ◽  
Author(s):  
Hidenori Matsui ◽  
Masato Suzuki ◽  
Yasunori Isshiki ◽  
Chie Kodama ◽  
Masahiro Eguchi ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Salmonella Enterica ◽  
Peyer's Patches ◽  
Oral Challenge ◽  
Secretory Iga ◽  
Peyer’S Patches ◽  
Lon Protease ◽  
Mesenteric Lymph Nodes ◽  
Mesenteric Lymph ◽  
Serovar Typhimurium

ABSTRACT We evaluated the efficacy of mutants with a deletion of the stress response protease gene as candidates for live oral vaccine strains against Salmonella infection through infection studies with mice by using a Salmonella enterica serovar Typhimurium mutant with a disruption of the ClpXP or Lon protease. In vitro, the ClpXP protease regulates flagellum synthesis and the ClpXP-deficient mutant strain exhibits hyperflagellated bacterial cells (T. Tomoyasu et al., J. Bacteriol. 184:645-653, 2002). On the other hand, the Lon protease negatively regulates the efficacy of invading epithelial cells and the expression of invasion genes (A. Takaya et al., J. Bacteriol. 184:224-232, 2002). When 5-week-old BALB/c mice were orally administered 5 × 108 CFU of the ClpXP- or Lon-deficient strain, bacteria were detected with 103 to 104 CFU in the spleen, mesenteric lymph nodes, Peyer's patches, and cecum 1 week after inoculation and the bacteria then decreased gradually in each tissue. Significant increases of lipopolysaccharide-specific immunoglobulin G (IgG) and secretory IgA were detected at week 4 and maintained until at least week 12 after inoculation in serum and bile, respectively. Immunization with the ClpXP- or Lon-deficient strain protected mice against oral challenge with the serovar Typhimurium virulent strain. Both the challenged virulent and immunized avirulent salmonellae were completely cleared from the spleen, mesenteric lymph nodes, Peyer's patches, and even cecum 5 days after the challenge. These data indicate that Salmonella with a disruption of the ATP-dependent protease ClpXP or Lon can be useful in developing a live vaccine strain.

Increased apoptosis of peripheral blood T cells following allogeneic hematopoietic cell transplantation

Blood ◽  
2000 ◽  
Vol 95 (12) ◽  
pp. 3832-3839 ◽  
Author(s):  
Ming-Tseh Lin ◽  
Li-Hui Tseng ◽  
Haydar Frangoul ◽  
Ted Gooley ◽  
Ji Pei ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Cell Transplantation ◽  
Cell Apoptosis ◽  
Hematopoietic Cell Transplantation ◽  
Hematopoietic Cell ◽  
Allogeneic Hematopoietic Cell Transplantation ◽  
Cd4 T Cell ◽  
Spontaneous Apoptosis ◽  
T Cell Apoptosis

Lymphopenia and immune deficiency are significant problems following allogeneic hematopoietic cell transplantation (HCT). It is largely assumed that delayed immune reconstruction is due to a profound decrease in thymus-dependent lymphopoiesis, especially in older patients, but apoptosis is also known to play a significant role in lymphocyte homeostasis. Peripheral T cells from patients who received HCT were studied for evidence of increased cell death. Spontaneous apoptosis was measured in CD3+ T cells following a 24-hour incubation using 7-amino-actinomycin D in conjunction with the dual staining of cell surface antigens. Apoptosis was significantly greater among CD3+ T cells taken from patients 19-23 days after transplantation (30.4% ± 12.5%,P < .05), and 1 year after transplantation (9.7% ± 2.8%, P < .05) compared with healthy controls (4.0% ± 1.5%). Increased apoptosis occurred preferentially in HLA (human leukocyte antigen)-DR positive cells and in both CD3+/CD4+ and CD3+/CD8+ T-cell subsets, while CD56+/CD3− natural killer cells were relatively resistant to apoptosis. The extent of CD4+T-cell apoptosis was greater in patients with grade II-IV acute graft-versus-host disease (GVHD) (33.9% ± 11.3%) compared with grade 0-I GVHD (14.6 ± 6.5%, P < .05). T-cell apoptosis was also greater in patients who received transplantations from HLA-mismatched donors (39.5% ± 10.4%,P < .05) or HLA-matched unrelated donors (32.1% ± 11.4%, P < .05) compared with patients who received transplantations from HLA-identical siblings (19.6% ± 6.7%). The intensity of apoptosis among CD4+ T cells was significantly correlated with a lower CD4+ T-cell count. Together, these observations suggest that activation of T cells in vivo, presumably by alloantigens, predisposes the cells to spontaneous apoptosis, and this phenomenon is associated with lymphopenia. Activation-induced T-cell apoptosis may contribute to delayed immune reconstitution following HCT.

scholarly journals Murine Lung Cancer Increases CD4+ T Cell Apoptosis and Decreases Gut Proliferative Capacity in Sepsis

PLoS ONE ◽  
2016 ◽  
Vol 11 (3) ◽  
pp. e0149069 ◽  
Author(s):  
John D. Lyons ◽  
Rohit Mittal ◽  
Katherine T. Fay ◽  
Ching-Wen Chen ◽  
Zhe Liang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
T Cell ◽  
Cell Apoptosis ◽  
Cd4 T Cell ◽  
Proliferative Capacity ◽  
Murine Lung ◽  
T Cell Apoptosis
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