LINE‐1 DNA methylation in Colombian school children is associated with birth weight and maternal BMI, and predicts physical growth

Background: Riskesdas in 2013 showed that Yogyakarta (DIY) had a prevalence of stunted new kid in school is less than the national average, which is 14.9% (MOH, 2013). Stunted or short, is a linear growth retardation has been widely used as an indicator to measure the nutritional status of individuals and community groups. Stunted can be influenced by several factors: birth weight, birth length match and genetic factors. Objective: To determine the weight, length of low birth weight and genetic factors as predictors of the occurrence of stunted on elementary school children. Methods: The study was a case control analytic. Research sites in SD Muhammadiyah Ngijon 1 Subdistrict Moyudan. The study was conducted in May and June 2015. The subjects were school children grade 1 to grade 5 the number of cases as many as 47 children and 94 control children. With the inclusion criteria of research subjects willing to become respondents, was present at the time of the study, they have a father and mother, and exclusion criteria have no data BB and PB birth, can not stand upright. The research variables are BBL, PBL, genetic factors and TB / U at this time. Data were analyzed by chi-square test and Odd Ratio (OR) calculation. Results: In case group as much as 91.5% of normal birth weight and length of 80.9% of normal birth weight, most of the height of a normal mother and father as many as 85.1%. In the control group as much as 78.7% of normal birth weight and 61.7% were born normal body length, height mostly normal mom and dad that 96.7% of women and 90.4% normal normal father. Statistical test result is no significant correlation between height mothers with stunted incidence in school children, and the results of chi-square test P = 0.026 with value Odd Ratio (OR) of 3.9 and a range of values from 1.091 to 14.214 Cl95%. Conclusion: High maternal body of mothers can be used as predictors of the occurrence of stunted school children and mothers with stunted nutritional status have 3.9 times the risk of having children with stunted nutritional status.

Download Full-text

A study on health status of school children in rural northeast Thailand. (1). Physical growth status and biochemical blood status.

Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene) ◽

10.1265/jjh.42.954 ◽

1987 ◽

Vol 42 (5) ◽

pp. 954-963

Author(s):

Mieko Kimura ◽

Hiroyuki Asakura ◽

Masahiro Matumoto ◽

Masaru Morikawa ◽

Yutaka Midorikawa ◽

...

Keyword(s):

Health Status ◽

School Children ◽

Physical Growth ◽

Northeast Thailand ◽

Growth Status

Download Full-text

GROWTH AND DEVELOPMENT OF THE CHILD

PEDIATRICS ◽

10.1542/peds.64.5.591 ◽

1979 ◽

Vol 64 (5) ◽

pp. 591-591

Author(s):

Keyword(s):

Birth Weight ◽

Adult Life ◽

Developed Countries ◽

Infant Mortality Rate ◽

Physical Growth ◽

Rural Populations ◽

Vicious Cycle ◽

Catch Up ◽

The Individual ◽

Dramatic Consequence

Deaths of infants and of their mothers may be the most dramatic consequence of ill health, but there are other serious consequences which affect the child and, indeed, may follow it throughout adult life. The damage done by infections and associated malnutrition to a young child in its formative years is manifested in retarded physical growth and mental development, which it may never be able to catch up on, thus impairing the potential for a full and active adult life. Poverty, ignorance, and ill health thus create a vicious cycle spanning from one generation to the next, and from which the individual has little chance of escape. A striking expression of this generation link is the frequency of "low birth weight" (LBW) babies, ie, babies weighing less than 2500 gm at birth. It is now known that this frequency is closely determined by the same adverse maternal and environmental factors which determine the nutritional status of the mother. It has also been observed in developed countries that the frequency is higher among mothers who smoke during pregnancy. About 21 million LBW (small for date) babies are born each year, the greatest majority of them in developing countries. The observed incidence rate ranges from about 4% in the most developed countries to over 30% in some poor rural populations. It is also known that LBW is the single most important factor determining the survival chances of the child. The infant mortality rate is about 20 times greater for all LBW babies than for other babies, and the lower the birth weight the lower is the survival chance.

Download Full-text

Abstract P098: Maternal Insulin/Glycemic Regulation, Leptin, and Adiposity Levels are Associated with Newborn Adiposity

Circulation ◽

10.1161/circ.129.suppl_1.p098 ◽

2014 ◽

Vol 129 (suppl_1) ◽

Author(s):

Julie Patenaude ◽

Catherine Allard ◽

Marilyn Lacroix ◽

Laeticia Guillemette ◽

Marie-Claude Battista ◽

...

Keyword(s):

Birth Weight ◽

Body Fat ◽

Medical Records ◽

Population Based ◽

Maternal Body Mass Index ◽

Fasting Insulin ◽

Metabolic Characteristics ◽

Neonatal Adiposity ◽

Glycemic Regulation ◽

Maternal Bmi

Introduction: Leptin is a hormone secreted by adipocytes that circulates in proportion to body fat. Placenta also produces leptin suggesting a specific role during pregnancy, maybe contributing to pregnancy-induced insulin resistance. Objective: To determine the associations between maternal levels of leptin, glucose and insulin and weight/adiposity measures in newborns. Methods: A population-based cohort of pregnant women in the region of Sherbrooke, Canada was recruited in early pregnancy (n=1040 at 1 st trimester). Maternal anthropometry was measured and blood samples were collected at the 1 st and 2 nd trimesters to measure glucose (hexokinase), leptin and insulin (ELISA Luminex, Millipore Canada). Birth weights were recorded from the medical records in 783 newborns (full term >36 weeks). We measured skinfolds in 199 newborns within 72h after birth, using a standardized caliper. We measured triceps, biceps, subscapular and supra-iliac skinfolds and the sum of skinfolds was used for analysis representing overall neonatal adiposity. Correlations and linear regression analyses were performed to evaluate the associations between maternal metabolic characteristics and neonatal weight/adiposity measures. Results: Birth weight was associated with maternal body mass index (BMI; r=0.18 and r=0.20 at 1st and 2 nd trimesters respectively; both P <0.001), percent body fat (%bf; r=0.25; P <0.001), weight gain over pregnancy (r=0.14; P <0.001), and fasting leptin (r=0.15, P <0.001). Surprisingly, crude birth weight was not associated with maternal glycemic or insulin levels at 1 st or 2 nd trimesters (all P >0.05). In contrast, sum of skinfolds was associated with maternal fasting glucose (r=0.17, P =0.01) and fasting insulin (r=0.24, P =0.001), in addition to fasting leptin (r=0.18, P =0.01) at 2 nd trimester. Sum of skinfolds was also associated with maternal BMI (r=0.18, P =0.008 at 1 st and r=0.21, P =0.003 at 2 nd trimester) and %bf (r=0.19; P =0.005). After adjustments for maternal BMI or %bf, sum of skinfolds remained significantly associated with maternal fasting insulin (all P <0.05), but not with maternal leptin levels ( P =0.16 to 0.35) Conclusion: These results suggest that maternal insulin/glycemic regulation has a greater impact on neonatal adiposity than overall crude birth weight. Birth weight and neonatal adiposity are both associated with maternal leptin levels, likely representing maternal own adiposity levels that might influence neonatal outcomes directly or indirectly.

Download Full-text

rs10732516 polymorphism at the IGF2/H19 locus associates with genotype-specific effects on placental DNA methylation and birth weight of newborns conceived by assisted reproductive technology

Clinical Epigenetics ◽

10.1186/s13148-018-0511-2 ◽

2018 ◽

Vol 10 (1) ◽

Cited By ~ 12

Author(s):

Heidi Marjonen ◽

Pauliina Auvinen ◽

Hanna Kahila ◽

Olga Tšuiko ◽

Sulev Kõks ◽

...

Keyword(s):

Dna Methylation ◽

Birth Weight ◽

Assisted Reproductive Technology ◽

Reproductive Technology ◽

Specific Effects

Download Full-text

Associations between maternal BMI, breastfeeding practices and infant anthropometric status in Colombia; secondary analysis of ENSIN 2010.

10.21203/rs.2.16479/v3 ◽

2020 ◽

Author(s):

Fanny Aldana-Parra ◽

Gilma Olaya ◽

Mary Fewtrell

Keyword(s):

Birth Weight ◽

Infant Feeding ◽

Maternal Education ◽

Secondary Analysis ◽

Maternal Body Mass Index ◽

Term Infants ◽

Feeding Mode ◽

Breastfeeding Practices ◽

Maternal Bmi ◽

Anthropometric Status

Abstract Background: Maternal malnutrition and infant feeding mode impact short and long term infant and child morbidity and mortality. The period of lactation may provide an opportunity to modulate the risk of disease later in life. Our aim was to estimate the effect of maternal body mass index (BMI) and infant feeding mode, particularly breastfeeding practices, on the anthropometric status of children under two years in Colombia. Methods: A secondary analysis was performed using the data from ENSIN 2010. Term infants under 2y, singleton, with a mother older than 18y, were included in the analysis. Outcomes were wasting (WLZ<-2SD), overweight (WLZ>+2SD) and stunting (LAZ<-2SD). Predictors were infant feeding (exclusive and predominant BF constructed from 24-hour recall, age at introduction of liquids, semisolids and solids) and maternal BMI. Socioeconomic variables, maternal education and age, conditions during pregnancy and birth weight were analyzed as covariates. Results: Mothers of overweight infants had higher BMI (Mean dif=1.47 kg/m2; 95% CI=2.1, 0.8) than those with normal weight infants. Stunting and wasting were not predicted by maternal anthropometry or infant feeding mode. Fewer maternal years of education were associated with wasting (OR=0.90; 95% CI=0.86, 0.97; p=0.003) and stunting (OR=0.92; 95% CI=0.89, 0.94; p<0.0001), while more maternal years of education were associated with overweight (OR=1.06; 95% CI=1.02, 1.01; p=0.001); higher birth weight was associated with overweight (OR=1.001; 95% CI=1.00, 1.001; p<0.0001) and lower birth was associated with stunting (OR=0.99; 95% CI=0.89; p<0.0001) in the final regression model. Conclusions: Maternal BMI is a modifiable target for public health policy to promote healthy infant growth. Infant nutritional status is affected by direct and indirect factors that need to be addressed in further studies.

Download Full-text