Healthful behaviors consistent with World Cancer Research Fund/American Institute for Cancer Research guidelines for cancer prevention and breast, prostate and colorectal cancer risk in the Framingham Offspring Cohort (1991‐2008) (370.4)

Post-treatment adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) lifestyle recommendations were associated with health-related quality of life (HRQoL), fatigue, and chemotherapy-induced peripheral neuropathy (CIPN) in colorectal cancer (CRC) survivors. In a prospective cohort among CRC survivors (n = 459), repeated home-visits were performed at 6 weeks, 6, 12, and 24 months post-treatment. Dietary intake, body composition, sedentary behaviour, and physical activity were assessed to construct a lifestyle score based on adherence to seven 2018 WCRF/AICR recommendations. Longitudinal associations of the lifestyle score with HRQoL, fatigue, and CIPN were analysed by confounder-adjusted linear mixed models. A higher lifestyle score was associated with better physical functioning and less activity-related fatigue, but not with CIPN. Adjustment for physical activity substantially attenuated observed associations, indicating its importance in the lifestyle score with regards to HRQoL. In contrast, adjustment for body composition and alcohol inflated observed associations, indicating that both recommendations had a counteractive influence within the lifestyle score. Our findings suggest that CRC survivors benefit from an overall adherence to the WCRF/AICR lifestyle recommendations in terms of HRQoL and fatigue, but not CIPN. Specific recommendations have a varying influence on these associations, complicating the interpretation and requiring further study.

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Adherence to the 2018 World Cancer Research Fund/American Institute for Cancer Research cancer prevention recommendations and pancreatic cancer incidence and mortality: A prospective cohort study

Cancer Medicine ◽

10.1002/cam4.3348 ◽

2020 ◽

Vol 9 (18) ◽

pp. 6843-6853

Author(s):

Zhi‐Qing Zhang ◽

Qu‐Jin Li ◽

Fa‐Bao Hao ◽

You‐Qi‐Le Wu ◽

Shan Liu ◽

...

Keyword(s):

Pancreatic Cancer ◽

Cancer Research ◽

Cohort Study ◽

Cancer Prevention ◽

Prospective Cohort Study ◽

Cancer Incidence ◽

Prospective Cohort ◽

Research Fund ◽

American Institute ◽

Incidence And Mortality

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Adherence to the cancer prevention recommendations of the World Cancer Research Fund/American Institute for Cancer Research and mortality: a census-linked cohort

American Journal of Clinical Nutrition ◽

10.3945/ajcn.116.135020 ◽

2016 ◽

Vol 104 (3) ◽

pp. 678-685 ◽

Cited By ~ 20

Author(s):

Tina Lohse ◽

David Faeh ◽

Matthias Bopp ◽

Sabine Rohrmann ◽

Keyword(s):

Cancer Research ◽

Cancer Prevention ◽

Research Fund ◽

American Institute ◽

The World

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Associations of the dietary World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) recommendations with patient-reported outcomes in colorectal cancer survivors 2–10 years post-diagnosis: a cross-sectional analysis

British Journal Of Nutrition ◽

10.1017/s0007114520003487 ◽

2020 ◽

pp. 1-13

Author(s):

Marlou-Floor Kenkhuis ◽

Bernadette W. A. van der Linden ◽

Jose J. L. Breedveld-Peters ◽

Janna L. Koole ◽

Eline H. van Roekel ◽

...

Keyword(s):

Colorectal Cancer ◽

Cancer Research ◽

Cancer Survivors ◽

Physical Functioning ◽

Patient Reported Outcomes ◽

Fruit And Vegetables ◽

Research Fund ◽

American Institute ◽

Cross Sectional ◽

Patient Reported

Abstract The World Cancer Research Fund and American Institute for Cancer Research (WCRF/AICR) advise cancer survivors to follow their lifestyle recommendations for cancer prevention. Adhering to these recommendations may have beneficial effects on patient-reported outcomes after a cancer diagnosis, but evidence is scarce. We aimed to assess associations of the individual dietary WCRF/AICR recommendations regarding fruit and vegetables, fibre, fast foods, red and processed meat, sugar-sweetened drinks and alcohol consumption with patient-reported outcomes in colorectal cancer (CRC) survivors. Cross-sectional data of 150 stage I–III CRC survivors, 2–10 years post-diagnosis, were used. Dietary intake was measured by 7-d dietary records. Validated questionnaires were used to measure health-related quality of life (HRQoL), fatigue and neuropathy. Confounder-adjusted linear regression models were used to analyse associations of each WCRF/AICR dietary recommendation with patient-reported outcomes. Higher vegetable intake (per 50 g) was associated with better global QoL (β 2·6; 95 % CI 0·6, 4·7), better physical functioning (3·3; 1·2, 5·5) and lower levels of fatigue (−4·5; −7·6, −1·4). Higher fruit and vegetables intake (per 100 g) was associated with better physical functioning (3·2; 0·8, 5·5) and higher intake of energy-dense food (per 100 kJ/100 g) with worse physical functioning (−4·2; −7·1, −1·2). No associations of dietary recommendations with neuropathy were found. These findings suggest that adhering to specific dietary WCRF/AICR recommendations is associated with better HRQoL and less fatigue in CRC survivors. Although the recommendations regarding healthy dietary habits may be beneficial for the well-being of CRC survivors, longitudinal research is warranted to gain insight into the direction of associations.

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