Effect of Resveratrol on Cardiovascular and Metabolic Function in Adult Male and Female Offspring Born Intrauterine Growth Restricted

Preeclampsia (PE) is a hypertensive disorder of pregnancy occurring in approximately 10% of women worldwide. While it is life threatening to both the mother and baby, the only effective treatment is delivery of the placenta and fetus, which is often preterm. Maternal obesity is a risk factor for PE, and the effects of both on offspring are long standing with increased incidence of cardiometabolic disease in adulthood. Obese BPH/5 mice spontaneously exhibit excessive gestational weight gain and late-gestational hypertension, similar to women with PE, along with fetal growth restriction and accelerated compensatory growth in female offspring. We hypothesized that BPH/5 male offspring will demonstrate cardiovascular and metabolic phenotypes similar to BPH/5 females. As previously described, BPH/5 females born to ad libitum-fed dams are overweight with hyperphagia and increased subcutaneous, peri-renal, and peri-gonadal white adipose tissue (WAT) and cardiomegaly compared to age-matched adult female controls. In this study, BPH/5 adult male mice have similar body weights and food intake compared to age-matched control mice but have increased inflammatory subcutaneous and peri-renal WAT and signs of cardiovascular disease: left ventricular hypertrophy and hypertension. Therefore, adult male BPH/5 do not completely phenocopy the cardiometabolic profile of female BPH/5 mice. Future investigations are necessary to understand the differences observed in BPH/5 male and female mice as they age. In conclusion, the impact of fetal programming due to PE has a transgenerational effect on both male and female offspring in the BPH/5 mouse model. The maternal obesogenic environment may play a role in PE pregnancy outcomes, including offspring health as they age.

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Pulmonary CYP1A1 and CYP1A2 levels and activities in adult male and female offspring of rats exposed during gestation and lactation to 2,3,7,8-tetrachlorodibenzo-p-dioxin11Abbreviations: AhR, aryl hydrocarbon receptor; ARNT, AhR nuclear translocator; AUC, area under the curve; B[a]P, benzo[a]pyrene; CYP1A, used to include CYP1A1 and CYP1A2; EROD, ethoxyresorufin O-deethylase; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; MeIQ, 2-amino-3,4-dimethylimidazo[4,5-f]quinoline; PCR, polymerase chain reaction; PhIP, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine; and TCDD, 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Biochemical Pharmacology ◽

10.1016/s0006-2952(01)00721-3 ◽

2001 ◽

Vol 62 (5) ◽

pp. 617-626 ◽

Cited By ~ 1

Author(s):

Michael M. Iba ◽

Jacqueline Fung

Keyword(s):

Polymerase Chain Reaction ◽

Aryl Hydrocarbon Receptor ◽

Adult Male ◽

Area Under The Curve ◽

Female Offspring ◽

Chain Reaction ◽

Male And Female ◽

Pcr Polymerase Chain Reaction ◽

Aryl Hydrocarbon ◽

Polymerase Chain

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Effect of prenatal nicotine exposure on heart susceptibility to ischemia/reperfusion injury in adult male and female offspring

The FASEB Journal ◽

10.1096/fasebj.21.6.a1225-a ◽

2007 ◽

Vol 21 (6) ◽

Author(s):

DaLiao Xiao ◽

Jennifer Lawrence ◽

Shumei Yang ◽

Lubo Zhang

Keyword(s):

Reperfusion Injury ◽

Adult Male ◽

Ischemia Reperfusion Injury ◽

Ischemia Reperfusion ◽

Female Offspring ◽

Nicotine Exposure ◽

Male And Female ◽

Prenatal Nicotine Exposure ◽

Prenatal Nicotine

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Intrauterine Growth Restricted Rats Exercised before and during Pregnancy: Maternal and Perinatal Repercussions

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2015/294850 ◽

2015 ◽

Vol 2015 ◽

pp. 1-10 ◽

Cited By ~ 6

Author(s):

S. B. Corvino ◽

G. T. Volpato ◽

M. V. C. Rudge ◽

D. C. Damasceno

Keyword(s):

Body Weight ◽

Physical Exercise ◽

Glucose Intolerance ◽

Intrauterine Growth Restriction ◽

Female Offspring ◽

Pregnant Rats ◽

Male And Female ◽

Intrauterine Growth ◽

Reduced Body ◽

General Adiposity

This study aimed at evaluating the effect of swimming before and during pregnancy on rats born with intrauterine growth restriction (IUGR) and their offspring. For this, nondiabetic and streptozotocin-induced severely diabetic (SD) pregnant rats were mated and generated offspring with appropriate (control, C) and small (IUGR) for pregnancy age, respectively. Following that, C and IUGR groups were further distributed into nonexercised control (C), exercised control (Cex), nonexercised IUGR (IUGR), and exercised IUGR (IUGRex). IUGR rats presented lower mating rate than control rats. Regardless of physical exercise IUGR rats presented decreased body weight from birth to lactation. At 90 days of life, IUGR rats presented glucose intolerance. Maternal organ weights were increased and relative adiposity of IUGRex rats was lower than Cex. IUGR and IUGRex offspring presented reduced body weight than C and Cex, respectively. IUGRex dams presented an increased rate of appropriate for pregnancy age newborns. IUGEex male and female offspring relative brain weight was increased compared with Cex. Therefore, swimming before and during pregnancy prevented glucose intolerance, reduced general adiposity, and increased maternal and offspring organ weight in rats, showing the benefit of physical exercise for IUGR rats.

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