The Nature of Antitrypsin in the Blood Serum and its Mode of Action

1910 ◽  
Vol 139 (5) ◽  
pp. 778
Author(s):  
O. SCHWARZ
Keyword(s):  
Blood Serum ◽  
Mode Of Action

scholarly journals ON THE MODE OF ACTION OF SULFANILAMIDE IN EXPERIMENTAL STREPTOCOCCUS EMPYEMA

1937 ◽  
Vol 66 (5) ◽  
pp. 535-548 ◽  
Author(s):  
Frederick P. Gay ◽  
Ada R. Clark
Keyword(s):  
Blood Serum ◽  
Mode Of Action ◽  
Direct Evidence ◽  
Test Tube ◽  
Visceral Pleura ◽  
Cell Reaction ◽  
Animal Body ◽  
Natural Defense ◽  
Repeated Doses ◽  
Pleural Exudate

Sulfanilamide prevents the evolution of an invariably fatal streptococcus empyema in rabbits when it is given repeatedly and in sufficient doses subcutaneously. Complete sterilization of the inoculated cavity occurs on approximately the 2nd day. The serum, defibrinated blood and artificial pleural exudate of similarly treated animals inhibits the growth of the same streptococcus in the test tube but even repeated doses of such treated blood serum fail to sterilize the culture. The coccal chains grown in such drugged serum are elongated and present pleomorphic and metachromatic organisms and may give rise to colonies that are at first less predominantly mucoid in appearance. Such organisms have, however, lost little if any of their virulence. Cooperation on the part of locally derived clasmatocytes is apparently required in complete sterilization of the animal body. This conclusion is reached not only by a process of exclusion from comparison with the test tube results, but through the direct histological demonstration of a precocious and increasing mobilization of clasmatocytes in the parietal and visceral pleura of treated animals. In other words, sulfanilamide apparently produces a bacteriostasis sufficiently marked to protect the accumulated leucocytes and to allow the natural defense macrophages to accumulate. There is direct evidence that the drug does not in itself stimulate the mobilization of the macrophages. There is no evidence that the cell reaction which finally accounts for disposal of the organisms is other than local.

scholarly journals The antiseptic action of substances of the Chloramine group

1916 ◽  
Vol 89 (614) ◽  
pp. 232-251 ◽  
Keyword(s):  
Blood Serum ◽  
Sodium Hypochlorite ◽  
Mode Of Action ◽  
Sodium Hypochlorite Solution ◽  
Necrotic Tissue ◽  
Hypochlorite Solution ◽  
Related Substances ◽  
Cent Concentration ◽  
Infected Wounds

In the course of experiments relating to the employment of antiseptics in the treatment of infected wounds, one of the present writers introduced a modification of the ordinary sodium hypochlorite solution which was found capable of giving useful results when properly employed. The advantages of this sodium hypochlorite preparation for the treatment of infected wounds compared with some commonly used antiseptics may be referred to the following properties—though powerfully germicidal it does not coagulate blood serum or other protein substances, while at the same time it dissolves necrotic tissue; it is freely soluble and can penetrate to a certain extent, and when properly prepared it is practically non-irritating at 0·5 per cent, concentration. Out of a very large number of antiseptics that were systematically examined, the hypochlorites seemed to be among the most generally useful. It was, therefore, of interest to study the mode of action of hypochlorites and to endeavour to find related substances which might prove to be of greater practical value.

Effects of 5-5'-Diphenyl-2-thiohydantoin (DPTH) and Thyroxine on the Ultrastructure and Chemical Composition of Rat Liver

1971 ◽  
Vol 29 ◽  
pp. 570-571
Author(s):  
E. A. Elfont ◽  
R. B. Tobin ◽  
D. G. Colton ◽  
M. A. Mehlman
Keyword(s):  
Chemical Composition ◽  
Rat Liver ◽  
Future Study ◽  
Mode Of Action ◽  
Liver Mitochondria ◽  
Rat Liver Mitochondria ◽  
Effective Inhibitor ◽  
Biochemical Effects ◽  
Glycerophosphate Dehydrogenase ◽  
Stimulation Of

Summary5,-5'-diphenyl-2-thiohydantoin (DPTH) is an effective inhibitor of thyroxine (T4) stimulation of α-glycerophosphate dehydrogenase in rat liver mitochondria. Because this finding indicated a possible tool for future study of the mode of action of thyroxine, the ultrastructural and biochemical effects of DPTH and/or thyroxine on rat liver mere investigated.Rats were fed either standard or DPTH (0.06%) diet for 30 days before T4 (250 ug/kg/day) was injected. Injection of T4 occurred daily for 10 days prior to sacrifice. After removal of the liver and kidneys, part of the tissue was frozen at -50°C for later biocheailcal analyses, while the rest was prefixed in buffered 3.5X glutaraldehyde (390 mOs) and post-fixed in buffered 1Z OsO4 (376 mOs). Tissues were embedded in Araldlte 502 and the sections examined in a Zeiss EM 9S.Hepatocytes from hyperthyroid rats (Fig. 2) demonstrated enlarged and more numerous mitochondria than those of controls (Fig. 1). Glycogen was almost totally absent from the cytoplasm of the T4-treated rats.

Concentration of selected micro-nutrients in saliva among women in menopausal period treated with hormone replacement therapy

2013 ◽  
Vol 22 (01) ◽  
pp. 46-51
Author(s):  
M. Rahnama ◽  
I. Jastrzêbska-Jamrogiewicz ◽  
R. Jamrogiewicz
Keyword(s):  
Bone Mineral Density ◽  
Hormone Replacement Therapy ◽  
Blood Serum ◽  
Replacement Therapy ◽  
Hormone Replacement ◽  
Surgical Removal ◽  
Femoral Bone ◽  
Mineral Density ◽  
Natural Menopause ◽  
Copper Zinc

Summary Objective: The aim of this study was to observe the variability of the level of copper, zinc and manganese in saliva amongst women with hypoestrogenia, treated and untreated with hormone replacement therapy (HRT). Methods: The study was conducted on a group of 60 women treated and untreated with HRT. Half of the patients were after natural menopause and other half was after surgical removal of ovaries. Research on micronutrients in non-stimulated saliva and blood serum was carried out in 2005. Tests on saliva were repeated in 2010. Investigation of bone mineral density (BMD) of femoral bone was performed in year 2010. Results: Statistical analysis of concentration of copper and zinc revealed a linear correlation between the levels of these microelements in blood serum and saliva. The study revealed that HRT has a beneficial effect on BMD and the concentration of copper and manganese in saliva and blood serum of patients after the menopause. Patients treated with HRT showed higher BMD values than groups not treated with hormones. Conclusions: Saliva appears to be a promising diagnostic material which can be used to analyze the content of trace elements, but further research should be carried out on a broader research group.

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