ACUTE LUNG INJURY SCORE DOES NOT PREDICT HOSPITAL MORTALITY IN ACUTE LUNG INJURY USING MULTIVARIABLE MODELING

1999 ◽  
Vol 27 (Supplement) ◽  
pp. 35A
Author(s):  
Jay Steingrub ◽  
Daniel Teres ◽  
Hui Li ◽  
Penny Pekow
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Hospital Mortality ◽  
Lung Injury Score ◽  
Injury Score ◽  
Predict Hospital Mortality

scholarly journals The assessment of severity of lung injury in sepsis

2004 ◽  
Vol 132 (11-12) ◽  
pp. 404-408
Author(s):  
Ljubica Arsenijevic ◽  
Nada Popovic ◽  
Zvezdana Kojic
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Distress Syndrome ◽  
Lung Injury Score ◽  
Pulmonary Dysfunction ◽  
Lethal Outcome ◽  
Injury Score ◽  
Respiratory Dysfunction

Adult respiratory distress syndrome (ARDS) is an acute and severe pulmonary dysfunction. It is clinically characterized by dyspnea and tachypnea, progressive hypoxemia (within 12-48 hours), reduction of pulmonary compliance and diffuse bilateral infiltrates seen on pulmonary radiogram. Etiological factors giving rise to development of the syndrome are numerous. The acute lung injury (AU) is defined as the inflammation syndrome and increased permeability, which is associated with radiological and physiological disorders. Lung injury score (LIS), which is composed of four components, is used for making a distinction between two separate but rather similar syndromes. The study was aimed at the assessment of the severity of the lung injury in patients who had suffered from sepsis of the gynecological origin and its influence on the outcome of the disease. The total of 43 female patients was analyzed. Twenty patients (46.51%) were diagnosed as having ARDS based on the lung injury score, while 23 patients (53.48%) were diagnosed with acute lung injury. In our series, lung injury score ranged from 0.7 to 3.3 in ARDS patients, and lethal outcome ensued in 11 (55%) cases in this group. As for the patients with the acute lung injury, the score values ranged from 0.3 to 1.3 and only one patient from this group died (4.34%). The obtained results indicate that high values of the lung injury score are suggestive of the severe respiratory dysfunction as well as that lethal outcome is dependent on LIS value.

scholarly journals Thaliporphine Derivative Improves Acute Lung Injury after Traumatic Brain Injury

2015 ◽  
Vol 2015 ◽  
pp. 1-10
Author(s):  
Gunng-Shinng Chen ◽  
Kuo-Feng Huang ◽  
Chien-Chu Huang ◽  
Jia-Yi Wang
Keyword(s):  
Traumatic Brain Injury ◽  
Acute Lung Injury ◽  
Brain Injury ◽  
Lung Injury ◽  
Weight Ratio ◽  
Dry Weight ◽  
Lung Injury Score ◽  
Injury Score ◽  
Aqp4 Expression ◽  
Protein Levels

Acute lung injury (ALI) occurs frequently in patients with severe traumatic brain injury (TBI) and is associated with a poor clinical outcome. Aquaporins (AQPs), particularly AQP1 and AQP4, maintain water balances between the epithelial and microvascular domains of the lung. Since pulmonary edema (PE) usually occurs in the TBI-induced ALI patients, we investigated the effects of a thaliporphine derivative, TM-1, on the expression of AQPs and histological outcomes in the lung following TBI in rats. TM-1 administered (10 mg/kg, intraperitoneal injection) at 3 or 4 h after TBI significantly reduced the elevated mRNA expression and protein levels of AQP1 and AQP4 and diminished the wet/dry weight ratio, which reflects PE, in the lung at 8 and 24 h after TBI. Postinjury TM-1 administration also improved histopathological changes at 8 and 24 h after TBI. PE was accompanied with tissue pathological changes because a positive correlation between the lung injury score and the wet/dry weight ratio in the same animal was observed. Postinjury administration of TM-1 improved ALI and reduced PE at 8 and 24 h following TBI. The pulmonary-protective effect of TM-1 may be attributed to, at least in part, downregulation of AQP1 and AQP4 expression after TBI.

Correlation between lung injury score and serum albumin levels in patients at risk for developing acute lung injury

Nutrition ◽  
2000 ◽  
Vol 16 (2) ◽  
pp. 91-94 ◽  
Author(s):  
Sanjeev Maskara ◽  
Nagamani Sen ◽  
John Prakash Raj ◽  
Ipeson Korah ◽  
B. Antonisamy
Keyword(s):  
At Risk ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Serum Albumin ◽  
Lung Injury Score ◽  
Injury Score ◽  
Patients At Risk

scholarly journals Impact of Different Positive End-Expiratory Pressures on Lung Mechanics in the Setting of Moderately Elevated Intra-Abdominal Pressure and Acute Lung Injury in a Porcine Model

2021 ◽  
Vol 10 (2) ◽  
pp. 306
Author(s):  
Mascha O. Fiedler ◽  
Emilis Simeliunas ◽  
B. Luise Deutsch ◽  
Dovile Diktanaite ◽  
Alexander Harms ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Transpulmonary Pressure ◽  
Lung Compliance ◽  
Lung Mechanics ◽  
Lung Injury Score ◽  
Abdominal Pressure ◽  
Injury Score ◽  
Group A ◽  
Over Time

The effects of a moderately elevated intra-abdominal pressure (IAP) on lung mechanics in acute respiratory distress syndrome (ARDS) have still not been fully analyzed. Moreover, the optimal positive end-expiratory pressure (PEEP) in elevated IAP and ARDS is unclear. In this paper, 18 pigs under general anesthesia received a double hit lung injury. After saline lung lavage and 2 h of injurious mechanical ventilation to induce an acute lung injury (ALI), an intra-abdominal balloon was filled until an IAP of 10 mmHg was generated. Animals were randomly assigned to one of three groups (group A = PEEP 5, B = PEEP 10 and C = PEEP 15 cmH2O) and ventilated for 6 h. We measured end-expiratory lung volume (EELV) per kg bodyweight, driving pressure (ΔP), transpulmonary pressure (ΔPL), static lung compliance (Cstat), oxygenation (P/F ratio) and cardiac index (CI). In group A, we found increases in ΔP (22 ± 1 vs. 28 ± 2 cmH2O; p = 0.006) and ΔPL (16 ± 1 vs. 22 ± 2 cmH2O; p = 0.007), with no change in EELV/kg (15 ± 1 vs. 14 ± 1 mL/kg) when comparing hours 0 and 6. In group B, there was no change in ΔP (26 ± 2 vs. 25 ± 2 cmH2O), ΔPL (19 ± 2 vs. 18 ± 2 cmH2O), Cstat (21 ± 3 vs. 21 ± 2 cmH2O/mL) or EELV/kg (12 ± 2 vs. 13 ± 3 mL/kg). ΔP and ΔPL were significantly lower after 6 h when comparing between group C and A (21 ± 1 vs. 28 ± 2 cmH2O; p = 0.020) and (14 ± 1 vs. 22 ± 2 cmH2O; p = 0.013)). The EELV/kg increased over time in group C (13 ± 1 vs. 19 ± 2 mL/kg; p = 0.034). The P/F ratio increased in all groups over time. CI decreased in groups B and C. The global lung injury score did not significantly differ between groups (A: 0.25 ± 0.05, B: 0.21 ± 0.02, C: 0.22 ± 0.03). In this model of ALI, elevated IAP, ΔP and ΔPL increased further over time in the group with a PEEP of 5 cmH2O applied over 6 h. This was not the case in the groups with a PEEP of 10 and 15 cmH2O. Although ΔP and ΔPL were significantly lower after 6 hours in group C compared to group A, we could not show significant differences in histological lung injury score.

MURRAY'S ACUTE LUNG INJURY SCORE AS A PREDICTOR OF TRACHEOSTOMY IN CRITICALLY ILL PATIENTS

CHEST Journal ◽  
2009 ◽  
Vol 136 (4) ◽  
pp. 61S ◽  
Author(s):  
Prashant R. Gundre ◽  
Tejal Shah ◽  
Yizhak Kupfer ◽  
Yatin Mehta ◽  
Sidney Tessler
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Lung Injury Score ◽  
Injury Score

scholarly journals Diagnosis of disorders of oxygenation and thoracopulmonary restriction during mechanical ventilation of lungs from the point of view of normal and pathological physiology

2015 ◽  
Vol 17 (2) ◽  
pp. 34
Author(s):  
M. G. Chechenin ◽  
V. V. Lomivorotov ◽  
A. N. Polukarov ◽  
T. I. Borshchikova
Keyword(s):  
Mechanical Ventilation ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Sensitivity And Specificity ◽  
Respiratory Function ◽  
Point Of View ◽  
Respiratory Support ◽  
Lung Injury Score ◽  
Injury Score ◽  
Pathological Physiology

The goal of the study was to develop methods for diagnosing oxygenation disorders and thoracopulmonary restriction during respiratory support and to evaluate their efficacy. 206 patients receiving prolonged respiratory support were included in the study. The developed method of diagnosing oxygenation disorders during respiratory support is 1.4 times faster than the Murrays lung ingury score. Sensitivity and specificity oftheauthorsmethod fordiagnosing thoracopulmonaryrestrictionamounted to0.897and 0.838 respectively as compared to 0.47 and 0.189 achieved by using the Murrays lung injury score. A new modification of the acute lung injury score including a respiratory function calculator was also developed.

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