Comparison of genotoxicity and oxidative stress in patients undergoing non-invasive surgery under isoflurane and propofol anaesthesia

2011 ◽  
Vol 28 ◽  
pp. 137
Author(s):  
M. G. Braz ◽  
D. T. Pierine ◽  
C. R. Correa ◽  
A. L.A. Ferreira ◽  
J. R.C. Braz ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Invasive Surgery ◽  
Non Invasive ◽  
And Oxidative Stress

scholarly journals Keratin-Based Epidermal Green Autofluorescence is a Common Biomarker of Organ Injury

2019 ◽  
Author(s):  
Mingchao Zhang ◽  
Yujia Li ◽  
Jiucun Wang ◽  
Huiru Tang ◽  
Zhong Yang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lung Cancer ◽  
Ischemic Stroke ◽  
Recovery Phase ◽  
The Body ◽  
Organ Injury ◽  
Lung Cancer Patients ◽  
Non Invasive ◽  
And Oxidative Stress ◽  
Invasive Evaluation

AbstractIt is critical to discover biomarkers for non-invasive evaluation of the levels of inflammation and oxidative stress in human body - two key pathological factors in numerous diseases. Our study has indicated keratin 1-based epidermal autofluorescence (AF) as a biomarker of this type: Inducers of both inflammation and oxidative stress dose-dependently increased epidermal green AF with polyhedral structure in mice, with the AF intensity being highly associated with the dosages of the inducers. Lung cancer also induced increased epidermal green AF of mice, which was mediated by inflammation. Significant and asymmetrical increases in green AF intensity with polyhedral structure were found in the Dorsal Index Fingers’ skin of acute ischemic stroke (AIS) patients. While the AF intensity of the subjects with high risk for developing AIS, ischemic stroke patients in recovery phase and lung cancer patients was significantly higher than that of healthy controls, both AF intensity and AF asymmetry of these four groups were markedly lower than those of the AIS patients, which have shown promise for AIS diagnosis. Several lines of evidence have indicated K1 as an origin of the AF, e.g., K1 siRNA administration attenuated the oxidative stress-induced AF increase of mice. Collectively, our study has indicated K1-based epidermal AF as a biomarker for non-invasive evaluation of the levels of inflammation and oxidative stress in the body. These findings have established a basis for novel keratin’s AF-based biomedical imaging technology for non-invasive, efficient and economic diagnosis and screening of such inflammation- and oxidative stress-associated diseases as AIS.

Minimally Invasive Surgery and Oxidative Stress Response

2013 ◽  
Vol 23 (1) ◽  
pp. 25-28 ◽  
Author(s):  
Eugenia Yiannakopoulou ◽  
Nikolaos Nikiteas ◽  
Despina Perrea ◽  
Christos Tsigris
Keyword(s):  
Oxidative Stress ◽  
Minimally Invasive Surgery ◽  
Stress Response ◽  
Minimally Invasive ◽  
Invasive Surgery ◽  
Oxidative Stress Response ◽  
And Oxidative Stress

scholarly journals Malondialdehyde in benign prostate hypertrophy: a useful marker?

2003 ◽  
Vol 12 (2) ◽  
pp. 127-128 ◽  
Author(s):  
Rosaria Alba Merendino ◽  
Francesco Salvo ◽  
Antonella Saija ◽  
Giuseppe Di Pasquale ◽  
Antonio Tomaino ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Specific Antigen ◽  
Serum Levels ◽  
Non Invasive ◽  
Common Benign Tumor ◽  
Benign Prostate Hypertrophy ◽  
Healthy Donors ◽  
Benign Prostate ◽  
And Oxidative Stress ◽  
Sensitive Marker

Benign prostate hypertrophy (BPH) is the most common benign tumor in men due to obstruction of the urethra and, finally, uremia. Malondialdehyde (MDA) is a product derived from peroxidation of polyunsaturated fatty acids and related esters. Evaluation of MDA in serum represents a non-invasive biomarker of oxidative stress. Prostate-specific antigen (PSA) is a sensitive marker for prostatic hypertrophy and cancer. We analyzed MDA serum levels to evaluate the oxidative stress in BPH. To this end, 22 BPH patients and 22 healthy donors were enrolled. Data show an increase of MDA level in BPH patients and a positive correlation between PSA and MDA levels. In conclusion, we describe a previously unknown relationship between PSA and MDA as an index of inflammation and oxidative stress in BPH.

scholarly journals Arabidopsis V-ATPase d2 subunit plays a role in plant responses to oxidative stress

2020 ◽  
Author(s):  
Shuang Feng ◽  
Yun Peng ◽  
Enhui Liu ◽  
Hongping Ma ◽  
Kun Qiao ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Developmental Stages ◽  
Plant Responses ◽  
Rna Seq ◽  
Wild Type ◽  
Phenotypic Analysis ◽  
Non Invasive ◽  
Atpase Gene ◽  
D Subunit ◽  
And Oxidative Stress

Abstract Background: Vacuolar-type H + -ATPase (V-ATPase) is a multisubunit proton pump located on the endomembranes, which plays an important role in plant growth. The Arabidopsis V-ATPase d subunit consists of two isoforms, AtVHA-d1 and AtVHA-d2. Results: In this study, the function of the AtVHA-d2 gene was investigated. Histochemical analysis revealed that the AtVHA-d1 and AtVHA-d2 genes were generally and highly overlapping expressed in multiple tissues at different developmental stages of Arabidopsis. Subcellular localization showed that AtVHA-d2 was mainly localized to the vacuole. The AtVHA-d2 expression was significantly induced by oxidative stress. Furthermore, the phenotypic analysis showed that the atvha-d2 mutant was sensitive to oxidative stress. The non-invasive micro-test measurement demonstrated that the net H + influx in the atvha-d2 roots was weaker than that of the wild type under normal conditions. However, oxidative stress resulted in the H + efflux in atvha-d2 roots, which was significantly different from the wild type. RNA-seq combined with qPCR analysis showed that the expression of several members of the plasma membrane H + -ATPase gene ( AtAHA ) family in atvha-d2 were significant different from wild type under normal and oxidative stress. Conclusion: Overall, our results indicate that AtVHA-d2 plays a role in Arabidopsis in response to oxidative stress by affecting H + flux and AtAHA gene expression.

scholarly journals CuATSM PET to diagnose age-related diseases: a systematic literature review

2020 ◽  
Vol 8 (6) ◽  
pp. 449-460
Author(s):  
Naďa Majerníková ◽  
Jenny Jia Yu ◽  
Andrea B. Maier
Keyword(s):  
Oxidative Stress ◽  
Disease Severity ◽  
Disease Duration ◽  
Web Of Science ◽  
Diagnosis And Management ◽  
Non Invasive ◽  
Age Related ◽  
Positron Emission ◽  
And Oxidative Stress ◽  
Lateral Sclerosis

Abstract Purpose Cu(II)-diacetyl-bis(N4-methylthiosemicarbazone) positron emission tomography (CuATSM PET) is a non-invasive imaging technique that can be used to detect hypoxia and inform prognosis in cancer. Hypoxia and oxidative stress are also hallmarks of various age-related diseases. Whether CuATSM PET has a role in the evaluation of hypoxia and oxidative stress in age-related diseases has yet to be established. The aim of this systematic review is to evaluate the utility of CuATSM PET in the diagnosis and management of age-related diseases. Methods EMBASE, Medline, Scopus, Web of Science and Psychinfo were systematically searched for articles published between January 1st 1997 and February 13th 2020. We included articles published in English reporting the use of CuATSM PET in the diagnosis and management of age-related diseases in humans or animals. Results Nine articles were included describing CuATSM PET measures in neurological and cardiovascular disease. There was higher CuATSM uptake in diseased compared to control subjects in Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), myocardial ischemia (MI), cardiac dysautonomia and atherosclerosis. Higher CuATSM uptake was seen in diseased compared to control anatomical areas in PD, cerebrovascular disease (CVD), MI and atherosclerosis. CuATSM uptake was associated with disease severity in PD, ALS, CVD and atherosclerosis. An association between CuATSM uptake and disease duration was shown in atherosclerosis. Conclusion CuATSM uptake is higher in neurological and cardiovascular diseases and associated with disease severity and duration. Further investigations using CuATSM PET in other age-related diseases are needed.

Association between calcitriol and paricalcitol with oxidative stress in patients with hemodialysis

2020 ◽  
pp. 1-8
Author(s):  
Hasan Haci Yeter ◽  
Berfu Korucu ◽  
Elif Burcu Bali ◽  
Ulver Derici
Keyword(s):  
Oxidative Stress ◽  
Vitamin D ◽  
Antioxidant Status ◽  
Total Antioxidant Status ◽  
Stress Index ◽  
Total Oxidant Status ◽  
Vitamin D Analog ◽  
Total Antioxidant ◽  
Oxidant Status ◽  
And Oxidative Stress

Abstract. Background: The pathophysiological basis of chronic kidney disease and its complications, including cardiovascular disease, are associated with chronic inflammation and oxidative stress. We investigated the effects of active vitamin D (calcitriol) and synthetic vitamin D analog (paricalcitol) on oxidative stress in hemodialysis patients. Methods: This cross-sectional study was composed of 83 patients with a minimum hemodialysis vintage of one year. Patients with a history of any infection, malignancy, and chronic inflammatory disease were excluded. Oxidative markers (total oxidant and antioxidant status) and inflammation markers (C-reactive protein and interleukin-6) were analyzed. Results: A total of 47% (39/83) patients were using active or analog vitamin D. Total antioxidant status was significantly higher in patients with using active or analog vitamin D than those who did not use (p = 0.006). Whereas, total oxidant status and oxidative stress index were significantly higher in patients with not using vitamin D when compared with the patients who were using vitamin D preparation (p = 0.005 and p = 0.004, respectively). On the other hand, total antioxidant status, total oxidant status, and oxidative stress index were similar between patients who used active vitamin D or vitamin D analog (p = 0.6; p = 0.4 and p = 0.7, respectively). Conclusion: The use of active or selective vitamin D analog in these patients decreases total oxidant status and increases total antioxidant status. Also, paricalcitol is as effective as calcitriol in decreasing total oxidant status and increasing total antioxidant status in patients with chronic kidney disease.

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