Children's beliefs about long-term health effects of alcohol and cocaine use

2001 ◽  
Vol 22 (2) ◽  
pp. 150
Author(s):  
CATHERINE L. GRUS
2021 ◽  
Vol 22 (10) ◽  
pp. 5349
Author(s):  
Mayes Alswady-Hoff ◽  
Johanna Samulin Erdem ◽  
Santosh Phuyal ◽  
Oskar Knittelfelder ◽  
Animesh Sharma ◽  
...  

There is little in vitro data available on long-term effects of TiO2 exposure. Such data are important for improving the understanding of underlying mechanisms of adverse health effects of TiO2. Here, we exposed pulmonary epithelial cells to two doses (0.96 and 1.92 µg/cm2) of TiO2 for 13 weeks and effects on cell cycle and cell death mechanisms, i.e., apoptosis and autophagy were determined after 4, 8 and 13 weeks of exposure. Changes in telomere length, cellular protein levels and lipid classes were also analyzed at 13 weeks of exposure. We observed that the TiO2 exposure increased the fraction of cells in G1-phase and reduced the fraction of cells in G2-phase, which was accompanied by an increase in the fraction of late apoptotic/necrotic cells. This corresponded with an induced expression of key apoptotic proteins i.e., BAD and BAX, and an accumulation of several lipid classes involved in cellular stress and apoptosis. These findings were further supported by quantitative proteome profiling data showing an increase in proteins involved in cell stress and genomic maintenance pathways following TiO2 exposure. Altogether, we suggest that cell stress response and cell death pathways may be important molecular events in long-term health effects of TiO2.


ILR Review ◽  
1992 ◽  
Vol 45 (3) ◽  
pp. 435-448 ◽  
Author(s):  
Charles A. Register ◽  
Donald R. Williams

Using data on marijuana and cocaine use from the 1984 National Longitudinal Survey of Youth, the authors examine the hypothesis that drug use reduces labor market productivity, as measured by wages. From an analysis that controls for the probability of employment and the endogeneity of drug use, they find that although long-term and on-the-job use of marijuana negatively affected wages, the net productivity effect for all marijuana users (both those who engaged in long-term or on-the-job use and those who did not) was positive. No statistically significant association was found between cocaine use and productivity.


2016 ◽  
Vol 71 ◽  
pp. 48-53 ◽  
Author(s):  
Don C. Des Jarlais ◽  
Kamyar Arasteh ◽  
Jonathan Feelemyer ◽  
Courtney McKnight ◽  
David M. Barnes ◽  
...  
Keyword(s):  

2004 ◽  
Vol 112 (1) ◽  
pp. 46-51 ◽  
Author(s):  
Perri Zeitz Ruckart ◽  
Kirsten Kakolewski ◽  
Frank J Bove ◽  
Wendy E Kaye

2019 ◽  
Vol 65 (3) ◽  
Author(s):  
Aleksandra Słojewska ◽  
Izabela Gutowska

Introduction: Food is a carrier of many pollutants nowadays. For cadmium and dioxins, it is the main source of these compounds in the general population. Hence, the aim of this work was to collect data on the health effects associated with exposure to cadmium and dioxins which get into the human body through food.Materials and methods: A literature review was conducted by searching the scientific Medline database (PubMed) and Google Scholar.Results: Health effects associated with a long-term exposure to low doses of cadmium and dioxins may be nonspecific and are rarely attributed to food sources. These may cause disorders affecting hormonal balance, kidney function, lipid metabolism, fertility, cognitive function, bone mineralization, and susceptibility to diseases and allergies. These compounds may also lead to cancer development.Conclusions: The general population faces the problem of longterm exposure to small doses of these substances due to their accumulation in the body, even if their amounts do not exceed the relevant standards. The health effects of this type of exposure may be significantly delayed and are not likely to be attributed to the consumption of contaminated food. Consumers wishing to reduce the amounts of these compounds delivered to the body should limit the consumption of grilled and smoked products, and should also opt for organic food.


Sign in / Sign up

Export Citation Format

Share Document