A polyvinyl alcohol powder accelerates healing of open, infected skin wounds in rats and patients

1983 ◽  
Vol 72 (2) ◽  
pp. 278
Author(s):  
Serge Krupp
Amino Acids ◽  
2015 ◽  
Vol 48 (1) ◽  
pp. 203-211 ◽  
Author(s):  
Istvan Sebe ◽  
Eszter Ostorhazi ◽  
Aron Fekete ◽  
Krisztian N. Kovacs ◽  
Romana Zelko ◽  
...  

Author(s):  
Wendi Ma ◽  
Wenying Dong ◽  
Shanshan Zhao ◽  
Tianhui Du ◽  
Yilong Wang ◽  
...  

Molecules ◽  
2019 ◽  
Vol 24 (8) ◽  
pp. 1627 ◽  
Author(s):  
Thiago A.F. Ferro ◽  
Eliene B. Souza ◽  
Mariela A.M. Suarez ◽  
João F.S. Rodrigues ◽  
Domingos M.S. Pereira ◽  
...  

Wound healing can be delayed following colonization and infection with the common bacterium Pseudomonas aeruginosa. While multiple therapies are used for their treatment, these are ineffective, expensive, and labour-intensive. Thus, there is an enormous unmet need for the treatment of infected wounds. Cinnamaldehyde, the major component of cinnamon oil, is well known for its antimicrobial properties. Herein, we investigated the effects of sub-inhibitory concentrations of cinnamaldehyde in the virulence of P. aeruginosa. We also assessed its healing potential in P. aeruginosa-infected mouse skin wounds and the mechanisms involved in this response. Sub-inhibitory concentrations of cinnamaldehyde reduced P. aeruginosa metabolic rate and its ability to form biofilm and to cause haemolysis. Daily topical application of cinnamaldehyde on P. aeruginosa-infected skin wounds reduced tissue bacterial load and promoted faster healing. Lower interleukin-17 (IL-17), vascular endothelial growth factor (VEGF) and nitric oxide levels were detected in cinnamaldehyde-treated wound samples. Blockage of transient receptor potential ankyrin 1, the pharmacological target of cinnamaldehyde, abrogated its healing activity and partially reversed the inhibitory actions of this compound on VEGF and IL-17 generation. We suggest that topical application of sub-inhibitory concentrations of cinnamaldehyde may represent an interesting approach to improve the healing of P. aeruginosa-infected skin wounds.


2019 ◽  
Vol Volume 14 ◽  
pp. 5943-5955 ◽  
Author(s):  
Fahimeh Hajiahmadi ◽  
Mohammad Yousef Alikhani ◽  
Hanifeh Shariatifar ◽  
Mohammad Reza Arabestani ◽  
Davoud Ahmadvand

2021 ◽  
Vol 156 ◽  
pp. 105592
Author(s):  
William Gustavo Lima ◽  
Júlio César Moreira de Brito ◽  
Valbert Nascimento Cardoso ◽  
Simone Odília Antunes Fernandes

ABOUTOPEN ◽  
2021 ◽  
Vol 8 (1) ◽  
pp. 14-22
Author(s):  
Alessandro Scalise

Superinfection of skin lesions is quite common, and often delays wound recovery. Infection control plays therefore a key role in the management of skin lesions, requiring the use of specific antimicrobials. Among available agents, topic antiseptic drugs are currently recommended as a first-choice option, to be preferred to antibiotics, given the growing resistance to these drugs. Compared to antibiotics, antiseptic drugs have a wider spectrum of action, including bacteria, fungi, virus, protozoa, and prions. The ideal antiseptic for the management of an infected skin lesion is expected to be both highly effective and well tolerated, in order to promote the physiologic process of tissue restoration. Among available antiseptics, the 0,05% sodium hypochlorite electrolytic solution meets these criteria: the product proved to be effective in vitro and in animal experimental models against a wide range of microorganisms, besides exerting an anti-inflammatory action in the absence of any irritating, cytotoxic or carcinogenic adverse effect, and being useful in biofilm removal. Similarly, in several clinical trials, the 0,05% sodium hypochlorite electrolytic solution was demonstrated to be very effective and safe in the management of infected skin wounds: based on these results, this product should be strongly considered among the first-choice options for the disinfection of skin wounds. The new formulation, developed according to the latest reference standards for wound healing and in agreement with current guidelines, is qualitatively improved, with an expected positive impact in every field of clinical application and a subsequent benefit for treated patients.


2021 ◽  
Vol 166 ◽  
pp. 203658
Author(s):  
Weitao Zhang ◽  
Xu Qu ◽  
Zhang Zhu ◽  
Liwen Wang ◽  
Qian Qi ◽  
...  

2014 ◽  
Vol 3 (1) ◽  
Author(s):  
Ethne L. Nussbaum ◽  
Facundo Las Heras ◽  
Kenneth P.H. Pritzker ◽  
Tony Mazzulli ◽  
Lothar Lilge

AbstractLow intensity laser irradiation remains a controversial treatment for non-healing wounds. This study examines the effect of low intensity light on healing of infected skin wounds in the rat.Wounds on the rat dorsum were inoculated withWounds that were irradiated using a wavelength of 635 nm (1 and 20 J/cmRed light improved healing of wounds. Only one 808-nm light protocol enhanced healing; lack of benefit using the remaining 808-nm light protocols may have been due to stimulatory effects of the light on


Sign in / Sign up

Export Citation Format

Share Document