THE RELATIONSHIP BETWEEN RENAL FUNCTION AND RENAL TRANSPLANT GRAFT FAILURE INCREASES OVER TIME

2010 ◽  
Vol 90 ◽  
pp. 723
Author(s):  
M. A. Schnitzler ◽  
D. Trivedi ◽  
G. J. LʼItalien
Keyword(s):  
Renal Function ◽  
Renal Transplant ◽  
Graft Failure ◽  
The Relationship ◽  
Over Time

Abstract 326: Group IIA Secretory Phospholipase A 2 Predicts Graft Failure and Cardiovascular Mortality in Renal Transplant Recipients by Mediating Decreased Kidney Function

2016 ◽  
Vol 36 (suppl_1) ◽  
Author(s):  
Wijtske Annema ◽  
Jan Freark de Boer ◽  
Arne Dikkers ◽  
Stephan J Bakker ◽  
Uwe J Tietge
Keyword(s):  
Renal Transplant ◽  
Transgenic Mice ◽  
Kidney Function ◽  
Graft Failure ◽  
Hazard Ratio ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
All Cause Mortality ◽  
Over Time

The acute phase protein group IIA secretory phospholipase A2 (sPLA2-IIA) has proatherosclerotic properties. The present study prospectively investigated whether plasma sPLA2-IIA levels are associated with graft failure, cardiovascular and all-cause mortality in renal transplant recipients (RTRs), patients known to be susceptible to accelerated atherosclerosis, both in the graft and in the systemic vasculature. In 495 RTRs (median follow-up 7.0 years) sPLA2-IIA was determined at baseline and was significantly higher in RTRs than in healthy controls (median 384 ng/dL [range 86-6951] vs. 185 ng/dL [range 104-271], P<0.001), but lower than in end-stage renal disease patients (median 1053 ng/mL [range 458-2599], P<0.001). Kaplan-Meier analysis demonstrated an increased risk for graft failure (P=0.002), cardiovascular (P<0.001) and all-cause mortality (P<0.001) with increasing gender-stratified quartiles of sPLA2-IIA. Cox regression analyses showed a strong association of sPLA2-IIA with increased risks of graft failure (hazard ratio=1.42[1.11-1.83], P=0.006), cardiovascular (hazard ratio=1.48[1.18-1.85], P=0.001) and all-cause mortality (hazard ratio=1.39[1.17-1.64], P<0.001). However, this association was largely explained by parameters of kidney function. Further analyses in RTRs demonstrated that patients with higher baseline sPLA2-IIA levels showed faster decline in renal function during follow-up. In addition, kidney function in human sPLA2-IIA transgenic mice deteriorated more rapid over time as compared with wild-type controls (urinary albumin:creatinine ratio at 48 weeks of age 774±156 vs. 193±60, P<0.01). In summary, this prospective study demonstrates that sPLA2-IIA is a significant predictive biomarker for the occurrence of chronic graft failure, overall and CVD mortality in RTRs dependent on kidney function. This dependency is explained by sPLA2-IIA impacting negatively on kidney function over time in humans and transgenic mice.

Residual Renal Function in a Large Cohort of Peritoneal Dialysis Patients: Change over Time, Impact on Mortality and Nutrition

2000 ◽  
Vol 20 (4) ◽  
pp. 439-444 ◽  
Author(s):  
Douglas Shemin ◽  
Andrew G. Bostom ◽  
Cynthia Lambert ◽  
Connie Hill ◽  
Jenny Kitsen ◽  
...  
Keyword(s):  
Renal Function ◽  
Serum Albumin ◽  
Serum Albumin Level ◽  
Renal Dialysis ◽  
Residual Renal Function ◽  
Albumin Level ◽  
The Mean ◽  
The Relationship ◽  
Over Time ◽  
Solute Clearance

Objective Residual renal function contributes importantly to total solute clearance in peritoneal dialysis (PD) patients. This study was designed to examine the progression of residual renal function over time and its impact on nutrition and mortality in PD patients in the six New England states (ME, NH, VT, CT, MA, RI) comprising End Stage Renal Disease (ESRD) Network 1. Design As part of the ESRD Clinical Indicators Project, data on 990 PD patients in Network 1 were abstracted from data supplied by dialysis units in the fourth quarter of 1997. This included demographic information; dose of PD in L/day; weekly renal, dialysis, and total Kt/V urea; weekly renal, dialysis, and total creatinine clearance (CCr); serum albumin level; and mortality and transplantation information. Data collection was repeated in the second and fourth quarters of 1998 and in the second quarter of 1999. Patients 990 PD patients in Network 1. Outcome Measures The change in total and renal solute clearances over time, the relationship between renal clearance and mortality, and the relationship between renal clearance and nutritional status, as represented by serum albumin. Results Over the 2-year period, mean weekly renal Kt/V urea and weekly renal CCr dropped significantly. To examine the effect of residual renal function on mortality, patients were divided into high and low (above and below the median) weekly renal Kt/V urea and weekly renal CCr groups. Patients above the median levels of both weekly renal Kt/V urea and weekly renal CCr had a significantly decreased risk of dying during the observation period, after controlling for age, gender, serum albumin level, and diabetic status [OR for high vs low renal Kt/V urea 0.54 (CI 0.34 – 0.84), OR for high vs low renal CCr 0.61 (CI 0.40 – 0.94)]. The mean weekly renal Kt/V urea was significantly and directly correlated with the mean serum albumin level by Spearman rank correlation ( R = 0.133, p < 0.001), as was the mean weekly renal CCr ( R = 0.115, p < 0.001). Conclusions Residual renal function is an important contributor to total solute clearance in PD patients. Even at low levels it is linked to decreased mortality and better nutritional status.

Investment Traits and Intelligence in Adulthood

2013 ◽  
Vol 34 (2) ◽  
pp. 82-89 ◽  
Author(s):  
Sophie von Stumm
Keyword(s):  
Individual Differences ◽  
Personality Traits ◽  
Fluid Intelligence ◽  
Need For Cognition ◽  
Openness To Experience ◽  
Intelligence Tests ◽  
Crystallized Intelligence ◽  
New Knowledge ◽  
The Relationship ◽  
Over Time

Intelligence-as-knowledge in adulthood is influenced by individual differences in intelligence-as-process (i.e., fluid intelligence) and in personality traits that determine when, where, and how people invest their intelligence over time. Here, the relationship between two investment traits (i.e., Openness to Experience and Need for Cognition), intelligence-as-process and intelligence-as-knowledge, as assessed by a battery of crystallized intelligence tests and a new knowledge measure, was examined. The results showed that (1) both investment traits were positively associated with intelligence-as-knowledge; (2) this effect was stronger for Openness to Experience than for Need for Cognition; and (3) associations between investment and intelligence-as-knowledge reduced when adjusting for intelligence-as-process but remained mostly significant.

Power Values and Power Distance Moderate the Relationship Between Workplace Supervisory Power and Job Satisfaction

2020 ◽  
Vol 19 (3) ◽  
pp. 135-141
Author(s):  
Kenneth D. Locke
Keyword(s):  
Job Satisfaction ◽  
Multilevel Modeling ◽  
Power Distance ◽  
European Social Survey ◽  
Social Survey ◽  
The Relationship ◽  
Workplace Power ◽  
Over Time

Abstract. Person–job (or needs–supplies) discrepancy/fit theories posit that job satisfaction depends on work supplying what employees want and thus expect associations between having supervisory power and job satisfaction to be more positive in individuals who value power and in societies that endorse power values and power distance (e.g., respecting/obeying superiors). Using multilevel modeling on 30,683 European Social Survey respondents from 31 countries revealed that overseeing supervisees was positively associated with job satisfaction, and as hypothesized, this association was stronger among individuals with stronger power values and in nations with greater levels of power values or power distance. The results suggest that workplace power can have a meaningful impact on job satisfaction, especially over time in individuals or societies that esteem power.

Emotional Impact Feedback Changes How We Remember Negative Autobiographical Experiences

2010 ◽  
Vol 57 (5) ◽  
pp. 354-359 ◽  
Author(s):  
Melanie K. T. Takarangi ◽  
Deryn Strange
Keyword(s):  
Well Being ◽  
The Other ◽  
Personal Perspective ◽  
Emotional Impact ◽  
Potential Mechanism ◽  
Negative Experiences ◽  
Negative Memory ◽  
The Relationship ◽  
Negative Memories ◽  
Over Time

When people are told that their negative memories are worse than other people’s, do they later remember those events differently? We asked participants to recall a recent negative memory then, 24 h later, we gave some participants feedback about the emotional impact of their event – stating it was more or less negative compared to other people’s experiences. One week later, participants recalled the event again. We predicted that if feedback affected how participants remembered their negative experiences, their ratings of the memory’s characteristics should change over time. That is, when participants are told that their negative event is extremely negative, their memories should be more vivid, recollected strongly, and remembered from a personal perspective, compared to participants in the other conditions. Our results provide support for this hypothesis. We suggest that external feedback might be a potential mechanism in the relationship between negative memories and psychological well-being.

Rethinking social remittances and the migration-development nexus from the perspective of time

2013 ◽  
Vol 10 (1) ◽  
pp. 11-22 ◽  
Author(s):  
Peggy Levitt ◽  
Deepak Lamba-Nieves
Keyword(s):  
Social Influence ◽  
Change Over Time ◽  
Social Remittances ◽  
The Relationship ◽  
Migration And Development ◽  
Over Time

This article explores how the conceptualization, management, and measurement of time affect the migration-development nexus. We focus on how social remittances transform the meaning and worth of time, thereby changing how these ideas and practices are accepted and valued and recalibrating the relationship between migration and development. Our data reveal the need to pay closer attention to how migration’s impacts shift over time in response to its changing significance, rhythms, and horizons. How does migrants’ social influence affect and change the needs, values, and mind-frames of non-migrants? How do the ways in which social remittances are constructed, perceived, and accepted change over time for their senders and receivers?

Changing Places: Rock Art and Holocene Landscapes in the Wadi al-Ajal, South-West Libya

2014 ◽  
Vol 12 (2) ◽  
pp. 165-182 ◽  
Author(s):  
Tertia Barnett ◽  
Maria Guagnin
Keyword(s):  
Spatial Analysis ◽  
Surface Water ◽  
Rock Art ◽  
Human Settlement ◽  
Gis Model ◽  
South West ◽  
Settlement Location ◽  
Central Sahara ◽  
The Relationship ◽  
Over Time

This article examines the relationship between rock art and landscape use by pastoral groups and early settled communities in the central Sahara from around 6000 BC to 1000 AD. During this period the region experienced significant climatic and environmental fluctuations. Using new results from a systematic survey in the Wadi al-Ajal, south-west Libya, our research combines data from over 2000 engraved rock art panels with local archaeological and palaeoenvironmental evidence within a GIS model. Spatial analysis of these data indicates a correspondence between the frequency of rock art sites and human settlement over time. However, while changes in settlement location were guided primarily by the constraints on accessibility imposed by surface water, the distribution of rock art relates to the availability of pasture and patterns of movement through the landscape. Although the reasons for these movements undoubtedly altered over time, natural routes that connected the Wadi al-Ajal and areas to the south continued to be a focus for carvings over several thousand years.

Soil and Stream Water Chemistry During Spring Snowmelt

1992 ◽  
Vol 23 (1) ◽  
pp. 13-26 ◽  
Author(s):  
W. H. Hendershot ◽  
L. Mendes ◽  
H. Lalande ◽  
F. Courchesne ◽  
S. Savoie
Keyword(s):  
Stream Water ◽  
Base Cations ◽  
Stream Chemistry ◽  
Stream Water Chemistry ◽  
The Matrix ◽  
Adsorption Desorption ◽  
The Relationship ◽  
Best Fit ◽  
Spring Snowmelt ◽  
Over Time

In order to determine how water flowpath controls stream chemistry, we studied both soil and stream water during spring snowmelt, 1985. Soil solution concentrations of base cations were relatively constant over time indicating that cation exchange was controlling cation concentrations. Similarly SO4 adsorption-desorption or precipitation-dissolution reactions with the matrix were controlling its concentrations. On the other hand, NO3 appeared to be controlled by uptake by plants or microorganisms or by denitrification since their concentrations in the soil fell abruptly as snowmelt proceeded. Dissolved Al and pH varied vertically in the soil profile and their pattern in the stream indicated clearly the importance of water flowpath on stream chemistry. Although Al increased as pH decreased, the relationship does not appear to be controlled by gibbsite. The best fit of calculated dissolved inorganic Al was obtained using AlOHSO4 with a solubility less than that of pure crystalline jurbanite.

Bk Polyoma Virus Nephropathy In An Immunocompromised Host.

2020 ◽  
Vol 01 ◽  
Author(s):  
Faraz Khan ◽  
Maroun El Khoury ◽  
Fahad Kouli ◽  
Aaron Han
Keyword(s):  
Renal Transplant ◽  
Graft Failure ◽  
Renal Transplant Patient ◽  
Relevant Literature ◽  
Late Complication ◽  
Solid Organ Transplantation ◽  
Immunocompromised Host ◽  
Polyoma Virus ◽  
Solid Organ ◽  
Early Graft

Background: Post-transplant Lymphopoliferative disorders(PTLD) are a well known late complication after solid organ transplantation including renal transplant. Among others, graft failure due to reactivation of BK polyoma virus in the grafted kidney is also a well recognized complication but tends to present early in the first several months after transplant. Case: Here we present the case of PTLD Burkitt's lymphoma(BL-PTLD) in a renal transplant patient who was successfully treated with multiagent chemo-immunotherapy but later developed BK polyoma virus nephropathy(BKVN) with graft failure only after completion of her systemic therapy for lymphoma and 7 years after transplant. Relevant literature is reviewed. Conclusion: In this case, reactivation and progression of BKVN was most likely associated with immunosuppression from chemoimmunotherapy for her BL–PTLD unlike early graft failures associated with BKVN.

Sign in / Sign up

Export Citation Format

Share Document