Metastasis suppressor genes: a role for raf kinase inhibitor protein (RKIP)

2004 ◽  
Vol 15 (7) ◽  
pp. 663-669 ◽  
Author(s):  
Evan T. Keller
Keyword(s):  
Kinase Inhibitor ◽  
Metastasis Suppressor ◽  
Inhibitor Protein ◽  
Suppressor Genes ◽  
Metastasis Suppressor Genes ◽  
Raf Kinase ◽  
Raf Kinase Inhibitor Protein

scholarly journals Metastasis suppressor gene Raf kinase inhibitor protein (RKIP) is a novel prognostic marker in prostate cancer

The Prostate ◽  
2006 ◽  
Vol 66 (3) ◽  
pp. 248-256 ◽  
Author(s):  
Zheng Fu ◽  
Yasuhide Kitagawa ◽  
Ronglai Shen ◽  
Rajal Shah ◽  
Rohit Mehra ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Prognostic Marker ◽  
Kinase Inhibitor ◽  
Suppressor Gene ◽  
Metastasis Suppressor ◽  
Metastasis Suppressor Gene ◽  
Inhibitor Protein ◽  
Raf Kinase ◽  
Raf Kinase Inhibitor Protein

scholarly journals RAF Kinase Inhibitor Protein in Myeloid Leukemogenesis

2019 ◽  
Vol 20 (22) ◽  
pp. 5756 ◽  
Author(s):  
Armin Zebisch ◽  
Veronica Caraffini ◽  
Heinz Sill
Keyword(s):  
Intracellular Signaling ◽  
Kinase Inhibitor ◽  
Current Knowledge ◽  
Metastasis Suppressor ◽  
Inhibitor Protein ◽  
Raf Kinase ◽  
Raf Kinase Inhibitor Protein ◽  
Frequent Event

RAF kinase inhibitor protein (RKIP) is an essential regulator of intracellular signaling. A somatic loss of RKIP expression is a frequent event in solid human cancers, and a role of RKIP as metastasis-suppressor is widely accepted nowadays. Recently, RKIP loss has been described in acute myeloid leukemia (AML) and a series of other myeloid neoplasias (MNs). Functional in vitro and in vivo experiments revealed that RKIP is an essential player within the development of these liquid tumors; however, the respective role of RKIP seems to be complex and multi-faceted. In this review, we will summarize the current knowledge about RKIP in myeloid leukemogenesis. We will initially describe its involvement in physiologic hematopoiesis, and will then proceed to discuss its role in the development of AML and other MNs. Finally, we will discuss potential therapeutic implications arising thereof.

Raf kinase inhibitor protein (RKIP) and phospho-RKIP expression in melanomas

2013 ◽  
Vol 115 (8) ◽  
pp. 795-802 ◽  
Author(s):  
Venera Cardile ◽  
Grazia Malaponte ◽  
Carla Loreto ◽  
Massimo Libra ◽  
Silvia Caggia ◽  
...  
Keyword(s):  
Kinase Inhibitor ◽  
Inhibitor Protein ◽  
Raf Kinase ◽  
Raf Kinase Inhibitor Protein

scholarly journals Frequent loss of RAF kinase inhibitor protein expression in acute myeloid leukemia

Leukemia ◽  
2012 ◽  
Vol 26 (8) ◽  
pp. 1842-1849 ◽  
Author(s):  
A Zebisch ◽  
A Wölfler ◽  
I Fried ◽  
O Wolf ◽  
K Lind ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Protein Expression ◽  
Myeloid Leukemia ◽  
Kinase Inhibitor ◽  
Inhibitor Protein ◽  
Raf Kinase ◽  
Raf Kinase Inhibitor Protein ◽  
Acute Myeloid
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