A comparison between the effects of topical application of honey and that of amino acids on improving wound healing in aged rats

Diabetic foot ulcers are a common cause of morbidity in diabetic patients. One of the main pathogens found in these ulcers is methicillin-resistant Staphylococcus aureus (MRSA). MRSA often carries resistance to several classes of antibiotics and their infections are becoming harder to treat. Therefore, new alternatives are urgently needed. Thus, this study aimed to investigate the capacity of topical ozonated oil application on the treatment of early-stage skin infected with MRSA in an animal model. Ozonated oil was prepared from a mixture of oils subjected to a gas stream of O2/O3 mixture. Sixteen Wistar rats were inoculated by an intradermic injection of MRSA suspension, producing an abscess lesion. After 3 days, the skin epidermis was removed to open the wound. Group 1 received an application of oil mixture without ozone treatment and Group 2 received an application of ozonated oil. After the treatment period, skin was collected, colony-forming units (CFU) of bacteria were quantified and the histological analysis of the skin was carried out. Skin samples from the control 1 and 2 had a bacterial load was of 1.1 × 105 and 5.7 × 103 CFU/mL, respectively. Group 2 showed better wound healing from mild to moderate epidermal regeneration. Topical application of ozonated vegetable oil in MRSA-infected skin in rats showed a small reduction of the bacterial load and better wound healing.

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Acceleration of wound healing by topical application of honey

The American Journal of Surgery ◽

10.1016/0002-9610(83)90204-0 ◽

1983 ◽

Vol 145 (3) ◽

pp. 374-376 ◽

Cited By ~ 121

Author(s):

Arieh Bergman ◽

Joseph Yanai ◽

Jerry Weiss ◽

David Bell ◽

Menachem P. David

Keyword(s):

Wound Healing ◽

Topical Application

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Topical Application of Sadat-Habdan Mesenchymal Stimulating Peptide (SHMSP) Accelerates Wound Healing in Diabetic Rabbits

Experimental Diabetes Research ◽

10.1155/2012/531961 ◽

2012 ◽

Vol 2012 ◽

pp. 1-6

Author(s):

Abdulmohsen H. Al-Elq ◽

Mir Sadat-Ali ◽

Mohamed Elsharawy ◽

Ibrahim Al-Habdan ◽

Fatin Othman Al-Aqeel ◽

...

Keyword(s):

Wound Healing ◽

Blood Vessel ◽

Topical Application ◽

Inflammatory Cell ◽

Inflammatory Cell Infiltration ◽

Cell Infiltration ◽

Control Group ◽

Collagen Deposition ◽

Peptide Group ◽

Diabetic Rabbits

Objective. Diminished wound healing is a common problem in diabetic patients due to diminished angiogenesis. SHMSP was found to promote angiogenesis. The present study was carried out to examine the effect of this peptide in healing of wounds in diabetic rabbits.Materials and Methods. Twenty male New Zealand rabbits were used in this study. Diabetes mellitus was induced and the rabbits were randomly divided into two equal groups: control group and peptide group. A-full thickness punch biopsy was made to create a wound of about 10 mm on the right ears of all rabbits. Every day, the wound was cleaned with saline in control groups. In the peptide group, 15 mg of SHMSP was applied after cleaning. On day 15th, all animals were sacrificed, and the wounds were excised with a rim of 5 mm of normal surrounding tissue. Histo-pathological assessment of wound healing, inflammatory cell infiltration, blood vessel proliferation, and collagen deposition was performed.Results. There were no deaths among the groups. There was significant increase in wound healing, blood vessel proliferation and collagen deposition, and significant decrease in inflammatory cell infiltration in the peptide group compared to the control group.Conclusion. Topical application of SHMSP improves wound healing in diabetic rabbits.

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Effectiveness Of Topical Application Of Chlorhexidine And Prevailing Practices On Episiotomy Wound Among Postnatal Mothers

Asian Journal of Health Sciences ◽

10.15419/ajhs.v2i1.422 ◽

2014 ◽

Vol 2 (1) ◽

Author(s):

Rincy Michael ◽

Soney N Toppo ◽

Varsha Hariharan

Keyword(s):

Wound Healing ◽

Topical Application ◽

Controlled Trial ◽

Demographic Data ◽

Assessment Scale ◽

Research Centre ◽

Control Group ◽

Significant Difference ◽

Postnatal Mothers ◽

Experimental Group

Puerperium is a period when the mother experiences intense physical and emotional stress due to exhaustion, anxiety and excitement. Each mother has to adjust to physical changes in her own body due to involution and lactation as well as cope up with the new demands on her time and emotions made by the new born baby. Episiotomy, despite evidences that it is an unnecessary intervention, is one of the most common surgical procedures performed during the second stage of labour, especially in primigravida woman. Thus, a randomized controlled trial to assess the effectiveness of topical application of chlorhexidine and prevailing practices on episiotomy wound among postnatal mothers at selected hospital of Indore was undertaken. True experimental approach with pre test post test research design was adopted. Simple random sampling was taken to select 40 postnatal mothers with episiotomy wound and three days postpartum hospital stay in Choithram Hospital & Research Centre, Indore as per the inclusion criteria. Data was collected with help of questionnaire for socio demographic data and obstetrical data and the wound healing was assessed by REEDA wound healing assessment scale. Samples in the experimental group were applied with chlorhexidine on episiotomy wound and the samples in the control group received routine care with betadine or nadoxin. Post assessment score was taken on third day (evening) by REEDA wound assessment scale. Finding of the study related to effectiveness of chlorhexidine among postnatal mothers in experimental group revealed that there was a significant difference in the healing of episiotomy wound by the application of chlorhexidine among postnatal mothers in experimental group at t19 = 11.40 at the level of p< 0.001. Hence it was inferred that topical application of chlorhexidine on episiotomy wound promotes wound healing.

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Review: Aktivitas Farmakologi Dan Perkembangan Produk Dari Lidah Buaya (Aloe vera L.)

Jurnal Pharmascience ◽

10.20527/jps.v6i1.6073 ◽

2019 ◽

Vol 6 (1) ◽

pp. 38

Author(s):

Dian Kurnia ◽

Prima Happy Ratnapuri

Keyword(s):

Amino Acids ◽

Wound Healing ◽

Aloe Vera ◽

Chemical Compounds ◽

Pharmaceutical Products ◽

Therapeutic Effects ◽

Pharmacological Activities

ABSTRAK Lidah buaya (Aloe vera L.) diketahui mengandung banyak senyawa kimia alami, seperti antrakuinon, asam amino, acemannan, aloesin, glukomanan yang bertanggungjawab memberikan efek teraupetik yang bermanfaat dalam dunia farmasi. Review ini bertujuan untuk memberikan informasi terkait aktivitas farmakologi dan perkembangan produk dari lidah buaya dalam bidang farmasi. Pada Review artikel ini data yang disajikan diperoleh dari literatur online berupa jurnal dan artikel ilmiah publikasi lokal maupun internasional dan literatur offline berupa buku dan e-book. Diketahui bahwa lidah buaya memiliki berbagai aktivitas farmakologi yaitu sebagai antiinflamasi, berperan dalam penyembuhan luka, antibakteri, antifungi, antivirus, antioksidan, antikanker, antitumor, antikolesterol, dan antiulcer. Penggunaan lidah buaya dalam produk farmasi juga telah mengalami perkembangan diantaranya yaitu sediaan nano partikel, tablet, suppositoria, gel dan krim. Kata Kunci— Aloe vera L., Aktivitas farmakologi, Perkembangan produk ABSTRACT Aloe vera L. contains many natural chemical compounds, such as anthraquinone, amino acids, acemannan, aloesin, glucomannan which are responsible for providing therapeutic effects that are useful in pharmaceutical. The aims of this review is to provide information about pharmacological activities and products development of Aloe vera. In this article review, online and offline literatures were used. Online literature such us journals and articles obtained from local and international, while the offline literature such us books and e-books. It is known that aloe vera has a variety of pharmacological activities, that act as antiinflammatory, wound healing, antibacterial, antifungal, antiviral, antioxidant, anticancer, antitumor, anticholesterol, and antiulcer. Pharmaceutical products of Aloe vera also have been developed such us nanoparticles products, tablets, suppositories, gels and creams. Keywords— Aloe vera L., Pharmacological activities, Products development

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