OS 04-08 THE RELATIONSHIP BETWEEN CHILDHOOD RISK FACTORS AND LONG-TERM ARTERIAL STIFFNESS — A 26-YEAR FOLLOW-UP STUDY

2016 ◽  
Vol 34 (Supplement 1) ◽  
pp. e57
Author(s):  
Jianjun Mu ◽  
Chao Chu ◽  
Dan Wang ◽  
Tongshuai Guo ◽  
Yang Wang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Arterial Stiffness ◽  
Follow Up Study ◽  
Childhood Risk Factors ◽  
The Relationship

Incidence and risk factors for trocar site hernia following laparoscopic cholecystectomy: A long-term follow-up study

Hernia ◽  
2012 ◽  
Vol 16 (4) ◽  
pp. 431-437 ◽  
Author(s):  
E. Erdas ◽  
C. Dazzi ◽  
F. Secchi ◽  
S. Aresu ◽  
A. Pitzalis ◽  
...  
Keyword(s):  
Risk Factors ◽  
Laparoscopic Cholecystectomy ◽  
Trocar Site ◽  
Follow Up Study ◽  
Trocar Site Hernia ◽  
Long Term Follow Up

scholarly journals HGG-47. DECREASED GROWTH VELOCITY WITH LONG TERM USE OF BRAFV600e AND MEK INHIBITION IN A PATIENT WITH ANAPLASTIC GANGLIOGLIOMA

2020 ◽  
Vol 22 (Supplement_3) ◽  
pp. iii352-iii352
Author(s):  
Hung Tran ◽  
Robert Cooper
Keyword(s):  
Growth Velocity ◽  
Direct Result ◽  
Chromosomal Microarray ◽  
Mek Inhibition ◽  
Follow Up Study ◽  
The Family ◽  
The Relationship

Abstract PURPOSE To describe decreased growth velocity with long term use of BRAFV600e and MEK inhibition in a patient with anaplastic ganglioglioma. RESULTS 4-year-old patient was found to have a 6 x 4.6 x 5 cm mass in the hypothalamus. Pathology consistent with anaplastic ganglioglioma and chromosomal microarray revealed a BRAFV600e mutation. Patient started on dabrafenib and trametinib and tumor decreased 85% after 3 months. She is stable without significant toxicities 39 months on therapy, and is now 8 years old. Patient had been growing at the 25% for weight and 12% for height but is now 65% for weight and 0.5% for height. It is difficult to tease out the relationship between the tumor, the location of the tumor, and the BRAF and MEK inhibitors and their effect on growth. Discussions with the family and endocrinology are ongoing but being <1% for height will lead to decrease in quality of life. CONCLUSIONS Further follow-up study is needed to determine if this is truly a long-term toxicity, or if this may just be a direct result of the location of the tumor. Would supplementation with growth hormone in this patient lead to losing control of a high grade tumor, or would it simply replace a hormone that is not produced?

scholarly journals Progression of vertebral fractures in long-term controlled acromegaly: a 9-year follow-up study

2020 ◽  
Vol 183 (4) ◽  
pp. 427-437 ◽  
Author(s):  
I C M Pelsma ◽  
N R Biermasz ◽  
A M Pereira ◽  
W R van Furth ◽  
N M Appelman-Dijkstra ◽  
...  
Keyword(s):  
Risk Factors ◽  
Growth Hormone ◽  
Vertebral Fracture ◽  
Follow Up Study ◽  
Total Incidence ◽  
Point Increase ◽  
Associated Risk Factors ◽  
Spine Radiographs

Objective: Growth hormone (GH) and insulin-like growth factor 1 (IGF-1) excess results in both reversible and irreversible musculoskeletal damage, including increased vertebral fracture (VF) risk. The prevalence of VFs is approximately 60% in controlled acromegaly patients, and these VFs can progress in time. We aimed to identify the course of VFs in a cohort of acromegaly patients in long-term remission and their associated risk factors during prolonged follow-up. Methods: Thirty-one patients with acromegaly (49% female, median age 60 years (IQR 53–66)), who were in remission for ≥2 years, were included in this longitudinal, prospective, follow-up study. Spine radiographs of vertebrae Th4 to L4 were assessed for VFs using the Genant score, at baseline, after 2.6 years and 9.1 years. Progression was defined as either a new fracture or a ≥1-point increase in Genant score. Results: The prevalence of VF at baseline was 87% (27/31 patients). Progression of VFs was observed in eleven patients (35.5%) during the 9.1-year follow-up period, with a total incidence rate of 65.5 per 1000 person years (males 59.8 per 1000 person years vs females 71.6 per 1000 person years). Patients treated with surgery or radiotherapy had a higher risk of VF progression in this cohort (P = 0.030). Conclusions: In this cohort of long-term, well-controlled acromegalic patients, the prevalence and progression of VFs was high, showing that the deleterious effects of GH and IGF-1 excess on bone persist despite achievement of longstanding remission.

scholarly journals Risk factors for development of gastric cancer in chronic atrophic gastritis: A long-term follow-up study

2018 ◽  
Vol 26 (31) ◽  
pp. 1812-1817 ◽  
Author(s):  
Hua-Ying Zhang ◽  
Xin-Yu Huang ◽  
Hui-Guang Xue ◽  
Ai-Hua Yang ◽  
Xue-Guo Sun ◽  
...  
Keyword(s):  
Risk Factors ◽  
Gastric Cancer ◽  
Atrophic Gastritis ◽  
Chronic Atrophic Gastritis ◽  
Follow Up Study ◽  
Long Term Follow Up ◽  
Development Of Gastric Cancer

Long-term effect of exercise on improving fatty liver and cardiovascular risk factors in obese adults: A 1-year follow-up study

2016 ◽  
Vol 19 (2) ◽  
pp. 284-289 ◽  
Author(s):  
Hui-Jie Zhang ◽  
Ling-Ling Pan ◽  
Zhi-Min Ma ◽  
Zheng Chen ◽  
Zhu-Feng Huang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Fatty Liver ◽  
Cardiovascular Risk Factors ◽  
Term Effect ◽  
Obese Adults ◽  
Follow Up Study ◽  
Long Term Effect

NATURAL HISTORY OF BRAIN ARTERIOVENOUS MALFORMATIONS

Neurosurgery ◽  
2008 ◽  
Vol 63 (5) ◽  
pp. 823-831 ◽  
Author(s):  
Juha A. Hernesniemi ◽  
Reza Dashti ◽  
Seppo Juvela ◽  
Kristjan Väärt ◽  
Mika Niemelä ◽  
...  
Keyword(s):  
Risk Factors ◽  
Arteriovenous Malformations ◽  
Univariate Analysis ◽  
Incidence Rates ◽  
Cox Proportional Hazards ◽  
Follow Up Study ◽  
Brain Arteriovenous Malformations ◽  
Long Term Follow Up

Abstract OBJECTIVE Long-term follow-up studies in patients with brain arteriovenous malformations (AVM) have yielded contradictory results regarding both risk factors for rupture and annual rupture rate. We performed a long-term follow-up study in an unselected, consecutive patient population with AVMs admitted to the Department of Neurosurgery at Helsinki University Central Hospital between 1942 and 2005. METHODS Patients with untreated AVMs were followed from admission until death, occurrence of AVM rupture, initiation of treatment, or until the end of 2005. Patients with at least 1 month of follow-up were included in further analysis. Annual and cumulative incidence rates of AVM rupture as well as several potential risk factors for rupture were analyzed using Kaplan-Meier life table analyses and Cox proportional hazards regression models. RESULTS We identified 238 patients with a mean follow-up period of 13.5 years (range, 1 month–53.1 years). The average annual risk of hemorrhage from AVMs was 2.4%. The risk was highest during the first 5 years after diagnosis, decreasing thereafter. Risk factors predicting subsequent AVM hemorrhage in univariate analysis were young age, previous rupture, deep and infratentorial locations, and exclusively deep venous drainage. Previous rupture, large AVM size, and infratentorial and deep locations were independent risk factors according to multivariate models. CONCLUSION According to this long-term follow-up study, AVMs with previous rupture and large size, as well as with infratentorial and deep locations have the highest risk of subsequent hemorrhage. This risk is highest during the first few years after diagnosis but remains significant for decades.

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