scholarly journals ANGIOTENSIN AT2 RECEPTORS IN THE NUCLEUS OF THE SOLITARY TRACT REDUCE BLOOD PRESSURE VIA INHIBITION OF GABA SIGNALING

2021 ◽  
Vol 39 (Supplement 1) ◽  
pp. e64
Author(s):  
Mazher Mohammed ◽  
Colin Sumners ◽  
Dominique Johnson ◽  
Karen Scott ◽  
Eric Krause ◽  
...  
2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1
Author(s):  
Mazher Mohammed ◽  
Colin Sumners ◽  
Wanhui Sheng ◽  
Scott W. Harden ◽  
Charles J. Frazier ◽  
...  

2014 ◽  
Author(s):  
I. Nyklicek ◽  
P. M. C. Mommersteeg ◽  
S. Van Beugen ◽  
C. Ramakers ◽  
G. J. Van Boxtel

2019 ◽  
Vol 10 (01) ◽  
pp. 33-44
Author(s):  
N.L.G. Sudaryati ◽  
I P. Sudiartawan ◽  
Dwi Mertha Adnyana

The aim of the study was to determine the effectiveness of giving hydrotherapi foot soak in hypertensive patients. The study was conducted with one group pretestposttest design without a control group by measuring blood pressure (pretest) before being given an intervention in the form of foot soak hydrotherm against 15 people with hypertension in Banjar Sri Mandala, Dauhwaru Village, Jembrana Subregency. Then do the blood pressure measurement again (posttest) after finishing the intervention. After the study was completed, the results showed that before the hydrotherapi foot bath intervention, there were 0% of patients classified as normal, 13.32% in prehypertension category, 60.08% in hypertension category I and 26.60% in hypertension category II. After the intervention was given, there were 13.32% of the patients classified as normal, 66.68% in the prehypertension category, 20.00% in the first category of hypertension and no patients belonging to the second grade hypertension category. There is a decrease of 20-30 mmHg for systolic blood pressure and 0-10 mmHg for diastolic blood pressure after intervention. Based on the results of the study it can be concluded that the hydrotherapi foot bath is effectively used to reduce blood pressure in hypertensive patients in the Banjar Sri Mandala, Dauhwaru Village, Jembrana District.


2013 ◽  
Vol 154 (6) ◽  
pp. 203-208 ◽  
Author(s):  
Gábor Simonyi ◽  
J. Róbert Bedros ◽  
Mihály Medvegy

It is well known that hypertension is an independent cardiovascular risk factor. Treatment of hypertension frequently includes administration of three or more drugs. Resistant hypertension is defined when blood pressure remains above target value despite full doses (the patient’s maximum tolerated dose) of antihypertensive medication consisting of at least three different classes of drugs including a diuretic. Pharmacological treatment of hypertension is often unsuccessful despite the increasing number of drug combinations. Uncontrolled hypertension, however, increases the cardiovascular risk. Device treatment of resistant hypertension is currently testing two major fields. One of them the stimulation of baroreceptors in the carotid sinus and the other is radiofrequency ablation of sympathetic nerve fibers around renal arteries to reduce blood pressure in drug resistant hypertension. Orv. Hetil., 2013, 154, 203–208.


2019 ◽  
Vol 2 (1) ◽  
pp. 18-23
Author(s):  
Herri Novita Br Tarigan ◽  
Prista Hotmarina Purba

Hypertension is a disease that is not uncommon in the community, including the Bukit Lau Kersik village. People with hypertension often do not show long-term symptoms and can be life-threatening. However, one of the management of hypertension that can be used as non-pharmacological therapy is consuming starfruit juice and cucumber which is quite easy to find in the Bukit Lau Kersik village. This combination of juices contains potassium which can reduce blood pressure in patients with hypertension. This study used Equivalent Time Sample Design with 14 subjects with hypertension in the Bukit Lau Kersik Village, Gunung Sitember Subdistrict, Dairi District. The technique of this research sample used Non-Probability Sampling with Saturated Sampling. The instrument used was a sphygmomanometer and a stethoscope. Bivariate data analysis in this study was the Wilcoxon statistical test. Based on the data analysis performed, the value of p = 0.011 (p= < 0.05) was obtained, meaning that there was a significant relationship between giving star fruit juice and cucumber to hypertensive patients. Then it can be concluded that there is an influence between giving star fruit and cucumber juice to blood pressure reduction in hypertensive patients in Bukit Lau Kersik Village Gunung Sitember Subdistrict, Dairi District in 2019. Suggestion: The factors that affect blood pressure in hypertensive patients and checking blood pressure before drinking star fruit juice and cucumber.


2018 ◽  
Vol 6 (1) ◽  
Author(s):  
Hartin Suidah ◽  
Ninik Murtiyani ◽  
Arif Susanto ◽  
Yufi Aris Lestari ◽  
Shindy Sofyaning Fitra

ABSTRAKMasih tingginya penderita hipertensi merupakan salah satu masalah yang berpengaruh terhadap gaya hidup dan sikap yang mendorong timbulnya hipertensi. Untuk menangani tekanan darah pada penderita hipertensi umumnya minum obat-obatan dari puskesmas, rutinitas ini sering tidak disukai oleh penderita. Penelitian ini bertujuan untuk mengetahui efektifitas air rebusan daun seledri terhadap perubahan tekanan darah pada lansia di Posyandu Ngudi Konco Desa Donomulyo Kecamatan Donomulyo Kabupaten Malang.Desain penelitian ini Pre-Experimental dengan rancangan One- Group Pre-Post test design. Populasi dalam penelitian ini adalah semua lansia penderita hipertensi di Posyandu Ngudi Konco Desa Donomulyo Kecamatan Donomulyo Kabupaten Malang sebanyak 30 responden. Sampel diambil dengan teknik total sampling. Variabel penelitian yaitu pemberian air rebusan daun seledri sebagai variabel independent dan tekanan darah sebagai variabel dependen. Data yang di dapat melalui lembar observasi tekanan darah kemudian di uji dengan menggunakan uji paired t Test.Hasil uji paired t Test menunjukkan bahwa p = 0,000 α= 0,05 Ho di tolak dan H1 diterima sehingga air rebusan daun seledri efektif terhadap perubahan tekanan darah pada lansia di Posyandu Ngudi Konco Desa Donomulyo Kecamatan Donomulyo Kabupaten Malang.Terdapat penurunan jumlah penderita hipertensi sebelum dan sesudah diberikan air rebusan daun seledri. Responden agar dapat meningkatkan informasi tentang pelaksanaan tekanan darah sehingga dapat mengurangi tekanan darah yang dialami dengan cara non formakologi sehingga responden tidak hanya menggantungkan pada obat-obatan farmakologi dalam menurunkan tekanan darah.Kata kunci : Air Rebusan Daun Seledri, Tekanan Darah, Lansia ABSTRACTStill high hypertension was  one of the problems that affect the lifestyle and attitudes that encourage the emergence of hypertension. To handle blood pressure in people with hypertension generally take  medication from puskesmas, this routine was often disliked by the patient. This study aims to determine the effectiveness of boiling water celery leaves on changes in blood pressure in the elderly at Posyandu Ngudi Konco Donomulyo Village Donomulyo District Malang Regency.The design of this research was  Pre-Experimental with the design of One- Group Pre-Post test design. Population in this research was all elderly patient of hypertension in Posyandu Ngudi Konco Village Donomulyo District Donomulyo Malang Regency as many as 30 respondents. Samples were taken with total sampling technique. The research variable was giving boiled water of celery leaves as independent variable and blood pressure as dependent variable. The data can be through blood pressure observation sheet then tested by using paired t test.The result of paired t - test showed that p = 0.000 α = 0.05 Ho in rejection and H1 accepted so that boiling water celery leaf effective against blood pressure changes in elderly at Posyandu Ngudi Konco Donomulyo Village Donomulyo District Malang Regency. There was a decrease in the number of hypertensive patients before and after being given boiled water of celery leaves. Respondents in order to improve information about the implementation of blood pressure so as to reduce blood pressure experienced by non-formakologi way so that respondents not only rely on pharmacological drugs in lowering blood pressure. Key Words: Water Stew of Celery leaves, Blood Pressure, Elderly


2021 ◽  
Author(s):  
Mazher Mohammed ◽  
Dominique N Johnson ◽  
Lei A Wang ◽  
Scott W Harden ◽  
Wanhui Sheng ◽  
...  

Abstract Aims These studies evaluate whether angiotensin type-2 receptors (AT2Rs) that are expressed on γ-aminobutyric acid (GABA) neurons in the nucleus of the solitary tract (NTS) represent a novel endogenous blood pressure-lowering mechanism. Methods and results Experiments combined advanced genetic and neuroanatomical techniques, pharmacology, electrophysiology, and optogenetics in mice to define the structure and cardiovascular-related function of NTS neurons that contain AT2R. Using mice with Cre-recombinase directed to the AT2R gene, we discovered that optogenetic stimulation of AT2R-expressing neurons in the NTS increases GABA release and blood pressure. To evaluate the role of the receptor, per se, in cardiovascular regulation, we chronically delivered C21, a selective AT2R agonist, into the brains of normotensive mice and found that central AT2R activation reduces GABA-related gene expression and blunts the pressor responses induced by optogenetic excitation of NTS AT2R neurons. Next, using in situ hybridization, we found that the levels of Agtr2 mRNAs in GABAergic NTS neurons rise during experimentally induced hypertension, and we hypothesized that this increased expression may be exploited to ameliorate the disease. Consistent with this, final experiments revealed that central administration of C21 attenuates hypertension, an effect that is abolished in mice lacking AT2R in GABAergic NTS neurons. Conclusion These studies unveil novel hindbrain circuits that maintain arterial blood pressure, and reveal a specific population of AT2R that can be engaged to alleviate hypertension. The implication is that these discrete receptors may serve as an access point for activating an endogenous depressor circuit.


2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Rodrigo Ferrari ◽  
◽  
Leandro de Oliveira Carpes ◽  
Lucas Betti Domingues ◽  
Alexandre Jacobsen ◽  
...  

Abstract Background Different physical activities are widely recommended as non-pharmacological therapies to reduce blood pressure. However, the effectiveness of exercise programs is associated with its continuity and regularity, and the long-term adherence to traditional exercise interventions is often low. Recreational sports emerge as an alternative, being more captivating and able to retain individuals for longer periods. Besides, sport interventions have demonstrated improvements in physical fitness components that are associated with a lower incidence of hypertension. However, no studies have investigated the effects of recreational sports on 24 h ambulatory blood pressure. The aim of the present study is to evaluate the effect of beach tennis training on ambulatory blood pressure and physical fitness in individuals with hypertension. Methods This study will be a randomized, single-blinded, two-arm, parallel, and superiority trial. Forty-two participants aged 35–65 years with previous diagnosis of hypertension will be randomized to 12 weeks of beach tennis training group (two sessions per week lasting 45–60 min) or a non-exercising control group. Ambulatory (primary outcome) and office blood pressures, cardiorespiratory fitness, muscle strength/power and quality of life will be assessed at baseline and after the intervention period. Discussion Our conceptual hypothesis is that beach tennis training will reduce ambulatory blood pressure and improve fitness parameters in middle-aged individuals with hypertension. The results of this trial are expected to provide evidences of efficacy of recreational beach tennis practice on blood pressure management and to support sport recommendations for clinical scenario in higher risk populations. Trial registration ClinicalTrials.gov, NCT03909321. Registered on April 10, 2019.


2019 ◽  
Vol 51 (11) ◽  
pp. 553-561 ◽  
Author(s):  
David J. Ferland ◽  
Emma D. Flood ◽  
Hannah Garver ◽  
Steve T. Yeh ◽  
Stanley Riney ◽  
...  

Chemerin is a contractile adipokine, produced in liver and fat, and removal of the protein by antisense oligonucleotides (ASO) lowers blood pressure in the normal Sprague Dawley rat. In humans, chemerin is positively associated with blood pressure and obesity so we hypothesized that in a model of hypertension derived from high-fat (HF) feeding, the chemerin ASO would reduce blood pressure more than a high-salt (HS) model. Male Dahl S rats were given a HF (60% kcal fat; age 3–24 wk) or HS diet (4% salt; age 20–24 wk to match age and blood pressure of HF animals). Scrambled control, whole body, or liver-specific ASOs that knock down chemerin were delivered subcutaneously once per week for 4 wk with tissue and blood collected 2 days after the last injection. Conscious blood pressure was measured 24 h/day by radiotelemetry. By the end of whole body ASO administration, blood pressure of HF animals had fallen 29 ± 2 mmHg below baseline, while blood pressure of HS-diet animals fell by only 12 ± 4 mmHg below baseline. Administration of a liver-specific ASO to HF Dahl S resulted in a 6 ± 2 mmHg fall in blood pressure below baseline. Successful knockdown of chemerin in both the whole body and liver-specific administration was confirmed by Western and PCR. These results suggest that chemerin, not derived from liver but potentially from adipose tissue, is an important driver of hypertension associated with high fat. This knowledge could lead to the development of antihypertensive treatments specifically targeted to obesity-associated hypertension.


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