Natural History of Plasma Leakage in Dengue Hemorrhagic Fever

2007 ◽  
Vol 26 (4) ◽  
pp. 283-290 ◽  
Author(s):  
Anon Srikiatkhachorn ◽  
Anchalee Krautrachue ◽  
Warangkana Ratanaprakarn ◽  
Lawan Wongtapradit ◽  
Narong Nithipanya ◽  
...  
Keyword(s):  
Natural History ◽  
Dengue Hemorrhagic Fever ◽  
Hemorrhagic Fever ◽  
History Of ◽  
Plasma Leakage

scholarly journals Hyperventilation in Children with Dengue Hemorrhagic Fever (DHF)

2019 ◽  
Vol 31 (9-10) ◽  
pp. 245-56
Author(s):  
Kasim Y. A. ◽  
Anky Tri Rini K. E. ◽  
Sumarmo S. P. S.
Keyword(s):  
Dengue Hemorrhagic Fever ◽  
Dengue Shock Syndrome ◽  
Hemorrhagic Fever ◽  
Lung Edema ◽  
Respiratory Problems ◽  
Ventilatory Pattern ◽  
Grade Ii ◽  
Plasma Leakage ◽  
The Difference ◽  
Respiratory Disturbance

Many studies of Dengue Hemorrhagic Fever (DHF) have been done but only a few revealed the respiratory status. Respiratory problems arise. because of plasma leakage through the 'damaged capillaries, causing lung edema and in turn result in hypoxemia. This later on will be compensated by a hyperventilation state. During a 6-month-period (May to September 1988), two aspects were studied in 85 patients hospitalized with DHF. First, the ventilatory pattern and second, the result of giving oxygen support in improving the respiratory disturbance, in this case alveolar hyperventilation. The incidence of alveolar hyperventilation in DHF grade II (DHF II) and Dengue Shock Syndrome (DSS) differed significantly. Hypoxemia occurred in DHF II and DSS with no significant differences. The difference of the incidence of metabolic acidosis in DHF II and DSS were significant. In DHF II patients having had hyperventilation state, oxygen therapy decreased respiration rate significantly and increased the PaC02 though not significantly.

scholarly journals Emphysematous pyelonephritis with Dengue hemorrhagic fever: A successful medical management of a fatal scenario

2017 ◽  
Vol 8 (5) ◽  
pp. 101-103
Author(s):  
Robin George Manappallil ◽  
Prathap Reddy Muthyala
Keyword(s):  
Dengue Fever ◽  
Hemorrhagic Fever ◽  
Severe Form ◽  
Medical Sciences ◽  
Emphysematous Pyelonephritis ◽  
Associated Gas ◽  
Acute Necrotizing ◽  
Life Threatening ◽  
History Of ◽  
Plasma Leakage

Emphysematous pyelonephritis is a life threatening acute necrotizing infection with associated gas formation involving the renal parenchyma and perinephric tissues. Dengue fever, according to the WHO, is the most rapidly spreading mosquito borne viral infection in the world. Dengue Hemorrgahic Fever is a more severe form of dengue fever and is characterized by fever, bleeding manifestations, plasma leakage and thrombocytopenia. This is a case of a 56 year old female, who presented with history of fever, headache, myalgia and dysuria; and was diagnosed to have emphysematous pyelonephritis with Dengue Hemorrgahic Fever. She was successfully managed with intravenous antibiotics and platelet transfusions, without any urological interventions. Asian Journal of Medical Sciences Vol.8(5) 2017 101-103

Shock Prognostic Factors in Hospitalized Dengue Hemorrhagic Fever Children

2018 ◽  
Vol 24 (8) ◽  
pp. 6221-6224
Author(s):  
Hindra Irawan Satari ◽  
Rossy Agus Mardani ◽  
Hartono Gunardi
Keyword(s):  
Prognostic Factors ◽  
Dengue Hemorrhagic Fever ◽  
Dengue Infection ◽  
Clinical Manifestations ◽  
Dengue Shock Syndrome ◽  
Hemorrhagic Fever ◽  
Health Department ◽  
Abdominal Tenderness ◽  
Diverse Area ◽  
Plasma Leakage

Various clinical manifestations, complex pathogenesis and different virus serotypes in diverse area make us difficult to predict course of disease, even the child admitted in early. Prognostic factors are very important to predict cases progressing to become DSS. Dengue shock syndrome (DSS) occurs in 15.53% of Dengue hemorrhagic fever (DHF) patients with 7.81% mortality rate. Aim: To explore the prognostic factors of shock in hospitalized DHF children regarding the new 2011 WHO dengue virus infection classification guideline. This was a retrospective study using medical records of children age below 18 years old with WHO fulfilled grade 1 and 2 DHF diagnosis from January 2013–December 2016 in Child Health Department of Dr. Cipto Mangunkusumo Hospital, Jakarta. Independent variables were sex, age, nutritional status, secondary dengue infection, leucopenia, abdominal tenderness, gastrointestinal bleeding, hepatomegaly and plasma leakage. Shock was dependent variable. Multivariate analysis was done by using logistic regresion analysis. There were 98 DHF subjects, 5 subjects became DSS during hospitalization. DSS subject characteristics were age of >5 years old, female, malnutrition, abdominal tenderness, hemoconcentration ≥20%, secondary dengue infection, leucocyte ≥5.000 mm3 and thrombocyte <50.000 mm3. Multivaryate analysis showed malnutrition and hepatomegaly were prognosis factors of DSS. Malnutrition and hepatomegaly were prognotic factors of dengue shock syndrome. Clinicians should be more aware with these factors when managed hospitalized DHF patients.

scholarly journals Bleeding complications in dengue are not associated with significant changes in the modulators of the endothelial barrier

2014 ◽  
Vol 8 (06) ◽  
pp. 799-803 ◽  
Author(s):  
Fernanda Andrade Orsi ◽  
Rodrigo Nogueira Angerami ◽  
Bruna Moraes Mazetto ◽  
Susan Kelly Picoli Quaino ◽  
Erich Vinícius De Paula ◽  
...  
Keyword(s):  
Dengue Hemorrhagic Fever ◽  
Plasma Levels ◽  
Who Classification ◽  
Hemorrhagic Fever ◽  
Microvascular Permeability ◽  
Endothelial Barrier ◽  
Bleeding Complications ◽  
Soluble Receptors ◽  
Plasma Leakage ◽  
Barrier Breakdown

Bleeding complications in dengue may occur irrespective of the presence of plasma leakage. We compared plasma levels of modulators of the endothelial barrier among three dengue groups: bleedings without plasma leakage, dengue hemorrhagic fever, and non-complicated dengue. The aim was to evaluate whether the presence of subtle alterations in microvascular permeability could be detected in bleeding patients. Plasma levels of VEGF-A and its soluble receptors were not associated with the occurrence of bleeding in patients without plasma leakage. These results provide additional rationale for considering bleeding as a complication independent of endothelial barrier breakdown, as proposed by the 2009 WHO classification.

scholarly journals Community Behavior Patterns That Influence The Causes of Dengue Hemorrhagic Fever (DHF) in The Pondok Petir Elementary Region

2021 ◽  
Vol 1 (1) ◽  
pp. 811-820
Author(s):  
Aulia Saputra
Keyword(s):  
Dengue Hemorrhagic Fever ◽  
Health Workers ◽  
Hemorrhagic Fever ◽  
World Health ◽  
Hemorrhagic Diathesis ◽  
Behavioral Patterns ◽  
Water Reservoirs ◽  
History Of ◽  
Dengue Prevention ◽  
Used Goods

Dengue Hemorrhagic Fever (DHF) is a disease caused by the bite of the Aedes Aegypti mosquito infected with one of the four types of dengue virus with clinical manifestations of fever, muscle aches, and/or joint pain accompanied by leukopenia, rash, lymphadenopathy, thrombocytopenia and hemorrhagic diathesis. In dengue hemorrhagic fever, plasma leakage occurs which is characterized by hemoconcentration (increased hematocrit) or fluid accumulation in body cavities (World Health Organization). Dengue Hemorrhagic Fever Penyakit (DHF) is still one of the main public health problems in Indonesia. The number of sufferers and the area of ​​spread of DHF is increasing along with the increase in mobility and population density, especially in tropical and sub-tropical areas (Kemenkes RI, 2010). At the beginning of 2019, Dengue Hemorrhagic Fever (DHF) again increased in several areas, even becoming an Extraordinary Event (KLB) status. In January 2019 there were 15,132 DHF sufferers with 145 people dying in 34 provinces. This figure is twice as high as the figure at the end of January 2018 which recorded 6,167 DHF sufferers with 43 people dying. To find out the behavioral factors of DHF disease in the community in the Pondok Petir sub-district area in 2020. Research Setting: According to data in 2019, Dengue Hemorrhagic Fever (DHF) has increased again in several areas, even becoming an Extraordinary Event (KLB) status. In January 2019 there were 15,132 DHF sufferers with 145 people dying in 34 provinces. This figure is twice as high as the figure at the end of January 2018 which recorded 6,167 DHF sufferers with 43 people dying. East Java, West Java, and DKI Jakarta are the three provinces that experienced an increase in the number of dengue cases compared to the previous year. This research uses the Simple Random Sampling technique. This study studied the incidence of dengue in children to adults (dependent variable), with respondent characteristics (age, history of dengue disease), counseling (knowledge), attitudes (family attitudes), and behavioral patterns (behavior of health workers, rarely monitoring larvae). mosquitoes, distribution of abate powder, fogging activities), and increasing community participation in dengue prevention (independent variable). To obtain the data, an in-depth interview and document review approach was conducted with the community at Pondok Petir. This research was conducted at Pondok Petir, South Tangerang in June 2021. The sub-categories in this study were DHF, Age, History of DHF, Knowledge, Family Attitude, Behavioral Patterns, Behavioral Patterns of Health Workers, Rarely Monitoring Mosquito Larvae, Distribution of Abate Powder, Fogging Activities, Facilities, Facilities, Increased Participation Society in Dengue Prevention. It takes a lot of education to the people of Pondok Petir to make people aware of the importance of knowing about DHF. The most effective and efficient prevention of dengue fever to date is the Mosquito Nest Eradication (PSN) activity using 3M Plus, namely: 1) Draining, is cleaning places that are often used as water reservoirs such as bathtubs, water buckets, water reservoirs drinking water, water reservoirs, refrigerators, etc. 2) Closing, namely closing water reservoirs such as drums, jugs, water towers, and so on; and 3) Reusing or recycling used goods that have the potential to become breeding grounds for dengue-transmitting mosquitoes.

scholarly journals Platelet count and AST can reliably predict the onset of plasma leakage in dengue, a low-cost triage tool during epidemics

2019 ◽  
Author(s):  
Arjuna Medagama ◽  
Chamara Dalugama ◽  
Darshani Lakmali ◽  
Gukes Meiyalakan
Keyword(s):  
Regression Analysis ◽  
Platelet Count ◽  
Dengue Fever ◽  
Dengue Hemorrhagic Fever ◽  
Low Cost ◽  
Clinical Signs ◽  
Hemorrhagic Fever ◽  
Severe Dengue ◽  
Upper Limit ◽  
Plasma Leakage

Abstract Background: Dengue is one of the most important mosquito-borne viral infections to affect humans. It is most often a self-limiting febrile illness but in some instances can progress to plasma leakage and in extreme cases culminate in death. The objective of this study was to identify reliable, low-cost, easily-accessible and objective predictors of Dengue hemorrhagic fever (DHF) that can be used as a triage tool in epidemic situations. Methods A cohort of dengue fever patients were selected and data on symptoms, clinical signs, routine lab tests, ultrasonography and packed cell volume measurements collected. The demographics and clinical characteristics of severe and non-severe dengue cases were described Bivariate and regression analysis were used to identify variables significantly correlated with plasma leak. Results Serologically confirmed 350 serial adult dengue patients were included in the study. 257 (73.4%) were classified as dengue fever (DF, non leakers) and 93 (26.5%) as DHF with plasma leakage. Bivariate and regression analysis showed platelet count (Pearson r 0.59), and AST (r 0.27) to be significantly correlated with plasma leakage and platelet count to have a moderate predictive association ( R 2 0.35) with plasma leakage. Platelet count <50,000/mm 3 (OR 23.7; 95% CI 12.2-45.9), AST> twice, upper limit of normal (OR 7.5; 95% CI 3.9-14.3) and ALT> twice, upper limit of normal (OR 2.4; 95%CI 1.4-3.6) increased the likelihood of DHF.In the final analysis, logistic regression identified platelet count <50,000/mm 3 (OR 17.2; 95% CI 8.6-34.1) and AST>2ULN (OR 5.1, 95% CI 2.1-12.1) at time of plasma leakage as significant independent predictors of DHF.ROC curve performed for Platelet count had an AUC of .89 and at a platelet count of 50,000/mm 3 predicted DHF with a sensitivity of 87% and specificity of 79%. AUC for AST was 0.72 and at 93Iu/L predicted DHF with a sensitivity of 85% and specificity of 60%. Conclusion: We have identified 2 laboratory parameters that could be used to identify plasma leakage and might be useful to stratify dengue-infected patients at risk for developing dengue hemorrhagic fever

scholarly journals PLASMA LEAKAGE PROFILES OF DENGUE HEMORRHAGIC FEVER PATIENTS IN RSUD Dr. SOETOMO, SURABAYA, EAST JAVA, INDONESIA JANUARY – JUNE 2014

2017 ◽  
Vol 6 (4) ◽  
pp. 92
Author(s):  
Ferdian Rizaliansyah ◽  
Aryati Aryati ◽  
Musofa Rusli
Keyword(s):  
Pleural Effusion ◽  
Dengue Hemorrhagic Fever ◽  
Pediatric Patients ◽  
Hemorrhagic Fever ◽  
Healthcare Services ◽  
Albumin Level ◽  
Adult Patients ◽  
Dengue Virus Infection ◽  
Plasma Leakage ◽  
Normal Albumin

Plasma leakage is one crucial point of dengue hemorrhagic fever (DHF) that differentiates it from dengue fever (DF). DHF has to meet 4 criteria which are 2 – 7 days of acute fever, hemorrhagic manifestation, thrombocytopenia (≤100.000 cells/mm3) and evidence of plasma leakage. Plasma leakage consists of increasing hematocrit ≥20%, hypoalbuminemia or evidence of pleural effusion or ascites. Often doctors only base their DHF diagnosis on the presence of thrombocytopenia. This study analyzed the presence of plasma leakage between adult and pediatric patients with a DHF diagnosis in RSUD Dr. Soetomo in order to make the diagnosis and healthcare services better in the future. This was a retrospective study which used medical records of DHF patients admitted from January to June 2014. 78 cases were included, 24 adult patients (31%) and 54 pediatric patients (69%). 29/78 (37%) patients had no evidence of plasma leakage. No adult patients had ascites whereas 11/54 (20%) pediatric patients presented with ascites. No adult patients had pleural effusion whereas 25/54 (53%) pediatric patients did. Most adult patients that had serum albumin checked had normal albumin levels (12/14 [86%]) while only 14/28 (52%) pediatric patients had normal albumin level. 5/22 (23%) adult patients versus 32/53 (60%) pediatric patients showed hematocrit increments ≥20%. Patients admitted with dengue virus infection may currently be often misclassified as DHF because there are no plasma leakage manifestation in some patients.. There are significant differences in plasma leakage manifestations between adult and pediatric patients which poses a theory that pediatric patients are more susceptible to have plasma leakage manifestations than adult patients.

scholarly journals DIFFERENT OF HEMATOCRIT VALUE MICROHEMATOCRIT METHODS AND AUTOMATIC METHODS IN DENGUE HEMORRHAGIC PATIENTS WITH HEMOCONCENTRATION

2019 ◽  
Vol 3 (2) ◽  
pp. 67
Author(s):  
Alvin Dwi Rizky Meilanie
Keyword(s):  
Dengue Fever ◽  
Dengue Hemorrhagic Fever ◽  
Statistical Tests ◽  
Hemorrhagic Fever ◽  
Automatic Method ◽  
Paired Sample ◽  
Hematology Analyzer ◽  
Automatic Methods ◽  
Plasma Leakage ◽  
Automated Hematology Analyzer

Background: Many people in Indonesia. Hematocrit examination is one of the important examinations to help diagnose dengue fever. Increased hematocrit (hemoconcentration) occurs with dengue hemorrhagic fever caused by plasma leakage. Hematocrit examination can be done by microhematocrit method and automatic method. The microhematocrit method has the principle that the blood with anticoagulants is centrifuged at a certain speed, the erythrocytes will separate from the plasma. While the automated hematology analyzer uses the principle of flowcytometry which detects based on the height of the erythrocyte pulse. Purpose: To know the differences in hematocrit values of the microhematocrit method and the automatic method in patients with hemoconcentration of Dengue Hemorrhagic Fever. Methods: The study was conducted by observational analytics in March 2019 with a total of 30 samples at RSU. Haji Surabaya. The data obtained was analyzed using the Paired Sample T-Test with the SPSS 16.0 program to determine whether there were significant differences in hematocrit values between the microhematocrit method and the automatic method. Results: The results showed that the hematocrit examination results of microhematocrit method obtained an average of 46.93%, while the automatic method obtained an average of 45%. This shows the hematocrit examination results of the microhematocrit method are higher than the automatic method. Based the results of paired sample statistical tests t Tests obtained a significance value of 0.00 were less than 0.05. Conclusion: There are significant differences between the hematocrit examination results of the microhematocrit method and the automatic method.

scholarly journals Rectus sheath haematoma complicating dengue haemorrhagic fever-a case report

2016 ◽  
Vol 5 (1) ◽  
pp. 354
Author(s):  
Harharpreet Kaur ◽  
Kawalinder Girgila
Keyword(s):  
Dengue Hemorrhagic Fever ◽  
Rectus Sheath ◽  
Hemorrhagic Fever ◽  
Haemorrhagic Fever ◽  
Course Of Illness ◽  
Acute Dyspnoea ◽  
Life Threatening ◽  
Plasma Leakage ◽  
In The Beginning ◽  
Rectus Sheath Hematoma

Dengue hemorrhagic fever manifests in various forms, ranging from petechial skin hemorrhages to life threatening hemorrhages. However it is very rare to have muscle hematomas in this condition. We report a case of spontaneous Rectus sheath hematoma complicating dengue hemorrhagic fever. Our patient was a 55 year old female positive for NS1antigen and anti-dengue IgM. She had thrombocytopenia with platelet counts as low as 12000 in the beginning. There was evidence of plasma leakage and acute dyspnoea during the course of illness. On the 5th day though the platelet count had recovered she developed haematoma in the left rectus sheath which was diagnosed on ultrasound and aspirated leading to relief of symptoms. This complication needs to be recognized so that it can be treated early.

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