Shock Prognostic Factors in Hospitalized Dengue Hemorrhagic Fever Children

2018 ◽  
Vol 24 (8) ◽  
pp. 6221-6224
Author(s):  
Hindra Irawan Satari ◽  
Rossy Agus Mardani ◽  
Hartono Gunardi
Keyword(s):  
Prognostic Factors ◽  
Dengue Hemorrhagic Fever ◽  
Dengue Infection ◽  
Clinical Manifestations ◽  
Dengue Shock Syndrome ◽  
Hemorrhagic Fever ◽  
Health Department ◽  
Abdominal Tenderness ◽  
Diverse Area ◽  
Plasma Leakage

Various clinical manifestations, complex pathogenesis and different virus serotypes in diverse area make us difficult to predict course of disease, even the child admitted in early. Prognostic factors are very important to predict cases progressing to become DSS. Dengue shock syndrome (DSS) occurs in 15.53% of Dengue hemorrhagic fever (DHF) patients with 7.81% mortality rate. Aim: To explore the prognostic factors of shock in hospitalized DHF children regarding the new 2011 WHO dengue virus infection classification guideline. This was a retrospective study using medical records of children age below 18 years old with WHO fulfilled grade 1 and 2 DHF diagnosis from January 2013–December 2016 in Child Health Department of Dr. Cipto Mangunkusumo Hospital, Jakarta. Independent variables were sex, age, nutritional status, secondary dengue infection, leucopenia, abdominal tenderness, gastrointestinal bleeding, hepatomegaly and plasma leakage. Shock was dependent variable. Multivariate analysis was done by using logistic regresion analysis. There were 98 DHF subjects, 5 subjects became DSS during hospitalization. DSS subject characteristics were age of >5 years old, female, malnutrition, abdominal tenderness, hemoconcentration ≥20%, secondary dengue infection, leucocyte ≥5.000 mm3 and thrombocyte <50.000 mm3. Multivaryate analysis showed malnutrition and hepatomegaly were prognosis factors of DSS. Malnutrition and hepatomegaly were prognotic factors of dengue shock syndrome. Clinicians should be more aware with these factors when managed hospitalized DHF patients.

scholarly journals Hyperventilation in Children with Dengue Hemorrhagic Fever (DHF)

2019 ◽  
Vol 31 (9-10) ◽  
pp. 245-56
Author(s):  
Kasim Y. A. ◽  
Anky Tri Rini K. E. ◽  
Sumarmo S. P. S.
Keyword(s):  
Dengue Hemorrhagic Fever ◽  
Dengue Shock Syndrome ◽  
Hemorrhagic Fever ◽  
Lung Edema ◽  
Respiratory Problems ◽  
Ventilatory Pattern ◽  
Grade Ii ◽  
Plasma Leakage ◽  
The Difference ◽  
Respiratory Disturbance

Many studies of Dengue Hemorrhagic Fever (DHF) have been done but only a few revealed the respiratory status. Respiratory problems arise. because of plasma leakage through the 'damaged capillaries, causing lung edema and in turn result in hypoxemia. This later on will be compensated by a hyperventilation state. During a 6-month-period (May to September 1988), two aspects were studied in 85 patients hospitalized with DHF. First, the ventilatory pattern and second, the result of giving oxygen support in improving the respiratory disturbance, in this case alveolar hyperventilation. The incidence of alveolar hyperventilation in DHF grade II (DHF II) and Dengue Shock Syndrome (DSS) differed significantly. Hypoxemia occurred in DHF II and DSS with no significant differences. The difference of the incidence of metabolic acidosis in DHF II and DSS were significant. In DHF II patients having had hyperventilation state, oxygen therapy decreased respiration rate significantly and increased the PaC02 though not significantly.

scholarly journals Serotype Infectivity and Phylogenetic of Dengue Virus cause of Dengue Fever (DF), Dengue Hemorrhagic Fever (DHF), and Dengue Shock Syndrome (DSS) in Surabaya- Indonesia

2020 ◽  
Vol 4 (1) ◽  
pp. 1
Author(s):  
Fedik Rantam
Keyword(s):  
Phylogenetic Analysis ◽  
Nucleotide Sequence ◽  
Dengue Virus ◽  
Dengue Infection ◽  
Dengue Shock Syndrome ◽  
Hemorrhagic Fever ◽  
Rt Pcr ◽  
Who Criteria ◽  
Plasma Leakage ◽  
Degree Of Severity

Infection with DENV causes a spectrum of clinical disease ranging. The aim of this study is to investigate the infectivity of DENV with degree of severity dengue infection in Surabaya. Dengue infection was established by IgM anti dengue, and two step multiplex RT PCR and Nucleotide sequence. Grading of degree severity infection follow the WHO criteria 2011. DSS cases found 3 from 36 patients caused by DENV 2. The most uninfective was DENV 1, and the most prevalence dengue infection caused  by  DENV  3.  The  infectivity of  dengue  infection shown 16 patients lead to severity with plasma leakage. All of sera patients detecting using multiplex RT-PCR were positive, but it were analyzed using Duo ELISA only 22 serum sera positive IgM and IgG from 36 sera. . The Phylogenetic analysis indicates that the isolates from 2011 to 2012 close related with dengue isolate from 1998 and belong to 2009 to 2020.In this study it indicates that DENV 2 predominantly is the cause of DSS.

scholarly journals Pengaruh Kesehatan Lingkungan terhadap Perubahan Epidemiologi Demam Berdarah di Indonesia

e-CliniC ◽  
2017 ◽  
Vol 5 (2) ◽  
Author(s):  
Ribka Wowor
Keyword(s):  
High Risk ◽  
Environmental Factors ◽  
Dengue Hemorrhagic Fever ◽  
Health Problem ◽  
Human Population ◽  
Dengue Infection ◽  
Clinical Manifestations ◽  
Hemorrhagic Fever ◽  
Effective Control ◽  
High Risk Population

Abstract: In Indonesia, dengue hemorrhagic fever (DHF) is a serious health problem. Infection of dengue has occurred in Indonesia for the last two decades. It is a self limiting disease, however, its clinical manifestations has become worsened since several years ago. Epidemiologic pattern of dengue infection changes every year, and there is a peak of new cases every 10 years. Nowadays, adolescence and adult individuals belong to the high risk population of this infection. This epidemiologic changing of DHF is influenced by several environmental factors, inter alia: 1) increasing of human population; 2) uncontrolled urbanization; 3) no effective control of mosquitoes in endemic areas; and 4) modernized public transportation.Keywords: environmental sanitation, epidemiology, dengue hemorrhagic fever Abstrak: Di Indonesia, demam berdarah dengue (DBD) masih merupakan masalah kesehatan masyarakat yang penting. Infeksi dengue terjadi secara endemis di Indonesia selama dua abad terakhir. Penyakit ini bersifat self limiting namun dalam beberapa tahun terakhir memperlihatkan manifestasi klinis yang semakin berat sebagai DBD dan frekuensi kejadian luar biasanya semakin meningkat. Pola epidemiologi infeksi dengue mengalami perubahan dari tahun ke tahun, jumlah kasus memuncak setiap siklus 10 tahunan. Kelompok usia yang terserang dengue berubah menjadi kelompok remaja dan dewasa. Perubahan epidemiologi DBD ini turut dipengaruhi oleh faktor kesehatan lingkungan. Faktor-faktor yang memengaruhi peningkatan dan penyebaran kasus DBD sangat kompleks yaitu, antara lain: 1) pertumbuhan penduduk yang tinggi dan cepat; 2) urbanisasi yang tidak terencana dan tidak terkendali; 3) tidak adanya kontrol vektor nyamuk yang efektif di daerah endemis; serta 4) peningkatan sarana transportasi.Kata kunci: kesehatan lingkungan, epidemiologi, demam berdarah dengue

scholarly journals Importance of Platelet Count and Hematocrit in Dengue Fever in Children

2021 ◽  
Vol 44 (2) ◽  
pp. 74-77
Author(s):  
Farhana Rahat ◽  
Morsheda Khanam ◽  
Kazi Iman ◽  
UK Ghosh ◽  
NK Ghosh
Keyword(s):  
Platelet Count ◽  
Dengue Fever ◽  
Dengue Hemorrhagic Fever ◽  
Dengue Infection ◽  
Tertiary Care ◽  
Dengue Shock Syndrome ◽  
Hemorrhagic Fever ◽  
Warning Signs ◽  
Care Hospital ◽  
Pediatric Age Group

Background: Dengue fever has become one of the most important public health concerns now a day due to increasing complications and fatal outcomes. Dengue hemorrhagic fever and dengue shock syndrome are life threatening but reversible complications of dengue fever. Objectives: This study was performed to evaluate the relationship between platelet count and hematocrit with the severity of dengue infection in pediatric age group. Materials & Methods: This was a prospective observational study which included 280 dengue seropositive children of 1 month to 15 years, conducted during 1st June to 30th November, 2018 in a tertiary care hospital of Dhaka. Results: Out of 280 dengue cases, 187(66.78%) had thrombocytopenia and 88(47%) had raised hematocrit. Among the thrombocytopenic patients 44% had dengue fever, 47% had dengue hemorrhagic fever and 9% dengue shock syndrome. A significant co-relation was observed between the severities of thrombocytopenia and raised hematocrit with the appearance of dengue warning signs in case of dengue hemorrhagic fever. Conclusion: Thrombocytopenia and raised hematocrit were related to the severity of dengue hemorrhagic fever. Bangladesh J Child Health 2020; VOL 44 (2) :74-77

scholarly journals DENGUE HEMORRHAGIC FEVER / DENGUE SHOCK SYNDROME

2012 ◽  
Vol 19 (05) ◽  
pp. 661-667
Author(s):  
AMIR RASHID ◽  
HUMAYUN IQBAL KHAN ◽  
NADEEM- UR-RASOOL
Keyword(s):  
General Hospital ◽  
Dengue Hemorrhagic Fever ◽  
Care Center ◽  
Tertiary Care ◽  
Clinical Manifestations ◽  
Dengue Shock Syndrome ◽  
Hemorrhagic Fever ◽  
Medical Institute ◽  
Questionnaire Form ◽  
Dengue Epidemic

Objective: To study the clinical spectrum of Dengue Hemorrhagic Fever (DHF) and Dengue Shock Syndrome (DSS) in childrenadmitted in a tertiary care center during 2011 dengue epidemic in Lahore. Setting: This study was conducted in department of PediatricsLahore General Hospital (LGH) / Postgraduate Medical Institute (PGMI) Lahore, Pakistan. Design: Retrospective descriptive study. Period: 1stAugust to 31st October 2011. Method: All the children (<18 years) with clinical features of Dengue Hemorrhagic Fever and Dengue shockSyndrome (DHF/DSS) admitted to the Pediatric ward Lahore General Hospital, Lahore during the period of 1st August to 31st October 2011were enrolled in the study. The clinical manifestation were recorded on a standard questionnaire form. Clinically DHF/DSS cases wereconfirmed in the laboratory by different investigations. All the patient were diagnosed, managed and discharged according to WHO protocol.Results: A total of 254 patients were admitted in the ward labeled as dengue fever (DF) clinically. Out of these 142(55.9 %) were confirmed byserology. Of 254 DF cases 37(14.57%) were labeled as DHF and 02(0.79%) as DSS on their clinical manifestations and fulfilling the WHOcriteria. 55% were male and 45%females. Common symptoms were fever seen in 100%, headache 71.79% and vomiting seen in 58.97% of thecases. The most common bleeding manifestations were epistaxis seen in 69.23% of the cases. Positive IgM was noted in 53.9% and IgG in36.6% cases. A decrease in platelet count and increase in Heamatocrit ( Hct) during stay in ward was noted. Out of 39 patients only one patientexpired (2.56%).

scholarly journals Clinical manifestations and hematological and serological findings in children with dengue infection

2011 ◽  
Vol 51 (3) ◽  
pp. 157 ◽  
Author(s):  
Mulya Rahma Karyanti
Keyword(s):  
Public Health ◽  
Dengue Infection ◽  
Clinical Manifestations ◽  
Public Health Problem ◽  
Dengue Shock Syndrome ◽  
Signs And Symptoms ◽  
Hemorrhagic Fever ◽  
Severe Dengue ◽  
The Mean ◽  
Serological Data

Background Dengue hemorrhagic fever (DHF) is endemic to Indonesia and remains a public health problem, with its highest incidence in children. There have been few reports on the clinical, hematological and serological data in children \\lith dengue.Objective To assess the clinical and laboratory profiles of children \\lith dengue infection in Cipto Mangunkusumo Hospital, Jakarta, Indonesia.Methods Clinical, hematological and serological infonnation from children diagnosed v.ith dengue infection in Cipto Mangunkusumo Hospital were collected from 2007 to 2009.Results Of611 children admitted with dengue, 143 (23.4%) had dengue fever (DF), 252 (41.2%) had DHF grades I and II; and 216 (35.4%) had DHF grades III and IV. Of the 81 cases where dengue serotypes were identified, 12.3% were DENV1, 35.8% were DENV-2, 48.2% were DENV-3 and 3.7% were DENV-4. Mean age of subjects was 8.9 years (SD 4.4), and 48.4% of cases were boys. The mean length of fever before hospital admission was 4.2 days (SD 1.1) and mean length of stay in the hospital was 4 days (SD 2.7). Common symptoms observed were petechiae, hepatomegaly and epistaxis. Complications found mostly in those with dengue shock syndrome (DSS) were hematemesis (30 cases, 4.9% of all patients), encephalopathy (19 cases, 3.1 %) and melena (17 cases, 2.8%).Conclusion Signs and symptoms of fever, bleeding manifestations and thrombocytopenia were present in children 'With DF and DHF, while signs of increased vascular permeability were found only in those 'With DHF. Encephalopathy and gastrointestinal bleeding were found mostly in DSS cases. At admission, leukopenia was found in more DF patients than in DHF patients. Absence of leukopenia may be a sign of more severe dengue infection. 

scholarly journals Correlation Analysis between Ratio of C-Reactive Protein/Albumin and Severity of Dengue Hemorrhagic Fever in Children

2021 ◽  
Vol 9 (3) ◽  
pp. 136
Author(s):  
Agustin Iskandar ◽  
Yuyun Norwahyuni ◽  
Aryati Aryati ◽  
Andrea Aprilia
Keyword(s):  
Dengue Hemorrhagic Fever ◽  
Pearson Correlation ◽  
Dengue Infection ◽  
Dengue Shock Syndrome ◽  
Hemorrhagic Fever ◽  
Bromocresol Green ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Albumin Ratio ◽  
Reactive Protein

Dengue Hemorrhagic Fever (DHF) is a dengue infection which can cause shock and leads to mortality. Hypoalbuminemia is a marker of plasma leakage in DHF and correlated with severity of in fl ammatory response triggered by infection, including DHF. C-Reactive Protein (CRP) is a proin fl ammatory marker that also increases in DHF. This study aims to determine a correlation of CRP/albumin ratio with severity of DHF. Cross sectional study on pediatric patients diagnosed as DHF at Saiful Anwar Malang Hospital was done in July-December 2016. CRP levels were examined using immunoturbidimetry method, while albumin was examined by using Bromocresol Green (BCG) method. Correlation of CRP/albumin ratio with DHF severity was analyzed by using Pearson correlation test.The result showed that there were signi fi cant diff erences in CRP levels and CRP/albumin ratios in the Dengue Shock Syndrome (DSS) and non-DSS group (p = 0.002, p = 0.001, α<0.05). There was no signi fi cant diff erence in albumin level in the same group (p = 0.207, α <0.05). Positive correlation found in CRP and CRP/albumin ratio (r = 0.46, r = 0.49, α <0.01). On the contrary the negative correlation was found in albumin (r = -0.21, α <0.01). This is presumably because albumin is an acute phase protein which will decrease along with the severity of infection. In contrast, CRP will increase during the critical phase of infection. It can be concluded that the CRP/albumin ratio was positively correlated with DHF severity, as well as CRP levels, but not positively correlatedwith albumin. 

scholarly journals Prognosis factors for dengue shock syndrome in children

2021 ◽  
Vol 6 (1) ◽  
pp. 033-037
Author(s):  
Ningrum Eka Fitri Sari
Keyword(s):  
Multivariate Analysis ◽  
Prognostic Factors ◽  
Gastrointestinal Bleeding ◽  
Liver Enzymes ◽  
Dengue Infection ◽  
Clinical Manifestations ◽  
Dengue Shock Syndrome ◽  
World Health ◽  
Who Guidelines ◽  
Elevated Liver Enzymes

Background: Varied clinical manifestations, complex pathogenesis, and different viral serotypes make it difficult to predict the course of dengue disease. Many studies have been conducted on the prognostic factors for the occurrence of dengue shock syndrome (SSD), but all use the 2017 World Health Organization (WHO) guidelines.  Aim: This study aims to determine the prognostic factors for the occurrence of SSD based on WHO guidelines in 2011.  Method: Retrospective study using medical record data of pediatric patients aged 0 to <18 years with a diagnosis of dengue fever dengue (DHF), SSD, and expanded dengue syndrome (EDS) that meet WHO criteria in 2011 at the reputable database from 2017 to December 2020. Independent variables, namely gender, age, nutritional status, secondary dengue infection, leukopenia, abdominal pain, gastrointestinal bleeding, hepatomegaly, and plasma leakage. Shock is the dependent variable. Multivariate analysis using logistic regression analysis.  Results: Subjects who met the study criteria were 145 patients, 52 (35.8%) of whom had SSD. Five of 52 SSD patients went into shock during hospitalization. The bivariate analysis yielded significant factors including, malnutrition, overnutrition and obesity, gastrointestinal bleeding, hemoconcentration, ascites, leukocytes 5,000 mm 3, encephalopathy, enzyme elevation heart, and overload. The results of multivariate analysis showed that hemoconcentration variables and elevated liver enzymes were factors of SSD Prognosis.  Conclusion: Hemoconcentration and elevated liver enzymes are prognostic factors for SSD. 

Comparative Study of Gene Expression Profiling Unravels Functions Associated with Pathogenesis of Dengue Infection

2020 ◽  
Vol 26 (41) ◽  
pp. 5293-5299
Author(s):  
Mohiuddin K. Warsi ◽  
Mohammad A. Kamal ◽  
Mohammed N. Baeshen ◽  
Mohammad A. Izhari ◽  
Ahmad Firoz ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gene Expression Profiling ◽  
Dengue Hemorrhagic Fever ◽  
Expression Profiling ◽  
Dengue Infection ◽  
Gene Expression Pattern ◽  
Dengue Shock Syndrome ◽  
Hemorrhagic Fever ◽  
Critical Pathways ◽  
Temporal Gene Expression

Background: Dengue virus is a potential source of propagating dengue hemorrhagic fever. This virus leads to dengue hemorrhagic fever/dengue shock syndrome, benign syndrome, and severe syndrome and due to its infection, there occurs alterations at multiple levels such as gene expression and pathway levels. So, it is critical to understand the pathogenesis of dengue infection in terms of gene expression and the associated functions. Methods: For this purpose, here, we have analyzed the temporal gene expression profiling for the dengue hemorrhagic fever dataset at 12, 24, and 48 hours. Results: The outcome appears that the dengue hemorrhagic fever evolves differently at different time periods or stages. Counclusions: The change in the gene expression pattern increases exponentially from 12 hours to 48 hours and the number of altered functions (pathways) also increases. Wnt, apoptosis, and transcription signaling are among the critical pathways which are dominantly altered. In the initial phase (first 12 hours), only two pathways are altered due to dengue infection, while in the next 12 hours, eight pathways are altered, and finally, in the next 24 hours, 11 pathways are altered and most of these 11 pathways are very critical in terms of biological pathways and functions.

scholarly journals Spontaneous muscle hematoma complicating dengue hemorrhagic fever: a case report

2019 ◽  
Vol 10 (1) ◽  
pp. 76-77
Author(s):  
Hasna Fahmima Haque ◽  
AKM Shaheen Ahmed ◽  
Fuad Bin Bashar ◽  
Rizwana Anjum
Keyword(s):  
Dengue Hemorrhagic Fever ◽  
Wide Spectrum ◽  
Clinical Manifestations ◽  
Hemorrhagic Fever ◽  
Recovery Phase ◽  
Computed Tomography Scan ◽  
Plasma Leakage ◽  
Tomography Scan ◽  
Mild Fever ◽  
Iliacus Muscle

Dengue is endemic in Bangladesh and is an emerging infection in many parts of the world. Its clinical manifestations are wide spectrum, may present as mild fever to shock. Muscle hematomas are rare complications in dengue hemorrhagic fever. We report a case of 21-year-old male with dengue hemorrhagic fever who developed right sided iliacus muscle hematoma. He presented with fever, progressive thrombocytopenia and evidence of plasma leakage. During the recovery phase, he developed severe pain in right hip during movement. Diagnosis was confirmed by pelvic computed-tomography scan and he was managed conservatively. Birdem Med J 2020; 10(1): 76-77

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