Guidelines change the diagnostic process of cow milk food allergy

2012 ◽  
Vol 12 (5) ◽  
pp. 564-569 ◽  
Author(s):  
Amal Assa’ad ◽  
Alessandro Fiocchi
Keyword(s):  
Food Allergy ◽  
Cow Milk ◽  
Diagnostic Process

scholarly journals RECURRENT APHTHOUS STOMATITIS RELATED TO PSYCHOLOGICAL STRESS, FOOD ALLERGY AND GERD

2019 ◽  
Vol 6 ◽  
pp. 45
Author(s):  
Rina Kartika Sari ◽  
Diah Savitri Ernawati ◽  
Bagus Soebadi
Keyword(s):  
Food Allergy ◽  
Psychological Stress ◽  
Oral Mucosa ◽  
Recurrent Aphthous Stomatitis ◽  
Predisposing Factors ◽  
Aphthous Stomatitis ◽  
Cow Milk ◽  
Esophageal Mucosa ◽  
History Of ◽  
Multiple Ulcers

Background: Recurrent Aphthous Stomatitis (RAS) is inflammation in oral mucosa characterized by recurrent single or multiple ulcers that usually affected in non keratinized mucosa. Etiology RAS is unknown but psychological stress, allergy, and gastrointestinal disease can be predisposing factors Case Management: A 23rd years old complained recurrent oral ulcer with free ulcer period for 3-5 days. The patient had a history of food allergy, GERD and psychological stress. Intraoral examination showed recurrent multiple ulcers in variation site of the mouth. DASS 42 screening showed high stress and high anxiety. Skin Prick Test showed positive allergy to kapok, beef, chicken, cow milk, white egg, duck egg, shrimp, cob fish, milkfish, chocolate, and peanut. Ulcers treated with nonsteroid antiinflammation Aloe Vera gel and stress management by reading assignment method.Discussion: Psychological stress altered the immune system so oral mucosa prone to inflammation, and make the history of GERD getting worse. Stress causes cortisol secretion that changes the imbalance of proinflammatory and antiinflammatory cytokines. Oral mucosa becomes more susceptible to hypersensitivity. In addition, stress decreased oral and esophageal mucosa resistance to GERDConclusion: RAS triggered by psychological stress, allergy, and GERD. Treatment of RAS is by elimination predisposing factors to prevent recurrence.

scholarly journals Prevalence, Risk Factors, Clinical Manifestation, Diagnosis Aspects and Nutrition Therapy in Relation to both IgE and IgG Cow’s Milk Protein Allergies among a Population of Saudi Arabia: A Literature Review

2021 ◽  
Vol 9 (2) ◽  
pp. 375-389
Author(s):  
Mashail A Baghlaf ◽  
Noura M S Eid
Keyword(s):  
Risk Factors ◽  
Saudi Arabia ◽  
Food Allergy ◽  
Clinical Manifestation ◽  
Milk Protein ◽  
Immunoglobulin E ◽  
Cow Milk ◽  
Cow’S Milk ◽  
Cow's Milk ◽  
Cow’S Milk Protein

Cow milk protein allergy (CMPA) becoming a major public health issue that has attracted the attention of health professionals and researchers. This paper aimed to review the important aspects of both IgE and IgG types of cow’s milk protein allergy in terms of prevalence, clinical manifestation, risk factors, other health-related issues and nutritional therapy proposed for such allergies in the adult and pediatric population in Saudi Arabia. A search on “cow’s milk allergy” was done using PubMed, Google Scholar and Scopus Engine for published papers between 1993 and 2020 to find studies yielding knowledge on that context. The prevalence of cow’s milk protein allergy (CMPA) among infants is now in the range of 2–3%. This type of allergy is also detected in adulthood but less frequently. CMPA is defined as an immunological reaction to specific proteins in milk. CMPA is classified based on its type as an immunoglobulin E (IgE)-mediated form and an immunoglobulin G (IgG)-mediated form, each type representing different immunological pathways. The presence of Genetic aspects, family history and short duration of breastfeeding in the infant are among the risk factors contributing to this form of allergy. Its manifestations mainly present as skin presentation, followed by the gastrointestinal and respiratory presentation in most cases in addition to a life-threatening anaphylactic reaction that may occur in 12% of cases. food allergy committees have developed strict diagnosis criteria, including blood testing for food-specific immunoglobulin E (sIgE), a skin prick test and double-blind placebo-controlled food challenges (DBPCFC) as the gold standard. A diet free of cow’s milk protein (CMP) allergen and including the appropriate alternative milk formula is the first line of prevention recommended by many organizations and food allergy experts. As for Saudi Arabia, more research and clinical trials are required to discuss the various aspects of adult and pediatric CMPA and to provide a better understanding along with good control strategies implementation.

scholarly journals Diagnosis of Feline Food Sensitivity and Intolerance Using Saliva: 1000 Cases

Animals ◽  
2019 ◽  
Vol 9 (8) ◽  
pp. 534
Author(s):  
W. Jean Dodds
Keyword(s):  
Food Allergy ◽  
Cow Milk ◽  
Clinical Samples ◽  
The Novel ◽  
White Potato ◽  
Skin Patch ◽  
Food Sensitivity ◽  
Collection Tube ◽  
Saliva Collection ◽  
Food Elimination

This prospective study assessed the efficacy of a novel saliva-based immunoassay of IgA- and IgM-antibodies in predicting feline food sensitivities and intolerances. Clinical samples were obtained from 1000 cats proven or suspected to have food intolerances. Most were of domestic shorthair breed type, over 10 years of age, and weighed around 5 kg; they were equally distributed between spayed females and neutered males. Saliva was collected after at least an 8-h fast with a dental cotton rope, placed in a double-sleeved saliva collection tube, and sent to the laboratory. Salivary antibodies elicited by 24 common foods were measured with goat anti-canine IgA and IgM. Low reacting foods were lamb, cow milk, pork, turkey, wheat (lowest) and white-colored fish, whereas high reacting foods were millet, white potato, rice (highest) and salmon. Thus, the novel salivary-based food sensitivity and intolerance test, described previously for canines, also provided a reliable and clinically predictive alternative to food elimination trials, serum-based food allergy testing, and skin patch testing in cats. Manufacturers of commercial cat foods and treats, as well as those making homemade diets and treats for cats, should consider avoiding the more highly reactive foods as determined by the present study.

scholarly journals Strategies and Future Opportunities for the Prevention, Diagnosis, and Management of Cow Milk Allergy

2021 ◽  
Vol 12 ◽  
Author(s):  
Benjamin Zepeda-Ortega ◽  
Anne Goh ◽  
Paraskevi Xepapadaki ◽  
Aline Sprikkelman ◽  
Nicolaos Nicolaou ◽  
...  
Keyword(s):  
Food Allergy ◽  
Primary Prevention ◽  
Oral Tolerance ◽  
Economic Benefits ◽  
Cow Milk ◽  
Allergy Prevention ◽  
Milk Allergy ◽  
Breastfed Infants ◽  
Cow Milk Allergy ◽  
History Of

The prevalence of food allergy has increased over the last 20-30 years, including cow milk allergy (CMA) which is one of the most common causes of infant food allergy. International allergy experts met in 2019 to discuss broad topics in allergy prevention and management of CMA including current challenges and future opportunities. The highlights of the meeting combined with recently published developments are presented here. Primary prevention of CMA should start from pre-pregnancy with a focus on a healthy lifestyle and food diversity to ensure adequate transfer of inhibitory IgG- allergen immune complexes across the placenta especially in mothers with a history of allergic diseases and planned c-section delivery. For non-breastfed infants, there is controversy about the preventive role of partially hydrolyzed formulae (pHF) despite some evidence of health economic benefits among those with a family history of allergy. Clinical management of CMA consists of secondary prevention with a focus on the development of early oral tolerance. The use of extensive Hydrolysate Formulae (eHF) is the nutrition of choice for the majority of non-breastfed infants with CMA; potentially with pre-, probiotics and LCPUFA to support early oral tolerance induction. Future opportunities are, among others, pre- and probiotics supplementation for mothers and high-risk infants for the primary prevention of CMA. A controlled prospective study implementing a step-down milk formulae ladder with various degrees of hydrolysate is proposed for food challenges and early development of oral tolerance. This provides a more precise gradation of milk protein exposure than those currently recommended.

scholarly journals Demodex gatoi infestation in British Shorthair cat treated chronically with immunosuppressive drugs

2017 ◽  
Vol 73 (4) ◽  
pp. 248-251
Author(s):  
Dawid Jańczak ◽  
Elżbieta Gołąb ◽  
Dominika Borkowska-Bąkała ◽  
Karolina Barszcz
Keyword(s):  
Food Allergy ◽  
Immunosuppressive Therapy ◽  
Young Male ◽  
Skin Layer ◽  
Immunosuppressive Drugs ◽  
Hair Follicles ◽  
Diagnostic Process ◽  
The World

To date, only a few cases of Demodex gatoi demodecosis have been reported around the world. D. gatoi is a species of mites that infest cats. The mite is much smaller than D. cati and inhabits the superficial keratin skin layer rather than hair follicles. We describe D. gatoi infestation in a young male British Shorthair cat with pruritic dermatosis treated chronically with immunosuppressive drugs for food allergy. In this report we present the diagnostic process and problems associated with the treatment of D. gatoi infestation in a cat undergoing immunosuppressive therapy

scholarly journals CLINICAL AND LABORATORY ASPECTS OF DETECTING SPECIFIC IgE ANTIBODIES TO COW’S MILK AND ITS COMPONENTS

2019 ◽  
Vol 21 (5) ◽  
pp. 937-944
Author(s):  
N. A. Alkhutova ◽  
N. A. Kovyazina ◽  
O. L. Zhizhina
Keyword(s):  
Food Allergy ◽  
Clinical Signs ◽  
Specific Ige ◽  
Infants And Children ◽  
Cow Milk ◽  
School Age ◽  
Milk Allergy ◽  
Ige Antibodies ◽  
Specific Ige Antibodies ◽  
Antibody Levels

Food allergy against cow milk and its components is highly prevalent among infants and children of pre-school and young school age being a sufficient factor influencing health condition of children during the maturation period. Clinical signs of the milk allergy are non-specific, and they may be pronounced or expressed in mild form, thus enabling hypodiagnistics of this disorder. Moreover, a variety of milk antigens determines different clinical course of this allergic condition and brings additional difficulties to its diagnostics and treatment. Meanwhile, a sensibilization for the cow milk proteins may sometimes trigger a generalized atopy and bronchial asthma, being a factor delayed growth and other health disorders. At the present time, there are no distinct risk criteria for milk allergy. Therefore, its successful prophylaxis and treatment largely depends on the competence of clinical allergologist and informativity of the diagnostic techniques used. So far, however, we have no generally approved laboratory algorithms for diagnostics and monitoring of treatment efficiency in the cow milk allergy and its compomemts.We have performed a laboratory study of 187 children at the age of 3 months to 10 years. An immunochemoluminescent assay of specific IgE antibody levels to the cow milk using IMMULITE 2000/XPi analyzer has revealed its good informative value at different approaches to prediction and evaluation of food allergy treatment, both oriented for a critical cutoff value of 3 МU/L, and by monitoring a decrease in antibody levels. The authors consider rational an extended indefinity principle during the patient-oriented interpretation of IgE assay results if clinical decision is based on critical value of the index. In cases of clinical monitoring, the limit of interim reproducibility should be taken into account. The prevalence of specific cow milk antibodies among the boys was higher than among girls, however, with lesser frequency of moderate/high reactivity among the males. Moreover. the cases were detected with higher levels of anti-beta-lactalbumin IgG than those against whole milk. This finding should be considered during the screening studies.On the basis of literature analysis and own results, the authors propose an extensive study of specific IgE antibodies against cow milk and its components in blood serum of infants and children form the pre-school and junior school age groups. 

scholarly journals Growth Parameters Impairment in Patients with Food Allergies

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Larissa Carvalho Costa ◽  
Erica Rodrigues Rezende ◽  
Gesmar Rodrigues Silva Segundo
Keyword(s):  
Food Allergy ◽  
Growth Parameters ◽  
Early Recognition ◽  
Cow Milk ◽  
Food Allergies ◽  
Common Disease ◽  
Lower Growth ◽  
Tertiary Centre ◽  
Allergy And Immunology ◽  
Food Allergy Diagnosis

Background and Aims. Food allergy (FA) is a common disease that is rapidly increasing in prevalence for reasons that remain unknown. Objective. The aim of this study was to analyze the clinical characteristics and anthropometric data of patients with food allergies followed in a tertiary centre of allergy and immunology. Methods. A retrospective study was performed that assessed the data records of patients with food allergy diagnosis, covering a period from February 2009 to February 2012. Results. 354 patients were evaluated in the period; 228 (69.1%) patients had a confirmed FA diagnosis. The z-scores for weight-for-age, height-for-age, and body mass indices-for-age showed lower significant values in the FA group compared with the non-FA group by Mann-Whitney test, with significance values of P=0.0005, P=0.0030, and P=0.0066, respectively. There were no statistical differences in sex, gestational age, birth type, breastfeeding period, and age of introduction of complementary formulas based on cow milk protein between groups. Conclusion. FA patients had a lower growth rate in comparison with patients without FA. The early recognition of food allergies with the establishment of protein-implicated diet exclusion, in association with an adequate nutrient replenishment, is important to reduce the nutritional impact of food allergies.

scholarly journals The estimation of efficiency of diet therapy in atopic dermatitis and food allergy in children

2012 ◽  
Vol 9 (4) ◽  
pp. 72-78
Author(s):  
V A Revyakina ◽  
K G Sharapova ◽  
E YU Berezina ◽  
T B Sentsova ◽  
O YU Monosova ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Food Allergy ◽  
Milk Protein ◽  
Goat Milk ◽  
Serum Levels ◽  
Diet Therapy ◽  
Cow Milk ◽  
Milk Formula ◽  
Igg Antibodies ◽  
Positive Skin

Background. Clinical and immunological estimation of efficiency of different special formulas in children with atopic dermatitis due to food allergy. Methods. Fifty four children with atopic dermatitis aged 0,5—3 years old were examined. Children were divided into three groups on the base of their diet therapy. The 1 st group included 15 patients on the hypoallergenic milk-free diet, the 2 nd group (18 patients) was fed by goat milk formula, and the 3 rd group (21 children) was fed by special formula with high hydrolyzed protein. The dynamics of serum levels of IgE and IgG antibodies to cow milk protein and its fractions, and dynamics of cytokine levels (IL-4, IL-5, and IL-10) were measured during different types of diet therapy. Results. The positive skin changes during diet therapy included decrease of erythema, exudation and itching, gradual regression of rash. In 3 months of therapy complete clinical remission was achieved in 10 (66,7%) children in the 1 st group, in 14 (77,8%) children in the 2 nd group and in 15 (71,7%) children in the 3 rd group. The significant decrease of levels of IgG antibodies levels to cow milk protein and its fractions in children during different elimination diets was determined. The significant decrease of levels of specific IgE antibodies to cow milk protein (p

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