CUL5-mediated Visfatin (NAMPT) degradation blocks endothelial proliferation and angiogenesis via the MAPK/PI3K-AKT signaling

Journal of Cardiovascular Pharmacology ◽

10.1097/fjc.0000000000001146 ◽

2021 ◽

Vol Publish Ahead of Print ◽

Author(s):

Zanhua Shi ◽

Jiamei Yao ◽

Xinhua Ma ◽

Daomiao Xu ◽

Guangfeng Ming

Keyword(s):

Akt Signaling ◽

Endothelial Proliferation

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Ionizing Radiation Enhances Matrix Metalloproteinase-2 Secretion and Invasion of Glioma Cells through Src/Epidermal Growth Factor Receptor-Mediated p38/Akt and Phosphatidylinositol 3-Kinase/Akt Signaling Pathways

Yearbook of Pathology and Laboratory Medicine ◽

10.1016/s1077-9108(08)70678-9 ◽

2008 ◽

Vol 2008 ◽

pp. 231-233

Author(s):

C. Horbinski

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Matrix Metalloproteinase ◽

Growth Factor Receptor ◽

Glioma Cells ◽

Akt Signaling ◽

Matrix Metalloproteinase 2 ◽

Phosphatidylinositol 3 Kinase ◽

Epidermal Growth

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Faculty Opinions recommendation of Human chorionic gonadotropin stimulates trophoblast invasion through extracellularly regulated kinase and AKT signaling.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1115242.571244 ◽

2008 ◽

Author(s):

John Aplin

Keyword(s):

Chorionic Gonadotropin ◽

Human Chorionic Gonadotropin ◽

Akt Signaling ◽

Trophoblast Invasion

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Faculty Opinions recommendation of Monocyte activation state regulates monocyte-induced endothelial proliferation through Met signaling.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.3022956.2761056 ◽

2010 ◽

Author(s):

Suzanne Crowe ◽

Anthony Jaworowski

Keyword(s):

Monocyte Activation ◽

Endothelial Proliferation

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Faculty Opinions recommendation of Rpn10 promotes tumor progression by regulating hypoxia-inducible factor 1 alpha through the PTEN/Akt signaling pathway in hepatocellular carcinoma.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.734911165.793580826 ◽

2020 ◽

Author(s):

Leonardo Salmena

Keyword(s):

Hepatocellular Carcinoma ◽

Tumor Progression ◽

Signaling Pathway ◽

Hypoxia Inducible Factor ◽

Akt Signaling ◽

Akt Signaling Pathway ◽

Hypoxia Inducible Factor 1

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Faculty Opinions recommendation of Loss of PDZK1 expression activates PI3K/AKT signaling via PTEN phosphorylation in gastric cancer.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.735438256.793580821 ◽

2020 ◽

Author(s):

Leonardo Salmena

Keyword(s):

Gastric Cancer ◽

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Effects of deguelin on proliferation and apoptosis of MCF-7 breast cancer cells by phosphatidylinositol 3-kinase/Akt signaling pathway

Journal of Chinese Integrative Medicine ◽

10.3736/jcim20110511 ◽

2011 ◽

Vol 9 (5) ◽

pp. 533-538 ◽

Author(s):

ZH Chu

Keyword(s):

Breast Cancer ◽

Cancer Cells ◽

Signaling Pathway ◽

Breast Cancer Cells ◽

Akt Signaling ◽

Akt Signaling Pathway ◽

Phosphatidylinositol 3 Kinase ◽

Proliferation And Apoptosis ◽

Mcf 7 ◽

Phosphatidylinositol 3

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Breast Cancer Chemoresistance Mechanisms Through PI 3-Kinase and Akt Signaling

10.21236/ada608893 ◽

2014 ◽

Author(s):

Alex Toker ◽

Kristin Brown

Keyword(s):

Breast Cancer ◽

Akt Signaling ◽

Cancer Chemoresistance

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Carbamylated Erythropoietin Regulates Immune Responses and Promotes Long-Term Kidney Allograft Survival Through Activation of PI3K/AKT Signaling

SSRN Electronic Journal ◽

10.2139/ssrn.3441801 ◽

2019 ◽

Author(s):

Ning Na ◽

Daqiang Zhao ◽

Jinhua Zhang ◽

Shicong Yang ◽

Dielai Xie ◽

...

Keyword(s):

Immune Responses ◽

Akt Signaling ◽

Allograft Survival ◽

Kidney Allograft ◽

Carbamylated Erythropoietin

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Ceramide-Enriched Membrane Domains Contribute to Targeted and Nontargeted Effects of Radiation Through Modulation of PI3K/AKT Signaling in HNSCC Cells

SSRN Electronic Journal ◽

10.2139/ssrn.3571515 ◽

2020 ◽

Author(s):

Riad Ladjohounlou ◽

Safa Louati ◽

Alexandra Lauret ◽

Arnaud Gauthier ◽

Dominique Ardail ◽

...

Keyword(s):

Akt Signaling ◽

Membrane Domains ◽

Effects Of Radiation

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Role of Regulatory Oncogenic or Tumor Suppressor miRNAs of PI3K/AKT Signaling Axis in the Pathogenesis of Colorectal Cancer

Current Pharmaceutical Design ◽

10.2174/1381612825666190110151957 ◽

2019 ◽

Vol 24 (39) ◽

pp. 4605-4610 ◽

Author(s):

Atena Soleimani ◽

Farzad Rahmani ◽

Gordon A. Ferns ◽

Mikhail Ryzhikov ◽

Amir Avan ◽

...

Keyword(s):

Colorectal Cancer ◽

Tumor Suppressor ◽

Current Knowledge ◽

Akt Signaling ◽

Tumor Tissues ◽

Radio Therapy ◽

Signaling Axis ◽

Cancer Tumor ◽

Novel Biomarkers

Colorectal cancer (CRC) is the leading cause of cancer death worldwide and its incidence is increasing. In most patients with CRC, the PI3K/AKT signaling axis is over-activated. Regulatory oncogenic or tumor suppressor microRNAs (miRNAs) for PI3K/AKT signaling regulate cell proliferation, migration, invasion, angiogenesis, as well as resistance to chemo-/radio-therapy in colorectal cancer tumor tissues. Thus, regulatory miRNAs of PI3K/AKT/mTOR signaling represent novel biomarkers for new patient diagnosis and obtaining clinically invaluable information from post-treatment CRC patients for improving therapeutic strategies. This review summarizes the current knowledge of miRNAs’ regulatory roles of PI3K/AKT signaling in CRC pathogenesis.

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