Breast Cancer Chemoresistance Mechanisms Through PI 3-Kinase and Akt Signaling

2014 ◽  
Author(s):  
Alex Toker ◽  
Kristin Brown
Keyword(s):  
Breast Cancer ◽  
Akt Signaling ◽  
Cancer Chemoresistance

scholarly journals A nuclear lncRNA Linc00839 as a Myc target to promote breast cancer chemoresistance via PI3K/AKT signaling pathway

2020 ◽  
Vol 111 (9) ◽  
pp. 3279-3291 ◽  
Author(s):  
Qi Chen ◽  
Huiling Shen ◽  
Xiaolan Zhu ◽  
Yueqin Liu ◽  
Hui Yang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Signaling Pathway ◽  
Akt Signaling ◽  
Akt Signaling Pathway ◽  
Cancer Chemoresistance ◽  
Promote Breast Cancer

Breast Cancer Chemoresistance Mechanisms Through PI 3-Kinase and Akt Signaling

2013 ◽  
Author(s):  
Alex Toker ◽  
Kristin Brown
Keyword(s):  
Breast Cancer ◽  
Akt Signaling ◽  
Cancer Chemoresistance

scholarly journals INPP4B promotes PI3Kα-dependent late endosome formation and Wnt/β-catenin signaling in breast cancer

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Samuel J. Rodgers ◽  
Lisa M. Ooms ◽  
Viola M. J. Oorschot ◽  
Ralf B. Schittenhelm ◽  
Elizabeth V. Nguyen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Growth ◽  
Breast Cancer Cells ◽  
Triple Negative ◽  
Akt Signaling ◽  
Late Endosome ◽  
Breast Cancers ◽  
Lysosomal Degradation ◽  
Late Endosomes ◽  
Mrna And Protein Expression

AbstractINPP4B suppresses PI3K/AKT signaling by converting PI(3,4)P2 to PI(3)P and INPP4B inactivation is common in triple-negative breast cancer. Paradoxically, INPP4B is also a reported oncogene in other cancers. How these opposing INPP4B roles relate to PI3K regulation is unclear. We report PIK3CA-mutant ER+ breast cancers exhibit increased INPP4B mRNA and protein expression and INPP4B increased the proliferation and tumor growth of PIK3CA-mutant ER+ breast cancer cells, despite suppression of AKT signaling. We used integrated proteomics, transcriptomics and imaging to demonstrate INPP4B localized to late endosomes via interaction with Rab7, which increased endosomal PI3Kα-dependent PI(3,4)P2 to PI(3)P conversion, late endosome/lysosome number and cargo trafficking, resulting in enhanced GSK3β lysosomal degradation and activation of Wnt/β-catenin signaling. Mechanistically, Wnt inhibition or depletion of the PI(3)P-effector, Hrs, reduced INPP4B-mediated cell proliferation and tumor growth. Therefore, INPP4B facilitates PI3Kα crosstalk with Wnt signaling in ER+ breast cancer via PI(3,4)P2 to PI(3)P conversion on late endosomes, suggesting these tumors may be targeted with combined PI3K and Wnt/β-catenin therapies.

The phosphatidyl inositol 3-kinase/AKT signaling pathway in breast cancer

2010 ◽  
Vol 29 (4) ◽  
pp. 751-759 ◽  
Author(s):  
Carlos A. Castaneda ◽  
Hernán Cortes-Funes ◽  
Henry L. Gomez ◽  
Eva M. Ciruelos
Keyword(s):  
Breast Cancer ◽  
Signaling Pathway ◽  
Phosphatidyl Inositol ◽  
Akt Signaling ◽  
Akt Signaling Pathway

scholarly journals PIK3R1 targeting by miR-21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT, and predicts clinical outcome of breast cancer

2015 ◽  
Vol 48 (2) ◽  
pp. 471-484 ◽  
Author(s):  
LI-XU YAN ◽  
YAN-HUI LIU ◽  
JIAN-WEN XIANG ◽  
QI-NIAN WU ◽  
LEI-BO XU ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Migration ◽  
Clinical Outcome ◽  
Tumor Cell ◽  
Akt Signaling ◽  
Migration And Invasion ◽  
Cell Migration And Invasion ◽  
Tumor Cell Migration

scholarly journals The lipid metabolism gene FTO influences breast cancer cell energy metabolism via the PI3K/AKT signaling pathway

2017 ◽  
Vol 13 (6) ◽  
pp. 4685-4690 ◽  
Author(s):  
Yazhuo Liu ◽  
Ruoyu Wang ◽  
Lichuan Zhang ◽  
Jianhua Li ◽  
Keli Lou ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lipid Metabolism ◽  
Energy Metabolism ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Akt Signaling ◽  
Akt Signaling Pathway ◽  
Cell Energy ◽  
Lipid Metabolism Gene ◽  
Metabolism Gene

scholarly journals Protein Phosphatase 1 Regulatory Subunit SDS22 Inhibits Breast Cancer Cell Tumorigenesis by Functioning as a Negative Regulator of the AKT Signaling Pathway

Neoplasia ◽  
2019 ◽  
Vol 21 (1) ◽  
pp. 30-40 ◽  
Author(s):  
Debasish Paul ◽  
Anil Bapu Bargale ◽  
Srikanth Rapole ◽  
Praveen Kumar Shetty ◽  
Manas Kumar Santra
Keyword(s):  
Breast Cancer ◽  
Signaling Pathway ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Protein Phosphatase ◽  
Akt Signaling ◽  
Negative Regulator ◽  
Protein Phosphatase 1 ◽  
Regulatory Subunit ◽  
Akt Signaling Pathway
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