Family history of premature myocardial infarction modifies the associations between bilateral oophorectomy and cardiovascular disease mortality in a US national cohort of postmenopausal women

Menopause ◽  
2020 ◽  
Vol 27 (6) ◽  
pp. 658-667 ◽  
Author(s):  
Duke Appiah ◽  
Chike C. Nwabuo ◽  
Damilola R. Owoade ◽  
Jaffer Samad ◽  
Imo Ebong ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Cardiovascular Disease ◽  
Family History ◽  
Postmenopausal Women ◽  
Bilateral Oophorectomy ◽  
Cardiovascular Disease Mortality ◽  
Disease Mortality ◽  
National Cohort ◽  
History Of ◽  
Premature Myocardial Infarction

scholarly journals Androgens, Bilateral Oophorectomy, and Cardiovascular Disease Mortality in Postmenopausal Women With and Without Diabetes: The Study of Osteoporotic Fractures

Diabetes Care ◽  
2015 ◽  
Vol 38 (12) ◽  
pp. 2301-2307 ◽  
Author(s):  
Duke Appiah ◽  
Stephen J. Winters ◽  
Susan B. Muldoon ◽  
Carlton A. Hornung ◽  
Jane A. Cauley
Keyword(s):  
Cardiovascular Disease ◽  
Postmenopausal Women ◽  
Osteoporotic Fractures ◽  
Bilateral Oophorectomy ◽  
Cardiovascular Disease Mortality ◽  
Disease Mortality

Apolipoprotein E genotypes in offspring with a positive and negative family history of premature myocardial infarction

2008 ◽  
Vol 53 (5) ◽  
pp. 387-390 ◽  
Author(s):  
Katarina Rašlová ◽  
Božena Smolková ◽  
Branislav Vohnout ◽  
Branislav Schifferdecker ◽  
Rudolf Poledne ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Family History ◽  
Apolipoprotein E ◽  
Negative Family History ◽  
Apolipoprotein E Genotypes ◽  
History Of ◽  
Premature Myocardial Infarction

scholarly journals The Risk Factors of Premature Myocardial Infarction: A Case Control Study in Iran

2016 ◽  
Vol 8 (11) ◽  
pp. 69 ◽  
Author(s):  
Mehdi Ehtesham ◽  
Ali Akbar Haghdoost ◽  
Seyed Vahid Ahmadi Tabatabaei ◽  
Hooman Bakhshandeh
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Family History ◽  
Case Control Study ◽  
Vascular Diseases ◽  
Current Smoking ◽  
History Of ◽  
Premature Myocardial Infarction ◽  
Cardio Vascular ◽  
Control Study

<p><strong>BACKGROUND:</strong> Although, our knowledge about the factors of cardio vascular diseases (CVD) is relatively acceptable, we have few publications about the risk factors of premature CVD particularly from developing countries such as Iran.</p><p><strong>OBJECTIVES:</strong> The present study is aimed to assess the risk of the modifiable risk factors of coronary heart disease (CHD) in the first cardiac attack of patients classified by age to check which risk factors might have a more significant impact to increase the risk of premature myocardial infarction (MI).</p><p><strong>METHODS:</strong> In a case control study, 122 and 266 cases and controls were recruited from one of the main referral centres in Tehran. Cases were those who were hospitalized because of their first myocardial infarction before the ages of 50 and 55 years in males and females respectively, and compared their risk factor profiles with those experienced first MI in higher age. Main independent variables in this study were: the demographic variables, distress, lipid profile, diabetes, smoking, family history of cardio vascular diseases, and physical activity.</p><p><strong>RESULTS: </strong>The results showed that distress (OR= 3.95), minorities (compare to Fars race) (OR= 3.30), higher education (OR= 1.30), family history of hyperlipidaemia (OR=1.89) significantly increased the risk of premature MI. We also found that family history of hypertension (OR=1.35), current smoking versus no smoking (OR=1.60), fast-food consumption (OR=1.48), non-alcoholic beverages (OR= 1.12) had also association with the risk of premature MI but only in crude model. We also found that regular physical activity (OR=0.42), ex-smoker versus current smoking (OR=0.27) and regular consumption of milk (OR=0.73) was protective against premature MI.</p><p><strong>CONCLUSION:</strong> Our findings demonstrate that the effect of most of risk factors were mostly related to their life-style (distress, smoking, physical inactivity and dietary pattern); while family history of diseases was also important.</p>

scholarly journals Impaired endothelial glycocalyx predicts adverse outcome in subjects without overt cardiovascular disease: a 6-year follow-up study

2021 ◽  
Vol 42 (Supplement_1) ◽  
Author(s):  
I Ikonomidis ◽  
J Thymis ◽  
P Simitsis ◽  
S Katsanos ◽  
C Triantafyllou ◽  
...  
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Cardiovascular Disease ◽  
Family History ◽  
Adverse Outcome ◽  
Endothelial Glycocalyx ◽  
Lipid Lowering ◽  
C Statistic ◽  
History Of

Abstract Aim Endothelial glycocalyx is involved in the clinical course of atherogenesis. The purpose of this study was to investigate whether disturbance of glycocalyx integrity is related with increased cardiovascular risk. Methods Perfused Boundary Region (PBR), a marker of glycocalyx integrity, was measured non-invasively in sublingual microvessels with a diameter ranging from 5–25 μm using a dedicated camera (Sideview, Darkfield Imaging). Increased PBR indicates reduced glycocalyx thickness. We measured baseline PBR in 400 apparently healthy subjects, without established cardiovascular disease. We prospectively monitored the occurrence of major cardiovascular events (MACE-death, myocardial infarction, stroke and heart failure hospitalization) during a 6-year follow-up period using electronic records and clinic visits. Results Forty-three MACE were documented during follow-up. Subjects with PBR at 5–9 μm microvessel diameter greater than 1.15 μm (mean value of the study cohort) had 2-fold higher risk for MACE than those with lower PBR in a model including sex, age, hyperlipidemia, diabetes, hypertension, current smoking, family history of coronary artery disease and treatment with ACEi/ARBs or lipid lowering agents (hazard ratio (HR): 2.49; 95% CI: 1.23–5.02, p=0.011, net reclassification improvement (NRI): 25%; C-statistic: 0.738). PBR5-9 ≥1.15 was an independent and additive predictor of outcome when added in a model including SCORE, risk factors not included in SCORE (diabetes, family history of CAD) and medication (HR: 2.48 NRI: 23.8%, C-statistic increase from 0.629 to 0.678, for all cardiac events and HR: 4.19, NRI: 33.1%, C-statistic increase from 0.654 to 0.734 for death myocardial infarction and stroke, p&lt;0.01). Conclusion Endothelial glycocalyx integrity is an independent and additive predictor to atherosclerotic risk factors for adverse outcome at 6 years follow-up in individuals without diagnosed cardiovascular disease. FUNDunding Acknowledgement Type of funding sources: None.

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