Metacarpal bone diameter increases constantly in adult females, but escalated resorption of the inner surface at menopause explains the observed decreased bone mineral density at digital X-ray radiogrammetry

Objectives. Early change in rheumatoid arthritis (RA) is characterised by periarticular osteopenia. We investigated the relationship of early metacarpal digital X-ray radiogrammetry bone mineral density (DXR-BMD) change rate (RC-BMD, mg/cm2/month) to longitudinal changes in hand and feet radiographic and wrist MRI scores over 1 year. Materials and Methods. 10 RA patients completed the study and had wrist 3T-MRI and hand and feet X-rays at various time points over 1 year. MRI was scored by RAMRIS, X-ray was done by van der Heijde modified Sharp scoring, and RC-BMD was analysed using dxr-online. Results. There was good correlation amongst the two scorers for MRI measures and ICC for erosions: 0.984, BME: 0.943, and synovitis: 0.657. Strong relationships were observed between RC-BMD at 12-week and 1-year change in wrist marrow oedema (BME) (r=0.78, P=0.035) but not with erosion, synovitis, or radiographic scores. Conclusion. Early RC-BMD correlates with 1-year wrist BME change, which is a known predictor of future erosion and joint damage. However, in our pilot study, early RC-BMD did not show relationships to MRI erosion or radiographic changes over 1 year. This may reflect a slower kinetic in the appearance of MRI/radiographic erosions, generating the hypothesis that RC-BMD may be a more sensitive and early structural prognostic marker in RA follow-up.

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Influence of angulation on metacarpal bone mineral density measurements using digital X-ray radiogrammetry

International Journal of Computer Assisted Radiology and Surgery ◽

10.1007/s11548-014-1076-y ◽

2014 ◽

Vol 10 (5) ◽

pp. 587-592 ◽

Cited By ~ 3

Author(s):

Alexander Pfeil ◽

Diane M. Renz ◽

Rosemarie Fröber ◽

Andreas Hansch ◽

Gabriele Lehmann ◽

...

Keyword(s):

Bone Mineral Density ◽

Bone Mineral ◽

Metacarpal Bone ◽

Mineral Density ◽

Density Measurements ◽

X Ray

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Third metacarpal bone mineral density assessment in the standing horse by dual X-ray absorptiometry

Veterinary and Comparative Orthopaedics and Traumatology ◽

10.1055/s-0038-1632924 ◽

2005 ◽

Vol 18 (01) ◽

pp. 26-30 ◽

Cited By ~ 5

Author(s):

C. Delguste ◽

G. Perona ◽

P. Lebecque ◽

F. Duboeuf ◽

O. Lepage ◽

...

Keyword(s):

Bone Mineral Density ◽

Bone Mineral ◽

Ex Vivo ◽

Metacarpal Bone ◽

Test Accuracy ◽

Mineral Density ◽

X Ray ◽

Highly Correlated ◽

Density Assessment

SummaryBone mineral density (BMD) is correlated to mechanical properties of bone. In the horse, dual energy X-ray absorptiometry (DXA) has yet only been performed ex-vivo, but a new portable DXA device would be ideal for in-vivo BMD measurement. We explored field suitability, precision and accuracy of this device for in-vivo third metacarpal density assessment. Precision was analysed by calculating measurement variation under repeated measurement tests with (reproducibility) and without (repeatability) limb repositioning. Repeatability and reproducibility were tested ex-vivo, at the same time that intra- and inter-operator reproducibility were assessed in-vivo. In order to test accuracy, bone mineral content (BMC) of several bone samples determined by DXA and ashing were compared. Repeatability was 1.47% and reproducibility 1.69% ex-vivo. In-vivo reproducibility varied between 2.91 and 4.06% for intraoperator test and between 3.13 and 5.53% for interoperator test. BMC measured by DXA and ash weight were highly correlated (R2>0.99). In conclusion, under described conditions this DXA device is usable, accurate and precise. Its sensitiveness reaches 8.23% in an individual longitudinal monitoring. Using the third metacarpal bone as an example, we have shown that this device is suitable for experimental or clinical monitoring.

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Reproducibility of Metacarpal Bone Mineral Density Measurements Obtained by Dual-Energy X-Ray Absorptiometry in Healthy Volunteers and Patients With Early Arthritis

Journal of Clinical Densitometry ◽

10.1016/j.jocd.2019.02.006 ◽

2020 ◽

Vol 23 (4) ◽

pp. 678-684 ◽

Cited By ~ 1

Author(s):

Irene Llorente ◽

Leticia Merino ◽

Eugenio Escolano ◽

Dolores Martínez Quintanilla ◽

Jesús A García-Vadillo ◽

...

Keyword(s):

Bone Mineral Density ◽

Healthy Volunteers ◽

Bone Mineral ◽

Dual Energy ◽

Metacarpal Bone ◽

Early Arthritis ◽

Mineral Density ◽

Density Measurements ◽

X Ray

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Bone health index by hand X-ray compared with bone mineral density by dual-energy X-ray absorptiometry in children with Duchenne muscular dystrophy

Bone Abstracts ◽

10.1530/boneabs.7.p91 ◽

2019 ◽

Author(s):

Jonathan J Bowden ◽

Ramkumar Krishnamurthy ◽

Houchun Hu ◽

Brent Adler ◽

Rajesh Krishnamurthy ◽

...

Keyword(s):

Bone Mineral Density ◽

Duchenne Muscular Dystrophy ◽

Muscular Dystrophy ◽

Bone Mineral ◽

Bone Health ◽

Dual Energy ◽

Health Index ◽

Mineral Density ◽

X Ray ◽

Bone Health Index

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Anxiety Levels Predict Bone Mineral Density in Postmenopausal Women Undergoing Oral Bisphosphonates: A Two-Year Follow-Up

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18158144 ◽

2021 ◽

Vol 18 (15) ◽

pp. 8144

Author(s):

Gabriella Martino ◽

Federica Bellone ◽

Carmelo M. Vicario ◽

Agostino Gaudio ◽

Andrea Caputo ◽

...

Keyword(s):

Bone Mineral Density ◽

Bone Mineral ◽

Rating Scale ◽

Osteoporotic Fractures ◽

Oral Bisphosphonates ◽

Mineral Density ◽

X Ray ◽

Hamilton Anxiety Rating Scale ◽

Anxiety Levels

Clinical psychological factors may predict medical diseases. Anxiety level has been associated with osteoporosis, but its role on bone mineral density (BMD) change is still unknown. This study aimed to investigate the association between anxiety levels and both adherence and treatment response to oral bisphosphonates (BPs) in postmenopausal osteoporosis. BMD and anxiety levels were evaluated trough dual-energy X-ray absorptiometry and the Hamilton Anxiety Rating Scale (HAM-A), respectively. Participants received weekly medication with alendronate or risedronate and were grouped according to the HAM-A scores into tertiles (HAM-A 3 > HAM-A 2 > HAM-A 1). After 24 months, BMD changes were different among the HAM-A tertiles. The median lumbar BMD change was significantly greater in both the HAM-A 2 and HAM-A 3 in comparison with the HAM-A 1. The same trend was observed for femoral BMD change. Adherence to BPs was >75% in 68% of patients in the HAM-A 1, 79% of patients in the HAM-A 2, and 89% of patients in the HAM-A 3 (p = 0.0014). After correcting for age, body mass index, depressive symptoms, and the 10-yr. probability of osteoporotic fractures, anxiety levels independently predicted lumbar BMD change (β = 0.3417, SE 0.145, p = 0.02). In conclusion, women with higher anxiety levels reported greater BMD improvement, highlighting that anxiety was associated with adherence and response to osteoporosis medical treatment, although further research on this topic is needed.

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POS0045 LEAST SIGNIFICANT CHANGE IN BONE DENSITOMETRY IN PATIENTS WITH OBESITY

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2021-eular.3819 ◽

2021 ◽

Vol 80 (Suppl 1) ◽

pp. 227.2-228

Author(s):

D. Claire ◽

M. Geoffroy ◽

L. Kanagaratnam ◽

C. Isabelle ◽

A. Hittinger ◽

...

Keyword(s):

Bone Mineral Density ◽

Lumbar Spine ◽

General Population ◽

Bone Mineral ◽

Bone Densitometry ◽

Dual Energy ◽

Mineral Density ◽

Least Significant Change ◽

X Ray ◽

Significant Change

Background:Dual energy X-ray absoprtiometry is the reference method to mesure bone mineral density (1). Loss of bone mineral density is significant if it exceeds the least significant change. The threshold value used in general population is 0,03 g/cm2 (2). Patients with obesity are known for having a higher bone mineral density due to metabolism and physiopathology characteristics (3,4).Objectives:The aim of our study was to determine the least significant change in bone densitometry in patients with obesity.Methods:We conducted an interventionnal study in 120 patients with obesity who performed a bone densitometry. We measured twice the bone mineral density at the lumbar spine, the femoral neck and the total hip in the same time (5,6). We determined the least significant change in bone densitometry from each pair of measurements, using the Bland and Altman method. We also determined the least significant change in bone densitometry according to each stage of obesity.Results:The least significant change in bone densitometry in patients with obesity is 0,046g/cm2 at the lumbar spine, 0.069 g/cm2 at the femoral neck and 0.06 g/cm2 at the total hip.Conclusion:The least significant change in bone densitometry in patients with obesity is higher than in general population. These results may improve DXA interpretation in this specific population, and may personnalize their medical care.References:[1]Lees B, Stevenson JC. An evaluation of dual-energy X-ray absorptiometry and comparison with dual-photon absorptiometry. Osteoporos Int. mai 1992;2(3):146-52.[2]Briot K, Roux C, Thomas T, Blain H, Buchon D, Chapurlat R, et al. Actualisation 2018 des recommandations françaises du traitement de l’ostéoporose post-ménopausique. Rev Rhum. oct 2018;85(5):428-40.[3]Shapses SA, Pop LC, Wang Y. Obesity is a concern for bone health with aging. Nutr Res N Y N. mars 2017;39:1-13.[4]Savvidis C, Tournis S, Dede AD. Obesity and bone metabolism. Hormones. juin 2018;17(2):205-17.[5]Roux C, Garnero P, Thomas T, Sabatier J-P, Orcel P, Audran M, et al. Recommendations for monitoring antiresorptive therapies in postmenopausal osteoporosis. Jt Bone Spine Rev Rhum. janv 2005;72(1):26-31.[6]Ravaud P, Reny JL, Giraudeau B, Porcher R, Dougados M, Roux C. Individual smallest detectable difference in bone mineral density measurements. J Bone Miner Res. août 1999;14(8):1449-56.Disclosure of Interests:None declared.

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