Influence of Body Mass Index on Tumor Pathology and Survival in Uterine Cancer: A Danish Register Study

ObjectiveTo evaluate the influence of body mass index (BMI) on endometrial tumor pathology, stage and complication rate and to identify individual prognostic factors, such as BMI, in types I and II endometrial cancer.DesignRegister study included all Danish women who underwent surgery for uterine cancer or atypical endometrial hyperplasia (International Classification of Diseases-10 codes D070, DC549) 2005 to 2012 (n = 6003).Main Outcome MeasuresImpact of BMI on type I and II endometrial cancer survival.Materials and MethodsDanish Gynecological Cancer Database data on women with type I and II endometrial cancer were retrieved. Kaplan-Meier plot was used to illustrate differences in survival in relation to BMI. Log-rank test was used to demonstrate difference between the curves. Cox regression hazard model was used to estimate hazard ratios (HR) of the effect of BMI on overall survival.ResultsFour thousand three hundred thirty women were included. Women with type I cancer had a significantly better overall survival compared with those with type II cancer. Low BMI was associated with increased mortality in type I (HR, 2.07; 95% confidence interval [CI], 1.20–3.55), whereas in type II both low (HR, 1.68; 95% CI, 1.03–2.74) and high BMI (BMI, 30–35: HR, 1.54; 95% CI, 1.01–2.26 and BMI >40: HR, 2.15; 95% CI, 1.12–4.11) were significantly associated with increased mortality.ConclusionAbnormal BMI is associated with increased mortality in subtypes of endometrial cancer. Underweight was associated with increased overall mortality in both types I and II, whereas obesity only disclosed a significant impact on overall mortality in type II.

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NADPH oxidase 4 expression in the normal endometrium and in endometrial cancer

Tumor Biology ◽

10.1177/1010428319830002 ◽

2019 ◽

Vol 41 (2) ◽

pp. 101042831983000 ◽

Cited By ~ 2

Author(s):

Christine Degasper ◽

Andrea Brunner ◽

Natalie Sampson ◽

Irina Tsibulak ◽

Verena Wieser ◽

...

Keyword(s):

Body Mass Index ◽

Endometrial Cancer ◽

Body Mass ◽

Prognostic Significance ◽

Clinicopathological Parameters ◽

Diabetic Patients ◽

Type I ◽

Prognostic Impact ◽

Normal Endometrium ◽

Nadph Oxidase 4

The aim of this study was to explore the role of NOX4 in the biology of the normal endometrium and endometrial cancer. NOX4 plays a key role in other adenocarcinomas and has been implicated in the pathogenesis of diabetes and obesity, which are important risk factors for endometrial cancer. NOX4 expression was assessed in 239 endometrial cancer and 25 normal endometrium samples by quantitative real-time polymerase chain reaction, in situ hybridization, and immunohistochemistry. DNA methylation of the NOX4 promoter was determined by means of MethyLight PCR. Data were correlated with clinicopathological parameters and analyzed in the context of diabetes and body mass index. In the normal endometrium, NOX4 microRNA expression was significantly higher in the secretory transformed compared with proliferative endometrium ( p = 0.008). In endometrial cancer specimens, NOX4 expression did not differ between diabetic and non-diabetic patients, but was the highest in patients with a body mass index ≤ 26 ( p = 0.037). The lowest NOX4 expression was found in carcinosarcomas ( p = 0.007). High NOX4 expression predicted poorer clinical outcome with regard to overall survival, especially in non-diabetic patients and those with a body mass index > 20. Independent prognostic significance of NOX4 transcripts was retained in type I endometrial cancer and was the most meaningful in patients with a body mass index > 20. No prognostic impact was shown for NOX4 promoter methylation in endometrial cancer. For the first time, we demonstrate that NOX4 plays a considerable role in the cycle-dependent changes in the normal endometrium and in the biology of endometrial cancer.

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Is body mass index a prognostic factor in patients with early-stage type II endometrial cancer?

Gynecologic Oncology ◽

10.1016/j.ygyno.2013.04.242 ◽

2013 ◽

Vol 130 (1) ◽

pp. e76-e77

Author(s):

R. Jalloul ◽

Z. Al-Wahab ◽

M. Alshaikh ◽

T. Buekers ◽

M. Mahan ◽

...

Keyword(s):

Body Mass Index ◽

Endometrial Cancer ◽

Prognostic Factor ◽

Body Mass ◽

Early Stage ◽

Type Ii

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Association of body mass index with ER, PR and 14-3-3σ expression in tumor and stroma of type I and type II endometrial carcinoma

Oncotarget ◽

10.18632/oncotarget.17209 ◽

2017 ◽

Vol 8 (26) ◽

pp. 42548-42559 ◽

Cited By ~ 6

Author(s):

Joseph F. Peevey ◽

Brandon-Luke L. Seagle ◽

Kruti P. Maniar ◽

J. Julie Kim

Keyword(s):

Body Mass Index ◽

Endometrial Carcinoma ◽

Body Mass ◽

Type I ◽

Type Ii

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erbB2Overexpression in Uterine Serous Cancer: A Molecular Target for Trastuzumab Therapy

Obstetrics and Gynecology International ◽

10.1155/2011/128295 ◽

2011 ◽

Vol 2011 ◽

pp. 1-5 ◽

Cited By ~ 8

Author(s):

Karim S. ElSahwi ◽

Alessandro D. Santin

Keyword(s):

Endometrial Cancer ◽

Early Stage ◽

Case Reports ◽

Uterine Cancer ◽

Female Genital Tract ◽

The United States ◽

Type I ◽

Type Ii ◽

Erbb2 Overexpression

Endometrial cancer is the most common female genital tract malignancy in the United States. Type I endometrial cancer is usually diagnosed at an early stage, and has a good prognosis. Type II is very aggressive, and is responsible for most uterine cancer relapses and deaths. Uterine serous adenocarcinomas (USC) constitute the majority of Type II variants. They have a higher propensity for lymph node and distant metastases. They are frequently aneuploid and associated with p53 mutations. erbB2 overexpression in USC has been described. The incidence, which is higher in African Americans, ranges from 18–80%. erbB2 overexpression was found to be associated with higher stage, chemoresistance, and worse survival. Trastuzumab a humanized mAb was approved by the FDA for treatment of breast cancers that overexpress erbB2 in combination with standard chemotherapy. Evidence of trastuzumab activity in USC has been reported in vitro, as well as in case reports of advanced and recurrent cases. Promising results were obtained in these heavily pretreated patients either with trastuzumab alone or in combination with chemotherapy. This supports the hypothesis that trastuzumab may very well be an attractive and viable treatment option for advanced stage USC tumors that overexpress the erbB2, and is worthy of further study.

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Relationship between Emotional Intelligence, Sleep Quality and Body Mass Index in Emergency Nurses

Healthcare ◽

10.3390/healthcare9050607 ◽

2021 ◽

Vol 9 (5) ◽

pp. 607

Author(s):

Noelia Miguez-Torres ◽

Alejandro Martínez-Rodríguez ◽

María Martínez-Olcina ◽

Laura Miralles-Amorós ◽

Cristina Reche-García

Keyword(s):

Body Mass Index ◽

Emotional Intelligence ◽

Sleep Quality ◽

Body Mass ◽

Working Hours ◽

Type I ◽

Emotional States ◽

Emergency Nurses ◽

Cross Sectional ◽

Lack Of Sleep

Nurses have long working hours with high psychological burdens. In addition, in the emergency department, nurses are required to quickly adapt emotionally. The aim of this study was to describe and relate emotional intelligence (EI) skills of emergency nurses, their body mass index (BMI) and sleep quality. For this purpose, a cross-sectional was carried out in which the perceived emotional intelligence test and the Pittsburgh sleep quality index were applied. Sixty-two emergency nurses (48 women and 14 men) participated. The results indicated that the majority of them present adequate levels of EI, with no differences by gender. Younger nurses showed a better ability to feel, express and understand emotional states than the older ones, while the ability to regulate emotional states occurred in the opposite way. Nurses who have been working for several years showed a better ability to regulate emotions than those with less experience. Those who were overweight grade II and obese type I expressed their feelings better, also the regulation of emotional states decreased as weight increased. Finally, it has been observed that the quality of sleep of emergency nurses is significantly altered, and that this lack of sleep may affect their ability to process emotions.

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