scholarly journals Association of body mass index with ER, PR and 14-3-3σ expression in tumor and stroma of type I and type II endometrial carcinoma

Oncotarget ◽  
2017 ◽  
Vol 8 (26) ◽  
pp. 42548-42559 ◽  
Author(s):  
Joseph F. Peevey ◽  
Brandon-Luke L. Seagle ◽  
Kruti P. Maniar ◽  
J. Julie Kim
Keyword(s):  
Body Mass Index ◽  
Endometrial Carcinoma ◽  
Body Mass ◽  
Type I ◽  
Type Ii

Influence of Body Mass Index on Tumor Pathology and Survival in Uterine Cancer: A Danish Register Study

2017 ◽  
Vol 27 (2) ◽  
pp. 281-288 ◽  
Author(s):  
Anne Bjerrum Kristensen ◽  
Helle Hare-Bruun ◽  
Claus Kim Høgdall ◽  
Martin Rudnicki
Keyword(s):  
Body Mass Index ◽  
Overall Survival ◽  
Endometrial Cancer ◽  
Body Mass ◽  
Uterine Cancer ◽  
Register Study ◽  
Type I ◽  
Type Ii ◽  
Tumor Pathology ◽  
Overall Mortality

ObjectiveTo evaluate the influence of body mass index (BMI) on endometrial tumor pathology, stage and complication rate and to identify individual prognostic factors, such as BMI, in types I and II endometrial cancer.DesignRegister study included all Danish women who underwent surgery for uterine cancer or atypical endometrial hyperplasia (International Classification of Diseases-10 codes D070, DC549) 2005 to 2012 (n = 6003).Main Outcome MeasuresImpact of BMI on type I and II endometrial cancer survival.Materials and MethodsDanish Gynecological Cancer Database data on women with type I and II endometrial cancer were retrieved. Kaplan-Meier plot was used to illustrate differences in survival in relation to BMI. Log-rank test was used to demonstrate difference between the curves. Cox regression hazard model was used to estimate hazard ratios (HR) of the effect of BMI on overall survival.ResultsFour thousand three hundred thirty women were included. Women with type I cancer had a significantly better overall survival compared with those with type II cancer. Low BMI was associated with increased mortality in type I (HR, 2.07; 95% confidence interval [CI], 1.20–3.55), whereas in type II both low (HR, 1.68; 95% CI, 1.03–2.74) and high BMI (BMI, 30–35: HR, 1.54; 95% CI, 1.01–2.26 and BMI >40: HR, 2.15; 95% CI, 1.12–4.11) were significantly associated with increased mortality.ConclusionAbnormal BMI is associated with increased mortality in subtypes of endometrial cancer. Underweight was associated with increased overall mortality in both types I and II, whereas obesity only disclosed a significant impact on overall mortality in type II.

scholarly journals Relationship between Emotional Intelligence, Sleep Quality and Body Mass Index in Emergency Nurses

Healthcare ◽  
2021 ◽  
Vol 9 (5) ◽  
pp. 607
Author(s):  
Noelia Miguez-Torres ◽  
Alejandro Martínez-Rodríguez ◽  
María Martínez-Olcina ◽  
Laura Miralles-Amorós ◽  
Cristina Reche-García
Keyword(s):  
Body Mass Index ◽  
Emotional Intelligence ◽  
Sleep Quality ◽  
Body Mass ◽  
Working Hours ◽  
Type I ◽  
Emotional States ◽  
Emergency Nurses ◽  
Cross Sectional ◽  
Lack Of Sleep

Nurses have long working hours with high psychological burdens. In addition, in the emergency department, nurses are required to quickly adapt emotionally. The aim of this study was to describe and relate emotional intelligence (EI) skills of emergency nurses, their body mass index (BMI) and sleep quality. For this purpose, a cross-sectional was carried out in which the perceived emotional intelligence test and the Pittsburgh sleep quality index were applied. Sixty-two emergency nurses (48 women and 14 men) participated. The results indicated that the majority of them present adequate levels of EI, with no differences by gender. Younger nurses showed a better ability to feel, express and understand emotional states than the older ones, while the ability to regulate emotional states occurred in the opposite way. Nurses who have been working for several years showed a better ability to regulate emotions than those with less experience. Those who were overweight grade II and obese type I expressed their feelings better, also the regulation of emotional states decreased as weight increased. Finally, it has been observed that the quality of sleep of emergency nurses is significantly altered, and that this lack of sleep may affect their ability to process emotions.

scholarly journals Outcome of breast cancer patients regarding obesity and complications: Analysis of risk factors

2021 ◽  
Vol 68 (1) ◽  
pp. 77-86
Author(s):  
Iuliana Pantelimon ◽  
◽  
Laurentia Nicoleta Gales ◽  
Maria Daniela Tanasescu ◽  
Irina Nita ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Body Mass Index ◽  
Prognostic Factors ◽  
Disease Progression ◽  
Body Mass ◽  
Type Ii Diabetes ◽  
The Body ◽  
Proliferation Index ◽  
Her2 Overexpression ◽  
Type Ii

Introduction. Breast cancer is the leading cause of cancer death in Romania. In the context in which the treatments available for this pathology have increased curability, the identification of negative prognostic factors involved in the evolution of this disease seems essential to improve the overall survival as well as the time to disease progression. Aim. The aim of this study is to identify the role of prognostic factors such as ki67 proliferation index, the presence of tumour estrogen receptors, HER2 overexpression, the presence of secondary determinations at diagnosis, the association of obesity and type II diabetes. Methods. 50 patients diagnosed with breast cancer treated in the Elias University Emergency Hospital Bucharest were retrospectively followed, for which the progression was documented at the time of elaboration of this study. Thus, a database was developed in which data were entered on age, body mass index, immunohistochemical characteristics of breast tumours, the presence/absence of metastases at diagnosis and the association of type II diabetes. Statistical calculations were performed to highlight a possible correlation between obesity (quantified by measuring body mass index) and tumour aggressiveness (quantified by ki67 proliferation index) as well as statistical evaluation of potential prognostic factors that would influence time, until the disease progresses. Results. Within this group, no correlation could be established between the presence of an increased body mass index and the value of the ki67 proliferation index (p = 0.38). The mean value of the body mass index for this group of unselected patients was 28.76 ± 4.81 (DS) most patients are therefore overweight or obese. The factors involved in the evolution of breast cancer that influenced the early progression of the disease were: the proliferation index ki67 (p <0.05), the presence of metastases at diagnosis (p < 0.0001) and the association of type II diabetes (p = 0.0085). The value of the body mass index did not influence the time to disease progression according to statistical calculations in this group probably due to the small number of normal weight patients included (p = 0.34).

scholarly journals Clinical and histopathological characteristics in patients with postmenopausal bleeding

2013 ◽  
Vol 21 (1) ◽  
pp. 5-10 ◽  
Author(s):  
Aljosa Mandic ◽  
Bojana Gutic ◽  
Tatjana Kapicl-Ivkovic ◽  
Ljiljana Segedi-Mladenovic ◽  
Mihaela Mocko-Kacanski
Keyword(s):  
Body Mass Index ◽  
Risk Factor ◽  
Endometrial Carcinoma ◽  
Body Mass ◽  
Transvaginal Ultrasound ◽  
Significant Risk ◽  
Histopathological Analysis ◽  
Postmenopausal Bleeding ◽  
Postmenopausal Period ◽  
Increased Risk

Background: Incidence of endometrial carcinoma in Vojvodina is 15-20/100 000. In 75% cases, endometrial carcinoma is diagnosed in postmenopausal period. In 90 % of patients, the first clinical sign is postmenopausal bleeding. The aim of the study was to investigate clinical and histopathological characteristics in patients with postmenopausal bleeding. Methods: The study included 122 patients with postmenopausal bleeding. All of these patients underwent gynecological examination and vaginal ultrasound. We obtained materials for histopathological analysis by fractionate explorative curettage. Once we had definitive histopathological findings, we divided patients in two groups A (endometrial carcinoma) and B (benign changes). Results: We confirmed significant statistical differences between examined group A and B, including age (64.49 compared with 58.81 years), postmenopausal period (13.67 instead 9.11 years), and length of uterine corpus (6.41 instead 5.25 cm). Conclusion: Elderly women with longer postmenopausal interval and postmenopausal bleeding had increased risk for endometrial carcinoma. Measurement of endometrial thickness by transvaginal ultrasound appeared to be insufficient parameter for differentiating the benign from the malignant changes of endometrium. Patients with endometrial carcinoma had significantly longer corpus of uterus comparing to patients with benign changes. Body mass index was not found to be significant risk factor in development of endometrial carcinoma in the examined groups. Obesity was diagnosed in both groups, suggesting that increased body mass index is a risk factor for development of pathological changes in endometrium, which could lead to postmenopausal bleeding.

A high body mass index is not a worse prognostic factor for endometrial carcinoma in a predominantly obese population

2012 ◽  
Vol 15 (3) ◽  
pp. 243-247 ◽  
Author(s):  
Leonardo Saúl Lino-Silva ◽  
David Cantú de León ◽  
Rosa Angélica Salcedo-Hernández ◽  
Claudia Cavazos-Saman ◽  
María Delia Pérez-Montiel
Keyword(s):  
Body Mass Index ◽  
Prognostic Factor ◽  
Endometrial Carcinoma ◽  
Body Mass ◽  
High Body Mass Index ◽  
High Body ◽  
Obese Population

Expansion Sphincter Pharyngoplasty: A New Technique for the Treatment of Obstructive Sleep Apnea

2007 ◽  
Vol 137 (1) ◽  
pp. 110-114 ◽  
Author(s):  
Kenny P. Pang ◽  
B. Tucker Woodson
Keyword(s):  
Body Mass Index ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Body Mass ◽  
Apnea Hypopnea Index ◽  
Type I ◽  
Pharyngeal Wall ◽  
Obstructive Sleep ◽  
Expansion Sphincter Pharyngoplasty ◽  
Sphincter Pharyngoplasty

OBJECTIVE: In this study, we assessed the efficacy of a new method (expansion sphincter pharyngoplasty [ESP]) to treat obstructive sleep apnea. STUDY DESIGN: We conducted a prospective, randomized controlled trial. METHODS: Forty-five adults with small tonsils, body mass index less than 30 kg/m 2 , of Friedman stage II or III, of type I Fujita, and with lateral pharyngeal wall collapse were selected for the study. RESULTS: The mean body mass index was 28.7 kg/m 2 . The apnea-hypopnea index improved from 44.2 ± 10.2 to 12.0 ± 6.6 ( P < 0.005) following ESP and from 38.1 ± 6.46 to 19.6 ± 7.9 in the uvulopalatopharyngoplasty group ( P < 0.005). Lowest oxygen saturation improved from 78.4 ± 8.52% to 85.2 ± 5.1% in the ESP group ( P = 0.003) and from 75.1 ± 5.9% to 86.6 ± 2.2% in the uvulopalatopharyngoplasty group ( P < 0.005). Selecting a threshold of a 50% reduction in apnea-hypopnea index and apnea-hypopnea index less than 20, success was 82.6% in ESP compared with 68.1% in uvulopalatopharyngoplasty ( P < 0.05). CONCLUSION/SIGNIFICANCE: The ESP may offer benefits in a selected group of OSA patients.

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