NADPH oxidase 4 expression in the normal endometrium and in endometrial cancer

The aim of this study was to explore the role of NOX4 in the biology of the normal endometrium and endometrial cancer. NOX4 plays a key role in other adenocarcinomas and has been implicated in the pathogenesis of diabetes and obesity, which are important risk factors for endometrial cancer. NOX4 expression was assessed in 239 endometrial cancer and 25 normal endometrium samples by quantitative real-time polymerase chain reaction, in situ hybridization, and immunohistochemistry. DNA methylation of the NOX4 promoter was determined by means of MethyLight PCR. Data were correlated with clinicopathological parameters and analyzed in the context of diabetes and body mass index. In the normal endometrium, NOX4 microRNA expression was significantly higher in the secretory transformed compared with proliferative endometrium ( p = 0.008). In endometrial cancer specimens, NOX4 expression did not differ between diabetic and non-diabetic patients, but was the highest in patients with a body mass index ≤ 26 ( p = 0.037). The lowest NOX4 expression was found in carcinosarcomas ( p = 0.007). High NOX4 expression predicted poorer clinical outcome with regard to overall survival, especially in non-diabetic patients and those with a body mass index > 20. Independent prognostic significance of NOX4 transcripts was retained in type I endometrial cancer and was the most meaningful in patients with a body mass index > 20. No prognostic impact was shown for NOX4 promoter methylation in endometrial cancer. For the first time, we demonstrate that NOX4 plays a considerable role in the cycle-dependent changes in the normal endometrium and in the biology of endometrial cancer.

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Influence of Body Mass Index on Tumor Pathology and Survival in Uterine Cancer: A Danish Register Study

International Journal of Gynecological Cancer ◽

10.1097/igc.0000000000000874 ◽

2017 ◽

Vol 27 (2) ◽

pp. 281-288 ◽

Cited By ~ 3

Author(s):

Anne Bjerrum Kristensen ◽

Helle Hare-Bruun ◽

Claus Kim Høgdall ◽

Martin Rudnicki

Keyword(s):

Body Mass Index ◽

Overall Survival ◽

Endometrial Cancer ◽

Body Mass ◽

Uterine Cancer ◽

Type I ◽

Type Ii ◽

Tumor Pathology ◽

Overall Mortality

ObjectiveTo evaluate the influence of body mass index (BMI) on endometrial tumor pathology, stage and complication rate and to identify individual prognostic factors, such as BMI, in types I and II endometrial cancer.DesignRegister study included all Danish women who underwent surgery for uterine cancer or atypical endometrial hyperplasia (International Classification of Diseases-10 codes D070, DC549) 2005 to 2012 (n = 6003).Main Outcome MeasuresImpact of BMI on type I and II endometrial cancer survival.Materials and MethodsDanish Gynecological Cancer Database data on women with type I and II endometrial cancer were retrieved. Kaplan-Meier plot was used to illustrate differences in survival in relation to BMI. Log-rank test was used to demonstrate difference between the curves. Cox regression hazard model was used to estimate hazard ratios (HR) of the effect of BMI on overall survival.ResultsFour thousand three hundred thirty women were included. Women with type I cancer had a significantly better overall survival compared with those with type II cancer. Low BMI was associated with increased mortality in type I (HR, 2.07; 95% confidence interval [CI], 1.20–3.55), whereas in type II both low (HR, 1.68; 95% CI, 1.03–2.74) and high BMI (BMI, 30–35: HR, 1.54; 95% CI, 1.01–2.26 and BMI >40: HR, 2.15; 95% CI, 1.12–4.11) were significantly associated with increased mortality.ConclusionAbnormal BMI is associated with increased mortality in subtypes of endometrial cancer. Underweight was associated with increased overall mortality in both types I and II, whereas obesity only disclosed a significant impact on overall mortality in type II.

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Prognostic significance of body mass index in breast cancer patients with hormone receptor-positive tumours after curative surgery

Clinical & Investigative Medicine ◽

10.25011/cim.v36i6.20627 ◽

2013 ◽

Vol 36 (6) ◽

pp. 297 ◽

Cited By ~ 4

Author(s):

Peng Xing ◽

Ji-Guang Li ◽

Feng Jin ◽

Ting-Ting Zhao ◽

Qun Liu ◽

...

Keyword(s):

Breast Cancer ◽

Body Mass Index ◽

Body Mass ◽

Hormone Receptor ◽

Univariate Analysis ◽

Prognostic Significance ◽

Axillary Lymph ◽

Nodal Stage ◽

Hormone Receptor Positive ◽

High Bmi

Purpose: Obesity has been recognized as a significant risk factor for postmenopausal breast cancer. The aim of this study is to investigate the prognostic significance of body mass index (BMI) in hormone receptor-positive, operable breast cancer. Methods: In this retrospective cohort study, 1,192 consecutive patients with curative resection of primary breast cancer were enrolled. Patients were assigned to two groups according to BMI: normal or underweight (BMI < 23.0 kg/m2) and overweight or obese (BMI ≥23.0 kg/m2). Associations among BMI and clinicopathological characteristics and prognosis of patients were assessed. Results: A high BMI was significantly (P < 0.01) correlated with age, nodal stage, ALNR, ER positivity, PR positivity and menopausal status at diagnosis. Univariate analysis revealed that BMI, pathologic T stage, nodal stage, axillary lymph node ratio (ALNR) and adjuvant radiotherapy history were significantly (P < 0.05) associated with disease-free survival and overall survival, irrespective of tumour hormone receptor status. Multivariate analysis revealed BMI as an independent prognostic factor in all cases and in hormone receptor-positive cases. Conclusion: A high BMI (≥23.0 kg/m^2) is independently associated with poor prognosis in hormone receptor-positive breast cancer.

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WAIST CIRCUMFERENCE AND BODY MASS INDEX CORRELATE WITH CEREBRAL GLUCOSE METABOLISM IN THE TEMPORAL LOBE IN DIABETIC PATIENTS

10.26226/morressier.571f103fd462b8028d88c5a2 ◽

2016 ◽

Author(s):

Natalia García-Casares

Keyword(s):

Body Mass Index ◽

Waist Circumference ◽

Glucose Metabolism ◽

Body Mass ◽

Temporal Lobe ◽

Cerebral Glucose Metabolism ◽

Diabetic Patients

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Effects of Triphala on Lipid and Glucose Profiles and Anthropometric Parameters: A Systematic Review

Journal of Evidence-Based Integrative Medicine ◽

10.1177/2515690x211011038 ◽

2021 ◽

Vol 26 ◽

pp. 2515690X2110110

Author(s):

Wiraphol Phimarn ◽

Bunleu Sungthong ◽

Hiroyuki Itabe

Keyword(s):

Body Mass Index ◽

Body Weight ◽

Blood Glucose ◽

Waist Circumference ◽

Lipid Profile ◽

Body Mass ◽

The Body ◽

Current Evidence ◽

Diabetic Patients ◽

Anthropometric Parameters

Aim. The efficacy of triphala on lipid profile, blood glucose and anthropometric parameters and its safety were assessed. Methods. Databases such as PubMed, ScienceDirect, Web of Science, and Thai Library Integrated System (ThaiLIS) were systematically searched to review current evidence of randomized controlled trials (RCT) on triphala. RCTs investigating the safety and efficacy of triphala on lipid profile, blood glucose and anthropometric parameters were included. Study selection, data extraction, and quality assessment were performed independently by 2 authors. Results. Twelve studies on a total of 749 patients were included. The triphala-treated groups showed significantly reduced low-density lipoprotein-cholesterol, total cholesterol and triglyceride in 6 studies. Five RCTs demonstrated triphala-treated groups led to statistically significant decrease in body weight, body mass index and waist circumference of obese patients. Moreover, triphala significantly decreased fasting blood glucose level in diabetic patients but not in people without diabetes. No serious adverse event associated with triphala was reported during treatment. Conclusions. This review summarized a current evidence to show triphala might improve the lipid profile, blood glucose, the body weight, body mass index and waist circumference under certain conditions. However, large well-designed RCTs are required to confirm this conclusion.

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Relationship between Emotional Intelligence, Sleep Quality and Body Mass Index in Emergency Nurses

Healthcare ◽

10.3390/healthcare9050607 ◽

2021 ◽

Vol 9 (5) ◽

pp. 607

Author(s):

Noelia Miguez-Torres ◽

Alejandro Martínez-Rodríguez ◽

María Martínez-Olcina ◽

Laura Miralles-Amorós ◽

Cristina Reche-García

Keyword(s):

Body Mass Index ◽

Emotional Intelligence ◽

Sleep Quality ◽

Body Mass ◽

Working Hours ◽

Type I ◽

Emotional States ◽

Emergency Nurses ◽

Cross Sectional ◽

Lack Of Sleep

Nurses have long working hours with high psychological burdens. In addition, in the emergency department, nurses are required to quickly adapt emotionally. The aim of this study was to describe and relate emotional intelligence (EI) skills of emergency nurses, their body mass index (BMI) and sleep quality. For this purpose, a cross-sectional was carried out in which the perceived emotional intelligence test and the Pittsburgh sleep quality index were applied. Sixty-two emergency nurses (48 women and 14 men) participated. The results indicated that the majority of them present adequate levels of EI, with no differences by gender. Younger nurses showed a better ability to feel, express and understand emotional states than the older ones, while the ability to regulate emotional states occurred in the opposite way. Nurses who have been working for several years showed a better ability to regulate emotions than those with less experience. Those who were overweight grade II and obese type I expressed their feelings better, also the regulation of emotional states decreased as weight increased. Finally, it has been observed that the quality of sleep of emergency nurses is significantly altered, and that this lack of sleep may affect their ability to process emotions.

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Laparoscopic-assisted vaginal hysterectomy for endometrial cancer in high body mass index (BMI) patients: a report of six cases

Gynecological Surgery ◽

10.1007/s10397-008-0427-5 ◽

2008 ◽

Vol 6 (2) ◽

pp. 119-123 ◽

Cited By ~ 2

Author(s):

H. Muppala ◽

J. Rafi ◽

S. K. Najia

Keyword(s):

Body Mass Index ◽

Endometrial Cancer ◽

Body Mass ◽

Vaginal Hysterectomy ◽

High Body Mass Index ◽

High Body ◽

Laparoscopic Assisted Vaginal Hysterectomy ◽

Laparoscopic Assisted

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Body Mass Index in Early Adulthood and Endometrial Cancer Risk for Mismatch Repair Gene Mutation Carriers

Obstetrics and Gynecology ◽

10.1097/aog.0b013e3182110ea3 ◽

2011 ◽

Vol 117 (4) ◽

pp. 899-905 ◽

Cited By ~ 18

Author(s):

Aung Ko Win ◽

James G. Dowty ◽

Yoland C. Antill ◽

Dallas R. English ◽

John A. Baron ◽

...

Keyword(s):

Body Mass Index ◽

Endometrial Cancer ◽

Cancer Risk ◽

Mismatch Repair ◽

Gene Mutation ◽

Body Mass ◽

Early Adulthood ◽

Mismatch Repair Gene ◽

Repair Gene ◽

Endometrial Cancer Risk

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Long-term prognostic impact of body mass index and waist circumference in hospital survivors of acute myocardial infarction. Data from the French FAST-MI 2005 registry

European Heart Journal ◽

10.1093/eurheartj/eht308.1948 ◽

2013 ◽

Vol 34 (suppl 1) ◽

pp. 1948-1948 ◽

Cited By ~ 1

Author(s):

N. Danchin ◽

E. Puymirat ◽

M. Zeller ◽

P. G. Steg ◽

J. Machecourt ◽

...

Keyword(s):

Myocardial Infarction ◽

Acute Myocardial Infarction ◽

Body Mass Index ◽

Waist Circumference ◽

Body Mass ◽

Prognostic Impact

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HER-2 Expression in Immunohistochemistry Has No Prognostic Significance in Gastric Cancer Patients

The Scientific World JOURNAL ◽

10.1100/2012/941259 ◽

2012 ◽

Vol 2012 ◽

pp. 1-6 ◽

Cited By ~ 23

Author(s):

Agnieszka Halon ◽

Piotr Donizy ◽

Przemyslaw Biecek ◽

Julia Rudno-Rudzinska ◽

Wojciech Kielan ◽

...

Keyword(s):

Gastric Cancer ◽

Test Score ◽

Prognostic Significance ◽

Clinicopathological Parameters ◽

Prognostic Impact ◽

Curative Surgery ◽

Regional Lymph Nodes ◽

Poorly Differentiated ◽

Her 2 ◽

Gastric Cancer Patients

The role of HER-2 expression as a prognostic factor in gastric cancer (GC) is still controversial. The aim of the study was to asses HER-2 status, its correlations with clinicopathological parameters, and prognostic impact in GC patients. Tumor samples were collected from 78 patients who had undergone curative surgery. In order to evaluate the intensity of immunohistochemical (IHC) reactions two scales were applied: the immunoreactive score according to Remmele modified by the authors and standardised Hercep test score modified for GC by Hofmann et al. The HER-2 overexpression was detected by IHC in 23 (29.5%) tumors in Hercep test (score 2+/3+) and in 24 (30.7%) in IRS scale (IRS 4–12). The overexpression of HER-2 was associated with poorly differentiated tumors, but this correlation was not significant (P=0.064). No relationship was found between HER-2 expression and primary tumor size and degree of spread to regional lymph nodes. Both univariate and multivariate analyses revealed that TNM stage and patient’s age were the crucial negative prognostic factors. No correlation was observed between patient survival and expression of HER-2 estimated using both scales. This research did not confirm HER-2 expression (evaluated with immunohistochemistry) value as a prognostic tool in GC.

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