Cytochrome P450 1A1 gene polymorphisms and cervical cancer risk

Objective. We aimed to derive a more precise estimation of the associations between human leukocyte antigens DP (HLA-DP) gene polymorphisms and cervical cancer risk by meta-analysis. Methods. PubMed, EMBASE, ScienceDirect, Web of Science, Chinese National Knowledge Infrastructure (CNKI), and Wanfang databases were systematically searched to identify studies investigating the relationship between HLA-DP gene polymorphisms and cervical cancer. The associations between them were evaluated by pooled OR and 95% CI. Results. A total of 11 studies including 5008 cases and 9322 controls with 11 HLA-DP alleles were included in the current meta-analysis. Results. The results showed that HLA-DPB1⁎03:01 was significantly associated with an increased risk of cervical cancer (OR=1.252, 95%CI: 1.116-1.403, Pz=0.001), while HLA-DPB1⁎04:02 and HLA-DP rs3117027 G allele were significantly associated with a decreased risk of cervical cancer (OR=0.744, 95%CI: 0.652-0.848, Pz=0.001; OR=0.790, 95%CI: 0.745-0.837, Pz=0.001), and HLA-DP rs9277535 G allele was significantly associated with a decreased risk of cervical cancer in Asia (OR=0.802, 95%CI: 0.753-0.855, Pz=0.001). Subgroup analyses based on race system showed that HLA-DPB1⁎13:01 was significantly associated with an increased risk of cervical cancer in Asia (OR=1.834, 95%CI: 1.107-3.039, Pz=0.019). No significant association was established for the HLA-DP following alleles: DPB1⁎02:01, DPB1⁎02:02, DPB1⁎04:01, DPB1⁎05:01, rs4282438, and rs3077. Conclusion. HLA-DP gene polymorphisms (HLA-DPB1⁎03:01, DPB1⁎04:02, DPB1⁎13:01, rs9277535, and rs3117027) were significantly associated with cervical cancer.

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Cytochrome P450 1A1 (CYP1A1) gene polymorphisms and ovarian cancer risk: a meta-analysis

Molecular Biology Reports ◽

10.1007/s11033-012-1860-0 ◽

2012 ◽

Vol 39 (11) ◽

pp. 9921-9930 ◽

Cited By ~ 9

Author(s):

Theodoros N. Sergentanis ◽

Konstantinos P. Economopoulos ◽

Souzana Choussein ◽

Nikos F. Vlahos

Keyword(s):

Ovarian Cancer ◽

Cytochrome P450 ◽

Cancer Risk ◽

Gene Polymorphisms ◽

Meta Analysis ◽

Ovarian Cancer Risk ◽

Cytochrome P450 1A1 ◽

Cyp1a1 Gene

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Stratification Analysis and Case-control Study of Relationships between Interleukin-6 Gene Polymorphisms and Cervical Cancer Risk in a Chinese Population

Asian Pacific Journal of Cancer Prevention ◽

10.7314/apjcp.2014.15.17.7357 ◽

2014 ◽

Vol 15 (17) ◽

pp. 7357-7362 ◽

Cited By ~ 11

Author(s):

Wen-Jing Shi ◽

Hao Liu ◽

Dan Wu ◽

Zhen-Hua Tang ◽

Yu-Chen Shen ◽

...

Keyword(s):

Cervical Cancer ◽

Cancer Risk ◽

Interleukin 6 ◽

Gene Polymorphisms ◽

Chinese Population ◽

Case Control Study ◽

Case Control ◽

Cervical Cancer Risk ◽

Control Study

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Interleukin 1β and Interleukin 1 Receptor Antagonist Gene Polymorphisms and Cervical Cancer: A Meta-analysis

International Journal of Gynecological Cancer ◽

10.1097/igc.0000000000000165 ◽

2014 ◽

Vol 24 (6) ◽

pp. 984-990 ◽

Cited By ~ 9

Author(s):

Shimu Wu ◽

Guiping Hu ◽

Jun Chen ◽

Guangyun Xie

Keyword(s):

Cervical Cancer ◽

Cancer Risk ◽

Receptor Antagonist ◽

Publication Bias ◽

Gene Polymorphisms ◽

Meta Analysis ◽

Interleukin 1 ◽

Interleukin 1Β ◽

Cervical Cancer Risk ◽

Increased Risk

ObjectivesPrevious studies investigating the association between interleukin 1β (IL-1β) and its receptor antagonist (IL-1RN) polymorphism and cervical cancer risk have reported controversial results. Thus, we examined these associations by performing meta-analyses.Methods and MaterialsFourteen studies testing the association between IL-1β and/or IL-1RN gene polymorphisms and cervical cancer were examined: 5 studies of IL-1β–511C/T, 3 studies of IL-1β–31T/C, and 6 studies of IL-1RN. Overall and ethnicity-specific summary odds ratios (ORs) and corresponding 95% confidence intervals (CIs) for cervical cancer associated with these polymorphisms were estimated using fixed- and random-effects models. Heterogeneity and publication bias were evaluated.ResultsMeta-analysis of all 6 studies showed variant genotypes of IL-1RN to be associated with an elevated cervical cancer risk (RN2/RN2 vs RN1/RN1: OR, 2.64; 95% CI, 1.29–5.40; recessive: OR, 2.15; 95% CI, 1.06–4.38; dominant: OR, 1.60; 95% CI, 1.07–2.38). Combined analysis indicated that IL-1β–511C/T polymorphism was also associated with increased risk of cervical cancer (TT vs CC: OR, 1.56; 95% CI, 1.22–1.99; CT vs CC: OR, 1.61; 95% CI, 1.31–1.99; dominant: OR, 1.60; 95% CI, 1.31–1.95). No significant association of IL-1β–31T/C and cervical cancer risk was detected. There was no evidence of publication bias.ConclusionsThis meta-analysis suggested that the IL-1RN and IL-1β–511C/T polymorphisms may contribute to genetic susceptibility of cervical cancer. More studies are needed to further evaluate the role of the IL-1β–31T/C polymorphism in the etiology of cancer.

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