scholarly journals Single-arm, open-label pilot intervention study to investigate an effect of oral 5-aminolevulinic acid plus sodium ferrous citrate on glucocorticoid reduction in patients with adult-onset Still disease

Medicine ◽  
2020 ◽  
Vol 99 (50) ◽  
pp. e22708
Author(s):  
Remi Sumiyoshi ◽  
Tomohiro Koga ◽  
Toshimasa Shimizu ◽  
Shuntaro Sato ◽  
Shigeki Tashiro ◽  
...  
Keyword(s):  
Intervention Study ◽  
Aminolevulinic Acid ◽  
Adult Onset ◽  
Open Label ◽  
Ferrous Citrate ◽  
Pilot Intervention ◽  
Still Disease

scholarly journals Safety Assessment of Oral 5-aminolevulinic Acid and Ferrous iron in Healthy Human Subjects: A Non-randomized, Open-label, Non-placebo-controlled Trial

2021 ◽  
Author(s):  
Hidenori Ito ◽  
Tohru Tanaka
Keyword(s):  
Safety Assessment ◽  
Aminolevulinic Acid ◽  
Human Subjects ◽  
Controlled Trial ◽  
Elevated Serum ◽  
Food Supplement ◽  
Open Label ◽  
Healthy Human ◽  
Ferrous Citrate ◽  
Combined Administration

Abstract The combination of 5-aminolevulinic acid (5-ALA) phosphate and sodium ferrous citrate (SFC) has been approved as an ingredient of food supplement in several countries because of its wide applicability to healthcare areas. We aimed to assess the safety of 5-ALA phosphate and SFC in healthy adult subjects at the dose several times higher than that available on market. This was an open, non-randomized, non-placebo-controlled trial that included 11 men and 11 women. Doses of 250 mg 5-ALA phosphate and 143.4 mg SFC (15 mg as Fe) per day were orally administered for 28 days. Blood and urine analyses and interviews were conducted to assess the safety. No test compound-related adverse events or abnormal values were observed, except for elevated serum iron levels, which were mild to moderate and transient. Combined administration of 5-ALA phosphate and SFC to healthy adults is well-tolerated and safe at the dose and duration investigated in this study.

P4.8 Results from a two-year open label intervention study with idebenone (Catena®) in Duchenne muscular dystrophy

2011 ◽  
Vol 21 (9-10) ◽  
pp. 706
Author(s):  
G.M. Buyse ◽  
D. Thijs ◽  
N. Goemans ◽  
M. van den Hauwe ◽  
H. Wei ◽  
...  
Keyword(s):  
Duchenne Muscular Dystrophy ◽  
Muscular Dystrophy ◽  
Intervention Study ◽  
Open Label

Aquatic aerobic exercise for children with cerebral palsy: a pilot intervention study

2013 ◽  
Vol 30 (2) ◽  
pp. 69-78 ◽  
Author(s):  
Maria A. Fragala-Pinkham ◽  
Hilary J. Smith ◽  
Kelly A. Lombard ◽  
Carrie Barlow ◽  
Margaret E. O’Neil
Keyword(s):  
Cerebral Palsy ◽  
Aerobic Exercise ◽  
Intervention Study ◽  
Children With Cerebral Palsy ◽  
Pilot Intervention

scholarly journals Severe Adult-onset Still Disease with Constrictive Pericarditis and Pleuritis That Was Successfully Treated with Tocilizumab in Addition to Corticosteroids and Cyclosporin A

2018 ◽  
Vol 57 (7) ◽  
pp. 1033-1038 ◽  
Author(s):  
Hoshimi Kawaguchi ◽  
Hiroto Tsuboi ◽  
Mizuki Yagishita ◽  
Toshihiko Terasaki ◽  
Mayu Terasaki ◽  
...  
Keyword(s):  
Cyclosporin A ◽  
Constrictive Pericarditis ◽  
Adult Onset ◽  
Still Disease

scholarly journals Effect of omega-3 polyunsaturated fatty acids on the cytoskeleton: an open-label intervention study

2015 ◽  
Vol 14 (1) ◽  
pp. 4 ◽  
Author(s):  
Simone Schmidt ◽  
Janina Willers ◽  
Sabine Riecker ◽  
Katharina Möller ◽  
Jan Schuchardt ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Intervention Study ◽  
Omega 3 ◽  
Open Label
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