Degradation Kinetics of Methionine5-Enkephalin by Cerebrospinal Fluid: In Vitro Studies

The objective this study was to evaluate the effect of maniçoba supplementation in sugar cane silage with respect to chemical-bromatological composition and the in vitro degradation kinetics of the silage. This experiment was conducted in a completely randomized design with four treatments (maniçoba levels: 0, 20, 30, and 40%) and six repetitions. Silage samples were analyzed for their chemical-bromatological composition, digestible energy, metabolizable energy, total digestible nutrients, in vitro gas production and degradability parameters. The silage with higher inclusion level had better bromatological composition (p < 0.05) than the silage without maniçoba for CP, NDF, ADF and MM (6.49, 56.64, 38.66 and 4.52% versus 2.21, 70.96, 49.95 and 2.78%). Higher ME content (2.35 MJ kg-1 MS versus 1.85 MJ kg-1 MS), DE (2.87 Mcal kg-1 MS versus 2.25 Mcal kg-1 MS) and TDN (65.16% versus 51.11%), respectively. The highest values for gas production were also observed in silage with added maniçoba due to higher NFC content (34.87%). With an increase in the proportion of maniçoba, there was an increase in the soluble a fraction, b fraction, and thus a higher effective degradability of dry matter (46.56%). The addition of maniçoba improves the nutritive value of sugarcane silage.

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In vitro degradation kinetics of pure PLA and Mg/PLA composite: Effects of immersion temperature and compression stress

Acta Biomaterialia ◽

10.1016/j.actbio.2016.11.001 ◽

2017 ◽

Vol 48 ◽

pp. 468-478 ◽

Cited By ~ 25

Author(s):

Xuan Li ◽

Chenglin Chu ◽

Yalin Wei ◽

Chenxi Qi ◽

Jing Bai ◽

...

Keyword(s):

Degradation Kinetics ◽

Compression Stress ◽

In Vitro Degradation ◽

Kinetics Of

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The In Vitro Degradation Kinetics of Polyurethane Prodrug Materials

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.399-401.1067 ◽

2011 ◽

Vol 399-401 ◽

pp. 1067-1070

Author(s):

Chun Yan Li ◽

Cong Cong Hu ◽

Zhi Guo Wen ◽

Sheng Xiong Dong

Keyword(s):

Drug Release ◽

High Performance ◽

Degradation Kinetics ◽

Hplc Method ◽

In Vitro Degradation ◽

Erosion Mechanism ◽

First Order ◽

First Order Kinetics ◽

Kinetics Of

The method of high performance liquid chromatography (HPLC) is established to determine the content of antibacterial agent — ciprofloxacin (CF) in the degradation solution of ciprofloxacin-polyurethane (CFPU) and investigate the in vitro degradation kinetics by plotting and fitting the cumulative release curves to inspect the effects of different medium and different concentrations on drug release. The results showed that the HPLC method is accurate, reliable and simple. The drug-release of CFPU was bioresponsive and could be accorded with first order kinetics. It was observed that CF was released from CFPU by a combination of diffusion and erosion mechanism, mainly in the manner of diffusion in the absence of infection while erosion mechanism in the presence of infection.

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Nonlinear Absorption Kinetics of Self-Emulsifying Drug Delivery Systems (SEDDS) Containing Tocotrienols as Lipophilic Molecules: In Vivo and In Vitro Studies

The AAPS Journal ◽

10.1208/s12248-013-9481-7 ◽

2013 ◽

Vol 15 (3) ◽

pp. 684-695 ◽

Cited By ~ 20

Author(s):

Saeed Alqahtani ◽

Alaadin Alayoubi ◽

Sami Nazzal ◽

Paul W. Sylvester ◽

Amal Kaddoumi

Keyword(s):

Drug Delivery ◽

Nonlinear Absorption ◽

Drug Delivery Systems ◽

Delivery Systems ◽

In Vitro Studies ◽

Absorption Kinetics ◽

Kinetics Of

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Ventriculoperitoneal shunt blockage due to spontaneous knot formation in the peritoneal catheter

Journal of Neurosurgery Pediatrics ◽

10.3171/ped/2008/1/2/142 ◽

2008 ◽

Vol 1 (2) ◽

pp. 142-143 ◽

Cited By ~ 10

Author(s):

Behzad Eftekhar ◽

Andrew Hunn

Keyword(s):

Umbilical Cord ◽

Ventriculoperitoneal Shunt ◽

Underlying Mechanism ◽

In Vitro Studies ◽

Peritoneal Catheter ◽

Surgical Exploration ◽

The Third ◽

Kinetics Of

✓The authors report the third case of ventriculoperitoneal shunt blockage due to spontaneous knot formation in the peritoneal catheter that had been placed in a 3.5-year-old boy 8 months earlier. On surgical exploration a double knot was found 10 cm from the distal end of the peritoneal catheter. Although the underlying mechanism remains unknown, the authors used the analogy of related physical studies and true knot formation in the umbilical cord and determined the possible causes as related to the catheter, volume and configuration of the abdomen, and kinetics of the catheter movements. If further study should reveal a significantly higher incidence of this complication, the authors suggest further in vitro studies, designed to investigate the optimal characteristics and safe range of length of peritoneal catheters in different situations.

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Computer-Aided 4D Modeling of Hydrolytic Degradation in Micropatterned Bioresorbable Membranes

Journal of Medical Devices ◽

10.1115/1.4024158 ◽

2013 ◽

Vol 7 (2) ◽

Author(s):

Ibrahim T. Ozbolat ◽

Michelle Marchany ◽

Joseph A. Gardella ◽

Bahattin Koc

Keyword(s):

Degradation Kinetics ◽

Morphological Changes ◽

Dynamic Geometry ◽

Hydrolytic Degradation ◽

Controlled Drug Release ◽

Polymeric Membranes ◽

Surface Erosion ◽

Computer Aided ◽

Kinetics Of

Real-time degradation studies of bioresorbable polymers can take weeks, months, and even years to conduct. For this reason, developing and validating mathematical models that describe and predict degradation can provide a means to accelerate the development of materials and devices for controlled drug release. This study aims to develop and experimentally validate a computer-aided model that simulates the hydrolytic degradation kinetics of bioresorbable polymeric micropatterned membranes for tissue engineering applications. Specifically, the model applies to circumstances that are conducive for the polymer to undergo surface erosion. The developed model provides a simulation tool enabling the prediction and visualization of the dynamic geometry of the degrading membrane. In order to validate the model, micropatterned polymeric membranes were hydrolytically degraded in vitro and the morphological changes were analyzed using optical microscopy. The model is then extended to predict spatiotemporal degradation kinetics of variational micropatterned architectures.

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