In vitro degradation kinetics of pure PLA and Mg/PLA composite: Effects of immersion temperature and compression stress

2017 ◽  
Vol 48 ◽  
pp. 468-478 ◽  
Author(s):  
Xuan Li ◽  
Chenglin Chu ◽  
Yalin Wei ◽  
Chenxi Qi ◽  
Jing Bai ◽  
...  
Keyword(s):  
Degradation Kinetics ◽  
Compression Stress ◽  
In Vitro Degradation ◽  
Kinetics Of

The In Vitro Degradation Kinetics of Polyurethane Prodrug Materials

2011 ◽  
Vol 399-401 ◽  
pp. 1067-1070
Author(s):  
Chun Yan Li ◽  
Cong Cong Hu ◽  
Zhi Guo Wen ◽  
Sheng Xiong Dong
Keyword(s):  
Drug Release ◽  
High Performance ◽  
Degradation Kinetics ◽  
Hplc Method ◽  
In Vitro Degradation ◽  
Erosion Mechanism ◽  
First Order ◽  
First Order Kinetics ◽  
Kinetics Of

The method of high performance liquid chromatography (HPLC) is established to determine the content of antibacterial agent — ciprofloxacin (CF) in the degradation solution of ciprofloxacin-polyurethane (CFPU) and investigate the in vitro degradation kinetics by plotting and fitting the cumulative release curves to inspect the effects of different medium and different concentrations on drug release. The results showed that the HPLC method is accurate, reliable and simple. The drug-release of CFPU was bioresponsive and could be accorded with first order kinetics. It was observed that CF was released from CFPU by a combination of diffusion and erosion mechanism, mainly in the manner of diffusion in the absence of infection while erosion mechanism in the presence of infection.

Cytotoxicity and in Vitro Degradation Kinetics of Foundry-Compatible Semiconductor Nanomembranes and Electronic Microcomponents

ACS Nano ◽  
2018 ◽  
Vol 12 (10) ◽  
pp. 9721-9732 ◽  
Author(s):  
Jan-Kai Chang ◽  
M. A. Bashar Emon ◽  
Chia-Shuo Li ◽  
Quansan Yang ◽  
Hui-Ping Chang ◽  
...  
Keyword(s):  
Degradation Kinetics ◽  
In Vitro Degradation ◽  
Kinetics Of

scholarly journals Chemical-bromatological composition and in vitro ruminal kinetics of sugar cane silage with maniçoba

2018 ◽  
Vol 40 (1) ◽  
pp. 42569
Author(s):  
Francisco Allan Leandro de Carvalho ◽  
Percivaldo Xavier Resende ◽  
Clístenes Amorim Benicio ◽  
Jackson De Oliveira Siqueira ◽  
Daniel Ribeiro Menezes ◽  
...  
Keyword(s):  
Sugar Cane ◽  
Nutritive Value ◽  
Degradation Kinetics ◽  
Gas Production ◽  
Metabolizable Energy ◽  
Randomized Design ◽  
In Vitro Gas Production ◽  
Inclusion Level ◽  
Kinetics Of

The objective this study was to evaluate the effect of maniçoba supplementation in sugar cane silage with respect to chemical-bromatological composition and the in vitro degradation kinetics of the silage. This experiment was conducted in a completely randomized design with four treatments (maniçoba levels: 0, 20, 30, and 40%) and six repetitions. Silage samples were analyzed for their chemical-bromatological composition, digestible energy, metabolizable energy, total digestible nutrients, in vitro gas production and degradability parameters. The silage with higher inclusion level had better bromatological composition (p < 0.05) than the silage without maniçoba for CP, NDF, ADF and MM (6.49, 56.64, 38.66 and 4.52% versus 2.21, 70.96, 49.95 and 2.78%). Higher ME content (2.35 MJ kg-1 MS versus 1.85 MJ kg-1 MS), DE (2.87 Mcal kg-1 MS versus 2.25 Mcal kg-1 MS) and TDN (65.16% versus 51.11%), respectively. The highest values for gas production were also observed in silage with added maniçoba due to higher NFC content (34.87%). With an increase in the proportion of maniçoba, there was an increase in the soluble a fraction, b fraction, and thus a higher effective degradability of dry matter (46.56%). The addition of maniçoba improves the nutritive value of sugarcane silage.  

Computer-Aided 4D Modeling of Hydrolytic Degradation in Micropatterned Bioresorbable Membranes

2013 ◽  
Vol 7 (2) ◽  
Author(s):  
Ibrahim T. Ozbolat ◽  
Michelle Marchany ◽  
Joseph A. Gardella ◽  
Bahattin Koc
Keyword(s):  
Degradation Kinetics ◽  
Morphological Changes ◽  
Dynamic Geometry ◽  
Hydrolytic Degradation ◽  
Controlled Drug Release ◽  
Polymeric Membranes ◽  
Surface Erosion ◽  
Computer Aided ◽  
Kinetics Of

Real-time degradation studies of bioresorbable polymers can take weeks, months, and even years to conduct. For this reason, developing and validating mathematical models that describe and predict degradation can provide a means to accelerate the development of materials and devices for controlled drug release. This study aims to develop and experimentally validate a computer-aided model that simulates the hydrolytic degradation kinetics of bioresorbable polymeric micropatterned membranes for tissue engineering applications. Specifically, the model applies to circumstances that are conducive for the polymer to undergo surface erosion. The developed model provides a simulation tool enabling the prediction and visualization of the dynamic geometry of the degrading membrane. In order to validate the model, micropatterned polymeric membranes were hydrolytically degraded in vitro and the morphological changes were analyzed using optical microscopy. The model is then extended to predict spatiotemporal degradation kinetics of variational micropatterned architectures.

Influence of the composition of in-vitro azo-reducing systems on the degradation kinetics of the model compound amaranth

2002 ◽  
Vol 54 (2) ◽  
pp. 197-203 ◽  
Author(s):  
B. Maris ◽  
L. Verheyden ◽  
C. Samyn ◽  
P. Augustijns ◽  
R. Kinget ◽  
...  
Keyword(s):  
Model Compound ◽  
Degradation Kinetics ◽  
Kinetics Of

Injectable polyelectrolyte complex-nascent HAP biodegradable antibiotic delivery system for the treatment of osteomyelitis

2021 ◽  
Author(s):  
Liz Hannah George ◽  
Aswin Arakkal ◽  
Prathapan Sreedharan ◽  
G. S. Sailaja
Keyword(s):  
Polyelectrolyte Complex ◽  
Degradation Kinetics ◽  
Diffusion Method ◽  
Alizarin Red ◽  
E Coli ◽  
Macromolecular Network ◽  
Ft Ir ◽  
Kinetics Of

Abstract An injectable osteoconductive polyelectrolyte complex –hydroxyapatite formulation capable of controlled delivery of ciprofloxacin has been developed from a novel biodegradable polyelectrolyte complex and antibiotic loaded nascent hydroxyapatite (n-HAP) for the treatment of osteomyelitis. A single source (chitosan) derived polyelectrolytes were complexed in situ in the presence of n-HAP, pre-loaded with ciprofloxacin. The PEC- (n-HAP) nanoformulation (HPEC) was characterized by FT-IR, XRD, TGA and TEM analyses. HPEC combines functionalities of n-HAP (crystallinity and osteoconductivity) as well as PEC (biodegradable hydrophilic electrostatically bound macromolecular network) imparting better control over swelling and degradation kinetics favourable for drug release and transport of micronutrients. MTT assay and cytoskeleton staining (MG 63 cells) established cytocompatibility of HPEC. Early biomimetic mineralization of apatite was manifested under simulated physiological condition with a Ca/P of 1.23 (day 3) and 1.55 (day 6) complimented by in vitro biomineralization of MG-63 and Human Osteosarcoma (HOS) cells in a week (Alizarin Red S staining), which was further validated by calcium quantification. Antibacterial efficacy of HPEC has been evaluated by delivery kinetics of ciprofloxacin and by disc diffusion method against S. aureus and E. coli. The injectable system therefore possesses unique combination of functionalities: osteoconduction enriched with early biomineralization, antibacterial activity and is biodegradable; hence highly suitable for osteomyelitis treatment.

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