Abnormal intrinsic brain activity in individuals with peripheral vision loss because of retinitis pigmentosa using amplitude of low-frequency fluctuations

Neuroreport ◽  
2018 ◽  
Vol 29 (15) ◽  
pp. 1323-1332 ◽  
Author(s):  
Xin Huang ◽  
Fu-Qing Zhou ◽  
Han-Dong Dan ◽  
Yin Shen
Keyword(s):  
Retinitis Pigmentosa ◽  
Vision Loss ◽  
Peripheral Vision ◽  
Brain Activity ◽  
Low Frequency ◽  
Frequency Fluctuations ◽  
Intrinsic Brain Activity

Comparison of intrinsic brain activity in individuals with low/moderate myopia versus high myopia revealed by the amplitude of low-frequency fluctuations

2019 ◽  
Vol 61 (4) ◽  
pp. 496-507 ◽  
Author(s):  
Yi Cheng ◽  
Xin Huang ◽  
Yu-Xiang Hu ◽  
Mu-Hua Huang ◽  
Bo Yang ◽  
...  
Keyword(s):  
White Matter ◽  
High Myopia ◽  
Brain Activity ◽  
Low Frequency ◽  
Anterior Lobe ◽  
Frequency Fluctuation ◽  
Healthy Controls ◽  
Optic Radiation ◽  
Frequency Fluctuations ◽  
Intrinsic Brain Activity

Background Previous neuroimaging studies demonstrated that individuals with high myopia are associated with abnormalities in anatomy of the brain. Purpose The purpose of this study was to explore alterations in the intrinsic brain activity by studying the amplitude of low-frequency fluctuations. Material and Methods A total of 64 myopia individuals (41 with high myopia with a refractive error <–600 diopter [D], 23 with low/moderate myopia with a refractive error between –100 and –600 D, and similarly 59 healthy controls with emmetropia closely matched for age) were recruited. The amplitude of low-frequency fluctuations method was conducted to investigate the difference of intrinsic brain activity across three groups. Results Compared with the healthy controls, individuals with low/moderate myopia showed significantly decreased amplitude of low-frequency fluctuation values in the bilateral rectal gyrus, right cerebellum anterior lobe/calcarine, and bilateral thalamus and showed significantly increased amplitude of low-frequency fluctuation values in left white matter (optic radiation), right prefrontal cortex, and left primary motor cortex (M1)/primary somatosensory cortex (S1). In addition, individuals with high myopia showed significantly decreased amplitude of low-frequency fluctuation values in the right cerebellum anterior lobe/calcarine/bilateral parahippocampal gyrus, bilateral posterior cingulate cortex, and bilateral middle cingulate cortex and significantly increased amplitude of low-frequency fluctuation values in left white matter (optic radiation), bilateral frontal parietal cortex, and left M1/S1. Moreover, we found that the amplitude of low-frequency fluctuation values of the different brain areas was closely related to the clinical features in the high myopia group. Conclusion Our results demonstrated that individuals with low/moderate myopia and high myopia had abnormal intrinsic brain activities in various brain regions related to the limbic system, default mode network, and thalamo-occipital pathway.

Assessment of cerebral low-frequency oscillations in patients with retinal vein occlusion: a preliminary functional MRI study

2019 ◽  
Vol 61 (6) ◽  
pp. 813-820 ◽  
Author(s):  
Qing Gao ◽  
Bin Peng ◽  
Xin Huang ◽  
Chen-Xing Qi ◽  
Yan Tong ◽  
...  
Keyword(s):  
Retinal Vein Occlusion ◽  
Brain Activity ◽  
Low Frequency ◽  
Frequency Fluctuation ◽  
Healthy Controls ◽  
Vein Occlusion ◽  
Lower Amplitude ◽  
Frequency Fluctuations ◽  
Middle Occipital Gyrus ◽  
Intrinsic Brain Activity

Background There is increasing evidence that patients with retinal vein occlusion exhibit cerebral vascular changes and are at an increased risk of stroke. However, it remains unknown whether patients with retinal vein occlusion exhibit changes in intrinsic brain activity. Purpose This study investigated intrinsic brain activity changes in patients with retinal vein occlusion by assessing the amplitude of low-frequency fluctuations. Material and Methods Forty-five patients with retinal vein occlusion (22 men, 23 women, mean age 56.55 ± 6.97 years) and 43 healthy controls (13 men, 30 women; mean age 53.53 ± 8.19 years) closely matched in age, sex, and education level underwent resting-state MRI scans. The amplitude of low-frequency fluctuation method was used to compare intrinsic brain activity between the two groups. Results Compared with healthy controls, patients with retinal vein occlusion exhibited significantly lower amplitude of low-frequency fluctuation values in the left middle occipital gyrus, right middle occipital gyrus, and right calcarine. However, patients with retinal vein occlusion showed significantly higher amplitude of low-frequency fluctuations in the bilateral cerebellum 6, right hippocampus, left insula, and left fusiform (voxel-level P < 0.01, Gaussian random field correction, cluster-level P < 0.05). Conclusion Our results demonstrated that patients with retinal vein occlusion showed abnormal spontaneous neural activities in the visual cortices, cerebellum, and Papez circuit, which might indicate impaired vision, cognition, and emotional function in patients with retinal vein occlusion. These findings offer important insights into the neural mechanism of retinal vein occlusion.

Abnormal Amplitude of Low-Frequency Fluctuations of Intrinsic Brain Activity in Alzheimer's Disease

2014 ◽  
Vol 40 (2) ◽  
pp. 387-397 ◽  
Author(s):  
Xuena Liu ◽  
Siqi Wang ◽  
Xinqing Zhang ◽  
Zhiqun Wang ◽  
Xiaojie Tian ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Brain Activity ◽  
Low Frequency ◽  
Frequency Fluctuations ◽  
Intrinsic Brain Activity

scholarly journals Longitudinal Spatial Patterns of Intrinsic Brain Activity and Functional Connectivity in Upper Limb Amputees Patients

2020 ◽  
Author(s):  
bingbo bao ◽  
xuyun hua ◽  
haifeng wei ◽  
pengbo luo ◽  
hongyi zhu ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Spatial Patterns ◽  
Brain Plasticity ◽  
Brain Activity ◽  
Low Frequency ◽  
Resting State Fmri ◽  
Brain Regions ◽  
Brain Network ◽  
Intrinsic Connectivity ◽  
Intrinsic Brain Activity

Abstract Background: Amputation in adults is a serious condition and most patients were associated with the remapping of representations in motor and sensory brain network. Methods: The present study includes 8 healthy volunteers and 16 patients with amputation. We use resting-state fMRI to investigate the local and extent brain plasticity in patients suffering from amputation simultaneously. Both the amplitude of low-frequency fluctuations (ALFF) and degree centrality (DC) were used for the assessment of neuroplasticity in central level. Results: We described changes in spatial patterns of intrinsic brain activity and functional connectivity in amputees in the present study and we found that not only the sensory and motor cortex, but also the related brain regions involved in the functional plasticity after upper extremity deafferentation. Conclusion: Our findings showed local and extensive cortical changes in the sensorimotor and cognitive-related brain regions, which may imply the dysfunction in not only sensory and motor function, but also sensorimotor integration and motor plan. The activation and intrinsic connectivity in the brain changed a lot showed correlation with the deafferentation status.

scholarly journals Investigation of changes in the activity and function of dry eye-associated brain regions using the amplitude of low frequency fluctuations(ALFF)method

2022 ◽  
Author(s):  
Tie Sun ◽  
Hui-Ye Shu ◽  
Jie-Li Wu ◽  
Ting Su ◽  
Yu-Ji Liu ◽  
...  
Keyword(s):  
Dry Eye ◽  
Brain Activity ◽  
Pearson Correlation ◽  
Inferior Frontal Gyrus ◽  
Low Frequency ◽  
Brain Regions ◽  
Middle Frontal Gyrus ◽  
Brain Areas ◽  
Spontaneous Brain Activity ◽  
Frequency Fluctuations

Objective: The local characteristics of spontaneous brain activity in patients with dry eye (DE) and its relationship with clinical characteristics were evaluated using the amplitude of low-frequency fluctuations (ALFF) method. Methods: A total of 27 patients with DE (10 males and 17 females) and 28 healthy controls (HCs) (10 males and 18 females) were recruited, matched according to sex, age, weight, and height, classified into the DE and HC groups, and examined using functional magnetic resonance imaging scans. Spontaneous brain activity changes were recorded using ALFF technology. Data were recorded and plotted on the receiver operating characteristic curve, reflecting changes in activity in different brain areas. Finally, Pearson correlation analysis was used to calculate the potential relationship between spontaneous brain activity abnormalities in multiple brain regions and clinical features in patients with DE. GraphPad Prism 8 (GraphPad Software, Inc.) was used to analyze the linear correlation between the Hospital Anxiety and Depression Scale and ALFF value. Results: Compared with HCs, the ALFF values of patients with DE were decreased in the right middle frontal gyrus/right inferior orbitofrontal cortex, left triangle inferior frontal gyrus, left middle frontal gyrus, and right superior frontal gyrus. In contrast, the ALFF value of patients with DE was increased in the left calcarine. Conclusion: There are significant fluctuations in the ALFF value of specific brain regions in patients with DE versus HCs. This corroborates previous evidence showing that the symptoms of ocular surface damage in patients with DE are related to dysfunction in specific brain areas.

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