Comparison of intrinsic brain activity in individuals with low/moderate myopia versus high myopia revealed by the amplitude of low-frequency fluctuations

Background Previous neuroimaging studies demonstrated that individuals with high myopia are associated with abnormalities in anatomy of the brain. Purpose The purpose of this study was to explore alterations in the intrinsic brain activity by studying the amplitude of low-frequency fluctuations. Material and Methods A total of 64 myopia individuals (41 with high myopia with a refractive error <–600 diopter [D], 23 with low/moderate myopia with a refractive error between –100 and –600 D, and similarly 59 healthy controls with emmetropia closely matched for age) were recruited. The amplitude of low-frequency fluctuations method was conducted to investigate the difference of intrinsic brain activity across three groups. Results Compared with the healthy controls, individuals with low/moderate myopia showed significantly decreased amplitude of low-frequency fluctuation values in the bilateral rectal gyrus, right cerebellum anterior lobe/calcarine, and bilateral thalamus and showed significantly increased amplitude of low-frequency fluctuation values in left white matter (optic radiation), right prefrontal cortex, and left primary motor cortex (M1)/primary somatosensory cortex (S1). In addition, individuals with high myopia showed significantly decreased amplitude of low-frequency fluctuation values in the right cerebellum anterior lobe/calcarine/bilateral parahippocampal gyrus, bilateral posterior cingulate cortex, and bilateral middle cingulate cortex and significantly increased amplitude of low-frequency fluctuation values in left white matter (optic radiation), bilateral frontal parietal cortex, and left M1/S1. Moreover, we found that the amplitude of low-frequency fluctuation values of the different brain areas was closely related to the clinical features in the high myopia group. Conclusion Our results demonstrated that individuals with low/moderate myopia and high myopia had abnormal intrinsic brain activities in various brain regions related to the limbic system, default mode network, and thalamo-occipital pathway.

Download Full-text

Assessment of cerebral low-frequency oscillations in patients with retinal vein occlusion: a preliminary functional MRI study

Acta Radiologica ◽

10.1177/0284185119879683 ◽

2019 ◽

Vol 61 (6) ◽

pp. 813-820 ◽

Cited By ~ 1

Author(s):

Qing Gao ◽

Bin Peng ◽

Xin Huang ◽

Chen-Xing Qi ◽

Yan Tong ◽

...

Keyword(s):

Retinal Vein Occlusion ◽

Brain Activity ◽

Low Frequency ◽

Frequency Fluctuation ◽

Healthy Controls ◽

Vein Occlusion ◽

Lower Amplitude ◽

Frequency Fluctuations ◽

Middle Occipital Gyrus ◽

Intrinsic Brain Activity

Background There is increasing evidence that patients with retinal vein occlusion exhibit cerebral vascular changes and are at an increased risk of stroke. However, it remains unknown whether patients with retinal vein occlusion exhibit changes in intrinsic brain activity. Purpose This study investigated intrinsic brain activity changes in patients with retinal vein occlusion by assessing the amplitude of low-frequency fluctuations. Material and Methods Forty-five patients with retinal vein occlusion (22 men, 23 women, mean age 56.55 ± 6.97 years) and 43 healthy controls (13 men, 30 women; mean age 53.53 ± 8.19 years) closely matched in age, sex, and education level underwent resting-state MRI scans. The amplitude of low-frequency fluctuation method was used to compare intrinsic brain activity between the two groups. Results Compared with healthy controls, patients with retinal vein occlusion exhibited significantly lower amplitude of low-frequency fluctuation values in the left middle occipital gyrus, right middle occipital gyrus, and right calcarine. However, patients with retinal vein occlusion showed significantly higher amplitude of low-frequency fluctuations in the bilateral cerebellum 6, right hippocampus, left insula, and left fusiform (voxel-level P < 0.01, Gaussian random field correction, cluster-level P < 0.05). Conclusion Our results demonstrated that patients with retinal vein occlusion showed abnormal spontaneous neural activities in the visual cortices, cerebellum, and Papez circuit, which might indicate impaired vision, cognition, and emotional function in patients with retinal vein occlusion. These findings offer important insights into the neural mechanism of retinal vein occlusion.

Download Full-text

Altered intrinsic brain activity in patients with familial cortical myoclonic tremor and epilepsy: An amplitude of low-frequency fluctuation study

Journal of the Neurological Sciences ◽

10.1016/j.jns.2015.03.005 ◽

2015 ◽

Vol 351 (1-2) ◽

pp. 133-139 ◽

Cited By ~ 6

Author(s):

Pu Wang ◽

Cheng Luo ◽

Li Dong ◽

Yi Bin ◽

Shi Ma ◽

...

Keyword(s):

Brain Activity ◽

Low Frequency ◽

Frequency Fluctuation ◽

Intrinsic Brain Activity

Download Full-text

White matter of perinatally HIV infected older youths shows low frequency fluctuations that may reflect glial cycling

Scientific Reports ◽

10.1038/s41598-021-82587-5 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Manoj K. Sarma ◽

Amrita Pal ◽

Margaret A. Keller ◽

Tamara Welikson ◽

Joseph Ventura ◽

...

Keyword(s):

White Matter ◽

Brain Activity ◽

Low Frequency ◽

Brain Regions ◽

Cerebral White Matter ◽

Frequency Fluctuations ◽

And Gender ◽

Latent Hiv ◽

The Right ◽

The Brain

AbstractIn perinatally HIV-infected (PHIV) children, neurodevelopment occurs in the presence of HIV-infection, and even with combination antiretroviral therapy (cART) the brain can be a reservoir for latent HIV. Consequently, patients often demonstrate long-term cognitive deficits and developmental delay, which may be reflected in altered functional brain activity. Our objective was to examine brain function in PHIV on cART by quantifying the amplitude of low frequency fluctuations (ALFF) and regional homogeneity (ReHo). Further, we studied ALFF and ReHo changes with neuropsychological performance and measures of immune health including CD4 count and viral loads in the HIV-infected youths. We found higher ALFF and ReHo in cerebral white matter in the medial orbital lobe for PHIV (N = 11, age mean ± sd = 22.5 ± 2.9 years) compared to controls (N = 16, age = 22.5 ± 3.0 years), with age and gender as co-variates. Bilateral cerebral white matter showed increased spontaneous regional activity in PHIV compared to healthy controls. No brain regions showed lower ALFF or ReHo in PHIV compared to controls. Higher log10 viral load was associated with higher ALFF and ReHo in PHIV in bilateral cerebral white matter and right cerebral white matter respectively after masking the outcomes intrinsic to the brain regions that showed significantly higher ALFF and ReHo in the PHIV compared to the control. Reductions in social cognition and abstract thinking in PHIV were correlated with higher ALFF at the left cerebral white matter in the left medial orbital gyrus and higher ReHo at the right cerebral white matter in the PHIV patients. Although neuroinflammation and associated neuro repair were not directly measured, the findings support their potential role in PHIV impacting neurodevelopment and cognition.

Download Full-text

Altered intrinsic brain activity in patients with toothaches using the amplitude of low-frequency fluctuations: a resting-state fMRI study

Neuropsychiatric Disease and Treatment ◽

10.2147/ndt.s189962 ◽

2019 ◽

Vol Volume 15 ◽

pp. 283-291 ◽

Cited By ~ 1

Author(s):

Jun Yang ◽

Bin Li ◽

Qiu-Yue Yu ◽

Lei Ye ◽

Pei-Wen Zhu ◽

...

Keyword(s):

Resting State ◽

Brain Activity ◽

Low Frequency ◽

Resting State Fmri ◽

Fmri Study ◽

Frequency Fluctuations ◽

Intrinsic Brain Activity

Download Full-text

Frequency-Dependent Amplitude Alterations of Resting-State Spontaneous Fluctuations in Late-Onset Depression

BioMed Research International ◽

10.1155/2015/505479 ◽

2015 ◽

Vol 2015 ◽

pp. 1-9 ◽

Cited By ~ 14

Author(s):

Yingying Yue ◽

Xize Jia ◽

Zhenghua Hou ◽

Yufeng Zang ◽

Yonggui Yuan

Keyword(s):

Resting State ◽

Late Onset ◽

Brain Activity ◽

Low Frequency ◽

Anterior Lobe ◽

Posterior Lobe ◽

Frequency Bands ◽

Relationship Analysis ◽

Intrinsic Brain Activity ◽

The Impact

There is limited amplitude of low-frequency fluctuation (ALFF) of resting-state functional magnetic resonance imaging (fMRI) studies in late-onset depression (LOD) but reported different results. This may be due to the impact of different frequency bands. In this study, we examined the ALFF in five different frequency bands (slow-6: 0–0.01 Hz; slow-5: 0.01–0.027 Hz; slow-4: 0.027–0.073 Hz; slow-3: 0.073–0.167 Hz, and slow-2: 0.167–0.25 Hz) within the whole brain during resting-state fMRI in 16 LOD patients and 16 normal control (NC) subjects. The ALFF of primary effect of disease was widely distributed over left cerebellum anterior lobe, left cerebellum posterior lobe, left middle orbitofrontal gyrus, left superior occipital, and right superior parietal, while the interaction effect of disease and frequency was distributed over right superior frontal gyrus. Further relationship analysis findings suggest these abnormal ALFF may relate to cognitive dysfunction of LOD. Therefore, our data show that LOD patients have widespread abnormalities in intrinsic brain activity, which is dependent on the frequency band, and suggest that future studies should take the frequency bands into account when measuring intrinsic brain activity.

Download Full-text