scholarly journals Developing a morphomics framework to optimize implant site-specific design parameters for islet macroencapsulation devices

2021 ◽  
Vol 18 (185) ◽  
Author(s):  
Barry McDermott ◽  
Scott Robinson ◽  
Sven Holcombe ◽  
Ruth E. Levey ◽  
Peter Dockery ◽  
...  
Keyword(s):  
Rectus Sheath ◽  
Cell Number ◽  
Design Parameters ◽  
Specific Design ◽  
Site Specific ◽  
Cell Dose ◽  
Posterior Rectus Sheath ◽  
Design Challenge ◽  
Transplant Site

Delivering a clinically impactful cell number is a major design challenge for cell macroencapsulation devices for Type 1 diabetes. It is important to understand the transplant site anatomy to design a device that is practical and that can achieve a sufficient cell dose. We identify the posterior rectus sheath plane as a potential implant site as it is easily accessible, can facilitate longitudinal monitoring of transplants, and can provide nutritive support for cell survival. We have investigated this space using morphomics across a representative patient cohort (642 participants) and have analysed the data in terms of gender, age and BMI. We used a shape optimization process to maximize the volume and identified that elliptical devices achieve a clinically impactful cell dose while meeting device manufacture and delivery requirements. This morphomics framework has the potential to significantly influence the design of future macroencapsulation devices to better suit the needs of patients.

scholarly journals Seismic Analysis Issues in Design Certification Applications for New Reactors

2011 ◽  
Author(s):  
Richard Morante ◽  
Manuel Miranda ◽  
Jim Xu
Keyword(s):  
Nuclear Power ◽  
Power Plants ◽  
Seismic Analysis ◽  
Nuclear Regulatory Commission ◽  
Design Parameters ◽  
Specific Design ◽  
Site Specific ◽  
Safety Issues ◽  
Standard Design ◽  
Regulatory Commission

The licensing framework established by the U.S. Nuclear Regulatory Commission under Title 10 of the Code of Federal Regulations (10 CFR) Part 52, “Licenses, Certifications, and Approvals for Nuclear Power Plants,” provides requirements for standard design certifications (DCs) and combined license (COL) applications. The intent of this process is the early resolution of safety issues at the DC application stage. Subsequent COL applications may incorporate a DC by reference. Thus, the COL review will not reconsider safety issues resolved during the DC process. However, a COL application that incorporates a DC by reference must demonstrate that relevant site-specific design parameters are within the bounds postulated by the DC, and any departures from the DC need to be justified. This paper provides an overview of several seismic analysis issues encountered during a review of recent DC applications under the 10 CFR Part 52 process, in which the authors have participated as part of the safety review effort.

scholarly journals Modified technique of extraperitoneal colostomy without incision of the posterior rectus sheath

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Tao Zhang ◽  
Daye Yang ◽  
Gongping Sun ◽  
Dewei Zhang
Keyword(s):  
Rectal Cancer ◽  
Abdominoperineal Resection ◽  
Parastomal Hernia ◽  
Retrospective Studies ◽  
Rectus Sheath ◽  
Lower Rectal Cancer ◽  
Modified Technique ◽  
Posterior Rectus Sheath ◽  
Rectal Sheath ◽  
Extraperitoneal Colostomy

AbstractExtraperitoneal colostomy is a widely used technique during abdominoperineal resection (APR) operation for lower rectal cancer. This technique has been reported to be effective to prevent the postoperative parastomal hernia in some retrospective studies, however, there is still a certain incidence of parastomal hernia. A modification of the extraperitoneal colostomy technique is described in this paper that keeps posterior rectal sheath intact instead of having a conventional incision, to further reduce the risk of parastomal hernia. Until now, this modified technique has been performed in 15 patients, no occurrence of parastomal hernia was observed.

Optimization of Solar Terrestrial Power Production Using Heat Engines

1970 ◽  
Vol 92 (2) ◽  
pp. 173-181 ◽  
Author(s):  
M. K. Selc¸uk ◽  
G. T. Ward
Keyword(s):  
Mathematical Model ◽  
Economic Performance ◽  
Storage System ◽  
Power Production ◽  
Design Parameters ◽  
Unsteady State ◽  
Labor Costs ◽  
Specific Design ◽  
Heat Engines ◽  
Power Costs

Mathematical model and computer programs have been developed for the analysis of the economic performance of a terrestrial solar power system using heat engines. Various combinations of cycle, collector, engine, storage system, and sink have been studied and the influence of design parameters on power costs examined for both the steady and unsteady state cases. Typical minimum power costs under central Australian conditions for units of 12 kw capacity at current levels of materials and labor costs range from 7 to 47 U. S. cents per kwh, according to the specific design of installation.

scholarly journals P037 TOTALLY ENDOSCOPIC SUBLAY REPAIR FOR DIASTASIS RECTI AND CONCOMITANT MIDLINE HERNIA: FIRST CASE VIDEO-REPORT

2021 ◽  
Vol 108 (Supplement_8) ◽  
Author(s):  
Camillo Leonardo Bertoglio ◽  
Lorenzo Morini ◽  
Simona Grimaldi ◽  
Pietro Carnevali ◽  
Giovanni Ferrari
Keyword(s):  
Polyvinylidene Fluoride ◽  
Rectus Sheath ◽  
Barbed Suture ◽  
Preperitoneal Space ◽  
Anterior Rectus Sheath ◽  
Linea Alba ◽  
First Case ◽  
Diastasis Recti ◽  
Posterior Rectus Sheath ◽  
Sublay Repair

Abstract Aim We describe in detail the step by step technique of the first case of TES repair at our institution. Methods We selected the case of a M2W3L3 hernia associated to xipho-umbilical diastasis recti in a young woman symptomatic for a progressively worsening back pain and local bulky sensation. Results The intervention is started directly with a suprapubic transverse incision of 2.5 cm and a circumferential, atraumatic retraction is inserted after a small incision of the anterior rectus sheath. Blunt dissection is further continued through this access by luxating the underlying rectus muscles to separate the preperitoneal space below the arcuate line. The pneumo-preperitoneum is then inducted through this port. Laparoscopic dissection allows for enlargement of the avascular space laterally and then two 5-mm trocars are placed on the bilateral aspects of rectus muscles. By means of a lap bipolar dissector the edge of posterior rectus sheath are incised from the arcuate line following the diastasis laterally up to the subxiphoid space. The Rives plane is recovered without opening of the linea alba. After reduction of the M2 hernia both the posterior sheath and the diastatic anterior fascia are sutured with a running long-resorbable 2/0 barbed suture. Polyvinylidene fluoride (PVDF) mesh fixed with the use of an hystoacrilic glue. Conclusion Minimally invasive extraperitoneal repair of small/medium hernia defects of the linea alba is gaining wide acceptance. Concomitant presence of rectum diastasis recti seems to be the ideal indication to approach the learning curve of such a technically demanding procedure

scholarly journals Impaired in vitro growth of purified (CD34+) hematopoietic progenitors in human immunodeficiency virus-1 seropositive thrombocytopenic individuals

Blood ◽  
1992 ◽  
Vol 79 (10) ◽  
pp. 2680-2687 ◽  
Author(s):  
G Zauli ◽  
MC Re ◽  
B Davis ◽  
L Sen ◽  
G Visani ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Liquid Culture ◽  
Cell Number ◽  
Hematopoietic Stem ◽  
Cd34 Cells ◽  
Immunodeficiency Virus ◽  
P24 Antigen ◽  
Hiv 1

Abstract In this report the role played by human immunodeficiency virus type-1 (HIV-1) in the pathogenesis of HIV-1-related thrombocytopenia was investigated. CD34+ hematopoietic stem/progenitor cells were purified from the bone marrow (BM) of HIV-1(+) thrombocytopenic patients, HIV- 1(+) nonthrombocytopenic individuals, HIV-1(-) patients with immune thrombocytopenic purpura, and HIV-1(-) normal donors. CD34+ cells from HIV-1(+) thrombocytopenic individuals alone showed a reduced capacity to give rise to megakaryocytic colonies (CFU-Meg) and also a progressive and significant decline in cell number when placed in liquid culture containing recombinant human interleukin-3 (rIL-3). This decline involved not only megakaryocyte but also erythroid and granulocyte/macrophage progenitors. The defects in megakaryocyte colony formation and CD34+ cell growth did not result from a productive HIV-1 infection of CD34+ cells. Moreover, HIV-1 DNA was absent from CD34+ cells in 10 of 12 thrombocytopenic patients examined. On the other hand, the decreased survival/proliferation of CD34+ cells in liquid culture, within the HIV-1(+) thrombocytopenic patients, was correlated with the presence of HIV-1 p24 antigen in BM plasma. These results demonstrate an impairment of CD34+ cells in HIV-1(+) individuals presenting thrombocytopenia as the only hematologic manifestation. Furthermore, these findings suggest that increased viral replication in the BM microenvironment may cause this impairment and possibly contributes to HIV-induced thrombocytopenia.

A Scanning X-Ray Fluorescence Microprobe with Synchrotron Radiation

1987 ◽  
Vol 31 ◽  
pp. 495-502 ◽  
Author(s):  
Y. Gohshj ◽  
S. Aoki ◽  
A. Iida ◽  
S. Hayakawa ◽  
H. Yamaji ◽  
...  
Keyword(s):  
Synchrotron Radiation ◽  
Relative Concentration ◽  
Trace Element Analysis ◽  
Design Parameters ◽  
Absolute Amount ◽  
Beam Size ◽  
Element Analysis ◽  
X Ray ◽  
Better Than

SummaryA scantling X-ray fluorescence(XRF) microprobe using WoIter type 1 optics was developed, and micro and trace element analysis was carried out using synchrotron radiation up to 10 keV as an excitation source. The design parameters of the optical system and the performance of the system, such as the beam size and the intensity, are described. The MDL obtained for Mn was 6 ppm in relative concentration and about 0.1 pg in absolute amount. The estimated spatial resolution was better than 10 um.

Elevated Levels of Serum-Soluble CD14 in Human Immunodeficiency Virus Type 1 (HIV-1) Infection: Correlation to Disease Progression and Clinical Events

Blood ◽  
1998 ◽  
Vol 92 (6) ◽  
pp. 2084-2092 ◽  
Author(s):  
Egil Lien ◽  
Pål Aukrust ◽  
Anders Sundan ◽  
Fredrik Müller ◽  
Stig S. Frøland ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Disease Progression ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Cell Number ◽  
Clinical Events ◽  
Immunodeficiency Virus ◽  
Hiv 1

Abstract Soluble (s) CD14, a marker for monocyte/macrophage activation and a mediator of bacterial lipopolysaccharide (LPS) action, was elevated in serum from human immunodeficiency virus type 1 (HIV- 1)-infected individuals (n = 92) compared with seronegative controls. The highest levels were found in patients with advanced clinical and immunological disease. Patients with ongoing clinical events had significantly higher sCD14 levels than symptomatic HIV-1-infected individuals without clinical events, with especially elevated levels in patients infected with Mycobacterium avium complex (MAC). On longitudinal testing of patients (n = 26) with less than 100 × 106CD4 lymphocytes/L at baseline, we found that increasing sCD14 serum concentrations per time unit were associated with death, whereas no differences in CD4 cell number decrease were found between survivors and nonsurvivors. In vitro studies showed that HIV-1 glycoprotein 120 and purified protein derivative (PPD) from M avium (MAC-PPD) stimulated normal monocytes to release sCD14. Furthermore, MAC-PPD induced tumor necrosis factor (TNF) release from monocytes through interactions with CD14 and, importantly, the addition of sCD14 enhanced this MAC-PPD stimulatory effect. Our findings suggest that the CD14 molecule may be involved in the immunopathogenesis of HIV-1 infection, and it is conceivable that serial determination of sCD14 may give useful predictive information concerning disease progression and survival in HIV-1-infected patients. © 1998 by The American Society of Hematology.

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