scholarly journals Within-host mathematical modelling of the incubation period of Salmonella Typhi

2019 ◽  
Vol 6 (9) ◽  
pp. 182143 ◽  
Author(s):  
Adedoyin Awofisayo-Okuyelu ◽  
Adrian Pratt ◽  
Noel McCarthy ◽  
Ian Hall
Keyword(s):  
Sensitivity Analysis ◽  
Infectious Diseases ◽  
Mathematical Models ◽  
Incubation Period ◽  
Late Phase ◽  
Experimental Studies ◽  
Systemic Infection ◽  
Salmonella Typhi ◽  
Bottle Neck ◽  
Clinical Illness

Mechanistic mathematical models are often employed to understand the dynamics of infectious diseases within a population or within a host. They provide estimates that may not be otherwise available. We have developed a within-host mathematical model in order to understand how the pathophysiology of Salmonella Typhi contributes to its incubation period. The model describes the process of infection from ingestion to the onset of clinical illness using a set of ordinary differential equations. The model was parametrized using estimated values from human and mouse experimental studies and the incubation period was estimated as 9.6 days. A sensitivity analysis was also conducted to identify the parameters that most affect the derived incubation period. The migration of bacteria to the caecal lymph node was observed as a major bottle neck for infection. The sensitivity analysis indicated the growth rate of bacteria in late phase systemic infection and the net population of bacteria in the colon as parameters that most influence the incubation period. We have shown in this study how mathematical models aid in the understanding of biological processes and can be used in estimating parameters of infectious diseases.

scholarly journals Executive Summary: 2016 Infectious Diseases Society of America (IDSA) Clinical Practice Guideline for the Treatment of Coccidioidomycosis

2016 ◽  
Vol 63 (6) ◽  
pp. 717-722 ◽  
Author(s):  
John N. Galgiani ◽  
Neil M. Ampel ◽  
Janis E. Blair ◽  
Antonino Catanzaro ◽  
Francesca Geertsma ◽  
...  
Keyword(s):  
At Risk ◽  
Infectious Diseases ◽  
Practice Guideline ◽  
Management Strategies ◽  
Systemic Infection ◽  
Western Hemisphere ◽  
Executive Summary ◽  
Valley Fever ◽  
Critical Elements ◽  
At Risk Populations

Abstract It is important to realize that guidelines cannot always account for individual variation among patients. They are not intended to supplant physician judgment with respect to particular patients or special clinical situations. Infectious Diseases Society of America considers adherence to these guidelines to be voluntary, with the ultimate determination regarding their application to be made by the physician in the light of each patient's individual circumstances. Coccidioidomycosis, also known as San Joaquin Valley fever, is a systemic infection endemic to parts of the southwestern United States and elsewhere in the Western Hemisphere. Residence in and recent travel to these areas are critical elements for the accurate recognition of patients who develop this infection. In this practice guideline, we have organized our recommendations to address actionable questions concerning the entire spectrum of clinical syndromes. These can range from initial pulmonary infection, which eventually resolves whether or not antifungal therapy is administered, to a variety of pulmonary and extrapulmonary complications. Additional recommendations address management of coccidioidomycosis occurring for special at-risk populations. Finally, preemptive management strategies are outlined in certain at-risk populations and after unintentional laboratory exposure.

scholarly journals The effects of flooding and weather conditions on leptospirosis transmission in Thailand

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Sudarat Chadsuthi ◽  
Karine Chalvet-Monfray ◽  
Anuwat Wiratsudakul ◽  
Charin Modchang
Keyword(s):  
Sensitivity Analysis ◽  
Public Education ◽  
Mathematical Models ◽  
Disease Transmission ◽  
Transmission Rate ◽  
Weather Conditions ◽  
Transmission Dynamics ◽  
Multiplication Rate ◽  
High Degree ◽  
Transmission Models

AbstractThe epidemic of leptospirosis in humans occurs annually in Thailand. In this study, we have developed mathematical models to investigate transmission dynamics between humans, animals, and a contaminated environment. We compared different leptospire transmission models involving flooding and weather conditions, shedding and multiplication rate in a contaminated environment. We found that the model in which the transmission rate depends on both flooding and temperature, best-fits the reported human data on leptospirosis in Thailand. Our results indicate that flooding strongly contributes to disease transmission, where a high degree of flooding leads to a higher number of infected individuals. Sensitivity analysis showed that the transmission rate of leptospires from a contaminated environment was the most important parameter for the total number of human cases. Our results suggest that public education should target people who work in contaminated environments to prevent Leptospira infections.

scholarly journals Enteric fever with severe pancytopenia in a four year girl

2010 ◽  
Vol 50 (180) ◽  
Author(s):  
R Pathak ◽  
A Sharma ◽  
A Khanal
Keyword(s):  
Bone Marrow ◽  
Enteric Fever ◽  
Hemophagocytic Syndrome ◽  
Systemic Infection ◽  
Salmonella Typhi ◽  
Bone Marrow Suppression ◽  
Major Health Problem ◽  
Major Health ◽  
Severe Pancytopenia ◽  
Paratyphoid Fever

Typhoid fever and paratyphoid fever (also known as enteric fever) are severe systemic illnesses caused by salmonella typhi and S. paratyphi respectively. Enteric fever is prevalent in developing countries including Nepal, where it still remains as a major health problem. There have been reports of pancytopenia with enteric fever which has been attributed to mechanisms like bone marrow suppression, infection associated hemophagocytic syndrome and disseminated intravascular coagulation. We report here a case of severe pancytopenia in enteric fever as a result of bone marrow suppression due to systemic infection. Keywords: enteric fever, pancytopenia, bone marrow suppression

scholarly journals Culture proven Salmonella typhi co-infection in a child with Dengue fever: a case report

2015 ◽  
Vol 9 (09) ◽  
pp. 1033-1035 ◽  
Author(s):  
Rangan Srinivasaraghavan ◽  
Parameswaran Narayanan ◽  
Thandapani Kanimozhi
Keyword(s):  
Risk Factors ◽  
Developing Countries ◽  
Case Report ◽  
Infectious Diseases ◽  
Typhoid Fever ◽  
Dengue Fever ◽  
Salmonella Typhi ◽  
Infectious Agents ◽  
Dengue Outbreak ◽  
Concurrent Infections

Infectious diseases are one of the major causes of morbidity and mortality in developing countries. Sometimes concurrent infections with multiple infectious agents may occur in one patient, which make the diagnosis and management a challenging task. The authors here present a case of co-infection of typhoid fever with dengue fever in a ten-year-old child and discuss the pertinent issues. The authors emphasize that the risk factors predicting the presence of such co-infections, if developed, will be immensely useful in areas where dengue outbreak occurs in the background of high transmission of endemic infections.

scholarly journals New edition of International Travel and Health book from WHO

2002 ◽  
Vol 6 (9) ◽  
Author(s):  
M Ciotti
Keyword(s):  
Infectious Diseases ◽  
Incubation Period ◽  
Health Risks ◽  
International Travel ◽  
Upward Trend ◽  
The World

International travel is undertaken by large, and ever increasing, numbers of people. More people travel longer distances and at greater speed than ever before; an upward trend that looks set to continue. Travellers are thus exposed to a variety of health risks in unfamiliar environments. Most of these risks, however, can be minimised by suitable precautions taken before, during, and after travel. Virtually any place in the world can be reached within 36 hours, less than the incubation period for most infectious diseases.

scholarly journals Pathogenesis and Treatment of Cytokine Storm Induced by Infectious Diseases

2021 ◽  
Vol 22 (23) ◽  
pp. 13009
Author(s):  
Xi-Dian Tang ◽  
Tian-Tian Ji ◽  
Jia-Rui Dong ◽  
Hao Feng ◽  
Feng-Qiang Chen ◽  
...  
Keyword(s):  
Immune System ◽  
Infectious Diseases ◽  
Targeted Therapies ◽  
Tissue Damage ◽  
Systemic Infection ◽  
Therapeutic Strategies ◽  
Targeted Treatment ◽  
Cytokine Storm ◽  
Pathophysiological Mechanisms ◽  
Circulating Cytokines

Cytokine storm is a phenomenon characterized by strong elevated circulating cytokines that most often occur after an overreactive immune system is activated by an acute systemic infection. A variety of cells participate in cytokine storm induction and progression, with profiles of cytokines released during cytokine storm varying from disease to disease. This review focuses on pathophysiological mechanisms underlying cytokine storm induction and progression induced by pathogenic invasive infectious diseases. Strategies for targeted treatment of various types of infection-induced cytokine storms are described from both host and pathogen perspectives. In summary, current studies indicate that cytokine storm-targeted therapies can effectively alleviate tissue damage while promoting the clearance of invading pathogens. Based on this premise, “multi-omics” immune system profiling should facilitate the development of more effective therapeutic strategies to alleviate cytokine storms caused by various diseases.

Calculation of the fire resistance of steel hollow structural section columns filled with plain concrete

1994 ◽  
Vol 21 (3) ◽  
pp. 382-385 ◽  
Author(s):  
T. T. Lie ◽  
D. C. Stringer
Keyword(s):  
Mathematical Models ◽  
Key Words ◽  
Fire Resistance ◽  
Experimental Studies ◽  
Plain Concrete ◽  
Building Codes ◽  
Aggregate Concrete ◽  
Parametric Studies ◽  
Hollow Structural Section ◽  
Hollow Structural Sections

Experimental studies were conducted to determine the fire resistance of circular and square hollow structural section columns filled with plain concrete. Mathematical models were developed and used to investigate the influence of important parameters that determine the fire resistance of these columns. The experimental and parametric studies provide information for the development of formulas for the calculation of the fire resistance of circular and square concentrically loaded columns filled with plain carbonate or siliceous aggregate concrete. Such formulas are suitable for incorporation into building codes. Key words: calculation, fire resistance, columns, concrete-filled, steel, hollow structural sections.

Sézary, A. et Friedmann, E. Duration of incubation in Nicolas-Favre disease. (Bull. Soc. Fr. Derm, et Syph., No. 8, 1936)

1937 ◽  
Vol 33 (7) ◽  
pp. 937-937
Keyword(s):  
Incubation Period ◽  
Experimental Studies ◽  
Point Of View ◽  
Case Histories

In recent years, the authors have observed more than 100 cases of lymphogranulomatosis. The greatest interest from the point of view of studying the duration of the incubation period in this disease deserves 11 cases, the case histories of which the authors cite in brief excerpts. In 8 cases, incubation was equal to one month, in 1 case 1 months and in 2 cases 3 months. The most probable and plausible period is 1 month. Experimental studies on animals show that they have an average incubation of 35 days. Touraine, in a debate on the authors' report, indicated that in the classical manuals and from his personal observations, the incubation period of the disease is 10-25 days.

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