scholarly journals The brain the sole centre of the human nervous system

It has been inferred by many physiologists, from experiments made on the lower animals, that portions of the human nervous system are isolated and independent of each other; but from the circumstance that in these animals the brain is only a small appendage to the rest of the nervous system, while in the human species it is the principal portion, the author takes an opposite view of the subject. In man, the grey matter, which is the source of the power of the brain, is largely agglomerated in that organ, but is only diffused in comparatively minute proportions throughout the other parts of the nervous apparatus, which, when detached from the central organ, speedily lose the power of exciting muscular contraction, because that power is derived exclusively from the brain, and only such a portion is retained in the grey matter of the spinal cord and the ganglia of the sympathetic as is requisite for the immediate actions of the parts which they supply with nerves. The opinions of Galen, of William,, and of the more recent physiologists, Louget, Muller, Duges, Carus, Pinel, Foville, Flourens, Cruveillier, are cited at some length in corroboration of the views of the author, and in opposition to those of Bichat, and others of the older physiologists, together with those of Sir C. Bell, Mr. Grainger, Dr. M. Hall, Kolliker, Stilling, and others, and tending also to disprove the excito-motory theory of Dr. M. Hall, as regards its applicability to medical practice. Quotations to the same effect are given from Valentin, Volkmann, Fauvel, Mery, Cabanis, and Legallois; and reference is likewise made to pathological illustra­tions, and to the instances of anencephalous infants, as leading to the following deductions :— 1. In man and the higher mammalia, the brain is the sole centre of the nervous system and the source of its power.

1815 ◽  
Vol 105 ◽  
pp. 65-90 ◽  

The following experiments were begun with a view to as­ certain the manner in which certain poisons act in destroying life. I soon found that, in order to make any considerable progress in such an inquiry, it is necessary to ascertain how far the powers of the nervous and sanguiferous systems di­rectly depend on each other. There seems never to have been any difference of opinion respecting the direct depend­ence of the nervous on the sanguiferous system. When the powers of circulation are increased or diminished, the nervous system always suffers a corresponding change, nor can the latter, under any circumstances, continue to perform its functions after the former are destroyed. I speak of the warm blooded animals. In cold blooded animals the process of dying is so slow, that the functions of the nervous system abate very gradually, after the circulation has wholly ceased. The converse of the above proposition is by no means so generally admitted. It is evident that certain changes of the nervous, produce corresponding changes in the sanguiferous, system ; yet, while some assert, that the action of the heart depends as immediately on the brain, as that of the latter does on the heart, others maintain, that the nervous power may be wholly destroyed without impairing the vigour of this organ. This point it is necessary to determine, before we can trace with precision the modus operandi of poisons. The following inquiry therefore may be divided into two parts. In the first, I shall endeavour to ascertain how far the power of the heart is influenced by the state of the nervous system; in the other, by what steps certain poisons destroy the powers of both. This I shall reserve for another paper, and here confine my­self to the first part of the subject. Till the time of Haller, it seems to have been the general opinion, that the muscles derive their power from the nervous system. He taught, that the power of the muscles depends on their mechanism, that the nervous influence is merely a stimulus which calls it into action, and consequently that those muscles, the heart for example, which act only by the appli­cation of one peculiar stimulus, unconnected with the nervous system, are wholly independent of it. This opinion seemed confirmed by its being generally admitted, that the action of the heart continues after it is removed from the body, and that it cannot be influenced by stimulating the brain, or spinal marrow, or the nerves which terminate in it. Haller and his followers maintain, that there are two distinct vital powers, one of the nervous and another of the sanguiferous system.


1814 ◽  
Vol 104 ◽  
pp. 102-106 ◽  

In a paper formerly communicated to this Society by Sir Everard Home, and since published in the Philosophical Transactions for the year 1809, some facts were stated which render it probable that the various animal secretions are dependent on the influence of the nervous system, and this opinion seemed to derive support from some physiological experiments which were afterwards instituted by myself, and in which it was observed, that after the functions of the brain had been destroyed, although the action of the heart continued, and the circulation of the blood was maintained as under ordinary circumstances, the secreting organs invariably ceased to perform their office. It has been attempted by former physiologists to determine how far the nerves are necessary to secretion, but there are considerable obstacles in the way of this inquiry, and no observations, that have been hitherto made, appear to throw a great deal of light on the subject. The only method, which can be devised, of ascertaining by direct experiment, whether the nerves are really necessary to secretion, is that of dividing the nervous branches by which the glands are supplied. But this, with respect to the greater number of the glands, is an experiment impossible to perform; and, with respect to others, can not be executed without so much disturbance and injury to the other parts, as must render it extremely difficult to arrive at any positive results. Perhaps in future investigations, some circumstances may arise, which will enable us to determine more satisfactorily this important physiological question. In the mean time, as the labours of physiologists have hitherto contributed so little to this purpose, any facts that tend to its elucidation may deserve to be recorded, and I am therefore induced to lay before the Society the following experiments, which afford one example of a secretion being dependent on the influence of the nerves.


1868 ◽  
Vol 158 ◽  
pp. 263-331 ◽  

Before I begin to describe the parts which form the subject of this communication, and to show how some of them are merely modified portions or developments of others that belong to the medulla oblongata , it will be advisable to recur to those morphological changes in the medulla, which I formerly pointed out as themselves arising from modifications of the spinal cord . And while in unravelling structures so extremely complex, such a course seems almost necessary to facilitate their comprehension, and convey to the reader a just notion of their morphological changes, in relation on the one hand, to the remaining parts of the encephalon, and on the other hand, to the spinal cord, it will afford me an opportunity of adding to this recapitulation some new facts that have been elicited by subsequent observation and a more extended experience. It is gratifying to know that many of the results of my previous researches have been found to throw considerable light on certain diseases of the nervous system, especially on some forms of paralysis; and my own pathological investigations, as well as a close study of nervous disorders, have not only enabled me to shape my present researches as much as possible in accordance with the requirements of the pathologist, but, by pointing to the probability of certain anatomical connexions suggested by morbid symptoms, they have sometimes been the means of directing the course of my dissections in a very peculiar way.


Development ◽  
1964 ◽  
Vol 12 (2) ◽  
pp. 317-331
Author(s):  
D. O. E. Gebhardt ◽  
P. D. Nieuwkoop

The influence of lithium on the amphibian egg has been the subject of a number of investigations. From the work of Lehmann (1937), Töndury (1938), and Pasteels (1945) it is known that exposure of amphibian embryos to lithium results in a progressive cranio-caudal reduction of the central nervous system and a simultaneous conversion of the presumptive notochord into somites. Whereas these experiments were made with whole embryos, attempts have been made in recent years to localize the lithium effect by transplanting or explanting specific parts of the embryo. Gallera (1949), for instance, concluded from his experiments with transplants containing lithium treated presumptive chorda mesoderm, that lithium had reduced the ‘morphogenetic potential’ of this inductor. Lombard (1952), on the other hand, claimed that the susceptibility of amphibian eggs towards lithium was the result of the ion's direct influence on the ectoderm rather than on the presumptive archenteron roof.


Author(s):  
Karl Zilles ◽  
Nicola Palomero-Gallagher

The pre- and post-natal development of the human nervous system is briefly described, with special emphasis on the brain, particularly the cerebral and cerebellar cortices. The central nervous system originates from a specialized region of the ectoderm—the neural plate—which develops into the neural tube. The rostral part of the neural tube forms the adult brain, whereas the caudal part (behind the fifth somite) differentiates into the spinal cord. The embryonic brain has three vesicular enlargements: the forebrain, the midbrain, and the hindbrain. The histogenesis of the spinal cord, hindbrain, cerebellum, and cerebral cortex, including myelination, is discussed. The chapter closes with a description of the development of the hemispheric shape and the formation of gyri.


1895 ◽  
Vol 41 (175) ◽  
pp. 622-635
Author(s):  
W. F. Robertson

There is at the present time great need of more complete and definite knowledge as to the pathology of the very marked structural changes that so commonly affect the pia-arachnoid in the insane. The subject is one of much importance to all of us as medical psychologists, for not only is the condition in question one of the most conspicuous lesions associated with mental disease, but it implicates a structure of primary importance in the economy of the central nervous system. It is by way of vessels that course through this membrane that nutriment is conveyed to the brain cortex, and the waste products resulting from metabolism in the cerebral tissues are mainly conveyed away in the fluid that circulates in its lymph spaces. Therefore it is evident that these morbid changes may very seriously interfere with the functions both of nutrition and excretion in the brain.


The intention of the author in the present paper, is, not to bring forwards any new facts, but to take a general review of the inferences deducible from the series of facts detailed by him in previous papers communicated to this Society. He divides the nerves into two classes, essentially differing in their functions. The first comprehends those nerves, which, proceeding directly from the brain and spinal cord to other parts, convey in the one case to those parts the influence of those organs only from which they originate, and thus excite to con­traction the muscles of voluntary motion ; and in the other case transmit to the sensorium impressions made on the parts to which they are distributed. The second class comprises what may betermed the Ganglionic nerves, or those which enter ganglions, pro­perly so called; that term being limited to such protuberances only as receive branches of nerves proceeding from the brain and spiral cord. These nerves are distributed more especially to the vital or­ gans, as the thoracic and abdominal viscera, and to the muscles sub­servient to their functions. The nerves belonging to this class also convey impressions to the sensorium, and occasionally excite the muscles of involuntary motion, which, in common with all muscles, possess an inherent power of contractility dependent solely on their own mechanism, and which in ordinary cases are excited by stimuli peculiar to themselves. But the most important function of the gan­glionic nerves, is that of supporting the processes of secretion and assimilation, which require for their performance the combined influ­ence of the whole brain and spinal cord. Viewed as a whole, the system of ganglionic nerves, therefore, constitutes, in the strictest sense, a vital organ. Thus the sensorium, though connected by means of the cerebral and spinal nerves only partially with the organs of sense and voluntary motion, is, by means of the ganglionic nerves, connected generally with all the functions of the animal body. Hence affections of the stomach and other vital organs extend their influence over every part of the frame; while those of a muscle of voluntary motion, or even of an organ of sense, although possessing greater sensibility, are confined to the injured part. From a due consideration of the phenomena of the nervous system, it would appear that they imply the operation of more than one prin­ciple of action. The sensorial power is wholly distinct from the ner­vous power; the former residing chiefly in the brain, while the latter belongs equally to the spinal cord and brain, and may be exercised independently of the sensorial power. In like manner, the muscular power resides in the muscles, and may be called into action by various irritations independently of the nervous power, though fre­quently excited by the action of that power. The muscles of volun­tary motion are subjected to the sensorial power through the inter­vention of the nervous system; and those of involuntary motion are also, under certain circumstances, capable of being excited through the nerves by the sensorial power, particularly when under the influ­ence of the passions. The same observation applies also to other actions which properly belong to the nervous power, such as the evolution of caloric from the blood, and the various processes of se­cretion and of assimilation. That the nervous power is in these instances merely the agent of other powers, and is independent of the peculiar organization of the nerves, is proved by the same effects being produced by galvanism, transmitted through conductors diffe­rent from the nerves. The successive subordination of these several powers is shown during death, when the sensorial functions are the first to cease, and the animal no longer feels or wills, but yet the nervous power still continues to exist, as is proved by the nerves be­ing capable, when stimulated, of exciting contractions in the muscles, both of voluntary and of involuntary motion,of producing the evolution of caloric and of renewing the processes of secretion. In like manner the power of contraction, inherent in the muscular fibre, survives the destniction of both the sensorial and nervous powers, having an existence independent of either, although in the entire state of the functions they are subjected to the entire influence of both.


1953 ◽  
Vol 99 (417) ◽  
pp. 689-697 ◽  
Author(s):  
Noel Alder

Corpora amylacea (C.A.) or amyloid bodies found in the brain and the product of amyloid degeneration in other organs derive their name from the starch-like reaction which they give with iodine (Virchow); otherwise these substances have few points in common, and while amyloid disease has become fairly rare nowadays, the presence of C.A. constitutes one of the regular changes in senile and senescent brains. This is perhaps why it has attracted much less attention than amyloid degeneration. For instance in 18 out of 25 papers, containing detailed accounts of the histo-pathological pictures, I found no references to C.A., yet one could hardly assume that amyloid bodies were overlooked. Most text-books pay scanty attention to the subject, while Buzzard and Greenfield (1921) consider it of no pathological significance. Since, however, C.A. are encountered under a variety of conditions (not merely senility), in greatly varying amounts and at different sites in the central nervous system, it may be worth while to investigate their nature, origin and occurrence in the light of recent observation.


2020 ◽  
Vol 57 (3) ◽  
pp. 288-292
Author(s):  
K. Taira ◽  
M. Takechi ◽  
H. K. Ooi

SummaryMigration of Baylisascaris potosis larvae in different mouse strains were compared, and infectivity of the persisting larvae in mice tissues were investigated. Five strains of mice, BALB/c, C57BL/6, AKR, B10.BR, and ICR were inoculated with 1,000 B. potosis eggs/mouse, and necropsied at week 13 post inoculation (PI). The other uninfected ICR mice (secondary host) were inoculated with 43 larvae/ mouse recovered from mice at week 13 PI with eggs, and necropsied at day 21 PI. Larvae in organs or tissues were counted at necropsy. One AKR mouse showed torticollis and circling at day 56 PI. At necropsy at week 13 PI, larvae were recovered from all mice. A mean total larvae recovered were 124.1 (n=40). Majority of larvae were found in the carcass (mean 113.9) and some in the viscera (mean 9.9). Zero to 1 larva were found in the brain or eyes of some mice. There were no differences among the mouse strains in the number of larvae, except in the viscera; more larvae were seen in BALB/c or ICR than in B10.BR mice. No larvae were found in the secondary host mice. Present study demonstrated that B. potosis larvae migrate well in the carcass of any strains of mice, however, the tissue larvae did not infect the secondary host. Results of our present study suggest that B. potosis larvae is less aggressive for the nervous tissue migration than that of B. procyonis larvae which is commonly known to migrate in central nervous system of mammals and birds.


1859 ◽  
Vol 5 (28) ◽  
pp. 286-289
Author(s):  
Reicharz ◽  
Edward Palmer

la describing the relative sizes of unequal pupils in the diseases of the central organ of the nervous system (as in incomplete general paralysis) most observers make special mention of the dilated pupil, and, under precisely similar essential conditions, we more frequently find one pupil characterised as being larger than the other, than the converse. Were there no prejudice at the bottom of this custom, there might be nothing to advance against it; but I believe that the views on which it is founded, are, more or less, conjectural. It is apparently assumed, in the first place, that inequality of the pupils is always caused by lesion of one iris only; that dilatation of the pupil is more truly and more frequently a morbid condition, than contraction; and, finally, that dilatation is always dependent on relaxation, resulting from paralysis. The iris, with the dilatated pupil is, thus, more often pointed out as being affected, and that with paralysis, than the one in which the pupil is contracted; and we find, moreover, that it is quite usual to adduce, not perhaps, mere inequality, but dilatation of the pupils generally, as an absolute sign and example of paralysis of single muscles.


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