THE EXISTENCE OF TRADITIONAL LAW REVIEWING FROM PANCASILA VALUES IN THE DEVELOPMENT OF NATIONAL LAW

The purpose of this study is to examine the existence of customary law in terms of Pancasila values in the development of national law and what factors influence the existence of customary law in terms of Pancasila values in the development of national law. The research method used is normative juridical. The Indonesian people have succeeded in carrying out legal reforms to the constitution. Legal reform must continue with the formation and renewal of laws replacing Dutch legacy laws. Having its own laws for the Indonesian people can reveal national identity. Legal development simply implies efforts to make improvements from unfavorable conditions to better ones. According to this understanding, development can be meaningful with renewal. Reform is an effort to reorient and reform something that will be pursued through policy. The development of national law is the process of building a legal system and its instruments. The development of national law must be able to replace all Dutch Colonial product laws replaced with their own product laws. Legal development cannot be separated from legal politics, because it is a direction in making and enforcing laws in order to achieve national goals and objectives. Law as mentioned in the Oxford English Dictionary is a collection of rules either as a result of formal legislation or custom, in which a certain state or society claims to be bound as members or as subjects. Law is a behavioral control system (ethical control). The legal form is a norm which is the product of a center of power that has the authority to create and apply the law. Law as a unidirectional control system carried out by a central organ that has power. Unidirectional control implies that control only takes place from a certain organ that is given the capacity and function for it. Unidirectional control is also automatic-mechanical that guides behavior.

УЛЬТРАСТРУКТУРНІ ОСОБЛИВОСТІ НЕЙРО-ГЛІАЛЬНО-КАПІЛЯРНИХ ВІДНОСИН СА3 ПОЛЯ ГІПОКАМПА ЧЕРЕЗ 21 ДОБУ ЗА УМОВ ЕКСПЕРИМЕНТАЛЬНОЇ ТЕРМІЧНОЇ ТРАВМИ

Severe thermal injury leads to a number of morphofunctional changes that occur in violation of integrity or loss of skin in deep burns and endogenous intoxication on the background of which significant structural and metabolic disorders in all organs and systems of the affected organism are developed. This is manifested in a complicated symptom complex of burn disease. Changes in the central nervous system play an important role in the pathogenesis of burn injury, the nature and depth of morphofunctional changes in individual cerebral structures, in particular in the hippocampus (central organ of the limbic system, which is especially sensitive to various pathogens), after thermal lesions remain poorly studied. The aim of our study was to establish the features of submicroscopic changes in the structural components of the hippocampus after 21 days under conditions of experimental thermal injury. The experimental study was performed on white laboratory male rats. Third-degree burns were applied under thiopental-sodium anesthesia with copper plates heated in boiled water to a temperature of 97–100°C. The size of the affected area was 18–20% of the rats’ body epilated surface. Histological changes were studied on the 21st day from the beginning of the experiment. For electron microscopy, the obtained ultrathin sections were contrasted with uranyl acetate and lead citrate according to the Reynolds method. It was found that on the 21st day after the experimental thermal injury significant alternative changes in neurons, glial cells and the microcirculatory tract of the hippocampus were defined which developed on the background of excessive endogenous intoxication. Neurons are hypochromic and sharply hyperchromic, disorganized and have an altered shape; there are cell-free areas. Endoplasmic reticulum, Golgi complex, mitochondria are destructively changed. Degeneration of macroglial cells has been noticed. Their nuclei are high in electron density in which heterochromatin predominates. Destruction and lysis of organelles, lysosomes have also been found in the cytoplasm. These changes of astrocytic glia lead to impaired trophic function and the relation between astrocytes and blood capillaries. Hemocapillaries wall remodeling is manifested by the total edema, compaction of the basement membrane. The lumenal surface of the plasmolemma of endothelial cells is homogeneous, indistinctly contoured. The cytoplasm of endothelial cells is swollen, enlightened, and poor in organelles; there is a small number of micropinocytic bubbles and vesicles.

Characteristics of hematopoiesis in primary and recurrent ovarian cancer

Introduction. An important aspect of cancer treatment today is the concept of immuno-targeted therapy, which requires a deep understanding of the characteristics of immune reactions in the body of a cancer patient. Bone marrow is the central organ of immunopoiesis, therefore, along with the study of tumor characteristics, attention is paid to the bone marrow. The study of the cellular composition of the bone marrow in some types of cancer revealed a number of features of hematopoiesis, which requires further deeper analysis.Purpose. To study the parameters of hematopoiesis in patients with primary and recurrent ovarian cancer.Materials and methods. The paper presents data from 68 patients with a verified diagnosis of primary (n = 43) and recurrent (n = 25) ovarian cancer. The study was dominated by serous adenocarcinoma of high grade. Stage I was established in 13.2 % of cases, II – in 5.9 %, III – in 60.3 %, IV – in 20.6 %. The bone marrow was harvested by puncture of the posterior iliac spine (spina iliaca posterior superior). Parameter assessment and myelogram calculation were performed by two physicians, morphologists. The content of myelokaryocytes, indicators of granulocyte, erythroid lineage, the content of lymphocytes, monocytes were analyzed, and myelogram indices were assessed. In all patients microscopy of bone marrow samples excluded metastatic lesions. Statistical data processing was performed using the SPSS Statistics v. 21 package.Results. The analysis of bone marrow samples from patients with ovarian cancer revealed differences with the norm for both primary and recurrent ovarian cancer. Most punctates were normocellular, but average myelokaryocyte count in both groups was below normal. With recurrent ovarian cancer, a reduced content of promyelocytes and metamyelocytes was noted, whereas with primary cancer, all young forms of neutrophils was below normal. An increase in segmented neutrophils without a change in the percentage of cells of the granulocytic lineage was observed in primary ovarian cancer, and in one third of the samples of bone marrow an increased number lymphocytes and monocytes were noted. With recurrent ovarian cancer lymphocytes were increased in 2/3 of samples, monocyte – in 48 %. A change in the proportion of cells of the erythroid lineage was observed in both recurrent and primary cancers: depletion of the pool of basophilic normoblasts and polychromatophils with an unchanged number of erythrokaryocytes, an increase in oxyphilic forms were noted.Conclusion. The revealed changes in hematopoiesis in ovarian cancer reflect the aggressive course of high-grade tumors, which can be considered as a result of the systemic influence of the tumor, and the obtained data can serve as the basis for a detailed immunophenotypic study of bone marrow in ovarian cancer.

Cholesterol-Induced M4-Like Macrophages Recruit Neutrophils and Induce NETosis

The liver is the central organ for cholesterol synthesis and homeostasis. The effects of dietary cholesterol on hepatic injury, mainly of oxidized low-density lipoproteins (OxLDL), are not fully understood. Here, we show that the degree of cholesterol oxidation had different impacts on the global gene expression of human M2-like macrophages, with highly oxidized LDL causing the most dramatic changes. M2-like macrophages and Kupffer cells undergo M4-like polarization, decreasing the expression of important markers, such as IL10, MRC1, and CD163. These cells also displayed functional changes, with reduced phagocytic capacity, increased neutrophil recruitment, and more effective neutrophil extracellular traps (NETs) induction. Our findings provide a link between LDL oxidation and modification of peripheral and liver macrophage function.

Age Wise Internal Morphometrical Studies on the Heart of Pre-natal Non-descript Sheep

Background: Heart is the central organ of circulatory system that pumps blood into the blood vessels and performs many vital functions. Its development before birth must be studied to safeguard the animal from the occurrence and consequences of various developmental anomalies. The detailed morphometry of different internal parameters of heart especially in pre-natal sheep has not yet been reported. Methods: The foeti of sheep were divided into two age groups viz. mid prenatal (51-100 days) and late prenatal (101 to 150 days) with fifteen animals in each age group. The various internal parameters were recorded by using digital weighing machine, graduated measuring cylinder, digital Vernier’s calliper, non-stretchable nylon thread and graduated scale. The data recorded was statistically analysed by independent t test with IBM SPSS 25.0 version software. Result: The average thickness of left ventricular wall of heart was measured as 2.85±0.15mm and 4.28±0.07mm in mid prenatal and late prenatal stages respectively with significant (p£0.01) differences between the ages. Similarly, the average diameter of left atrio-ventricular opening of heart was measured as 2.06±0.27mm and 6.08±0.36mm in mid prenatal and late prenatal stages respectively with significant (p£0.01) differences between the ages. The average length of septal papillary muscle in right ventricle was measured as 1.12±0.10mm and 3.29±0.21mm in mid prenatal and late prenatal stages respectively with significant (p£0.01) differences between the ages. Further, the average length of moderator band in heart was measured as 1.45±0.11mm and 4.34±0.23mm in mid prenatal and late prenatal stages respectively with significant (p£0.01) differences between the ages. Similarly, the average length of chordae tendinae in right ventricle of heart was measured as 0.97±0.09mm and 3.50±0.34mm in mid prenatal and late prenatal stages respectively with significant (p£0.01) differences between the ages.

Copper Toxicity Is Not Just Oxidative Damage: Zinc Systems and Insight from Wilson Disease

Essential metals such as copper (Cu) and zinc (Zn) are important cofactors in diverse cellular processes, while metal imbalance may impact or be altered by disease state. Cu is essential for aerobic life with significant functions in oxidation-reduction catalysis. This redox reactivity requires precise intracellular handling and molecular-to-organismal levels of homeostatic control. As the central organ of Cu homeostasis in vertebrates, the liver has long been associated with Cu storage disorders including Wilson Disease (WD) (heritable human Cu toxicosis), Idiopathic Copper Toxicosis and Endemic Tyrolean Infantile Cirrhosis. Cu imbalance is also associated with chronic liver diseases that arise from hepatitis viral infection or other liver injury. The labile redox characteristic of Cu is often discussed as a primary mechanism of Cu toxicity. However, work emerging largely from the study of WD models suggests that Cu toxicity may have specific biochemical consequences that are not directly attributable to redox activity. This work reviews Cu toxicity with a focus on the liver and proposes that Cu accumulation specifically impacts Zn-dependent processes. The prospect that Cu toxicity has specific biochemical impacts that are not entirely attributable to redox may promote further inquiry into Cu toxicity in WD and other Cu-associated disorders.

The Torpid State: Recent Advances in Metabolic Adaptations and Protective Mechanisms†

Torpor and hibernation are powerful strategies enabling animals to survive periods of low resource availability. The state of torpor results from an active and drastic reduction of an individual’s metabolic rate (MR) associated with a relatively pronounced decrease in body temperature. To date, several forms of torpor have been described in all three mammalian subclasses, i.e., monotremes, marsupials, and placentals, as well as in a few avian orders. This review highlights some of the characteristics, from the whole organism down to cellular and molecular aspects, associated with the torpor phenotype. The first part of this review focuses on the specific metabolic adaptations of torpor, as it is used by many species from temperate zones. This notably includes the endocrine changes involved in fat- and food-storing hibernating species, explaining biomedical implications of MR depression. We further compare adaptive mechanisms occurring in opportunistic vs. seasonal heterotherms, such as tropical and sub-tropical species. Such comparisons bring new insights into the metabolic origins of hibernation among tropical species, including resistance mechanisms to oxidative stress. The second section of this review emphasizes the mechanisms enabling heterotherms to protect their key organs against potential threats, such as reactive oxygen species, associated with the torpid state. We notably address the mechanisms of cellular rehabilitation and protection during torpor and hibernation, with an emphasis on the brain, a central organ requiring protection during torpor and recovery. Also, a special focus is given to the role of an ubiquitous and readily-diffusing molecule, hydrogen sulfide (H2S), in protecting against ischemia-reperfusion damage in various organs over the torpor-arousal cycle and during the torpid state. We conclude that (i) the flexibility of torpor use as an adaptive strategy enables different heterothermic species to substantially suppress their energy needs during periods of severely reduced food availability, (ii) the torpor phenotype implies marked metabolic adaptations from the whole organism down to cellular and molecular levels, and (iii) the torpid state is associated with highly efficient rehabilitation and protective mechanisms ensuring the continuity of proper bodily functions. Comparison of mechanisms in monotremes and marsupials is warranted for understanding the origin and evolution of mammalian torpor.

Mechanisms of Reciprocal Regulation of Gonadotropin-Releasing Hormone (GnRH)-Producing and Immune Systems: The Role of GnRH, Cytokines and Their Receptors in Early Ontogenesis in Normal and Pathological Conditions

Different aspects of the reciprocal regulatory influence on the development of gonadotropin-releasing hormone (GnRH)-producing- and immune systems in the perinatal ontogenesis and their functioning in adults in normal and pathological conditions are discussed. The influence of GnRH on the development of the immune system, on the one hand, and the influence of proinflammatory cytokines on the development of the hypothalamic-pituitary-gonadal system, on the other hand, and their functioning in adult offspring are analyzed. We have focused on the effects of GnRH on the formation and functional activity of the thymus, as the central organ of the immune system, in the perinatal period. The main mechanisms of reciprocal regulation of these systems are discussed. The reproductive health of an individual is programmed by the establishment and development of physiological systems during critical periods. Regulatory epigenetic mechanisms of development are not strictly genetically controlled. These processes are characterized by a high sensitivity to various regulatory factors, which provides possible corrections for disorders.

Sollicitudo omnium ecclesiarum: Kepedulian Dan Kerjasama Gerejawi Untuk Tanah Misi Dan Di Tanah Misi

The concern to the situation and condition to all other members of the Church and the collaboration for the welfare of the entire Church is the expression of communio (communion) which is the character of Christ Church. The arise of Church in the mission land and its development which like the mustard seed is the fruit of the concern and collaboration of the missionaries showed by the community and Church which have been founded along the history. Considering Church resources are always limited, every form of across continents concern and collaboration should be done effectively. In the process of the evangelization in the mission land, these concern and collaboration encounter various forms of initiatives; starting from the simple, spontaneous, sporadic and individual to the consistent, coordinated organizations. These concern and collaboration often find frictions, conflicts of interest, impartialities, and injustice; especially concerning the implementation of the power of jurisdiction in the mission land and the submission to the superiority of the mission leaders. The negative excesses are seen and observed objectively and corrected to attain the more effective concerns and collaboration for the sake of the development of the mission work. The apostolic see is the central organ has explored and successfully founded an effective and sustainable missionary collaboration system, from the commissio to the mandate system. Nowadays, the missionary concern and collaboration across particular churches have not been centralized, but assigned to each local communities and particular Churches, to develop mutual collaboration according to the mutual need and projects through the written agreement to mutual minister

ArchbotLit—the archaeobotanical literature database: an update of the search engine for literature on archaeological remains of cultivated plants since 1981

The online Archaeobotanical Literature Database (ArchbotLit) is an important tool for getting targeted access to archaeobotanical publications. It offers the opportunity for archaeobotanists, archaeologists, freelancers, students and an interested public to easily obtain information about cultivated plants and their development. In addition it increases the visibility of archaeobotanical studies beyond the inner circle and supports teaching in environmental archaeology. The ArchbotLit database builds upon the efforts of Jürgen Schultze-Motel, Gatersleben, and Helmut Kroll, Kiel, who have collected offprints of papers from archaeobotanists worldwide since the 1980s. The content was transferred into referenced plant lists that were published annually from 1992 to 2001 in the central organ of the “International Workgroup for Palaeoethnobotany (IWGP)”, the journal “Vegetation History and Archaeobotany” and as contributions entitled “Literature on archaeological remains of cultivated plants”. These were succeeded by the online database “archaeobotany.de”, comprising the literature from 1981 to 2004. To sustain this online-database in the public domain it was recently converted into the wiki-platform “ArchbotLit”, hosted at Kiel University. Here, we introduce the new wiki-online-database and its functionalities for data upload and as a search engine.